{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T02:52:36Z","timestamp":1774493556324,"version":"3.50.1"},"reference-count":64,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytokine"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.cyto.2024.156801","type":"journal-article","created":{"date-parts":[[2024,11,10]],"date-time":"2024-11-10T18:03:37Z","timestamp":1731261817000},"page":"156801","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["The cGAS-STING pathway as a novel therapeutic strategy for pancreatic diseases"],"prefix":"10.1016","volume":"184","author":[{"given":"Zhengda","family":"Pei","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengxiang","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.cyto.2024.156801_b0005","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1038\/s41588-019-0350-x","article-title":"Causal relationships among the gut microbiome, short-chain fatty acids and metabolic diseases","volume":"51","author":"Sanna","year":"2019","journal-title":"Nat. Genet."},{"issue":"10","key":"10.1016\/j.cyto.2024.156801_b0010","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1038\/ni.3558","article-title":"Regulation and function of the cgas-sting pathway of cytosolic DNA sensing","volume":"17","author":"Chen","year":"2016","journal-title":"Nat. Immunol."},{"issue":"12","key":"10.1016\/j.cyto.2024.156801_b0015","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1038\/s41423-023-01086-x","article-title":"Mitochondrial DNA-triggered innate immune response: Mechanisms and diseases","volume":"20","author":"Hu","year":"2023","journal-title":"Cell. Mol. Immunol."},{"issue":"4","key":"10.1016\/j.cyto.2024.156801_b0020","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.molcel.2022.12.034","article-title":"Cytosolic DNA sensing by cgas\/sting promotes trpv2-mediated ca(2+) release to protect stressed replication forks","volume":"83","author":"Li","year":"2023","journal-title":"Mol. Cell"},{"issue":"4","key":"10.1016\/j.cyto.2024.156801_b0025","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1001\/jama.2020.20317","article-title":"Acute pancreatitis: A review","volume":"325","author":"Mederos","year":"2021","journal-title":"J. Am. Med. Assoc."},{"issue":"10252","key":"10.1016\/j.cyto.2024.156801_b0030","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/S0140-6736(20)31310-6","article-title":"Acute pancreatitis","volume":"396","author":"Boxhoorn","year":"2020","journal-title":"Lancet"},{"issue":"10249","key":"10.1016\/j.cyto.2024.156801_b0035","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/S0140-6736(20)31318-0","article-title":"Chronic pancreatitis","volume":"396","author":"Beyer","year":"2020","journal-title":"Lancet"},{"issue":"9","key":"10.1016\/j.cyto.2024.156801_b0040","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1056\/NEJMcp1809396","article-title":"Chronic pancreatitis","volume":"386","author":"Vege","year":"2022","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cyto.2024.156801_b0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.canlet.2021.06.027","article-title":"Advances in the epidemiology of pancreatic cancer: Trends, risk factors, screening, and prognosis","volume":"520","author":"Cai","year":"2021","journal-title":"Cancer Lett."},{"issue":"5","key":"10.1016\/j.cyto.2024.156801_b0050","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1053\/j.gastro.2023.02.012","article-title":"Pancreatic cancer: Changing epidemiology and new approaches to risk assessment, early detection, and prevention","volume":"164","author":"Stoffel","year":"2023","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.cyto.2024.156801_b0055","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.immuni.2020.05.013","article-title":"Structures and mechanisms in the cgas-sting innate immunity pathway","volume":"53","author":"Zhang","year":"2020","journal-title":"Immunity"},{"issue":"6403","key":"10.1016\/j.cyto.2024.156801_b0060","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1126\/science.aat1022","article-title":"DNA-induced liquid phase condensation of cgas activates innate immune signaling","volume":"361","author":"Du","year":"2018","journal-title":"Science"},{"issue":"7874","key":"10.1016\/j.cyto.2024.156801_b0065","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/s41586-021-03743-5","article-title":"Cgas-like receptors sense rna and control 3'2'-cgamp signalling in drosophila","volume":"597","author":"Slavik","year":"2021","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.cyto.2024.156801_b0070","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/s41594-023-00933-9","article-title":"Cgamp-activated cgas-sting signaling: Its bacterial origins and evolutionary adaptation by metazoans","volume":"30","author":"Patel","year":"2023","journal-title":"Nat. Struct. Mol. Biol."},{"issue":"214","key":"10.1016\/j.cyto.2024.156801_b0075","doi-asserted-by":"crossref","first-page":"p. ra20","DOI":"10.1126\/scisignal.2002521","article-title":"Sting specifies irf3 phosphorylation by tbk1 in the cytosolic DNA signaling pathway","volume":"5","author":"Tanaka","year":"2012","journal-title":"Sci. Signal."},{"issue":"5","key":"10.1016\/j.cyto.2024.156801_b0080","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/ni921","article-title":"Ikkepsilon and tbk1 are essential components of the irf3 signaling pathway","volume":"4","author":"Fitzgerald","year":"2003","journal-title":"Nat. Immunol."},{"issue":"14","key":"10.1016\/j.cyto.2024.156801_b0085","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2100225118","article-title":"Tbk1 recruitment to sting activates both irf3 and nf-\u03bab that mediate immune defense against tumors and viral infections","volume":"118","author":"Yum","year":"2021","journal-title":"PNAS"},{"issue":"8","key":"10.1016\/j.cyto.2024.156801_b0090","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/s41575-019-0158-2","article-title":"New insights into acute pancreatitis","volume":"16","author":"Lee","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"2","key":"10.1016\/j.cyto.2024.156801_b0095","doi-asserted-by":"crossref","first-page":"180","DOI":"10.4049\/jimmunol.2200484","article-title":"Jmjd3 is required for acute pancreatitis and pancreatitis-associated lung injury","volume":"210","author":"Chen","year":"2023","journal-title":"J. Immunol."},{"issue":"6","key":"10.1016\/j.cyto.2024.156801_b0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109977","article-title":"Tnf leads to mtdna release and cgas\/sting-dependent interferon responses that support inflammatory arthritis","volume":"37","author":"Willemsen","year":"2021","journal-title":"Cell Rep."},{"issue":"8","key":"10.1016\/j.cyto.2024.156801_b0105","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1016\/j.immuni.2022.06.007","article-title":"Oxidized DNA fragments exit mitochondria via mptp- and vdac-dependent channels to activate nlrp3 inflammasome and interferon signaling","volume":"55","author":"Xian","year":"2022","journal-title":"Immunity"},{"issue":"6","key":"10.1016\/j.cyto.2024.156801_b0110","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1053\/j.gastro.2018.01.065","article-title":"Sting signaling promotes inflammation in experimental acute pancreatitis","volume":"154","author":"Zhao","year":"2018","journal-title":"Gastroenterology"},{"issue":"3","key":"10.1016\/j.cyto.2024.156801_b0115","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1007\/s10753-021-01412-3","article-title":"Wip1 aggravates the cerulein-induced cell autophagy and inflammatory injury by targeting sting\/tbk1\/irf3 in acute pancreatitis","volume":"44","author":"Song","year":"2021","journal-title":"Inflammation"},{"issue":"1","key":"10.1016\/j.cyto.2024.156801_b0120","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s11658-024-00575-9","article-title":"Mitochondrial (mt)DNA-cyclic gmp-amp synthase (cgas)-stimulator of interferon genes (sting) signaling promotes pyroptosis of macrophages via interferon regulatory factor (irf)7\/irf3 activation to aggravate lung injury during severe acute pancreatitis","volume":"29","author":"Peng","year":"2024","journal-title":"Cell. Mol. Biol. Lett."},{"issue":"10","key":"10.1016\/j.cyto.2024.156801_b0125","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1089\/jir.2023.0077","article-title":"The role and potential regulatory mechanism of sting modulated macrophage apoptosis and differentiation in severe acute pancreatitis-associated lung injury","volume":"43","author":"Peng","year":"2023","journal-title":"J. Interferon Cytokine Res."},{"issue":"2","key":"10.1016\/j.cyto.2024.156801_b0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2023.113630","article-title":"Effect of sting signaling on intestinal barrier damage in severe acute pancreatitis","volume":"428","author":"Zhang","year":"2023","journal-title":"Exp. Cell Res."},{"issue":"1","key":"10.1016\/j.cyto.2024.156801_b0135","doi-asserted-by":"crossref","first-page":"49","DOI":"10.14309\/ajg.0000000000000421","article-title":"Chronic pancreatitis: Managing a difficult disease","volume":"115","author":"Hart","year":"2020","journal-title":"Am. J. Gastroenterol."},{"issue":"10","key":"10.1016\/j.cyto.2024.156801_b0140","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1136\/gutjnl-2018-317098","article-title":"Sting signalling protects against chronic pancreatitis by modulating th17 response","volume":"68","author":"Zhao","year":"2019","journal-title":"Gut"},{"issue":"4","key":"10.1016\/j.cyto.2024.156801_b0145","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1136\/gutjnl-2019-318597","article-title":"Degree of sting activation is associated with disease outcomes","volume":"69","author":"Hu","year":"2020","journal-title":"Gut"},{"issue":"7","key":"10.1016\/j.cyto.2024.156801_b0150","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2101848119","article-title":"A distinct role of sting in regulating glucose homeostasis through insulin sensitivity and insulin secretion","volume":"119","author":"Qiao","year":"2022","journal-title":"PNAS"},{"issue":"3","key":"10.1016\/j.cyto.2024.156801_b0155","doi-asserted-by":"crossref","DOI":"10.3390\/nu11030605","article-title":"Offspring of mice exposed to a low-protein diet in utero demonstrate changes in mtor signaling in pancreatic islets of langerhans, associated with altered glucagon and insulin expression and a lower \u03b2-cell mass","volume":"11","author":"King","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.cyto.2024.156801_b0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2024.155933","article-title":"Cgas suppresses \u03b2-cell proliferation by a sting-independent but cebp\u03b2-dependent mechanism","volume":"157","author":"Cai","year":"2024","journal-title":"Metabolism"},{"key":"10.1016\/j.cyto.2024.156801_b0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.ctrv.2021.102180","article-title":"Treatment landscape of metastatic pancreatic cancer","volume":"96","author":"De Dosso","year":"2021","journal-title":"Cancer Treat. Rev."},{"issue":"2","key":"10.1016\/j.cyto.2024.156801_b0170","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1158\/2159-8290.CD-22-0876","article-title":"Context-specific determinants of the immunosuppressive tumor microenvironment in pancreatic cancer","volume":"13","author":"Falcomat\u00e0","year":"2023","journal-title":"Cancer Discov."},{"issue":"9","key":"10.1016\/j.cyto.2024.156801_b0175","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/s41571-020-0363-5","article-title":"The tumour microenvironment in pancreatic cancer \u2013 clinical challenges and opportunities","volume":"17","author":"Ho","year":"2020","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"1","key":"10.1016\/j.cyto.2024.156801_b0180","doi-asserted-by":"crossref","first-page":"5123","DOI":"10.1038\/s41467-023-40727-7","article-title":"Single cell transcriptomic analyses implicate an immunosuppressive tumor microenvironment in pancreatic cancer liver metastasis","volume":"14","author":"Zhang","year":"2023","journal-title":"Nat. Commun."},{"issue":"7776","key":"10.1016\/j.cyto.2024.156801_b0185","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/s41586-019-1593-5","article-title":"Harnessing innate immunity in cancer therapy","volume":"574","author":"Demaria","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.cyto.2024.156801_b0190","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1146\/annurev-pathmechdis-032221-115501","article-title":"Innate immunity and cancer pathophysiology","volume":"17","author":"Maiorino","year":"2022","journal-title":"Annu. Rev. Pathol."},{"issue":"10","key":"10.1016\/j.cyto.2024.156801_b0195","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1016\/j.immuni.2023.07.018","article-title":"Targeting innate immune pathways for cancer immunotherapy","volume":"56","author":"Cao","year":"2023","journal-title":"Immunity"},{"key":"10.1016\/j.cyto.2024.156801_b0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2023.216409","article-title":"Cgas-sting signaling in the tumor microenvironment","volume":"577","author":"Liu","year":"2023","journal-title":"Cancer Lett."},{"issue":"5","key":"10.1016\/j.cyto.2024.156801_b0205","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1002\/cac2.12416","article-title":"Tumor microenvironment signaling and therapeutics in cancer progression","volume":"43","author":"Goenka","year":"2023","journal-title":"Cancer Commun. (lond)"},{"key":"10.1016\/j.cyto.2024.156801_b0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2022.215694","article-title":"Activation of sting in the pancreatic tumor microenvironment: A novel therapeutic opportunity","volume":"538","author":"Chamma","year":"2022","journal-title":"Cancer Lett."},{"issue":"12","key":"10.1016\/j.cyto.2024.156801_b0215","doi-asserted-by":"crossref","DOI":"10.3390\/ph16121675","article-title":"At the crossroads of the cgas-cgamp-sting pathway and the DNA damage response: Implications for cancer progression and treatment","volume":"16","author":"Korneenko","year":"2023","journal-title":"Pharmaceuticals (Basel)"},{"issue":"8","key":"10.1016\/j.cyto.2024.156801_b0220","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2021-003246","article-title":"High potency sting agonists engage unique myeloid pathways to reverse pancreatic cancer immune privilege","volume":"9","author":"Ager","year":"2021","journal-title":"J. Immunother. Cancer"},{"issue":"1","key":"10.1016\/j.cyto.2024.156801_b0225","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/s40425-019-0573-5","article-title":"Sting agonist inflames the pancreatic cancer immune microenvironment and reduces tumor burden in mouse models","volume":"7","author":"Jing","year":"2019","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.cyto.2024.156801_b0230","first-page":"3341038","article-title":"Siglec-15 regulates the inflammatory response and polarization of tumor-associated macrophages in pancreatic cancer by inhibiting the cgas-sting signaling pathway","volume":"2022","author":"Li","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"1","key":"10.1016\/j.cyto.2024.156801_b0235","doi-asserted-by":"crossref","first-page":"10466","DOI":"10.1038\/s41598-022-14297-5","article-title":"Cgas-sting signaling encourages immune cell overcoming of fibroblast barricades in pancreatic cancer","volume":"12","author":"Kabashima","year":"2022","journal-title":"Sci. Rep."},{"issue":"20","key":"10.1016\/j.cyto.2024.156801_b0240","doi-asserted-by":"crossref","first-page":"e2203264","DOI":"10.1002\/adhm.202203264","article-title":"In situ formed ros-responsive hydrogel with sting agonist and gemcitabine to intensify immunotherapy against pancreatic ductal adenocarcinoma","volume":"12","author":"Wang","year":"2023","journal-title":"Adv. Healthc. Mater."},{"issue":"1","key":"10.1016\/j.cyto.2024.156801_b0245","doi-asserted-by":"crossref","first-page":"2054105","DOI":"10.1080\/2162402X.2022.2054105","article-title":"Sting agonist cgamp enhances anti-tumor activity of car-nk cells against pancreatic cancer","volume":"11","author":"Da","year":"2022","journal-title":"Oncoimmunology"},{"key":"10.1016\/j.cyto.2024.156801_b0250","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.jare.2021.12.005","article-title":"Cisplatin and gemcitabine exert opposite effects on immunotherapy with pd-1 antibody in k-ras-driven cancer","volume":"40","author":"Glorieux","year":"2022","journal-title":"J. Adv. Res."},{"issue":"15","key":"10.1016\/j.cyto.2024.156801_b0255","doi-asserted-by":"crossref","first-page":"3940","DOI":"10.1158\/0008-5472.CAN-19-0761","article-title":"Inhibition of atm increases interferon signaling and sensitizes pancreatic cancer to immune checkpoint blockade therapy","volume":"79","author":"Zhang","year":"2019","journal-title":"Cancer Res."},{"issue":"7931","key":"10.1016\/j.cyto.2024.156801_b0260","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/s41586-022-05254-3","article-title":"Sting-induced regulatory b cells compromise nk function in cancer immunity","volume":"610","author":"Li","year":"2022","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.cyto.2024.156801_b0265","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1002\/med.21649","article-title":"Agonists and inhibitors of the sting pathway: Potential agents for immunotherapy","volume":"40","author":"Wu","year":"2020","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.cyto.2024.156801_b0270","doi-asserted-by":"crossref","first-page":"11932","DOI":"10.1038\/ncomms11932","article-title":"Activation of sting requires palmitoylation at the golgi","volume":"7","author":"Mukai","year":"2016","journal-title":"Nat. Commun."},{"issue":"7713","key":"10.1016\/j.cyto.2024.156801_b0275","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/s41586-018-0287-8","article-title":"Targeting sting with covalent small-molecule inhibitors","volume":"559","author":"Haag","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.cyto.2024.156801_b0280","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3390\/cancers13112695","article-title":"Sting Agonists as Cancer Therapeutics","volume":"13","author":"Amouzegar","year":"2021","journal-title":"Cancers (basel)"},{"issue":"4","key":"10.1016\/j.cyto.2024.156801_b0285","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/j.cell.2013.07.023","article-title":"Structure-function analysis of sting activation by c[g(2',5')pa(3',5')p] and targeting by antiviral dmxaa","volume":"154","author":"Gao","year":"2013","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.cyto.2024.156801_b0290","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s11912-023-01361-0","article-title":"The development of sting agonists and emerging results as a cancer immunotherapy","volume":"25","author":"Hines","year":"2023","journal-title":"Curr. Oncol. Rep."},{"issue":"1","key":"10.1016\/j.cyto.2024.156801_b0295","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/s41392-022-01252-z","article-title":"Multifaceted functions of sting in human health and disease: From molecular mechanism to targeted strategy","volume":"7","author":"Zhang","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"issue":"12","key":"10.1016\/j.cyto.2024.156801_b0300","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.1016\/j.apsb.2020.03.001","article-title":"Small molecules targeting the innate immune cgas-sting-tbk1 signaling pathway","volume":"10","author":"Ding","year":"2020","journal-title":"Acta Pharm. Sin. B"},{"issue":"11","key":"10.1016\/j.cyto.2024.156801_b0305","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.tips.2022.08.006","article-title":"Nanodelivery of cgas-sting activators for tumor immunotherapy","volume":"43","author":"Guo","year":"2022","journal-title":"Trends Pharmacol. Sci."},{"issue":"19","key":"10.1016\/j.cyto.2024.156801_b0310","doi-asserted-by":"crossref","first-page":"e2300260","DOI":"10.1002\/adhm.202300260","article-title":"Nanoparticle-mediated sting activation for cancer immunotherapy","volume":"12","author":"Li","year":"2023","journal-title":"Adv. Healthc. Mater."},{"issue":"3","key":"10.1016\/j.cyto.2024.156801_b0315","doi-asserted-by":"crossref","first-page":"e1873","DOI":"10.1002\/wnan.1873","article-title":"Improved cancer immunotherapy strategies by nanomedicine","volume":"15","author":"Guo","year":"2023","journal-title":"Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol."},{"key":"10.1016\/j.cyto.2024.156801_b0320","article-title":"Overcoming challenges in the delivery of sting agonists for cancer immunotherapy: A comprehensive review of strategies and future perspectives","volume":"23","author":"Huang","year":"2023","journal-title":"Mater. Today Bio"}],"container-title":["Cytokine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466624003053?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466624003053?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T23:29:56Z","timestamp":1731972596000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043466624003053"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":64,"alternative-id":["S1043466624003053"],"URL":"https:\/\/doi.org\/10.1016\/j.cyto.2024.156801","relation":{},"ISSN":["1043-4666"],"issn-type":[{"value":"1043-4666","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The cGAS-STING pathway as a novel therapeutic strategy for pancreatic diseases","name":"articletitle","label":"Article Title"},{"value":"Cytokine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cyto.2024.156801","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"156801"}}