{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T11:42:19Z","timestamp":1777290139359,"version":"3.51.4"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004826","name":"Beijing Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytokine"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.cyto.2025.156868","type":"journal-article","created":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T16:31:53Z","timestamp":1738341113000},"page":"156868","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Ficolin A and ficolin B aggravate poly(I:C) secondary LPS stimulation-induced acute lung injury by modulating alveolar and interstitial macrophages"],"prefix":"10.1016","volume":"188","author":[{"given":"Ziqi","family":"Hu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duoduo","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianhua","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingli","family":"Kong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Jie","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xulong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cyto.2025.156868_bb0005","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/S1473-3099(18)30310-4","article-title":"Estimates of the global, regional, and national morbidity, mortality, and aetiologies of lower respiratory infections in 195 countries, 1990\u20132016: a systematic analysis for the Global Burden of Disease Study 2016","volume":"18","author":"GBD 2016 Lower Respiratory Infections Collaborators","year":"2018","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.cyto.2025.156868_bb0010","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1002\/JLB.4RU0820-232R","article-title":"From virus to inflammation, how influenza promotes lung damage","volume":"110","author":"Klomp","year":"2021","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.cyto.2025.156868_bb0015","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1016\/j.ajpath.2014.08.030","article-title":"The role of viral, host, and secondary bacterial factors in influenza pathogenesis","volume":"185","author":"Kash","year":"2015","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.cyto.2025.156868_bb0020","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1111\/irv.12398","article-title":"The frequency of influenza and bacterial coinfection: a systematic review and meta-analysis","volume":"10","author":"Klein","year":"2016","journal-title":"Influenza Other Respi. Viruses"},{"key":"10.1016\/j.cyto.2025.156868_bb0025","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s13756-023-01234-y","article-title":"Risk factors for in-hospital mortality and secondary bacterial pneumonia among hospitalized adult patients with community-acquired influenza: a large retrospective cohort study","volume":"12","author":"Yi","year":"2023","journal-title":"Antimicrob. Resist. Infect. Control"},{"key":"10.1016\/j.cyto.2025.156868_bb0030","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms9061293","article-title":"Bacterial and viral coinfections with the human respiratory syncytial virus","volume":"9","author":"Pacheco","year":"2021","journal-title":"Microorganisms"},{"key":"10.1016\/j.cyto.2025.156868_bb0035","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.jcv.2016.02.014","article-title":"Pulmonary and extrapulmonary complications of human rhinovirus infection in critically ill patients","volume":"77","author":"K. K. To","year":"2016","journal-title":"J. Clin. Virol."},{"key":"10.1016\/j.cyto.2025.156868_bb0040","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1126\/science.1233632","article-title":"Role of tissue protection in lethal respiratory viral-bacterial coinfection","volume":"340","author":"Jamieson","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.cyto.2025.156868_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.vetmic.2021.109303","article-title":"Klebsiella pneumoniae infection following H9N2 influenza A virus infection contributes to the development of pneumonia in mice","volume":"264","author":"Li-Juan","year":"2022","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.cyto.2025.156868_bb0050","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.15252\/embr.201540473","article-title":"TRAIL+ monocytes and monocyte-related cells cause lung damage and thereby increase susceptibility to influenza-Streptococcus pneumoniae coinfection","volume":"16","author":"Ellis","year":"2015","journal-title":"EMBO Rep."},{"key":"10.1016\/j.cyto.2025.156868_bb0055","doi-asserted-by":"crossref","first-page":"3189","DOI":"10.3389\/fimmu.2018.03189","article-title":"Severe pneumonia caused by coinfection with influenza virus followed by methicillin-resistant Staphylococcus aureus induces higher mortality in mice","volume":"9","author":"Jia","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cyto.2025.156868_bb0060","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.pcl.2019.06.011","article-title":"Innate immunity","volume":"66","author":"Kaur","year":"2019","journal-title":"Pediatr. Clin. North Am."},{"key":"10.1016\/j.cyto.2025.156868_bb0065","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1002\/eji.201847811","article-title":"Soluble pattern recognition molecules: guardians and regulators of homeostasis at airway mucosal surfaces","volume":"50","author":"Smole","year":"2020","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.cyto.2025.156868_bb0070","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/nrmicro3231","article-title":"The co-pathogenesis of influenza viruses with bacteria in the lung","volume":"12","author":"McCullers","year":"2014","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.cyto.2025.156868_bb0075","doi-asserted-by":"crossref","DOI":"10.3390\/v13050824","article-title":"Complement proteins as soluble pattern recognition receptors for pathogenic viruses","volume":"13","author":"Murugaiah","year":"2021","journal-title":"Viruses"},{"key":"10.1016\/j.cyto.2025.156868_bb0080","doi-asserted-by":"crossref","first-page":"3875","DOI":"10.1016\/j.molimm.2007.06.005","article-title":"Complement activating soluble pattern recognition molecules with collagen-like regions, mannan-binding lectin, ficolins and associated proteins","volume":"44","author":"Thiel","year":"2007","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.cyto.2025.156868_bb0085","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.585243","article-title":"The influence of the lectin pathway of complement activation on infections of the respiratory system","volume":"11","author":"Swierzko","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cyto.2025.156868_bb0090","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s00281-017-0642-0","article-title":"Structural and functional diversity of collectins and ficolins and their relationship to disease","volume":"40","author":"Howard","year":"2018","journal-title":"Semin. Immunopathol."},{"key":"10.1016\/j.cyto.2025.156868_bb0095","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1159\/000228160","article-title":"Ficolins: complement-activating lectins involved in innate immunity","volume":"2","author":"Matsushita","year":"2010","journal-title":"J. Innate Immun."},{"key":"10.1016\/j.cyto.2025.156868_bb0100","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.molimm.2012.08.017","article-title":"Ficolins in complement activation","volume":"55","author":"Matsushita","year":"2013","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.cyto.2025.156868_bb0105","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.ygeno.2004.07.006","article-title":"Identification of the mouse H-ficolin gene as a pseudogene and orthology between mouse ficolins A\/B and human L\u2212\/M-ficolins","volume":"84","author":"Endo","year":"2004","journal-title":"Genomics"},{"key":"10.1016\/j.cyto.2025.156868_bb0110","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1111\/imr.12468","article-title":"A journey through the lectin pathway of complement-MBL and beyond","volume":"274","author":"Garred","year":"2016","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.cyto.2025.156868_bb0115","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1378\/chest.12-2610","article-title":"Toll-like receptor 3 stimulation causes corticosteroid-refractory airway neutrophilia and hyperresponsiveness in mice","volume":"144","author":"Kimura","year":"2013","journal-title":"Chest"},{"key":"10.1016\/j.cyto.2025.156868_bb0120","doi-asserted-by":"crossref","unstructured":"X. Tian, F. Xu, W. Y. Lung, C. Meyerson, A. A. Ghaffari, G. Cheng, J. C. Deng, Poly I:C enhances susceptibility to secondary pulmonary infections by gram-positive bacteria, PloS One 7(2012) e41879. doi:https:\/\/doi.org\/10.1371\/journal.pone.0041879.","DOI":"10.1371\/journal.pone.0041879"},{"key":"10.1016\/j.cyto.2025.156868_bb0125","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.cyto.2018.08.020","article-title":"Staphylococcus aureus lipoproteins augment inflammatory responses in poly I:C-primed macrophages","volume":"111","author":"Kang","year":"2018","journal-title":"Cytokine"},{"key":"10.1016\/j.cyto.2025.156868_bb0130","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1111\/imcb.12344","article-title":"Ficolin A derived from local macrophages and neutrophils protects against lipopolysaccharide-induced acute lung injury by activating complement","volume":"98","author":"Wu","year":"2020","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.cyto.2025.156868_bb0135","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/s12967-021-02745-1","article-title":"Panaxydol attenuates ferroptosis against LPS-induced acute lung injury in mice by Keap1-Nrf2\/HO-1 pathway","volume":"19","author":"Li","year":"2021","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.cyto.2025.156868_bb0140","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.4049\/jimmunol.1300014","article-title":"Depletion of alveolar macrophages during influenza infection facilitates bacterial superinfections","volume":"191","author":"Ghoneim","year":"2013","journal-title":"J. Immunol."},{"key":"10.1016\/j.cyto.2025.156868_bb0145","doi-asserted-by":"crossref","first-page":"2640","DOI":"10.3389\/fimmu.2018.02640","article-title":"Respiratory viral infection-induced microbiome alterations and secondary bacterial pneumonia","volume":"9","author":"Hanada","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cyto.2025.156868_bb0150","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1186\/s12879-018-3548-0","article-title":"The role of pneumonia and secondary bacterial infection in fatal and serious outcomes of pandemic influenza a(H1N1)pdm09","volume":"18","author":"MacIntyre","year":"2018","journal-title":"BMC Infect. Dis."},{"key":"10.1016\/j.cyto.2025.156868_bb0155","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1111\/1348-0421.12965","article-title":"Secondary streptococcal infection following influenza","volume":"66","author":"Okahashi","year":"2022","journal-title":"Microbiol. Immunol."},{"key":"10.1016\/j.cyto.2025.156868_bb0160","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2021.643326","article-title":"Virus-induced changes of the respiratory tract environment promote secondary infections with Streptococcus pneumoniae","volume":"11","author":"Sender","year":"2021","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.cyto.2025.156868_bb0165","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1093\/infdis\/jiv066","article-title":"Limited efficacy of antibacterial vaccination against secondary serotype 3 pneumococcal pneumonia following influenza infection","volume":"212","author":"Metzger","year":"2015","journal-title":"J Infect Dis"},{"key":"10.1016\/j.cyto.2025.156868_bb0170","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.cell.2020.08.020","article-title":"Patrolling alveolar macrophages conceal bacteria from the immune system to maintain homeostasis","volume":"183","author":"Neupane","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.cyto.2025.156868_bb0175","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.coi.2015.02.002","article-title":"The immunology of influenza virus-associated bacterial pneumonia","volume":"34","author":"Robinson","year":"2015","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.cyto.2025.156868_bb0180","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1097\/MCC.0000000000000435","article-title":"Pneumonia with bacterial and viral coinfection","volume":"23","author":"Cawcutt","year":"2017","journal-title":"Curr. Opin. Crit. Care"},{"key":"10.1016\/j.cyto.2025.156868_bb0185","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.cell.2006.02.015","article-title":"Pathogen recognition and innate immunity","volume":"124","author":"Akira","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.cyto.2025.156868_bb0190","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/s41590-019-0368-3","article-title":"Innate immunity to intracellular LPS","volume":"20","author":"Rathinam","year":"2019","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.cyto.2025.156868_bb0195","doi-asserted-by":"crossref","first-page":"2478","DOI":"10.4049\/jimmunol.1103786","article-title":"Human H-ficolin inhibits replication of seasonal and pandemic influenza A viruses","volume":"189","author":"Verma","year":"2012","journal-title":"J. Immunol."},{"key":"10.1016\/j.cyto.2025.156868_bb0200","doi-asserted-by":"crossref","first-page":"2637","DOI":"10.1056\/NEJMoa0900381","article-title":"Immunodeficiency associated with FCN3 mutation and ficolin-3 deficiency","volume":"360","author":"Munthe-Fog","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cyto.2025.156868_bb0205","doi-asserted-by":"crossref","first-page":"3205072","DOI":"10.1155\/2019\/3205072","article-title":"Ficolins and the recognition of pathogenic microorganisms: An overview of the innate immune response and contribution of single nucleotide polymorphisms","volume":"2019","author":"Bidula","year":"2019","journal-title":"J. Immunol. Res."},{"key":"10.1016\/j.cyto.2025.156868_bb0210","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1159\/000335670","article-title":"L-ficolin binds to the glycoproteins hemagglutinin and neuraminidase and inhibits influenza A virus infection both in vitro and in vivo","volume":"4","author":"Pan","year":"2012","journal-title":"J. Innate Immun."},{"key":"10.1016\/j.cyto.2025.156868_bb0215","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.bcp.2010.10.012","article-title":"Recombinant chimeric lectins consisting of mannose-binding lectin and L-ficolin are potent inhibitors of influenza A virus compared with mannose-binding lectin","volume":"81","author":"Chang","year":"2011","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.cyto.2025.156868_bb0220","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1177\/1753425916678470","article-title":"Collectins, H-ficolin and LL-37 reduce influence viral replication in human monocytes and modulate virus-induced cytokine production","volume":"23","author":"White","year":"2017","journal-title":"Innate Immun."},{"key":"10.1016\/j.cyto.2025.156868_bb0225","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.1038\/s41423-021-00737-1","article-title":"Ficolin A exacerbates severe H1N1 influenza virus infection-induced acute lung immunopathological injury via excessive complement activation","volume":"18","author":"Wu","year":"2021","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.cyto.2025.156868_bb0230","article-title":"Ficolin-2 defends against virulent Mycobacteria tuberculosis infection in vivo, and its insufficiency is associated with infection in humans","volume":"8","author":"Luo","year":"2013","journal-title":"PloS One"},{"key":"10.1016\/j.cyto.2025.156868_bb0235","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.3389\/fimmu.2018.01153","article-title":"The lectin complement pathway is involved in protection against Enteroaggregative Escherichia coli infection","volume":"9","author":"Adler","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cyto.2025.156868_bb0240","doi-asserted-by":"crossref","first-page":"5860","DOI":"10.4049\/jimmunol.1200836","article-title":"Mice deficient in ficolin, a lectin complement pathway recognition molecule, are susceptible to Streptococcus pneumoniae infection","volume":"189","author":"Endo","year":"2012","journal-title":"J. Immunol."},{"key":"10.1016\/j.cyto.2025.156868_bb0245","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0209657","article-title":"Ficolin-2 binds to serotype 35B pneumococcus as it does to serotypes 11A and 31, and these serotypes cause more infections in older adults than in children","volume":"13","author":"Geno","year":"2018","journal-title":"PloS One"},{"key":"10.1016\/j.cyto.2025.156868_bb0250","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.841062","article-title":"Ficolin-2 lectin complement pathway mediates capsule-specific innate immunity against invasive pneumococcal disease","volume":"13","author":"Nahm","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cyto.2025.156868_bb0255","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.molimm.2019.02.013","article-title":"The ficolin response to LPS challenge in mice","volume":"108","author":"Jarlhelt","year":"2019","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.cyto.2025.156868_bb0260","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/j.imbio.2015.11.015","article-title":"Alveolar recruitment of ficolin-3 in response to acute pulmonary inflammation in humans","volume":"221","author":"Plovsing","year":"2016","journal-title":"Immunobiology"},{"key":"10.1016\/j.cyto.2025.156868_bb0265","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110548","article-title":"Ficolin A knockout alleviates sepsis-induced severe lung injury in mice by restoring gut Akkermansia to inhibit S100A4\/STAT3 pathway","volume":"121","author":"Wu","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.cyto.2025.156868_bb0270","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/j.ajpath.2024.02.011","article-title":"Ficolin-A\/2 aggravates severe lung injury through neutrophil extracellular traps mediated by gasdermin D-induced pyroptosis","volume":"194","author":"Huang","year":"2024","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.cyto.2025.156868_bb0275","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1111\/imm.12741","article-title":"Ficolin-A\/2, acting as a new regulator of macrophage polarization, mediates the inflammatory response in experimental mouse colitis","volume":"151","author":"Yang","year":"2017","journal-title":"Immunology"}],"container-title":["Cytokine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466625000158?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466625000158?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T23:35:09Z","timestamp":1740526509000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043466625000158"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":55,"alternative-id":["S1043466625000158"],"URL":"https:\/\/doi.org\/10.1016\/j.cyto.2025.156868","relation":{},"ISSN":["1043-4666"],"issn-type":[{"value":"1043-4666","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ficolin A and ficolin B aggravate poly(I:C) secondary LPS stimulation-induced acute lung injury by modulating alveolar and interstitial macrophages","name":"articletitle","label":"Article Title"},{"value":"Cytokine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cyto.2025.156868","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"156868"}}