{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T15:34:37Z","timestamp":1791992077152,"version":"4.4.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100022833","name":"Rajiv Gandhi Centre for Biotechnology","doi-asserted-by":"publisher","award":["BT\/PR14154\/MED\/29\/965\/2015 Dated 15\/03\/2017"],"award-info":[{"award-number":["BT\/PR14154\/MED\/29\/965\/2015 Dated 15\/03\/2017"]}],"id":[{"id":"10.13039\/100022833","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001332","name":"Council for Scientific and Industrial Research, South Africa","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001332","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["SB\/YS\/LS-234\/2013 Dated 15\/05\/2014"],"award-info":[{"award-number":["SB\/YS\/LS-234\/2013 Dated 15\/05\/2014"]}],"id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytokine"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.cyto.2025.156981","type":"journal-article","created":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T12:33:12Z","timestamp":1750163592000},"page":"156981","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Leishmania donovani infection-driven high levels of IL-10 causes hypoalbuminemia in human visceral leishmaniasis"],"prefix":"10.1016","volume":"193","author":[{"given":"Bharat","family":"Singh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheetal","family":"Saini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Smita","family":"Kumari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arunim","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kulwant","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandra Prakash","family":"Chaturvedi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anuradha","family":"Dube","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amogh A.","family":"Sahatrabuddhe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandreshwar P.","family":"Thakur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ambak K.","family":"Rai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cyto.2025.156981_bb0005","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0009987","article-title":"Increased levels of cortisol are associated with the severity of experimental visceral leishmaniasis in a Leishmania (L.) infantum-hamster model","volume":"15","author":"Barros-Gon\u00e7alves","year":"2021","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.cyto.2025.156981_bb0010","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1084\/jem.194.10.1497","article-title":"The role of interleukin (IL)-10 in the persistence of Leishmania major in the skin after healing and the therapeutic potential of anti\u00e2\u20ac IL-10 receptor antibody for sterile cure","volume":"194","author":"Belkaid","year":"2001","journal-title":"J. Exp. Med."},{"issue":"2","key":"10.1016\/j.cyto.2025.156981_bb0015","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1067\/msy.2002.125354","article-title":"Interleukin-10 activates the transcription factor C\/EBP and the interleukin-6 gene promoter in human intestinal epithelial cells","volume":"132","author":"Robb","year":"2002","journal-title":"Surgery"},{"key":"10.1016\/j.cyto.2025.156981_bb0020","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1038\/nrmicro1748","article-title":"Visceral leishmaniasis: what are the needs for diagnosis, treatment and control?","volume":"5","author":"Chappuis","year":"2007","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.cyto.2025.156981_bb0025","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1080\/00034983.1989.11812358","article-title":"A rapid staining technique for Leishmania parasites in splenic aspirate smears","volume":"83","author":"Chunge","year":"1989","journal-title":"Ann. Tropical Med. & Parasitol."},{"key":"10.1016\/j.cyto.2025.156981_bb0030","first-page":"147","article-title":"Renal involvement in leishmaniasis: a review of the literature","volume":"4","author":"Clementi","year":"2011","journal-title":"Nephrol. Dialysis Trans. Plus"},{"key":"10.1016\/j.cyto.2025.156981_bb0035","doi-asserted-by":"crossref","first-page":"492","DOI":"10.5414\/CNP71492","article-title":"Renal tubular dysfunction in human visceral leishmaniasis (kala-azar)","volume":"71","author":"De Francesco Daher","year":"2009","journal-title":"Clin. Nephrol."},{"key":"10.1016\/j.cyto.2025.156981_bb0040","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1258\/td.2008.080369","article-title":"Severe adverse reactions to meglumine antimoniate in the treatment of visceral leishmaniasis: a report of 13 cases in the southwestern region of Brazil","volume":"39","author":"de Oliveira","year":"2009","journal-title":"Trop. Doct."},{"key":"10.1016\/j.cyto.2025.156981_bb0045","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1101\/gad.4.9.1541","article-title":"LAP, a novel member of the C\/EBP gene family, encodes a liver-enriched transcriptional activator protein","volume":"4","author":"Descombes","year":"1990","journal-title":"Genes Dev."},{"issue":"9","key":"10.1016\/j.cyto.2025.156981_bb0050","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1101\/gad.4.9.1541","article-title":"LAP, a novel member of the C\/EBP gene family, encodes a liver-enriched transcriptional activator protein","volume":"4","author":"Descombes","year":"1990","journal-title":"Genes Dev."},{"key":"10.1016\/j.cyto.2025.156981_bb0055","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1093\/jac\/dkp465","article-title":"Visceral leishmaniasis affects liver and spleen concentrations of amphotericin B following administration to mice","volume":"65","author":"Gershkovich","year":"2009","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.cyto.2025.156981_bb0060","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/S1473-3099(02)00347-X","article-title":"Visceral leishmaniasis: current status of control, diagnosis, and treatment, and a proposed research and development agenda","volume":"2","author":"Guerin","year":"2002","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.cyto.2025.156981_bb0065","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1159\/000090185","article-title":"Hypoalbuminemia in renal failure: pathogenesis and therapeutic considerations","volume":"28","author":"Haller","year":"2006","journal-title":"Kidney Blood Press. Res."},{"issue":"12","key":"10.1016\/j.cyto.2025.156981_bb0070","first-page":"940","article-title":"Albumin in health and disease: causes and treatment of hypoalbuminemia","volume":"26","author":"Throop","year":"2004","journal-title":"Compend. Contin. Educ. Pract. Vet."},{"key":"10.1016\/j.cyto.2025.156981_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.imlet.2024.106858","article-title":"Benzo [a] pyrene exposure causes exonal switch resulting in reduced surface CD5 expression in an AHR-dependent manner","volume":"267","author":"Kumari","year":"2024","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.cyto.2025.156981_bb0080","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","article-title":"Cleavage of structural proteins during the assembly of the head of bacteriophage T4","volume":"227","author":"Laemmli","year":"1970","journal-title":"Nature"},{"key":"10.1016\/j.cyto.2025.156981_bb0085","first-page":"20","article-title":"Liver biopsy for visceral leishmaniasis diagnosis in pregnancy: report of 2 cases. World journal of","volume":"3","author":"Lima","year":"2013","journal-title":"Clin. Infect. Dis."},{"issue":"4902","key":"10.1016\/j.cyto.2025.156981_bb0090","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1126\/science.2711183","article-title":"The role of cis-acting promoter elements in tissue-specific albumin gene expression","volume":"244","author":"Pascal","year":"1989","journal-title":"Science"},{"key":"10.1016\/j.cyto.2025.156981_bb0095","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1016\/j.cgh.2008.04.033","article-title":"High prevalence of functional liver derangement in visceral leishmaniasis at an Indian tertiary care center","volume":"6","author":"Mathur","year":"2008","journal-title":"Clin. Gastroenterol. Hepatol."},{"issue":"11","key":"10.1016\/j.cyto.2025.156981_bb0100","doi-asserted-by":"crossref","first-page":"6284","DOI":"10.1128\/IAI.70.11.6284-6293.2002","article-title":"Interleukin-10 (IL-10) in experimental visceral leishmaniasis and IL-10 receptor blockade as immunotherapy","volume":"70","author":"Murray","year":"2002","journal-title":"Infect. Immun."},{"key":"10.1016\/j.cyto.2025.156981_bb0105","article-title":"Immunobiology of visceral leishmaniasis","volume":"3","author":"Nylen","year":"2012","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cyto.2025.156981_bb0110","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.biochi.2022.03.002","article-title":"Retinoic acid restores the levels of cellular cholesterol in Leishmania donovani infected macrophages by increasing npc1 and npc2 expressions","volume":"198","author":"Prakash","year":"2022","journal-title":"Biochimie"},{"key":"10.1016\/j.cyto.2025.156981_bb0115","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.biochi.2020.04.024","article-title":"Preventive as well as therapeutic significances of linoleic acid in the containment of Leishmania donovani infection","volume":"175","author":"Saini","year":"2020","journal-title":"Biochimie"},{"key":"10.1016\/j.cyto.2025.156981_bb0120","doi-asserted-by":"crossref","DOI":"10.1111\/pim.12768","article-title":"Hamster, a close model for visceral leishmaniasis: opportunities and challenges","volume":"42","author":"Saini","year":"2020","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.cyto.2025.156981_bb0125","doi-asserted-by":"crossref","DOI":"10.1111\/pim.12964","article-title":"Organ-specific immune profiling of Leishmania donovani-infected hamsters","volume":"45","author":"Saini","year":"2023","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.cyto.2025.156981_bb0130","article-title":"Parasitic load determination by differential expressions of 5-lipoxygenase and PGE2 synthases in visceral leishmaniasis","volume":"147","author":"Saini","year":"2020","journal-title":"Prostaglandins Other Lipid Mediat."},{"key":"10.1016\/j.cyto.2025.156981_bb0135","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0121784","article-title":"Quercetin represses apolipoprotein B expression by inhibiting the transcriptional activity of C\/EBP\u03b2","volume":"10","author":"Shimizu","year":"2015","journal-title":"PloS One"},{"key":"10.1016\/j.cyto.2025.156981_bb0140","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1515\/ap-2018-0009","article-title":"Characterization of phosphate transporter (s) and understanding their role in Leishmania donovani parasite","volume":"63","author":"Sindhu","year":"2018","journal-title":"Acta parasitologica"},{"key":"10.1016\/j.cyto.2025.156981_bb0145","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1101\/gad.254532.114","article-title":"A KAP1 phosphorylation switch controls MyoD function during skeletal muscle differentiation","volume":"29","author":"Singh","year":"2015","journal-title":"Genes Dev."},{"key":"10.1016\/j.cyto.2025.156981_bb0150","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1128\/CDLI.9.5.951-958.2002","article-title":"Laboratory diagnosis of visceral leishmaniasis","volume":"9","author":"Sundar","year":"2002","journal-title":"Clin. Vaccine Immunol."},{"key":"10.1016\/j.cyto.2025.156981_bb0155","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.molbiopara.2016.06.005","article-title":"Pi inhibits intracellular accumulation of methylglyoxal in promastigote form of L. donovani","volume":"207","author":"Tiwari","year":"2016","journal-title":"Mol. Biochem Parasitol."},{"key":"10.1016\/j.cyto.2025.156981_bb0160","doi-asserted-by":"crossref","first-page":"22262","DOI":"10.1074\/jbc.271.36.22262","article-title":"C\/EBP-\u03b2 \/LAP controls down-regulation of albumin gene transcription during liver regeneration","volume":"271","author":"Christian","year":"1996","journal-title":"J. Biol. Chem."},{"issue":"36","key":"10.1016\/j.cyto.2025.156981_bb0165","doi-asserted-by":"crossref","first-page":"22262","DOI":"10.1074\/jbc.271.36.22262","article-title":"C\/EBP-\u03b2 \/LAP controls down-regulation of albumin gene transcription during liver regeneration","volume":"271","author":"Christian","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cyto.2025.156981_bb0170","doi-asserted-by":"crossref","first-page":"668","DOI":"10.4269\/ajtmh.2011.09-0171","article-title":"Hormonal disturbances in visceral leishmaniasis (kala-azar)","volume":"84","author":"Verde","year":"2011","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.cyto.2025.156981_bb0175","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s00436-018-6115-0","article-title":"Leishmania donovani reduces the levels of retinoic acid\u2013synthesizing enzymes in infected macrophages and favoring its own survival","volume":"118","author":"Verma","year":"2019","journal-title":"Parasitol. Res."}],"container-title":["Cytokine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466625001280?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466625001280?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T17:50:34Z","timestamp":1752601834000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043466625001280"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":35,"alternative-id":["S1043466625001280"],"URL":"https:\/\/doi.org\/10.1016\/j.cyto.2025.156981","relation":{},"ISSN":["1043-4666"],"issn-type":[{"value":"1043-4666","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Leishmania donovani infection-driven high levels of IL-10 causes hypoalbuminemia in human visceral leishmaniasis","name":"articletitle","label":"Article Title"},{"value":"Cytokine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cyto.2025.156981","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"156981"}}