{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T22:33:58Z","timestamp":1794004438661,"version":"4.8.0"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T00:00:00Z","timestamp":1738886400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytokine"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.cyto.2025.156889","type":"journal-article","created":{"date-parts":[[2025,2,8]],"date-time":"2025-02-08T22:12:36Z","timestamp":1739052756000},"page":"156889","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Are F2-isoprostanes a better marker of semen lipid peroxidation than MDA in reproductive pathologies with inflammatory basis?"],"prefix":"10.1016","volume":"188","author":[{"given":"Elena","family":"Moretti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cinzia","family":"Signorini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Menchiari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Liguori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Corsaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Gambera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Collodel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cyto.2025.156889_bb0005","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.redox.2015.01.002","article-title":"Oxidative stress: a concept in redox biology and medicine","volume":"4","author":"Sies","year":"2015","journal-title":"Redox Biol."},{"key":"10.1016\/j.cyto.2025.156889_bb0010","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1007\/s10815-014-0425-7","article-title":"Contemporary evidence on the physiological role of reactive oxygen species in human sperm function","volume":"32","author":"Du Plessis","year":"2015","journal-title":"J. Assist. Reprod. Genet."},{"key":"10.1016\/j.cyto.2025.156889_bb0015","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1002\/mrd.22871","article-title":"Reactive oxygen species as mediators of sperm capacitation and pathological damage","volume":"84","author":"Aitken","year":"2017","journal-title":"Mol. Reprod. Dev."},{"key":"10.1016\/j.cyto.2025.156889_bb0020","doi-asserted-by":"crossref","DOI":"10.1111\/and.13577","article-title":"Reactive oxygen species in male reproduction: a boon or a bane?","volume":"53","author":"Baskaran","year":"2021","journal-title":"Andrologia"},{"key":"10.1016\/j.cyto.2025.156889_bb0025","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.3390\/antiox10071025","article-title":"Sperm oxidative stress during in vitro manipulation and its effects on sperm function and embryo development","volume":"10","author":"Gualtieri","year":"2021","journal-title":"Antioxidants"},{"key":"10.1016\/j.cyto.2025.156889_bb0030","doi-asserted-by":"crossref","DOI":"10.1111\/and.13624","article-title":"Total antioxidant capacity-relevance, methods and clinical implications","volume":"53","author":"Gupta","year":"2021","journal-title":"Andrologia"},{"key":"10.1016\/j.cyto.2025.156889_bb0035","doi-asserted-by":"crossref","first-page":"393","DOI":"10.13075\/mp.5893.00137","article-title":"Today's oxidative stress markers","volume":"66","author":"Czerska","year":"2015","journal-title":"Med. Pr."},{"key":"10.1016\/j.cyto.2025.156889_bb0040","first-page":"199","article-title":"Laboratory tests for oxidative stress, Indian","volume":"33","author":"Agarwal","year":"2017","journal-title":"J. Urol."},{"key":"10.1016\/j.cyto.2025.156889_bb0045","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.ab.2016.10.021","article-title":"Assessment of lipid peroxidation by measuring malondialdehyde (MDA) and relatives in biological samples: analytical and biological challenges","volume":"524","author":"Tsikas","year":"2017","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.cyto.2025.156889_bb0050","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3390\/antiox10010043","article-title":"Mechanistic insight into the regulation of lipoxygenase-driven lipid peroxidation events in human spermatozoa and their impact on male fertility","volume":"10","author":"Walters","year":"2020","journal-title":"Antioxidants (Basel)."},{"key":"10.1016\/j.cyto.2025.156889_bb0055","article-title":"Evaluation of oxidative stress in biological samples using the Thiobarbituric acid reactive substances assay","volume":"159","author":"De Leon","year":"2020","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.cyto.2025.156889_bb0060","doi-asserted-by":"crossref","first-page":"72","DOI":"10.3390\/antiox8030072","article-title":"Measurement and clinical significance of lipid peroxidation as a biomarker of oxidative stress: oxidative stress in diabetes, atherosclerosis, and chronic inflammation","volume":"8","author":"Ito","year":"2019","journal-title":"Antioxidants"},{"key":"10.1016\/j.cyto.2025.156889_bb0065","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.redox.2017.04.028","article-title":"Classifying oxidative stress by F2-Isoprostane levels in human disease: the re-imagining of a biomarker","volume":"12","author":"Milne","year":"2017","journal-title":"Redox Biol."},{"key":"10.1016\/j.cyto.2025.156889_bb0070","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1080\/19396368.2020.1793032","article-title":"Role of isoprostanes in human male infertility","volume":"66","author":"Signorini","year":"2020","journal-title":"Syst Biol Reprod Med"},{"key":"10.1016\/j.cyto.2025.156889_bb0075","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.3390\/ijerph19031642","article-title":"A study to validate the relevance of semen F2-Isoprostanes on human male infertility","volume":"19","author":"Moretti","year":"2022","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.cyto.2025.156889_bb0080","doi-asserted-by":"crossref","DOI":"10.1111\/and.13126","article-title":"Role of oxidative stress, infection and inflammation in male infertility","volume":"50","author":"Agarwal","year":"2018","journal-title":"Andrologia"},{"key":"10.1016\/j.cyto.2025.156889_bb0085","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1080\/2090598X.2019.1599624","article-title":"Oxidative stress and sperm function: a systematic review on evaluation and management","volume":"17","author":"Dutta","year":"2019","journal-title":"Arab. J. Urol."},{"key":"10.1016\/j.cyto.2025.156889_bb0090","article-title":"Varicocele-associated infertility and the role of oxidative stress on sperm DNA fragmentation","volume":"29","author":"Wood","year":"2021","journal-title":"Front. Reprod. Health."},{"key":"10.1016\/j.cyto.2025.156889_bb0095","article-title":"Bacterial infections affect male fertility: a focus on the oxidative stress-autophagy Axis","volume":"9","author":"Wang","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.cyto.2025.156889_bb0100","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.biopha.2018.06.139","article-title":"Role of oxidative stress in pathology of chronic prostatitis\/chronic pelvic pain syndrome and male infertility and antioxidants function in ameliorating oxidative stress","volume":"106","author":"Ihsan","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.cyto.2025.156889_bb0105","doi-asserted-by":"crossref","first-page":"296","DOI":"10.5534\/wjmh.190055","article-title":"Male oxidative stress infertility (MOSI): proposed terminology and clinical practice guidelines for Management of Idiopathic Male Infertility","volume":"37","author":"Agarwal","year":"2019","journal-title":"World J. Mens. Health."},{"key":"10.1016\/j.cyto.2025.156889_bb0110","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1002\/eji.201848056","article-title":"Current perspectives on the interleukin-1 family as targets for inflammatory disease","volume":"49","author":"Hernandez-Santana","year":"2019","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.cyto.2025.156889_bb0115","series-title":"WHO Laboratory Manual for the Examination and Processing of Human Semen, sixth ed., World Health Organization, Geneva","year":"2021"},{"key":"10.1016\/j.cyto.2025.156889_bb0120","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1080\/13510002.2021.1884802","article-title":"Redox imbalance induced by docetaxel in the neuroblastoma SH-SY5Y cells: a study of docetaxel-induced neuronal damage","volume":"26","author":"Micheli","year":"2021","journal-title":"Redox Rep."},{"key":"10.1016\/j.cyto.2025.156889_bb0125","doi-asserted-by":"crossref","first-page":"837","DOI":"10.2307\/2531595","article-title":"Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach","volume":"44","author":"DeLong","year":"1988","journal-title":"Biometrics"},{"key":"10.1016\/j.cyto.2025.156889_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.jri.2020.103183","article-title":"Bacterial infection of the male reproductive system causing infertility","volume":"142","author":"Farsimadan","year":"2020","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.cyto.2025.156889_bb0135","doi-asserted-by":"crossref","DOI":"10.1111\/aji.13786","article-title":"Insight into inflammation involvement in varicocele: a narrative review","volume":"90","author":"Minas","year":"2023","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.cyto.2025.156889_bb0140","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/978-3-030-89340-8_9","article-title":"Oxidative stress and idiopathic male infertility","volume":"1358","author":"Sengupta","year":"2022","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.cyto.2025.156889_bb0145","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.3390\/antiox12081626","article-title":"On males, antioxidants and infertility (MOXI): certitudes, uncertainties and trends","volume":"12","author":"Alfaro G\u00f3mez","year":"2023","journal-title":"Antioxidants (Basel)."},{"key":"10.1016\/j.cyto.2025.156889_bb0150","first-page":"41","article-title":"Oxidative stress and male infertility, Reprod","volume":"20","author":"Takeshima","year":"2020","journal-title":"La Medicina Biologica"},{"key":"10.1016\/j.cyto.2025.156889_bb0155","doi-asserted-by":"crossref","first-page":"139","DOI":"10.7150\/ijbs.8.139","article-title":"Altered antioxidant status and increased lipid per-oxidation in seminal plasma of tunisian infertile men","volume":"8","author":"Atig","year":"2012","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.cyto.2025.156889_bb0160","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.rbmo.2012.05.011","article-title":"Differences in blood and semen oxidative status in fertile and infertile men, and their relationship with sperm quality","volume":"25","author":"Benedetti","year":"2012","journal-title":"Reprod. Biomed. Online"},{"key":"10.1016\/j.cyto.2025.156889_bb0165","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1111\/andr.297","article-title":"Semen characteristics and malondialdehyde levels in men with different reproductive problems","volume":"3","author":"Collodel","year":"2015","journal-title":"Andrology"},{"key":"10.1016\/j.cyto.2025.156889_bb0170","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1007\/s00018-002-8469-8","article-title":"Products of the isoprostane pathway: unique bioactive compounds and markers of lipid peroxidation","volume":"59","author":"Roberts","year":"2002","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.cyto.2025.156889_bb0175","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1472-6890-7-6","article-title":"Levels of oxidative stress biomarkers in seminal plasma and their relationship with seminal parameters","volume":"7","author":"Khosrowbeygi","year":"2007","journal-title":"BMC Clin. Pathol."},{"key":"10.1016\/j.cyto.2025.156889_bb0180","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/7508014","article-title":"Increased F2-Isoprostane levels in semen and Immunolocalization of the 8-Iso prostaglandin F2\u03b1 in spermatozoa from infertile patients with varicocele","volume":"2018","author":"Collodel","year":"2018","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.cyto.2025.156889_bb0185","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/3640450","article-title":"Fatty acid profile and metabolism are related to human sperm parameters and are relevant in idiopathic infertility and varicocele","volume":"2020","author":"Collodel","year":"2020","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.cyto.2025.156889_bb0190","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.3390\/antiox11051002","article-title":"Oxidation of polyunsaturated fatty acids as a promising area of research in infertility","volume":"11","author":"Collodel","year":"2022","journal-title":"Antioxidants (Basel)."},{"key":"10.1016\/j.cyto.2025.156889_bb0195","doi-asserted-by":"crossref","first-page":"325","DOI":"10.2164\/jandrol.106.001149","article-title":"Inflammatory mediators exert toxic effects of oxidative stress on human spermatozoa","volume":"28","author":"Fraczek","year":"2007","journal-title":"J. Androl."},{"key":"10.1016\/j.cyto.2025.156889_bb0200","doi-asserted-by":"crossref","first-page":"13467","DOI":"10.3390\/ijms222413467","article-title":"Mycoplasma genitalium provokes seminal inflammation among infertile males","volume":"22","author":"Tjagur","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cyto.2025.156889_bb0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2022.155834","article-title":"Interferon \u03b3, IL-17, and IL-1\u03b2 impair sperm motility and viability and induce sperm apoptosis","volume":"152","author":"Paira","year":"2022","journal-title":"Cytokine"},{"key":"10.1016\/j.cyto.2025.156889_bb0210","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.jri.2015.02.001","article-title":"Cytokines in the male reproductive tract and their role in infertility disorders","volume":"108","author":"Fraczek","year":"2015","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.cyto.2025.156889_bb0215","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1002\/j.1939-4640.2003.tb02693.x","article-title":"Male genital tract inflammation: the role of selected interleukins in regulation of pro-oxidant and antioxidant enzymatic substances in seminal plasma","volume":"24","author":"Sanocka","year":"2003","journal-title":"J. Androl."},{"key":"10.1016\/j.cyto.2025.156889_bb0220","first-page":"102","article-title":"Sperm lipid peroxidation and pro-inflammatory cytokines, Asian","volume":"9","author":"Mart\u00ednez","year":"2007","journal-title":"J. Androl."},{"key":"10.1016\/j.cyto.2025.156889_bb0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2023.156281","article-title":"Apelin is found in human sperm and testis and is raised in inflammatory pathological conditions","volume":"169","author":"Moretti","year":"2023","journal-title":"Cytokine"},{"key":"10.1016\/j.cyto.2025.156889_bb0230","doi-asserted-by":"crossref","first-page":"7261842","DOI":"10.1155\/2019\/7261842","article-title":"Relationships between ghrelin and Obestatin with MDA, Proinflammatory cytokines, GSH\/GSSG ratio, catalase activity, and semen parameters in infertile patients with Leukocytospermia and varicocele","volume":"2019","author":"Micheli","year":"2019","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.cyto.2025.156889_bb0235","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1016\/j.fertnstert.2014.09.044","article-title":"Sperm functional tests","volume":"102","author":"Oehninger","year":"2014","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.cyto.2025.156889_bb0240","doi-asserted-by":"crossref","DOI":"10.1111\/and.13625","article-title":"Diagnostic value of advanced semen analysis in evaluation of male infertility","volume":"53","author":"Barb\u0103ro\u0219ie","year":"2021","journal-title":"Andrologia"},{"key":"10.1016\/j.cyto.2025.156889_bb0245","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1080\/19396368.2016.1185654","article-title":"Validation of artificial neural network models for predicting biochemical markers associated with male infertility","volume":"62","author":"Vickram","year":"2016","journal-title":"Syst Biol Reprod Med"}],"container-title":["Cytokine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466625000365?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466625000365?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T23:36:40Z","timestamp":1740526600000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043466625000365"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":49,"alternative-id":["S1043466625000365"],"URL":"https:\/\/doi.org\/10.1016\/j.cyto.2025.156889","relation":{},"ISSN":["1043-4666"],"issn-type":[{"value":"1043-4666","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Are F2-isoprostanes a better marker of semen lipid peroxidation than MDA in reproductive pathologies with inflammatory basis?","name":"articletitle","label":"Article Title"},{"value":"Cytokine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cyto.2025.156889","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"156889"}}