{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T21:34:40Z","timestamp":1784064880922,"version":"3.55.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100011488","name":"Health and Family Planning Committee of Pudong New Area","doi-asserted-by":"publisher","award":["PWRd 2018\\u201302"],"award-info":[{"award-number":["PWRd 2018\\u201302"]}],"id":[{"id":"10.13039\/501100011488","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytokine"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.cyto.2025.156985","type":"journal-article","created":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T14:23:48Z","timestamp":1751379828000},"page":"156985","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Exploring the role of immune cell traits and circulating inflammatory cytokines in the development of diabetic neuropathy"],"prefix":"10.1016","volume":"194","author":[{"given":"Nuojin","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qijun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peicheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.cyto.2025.156985_bb0005","first-page":"711","article-title":"Tackling the global burden of diabetic neuropathy","volume":"19","author":"Wood","year":"2023","journal-title":"Nat. Rev. Neurol."},{"issue":"8","key":"10.1016\/j.cyto.2025.156985_bb0010","doi-asserted-by":"crossref","DOI":"10.1002\/dmrr.3702","article-title":"Prevalence and risk factors of diabetic peripheral neuropathy: a population-based cross-sectional study in China","volume":"39","author":"Wang","year":"2023","journal-title":"Diabetes Metab. Res. Rev."},{"issue":"6","key":"10.1016\/j.cyto.2025.156985_bb0015","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/s11916-024-01243-5","article-title":"Diabetic neuropathy: pathophysiology review","volume":"28","author":"Strand","year":"2024","journal-title":"Curr. Pain Headache Rep."},{"key":"10.1016\/j.cyto.2025.156985_bb0020","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.ejphar.2018.06.034","article-title":"Molecular mechanism of diabetic neuropathy and its pharmacotherapeutic targets","volume":"833","author":"Dewanjee","year":"2018","journal-title":"Eur. J. Pharmacol."},{"issue":"Suppl. 5","key":"10.1016\/j.cyto.2025.156985_bb0025","doi-asserted-by":"crossref","first-page":"v116","DOI":"10.1093\/annonc\/mdv304","article-title":"Diffuse large B-cell lymphoma (DLBCL): ESMO clinical practice guidelines for diagnosis, treatment and follow-up","volume":"26","author":"Tilly","year":"2015","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.cyto.2025.156985_bb0030","doi-asserted-by":"crossref","first-page":"7597382","DOI":"10.1155\/2019\/7597382","article-title":"Infiltration of blood-derived macrophages contributes to the development of diabetic neuropathy","volume":"2019","author":"Sun","year":"2019","journal-title":"J Immunol Res"},{"issue":"4","key":"10.1016\/j.cyto.2025.156985_bb0035","doi-asserted-by":"crossref","DOI":"10.1111\/cns.14477","article-title":"How inflammation dictates diabetic peripheral neuropathy: an enlightening review","volume":"30","author":"Cheng","year":"2024","journal-title":"CNS Neurosci. Ther."},{"issue":"4","key":"10.1016\/j.cyto.2025.156985_bb0040","article-title":"CD40-mediated HIF-1\u03b1 expression underlying microangiopathy in diabetic nerve pathology","volume":"11","author":"Kan","year":"2018","journal-title":"Dis. Model. Mech."},{"issue":"6","key":"10.1016\/j.cyto.2025.156985_bb0045","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.2337\/dc19-2277","article-title":"Metabolic factors, lifestyle habits, and possible polyneuropathy in early type 2 diabetes: a Nationwide study of 5,249 patients in the Danish Centre for Strategic Research in type 2 diabetes (DD2) cohort","volume":"43","author":"Christensen","year":"2020","journal-title":"Diabetes Care"},{"key":"10.1016\/j.cyto.2025.156985_bb0050","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1742-2094-7-27","article-title":"TNF-alpha and neuropathic pain--a review","volume":"7","author":"Leung","year":"2010","journal-title":"J. Neuroinflammation"},{"issue":"2","key":"10.1016\/j.cyto.2025.156985_bb0055","article-title":"Interleukin-6 levels in patients with diabetic polyneuropathy","volume":"14","author":"Chanda","year":"2022","journal-title":"Cureus"},{"issue":"6","key":"10.1016\/j.cyto.2025.156985_bb0060","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1210\/jc.2008-2385","article-title":"Microvascular reactivity and inflammatory cytokines in painful and painless peripheral diabetic neuropathy","volume":"94","author":"Doupis","year":"2009","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"4","key":"10.1016\/j.cyto.2025.156985_bb0065","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1002\/jrsm.1346","article-title":"Meta-analysis and Mendelian randomization: a review","volume":"10","author":"Bowden","year":"2019","journal-title":"Res. Synth. Methods"},{"issue":"11","key":"10.1016\/j.cyto.2025.156985_bb0070","doi-asserted-by":"crossref","first-page":"3253","DOI":"10.1681\/ASN.2016010098","article-title":"Mendelian randomization as an approach to assess causality using observational data","volume":"27","author":"Sekula","year":"2016","journal-title":"J. Am. Soc. Nephrol."},{"issue":"3","key":"10.1016\/j.cyto.2025.156985_bb0075","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1093\/ije\/dyr036","article-title":"Avoiding bias from weak instruments in Mendelian randomization studies","volume":"40","author":"Burgess","year":"2011","journal-title":"Int. J. Epidemiol."},{"issue":"10","key":"10.1016\/j.cyto.2025.156985_bb0080","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1038\/s41588-020-0684-4","article-title":"Complex genetic signatures in immune cells underlie autoimmunity and inform therapy","volume":"52","author":"Orr\u00f9","year":"2020","journal-title":"Nat. Genet."},{"issue":"9","key":"10.1016\/j.cyto.2025.156985_bb0085","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1038\/s41590-023-01588-w","article-title":"Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets","volume":"24","author":"Zhao","year":"2023","journal-title":"Nat. Immunol."},{"issue":"7","key":"10.1016\/j.cyto.2025.156985_bb0090","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1002\/gepi.21758","article-title":"Mendelian randomization analysis with multiple genetic variants using summarized data","volume":"37","author":"Burgess","year":"2013","journal-title":"Genet. Epidemiol."},{"issue":"4","key":"10.1016\/j.cyto.2025.156985_bb0095","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1002\/gepi.21965","article-title":"Consistent estimation in Mendelian randomization with some invalid instruments using a weighted median estimator","volume":"40","author":"Bowden","year":"2016","journal-title":"Genet. Epidemiol."},{"issue":"5","key":"10.1016\/j.cyto.2025.156985_bb0100","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s10654-017-0255-x","article-title":"Interpreting findings from Mendelian randomization using the MR-egger method","volume":"32","author":"Burgess","year":"2017","journal-title":"Eur. J. Epidemiol."},{"issue":"21","key":"10.1016\/j.cyto.2025.156985_bb0105","doi-asserted-by":"crossref","first-page":"2926","DOI":"10.1002\/sim.6522","article-title":"Detecting pleiotropy in Mendelian randomisation studies with summary data and a continuous outcome","volume":"34","author":"Greco","year":"2015","journal-title":"Stat. Med."},{"issue":"1","key":"10.1016\/j.cyto.2025.156985_bb0110","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1037\/1082-989X.7.1.83","article-title":"A comparison of methods to test mediation and other intervening variable effects","volume":"7","author":"MacKinnon","year":"2002","journal-title":"Psychol. Methods"},{"key":"10.1016\/j.cyto.2025.156985_bb0115","doi-asserted-by":"crossref","first-page":"69","DOI":"10.2147\/JPR.S186372","article-title":"Cytokine production capabilities of human primary monocyte-derived macrophages from patients with diabetes mellitus type 2 with and without diabetic peripheral neuropathy","volume":"12","author":"Alvarado-V\u00e1zquez","year":"2019","journal-title":"J. Pain Res."},{"issue":"1","key":"10.1016\/j.cyto.2025.156985_bb0120","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1172\/JCI88877","article-title":"Islet inflammation in type 2 diabetes and physiology","volume":"127","author":"Eguchi","year":"2017","journal-title":"J. Clin. Invest."},{"issue":"4","key":"10.1016\/j.cyto.2025.156985_bb0125","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1007\/s00125-014-3171-6","article-title":"Molecular mechanisms of diabetic cardiomyopathy","volume":"57","author":"Bugger","year":"2014","journal-title":"Diabetologia"},{"issue":"19","key":"10.1016\/j.cyto.2025.156985_bb0130","doi-asserted-by":"crossref","DOI":"10.3390\/ijms251910395","article-title":"Update on biomarkers of chronic inflammatory processes underlying diabetic neuropathy","volume":"25","author":"Stoian","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"19","key":"10.1016\/j.cyto.2025.156985_bb0135","doi-asserted-by":"crossref","DOI":"10.3390\/ijms221910835","article-title":"Inflammatory mechanisms in the pathophysiology of diabetic peripheral neuropathy (DN)-new aspects","volume":"22","author":"Baum","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.cyto.2025.156985_bb0140","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1016\/j.neuron.2017.02.005","article-title":"New horizons in diabetic neuropathy: mechanisms, bioenergetics, and pain","volume":"93","author":"Feldman","year":"2017","journal-title":"Neuron"},{"issue":"11","key":"10.1016\/j.cyto.2025.156985_bb0145","doi-asserted-by":"crossref","DOI":"10.1038\/emm.2017.173","article-title":"Lower serum extracellular superoxide dismutase levels are associated with polyneuropathy in recent-onset diabetes","volume":"49","author":"Strom","year":"2017","journal-title":"Exp. Mol. Med."},{"issue":"1","key":"10.1016\/j.cyto.2025.156985_bb0150","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/dme.12568","article-title":"Soluble CD163 levels are elevated in cerebrospinal fluid and serum in people with type 2 diabetes mellitus and are associated with impaired peripheral nerve function","volume":"32","author":"Kallestrup","year":"2015","journal-title":"Diabet. Med."},{"issue":"3","key":"10.1016\/j.cyto.2025.156985_bb0155","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s11892-016-0727-5","article-title":"Inflammation as a therapeutic target for diabetic neuropathies","volume":"16","author":"Pop-Busui","year":"2016","journal-title":"Curr. Diab. Rep."},{"issue":"8","key":"10.1016\/j.cyto.2025.156985_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.drudis.2024.104087","article-title":"Targeting neuroinflammation in distal symmetrical polyneuropathy in diabetes","volume":"29","author":"Chong","year":"2024","journal-title":"Drug Discov. Today"},{"issue":"3","key":"10.1016\/j.cyto.2025.156985_bb0165","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1002\/jcp.29106","article-title":"Cav-1 participates in the development of diabetic neuropathy pain through the TLR4 signaling pathway","volume":"235","author":"Jia","year":"2020","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.cyto.2025.156985_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2024.156548","article-title":"Causal relationships between circulating inflammatory cytokines and diabetic neuropathy: a Mendelian randomization study","volume":"177","author":"Wang","year":"2024","journal-title":"Cytokine"},{"issue":"3","key":"10.1016\/j.cyto.2025.156985_bb0175","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1111\/cts.12977","article-title":"Gene therapy for diabetic peripheral neuropathy: a randomized, placebo-controlled phase III study of VM202, a plasmid DNA encoding human hepatocyte growth factor","volume":"14","author":"Kessler","year":"2021","journal-title":"Clin. Transl. Sci."},{"issue":"1","key":"10.1016\/j.cyto.2025.156985_bb0180","doi-asserted-by":"crossref","first-page":"8316","DOI":"10.1038\/s41598-018-26704-x","article-title":"Hepatocyte growth factor (HGF) promotes peripheral nerve regeneration by activating repair Schwann cells","volume":"8","author":"Ko","year":"2018","journal-title":"Sci. Rep."},{"issue":"37","key":"10.1016\/j.cyto.2025.156985_bb0185","doi-asserted-by":"crossref","first-page":"12414","DOI":"10.1523\/JNEUROSCI.3135-10.2010","article-title":"Hepatocyte growth factor-met signaling is required for Runx1 extinction and peptidergic differentiation in primary nociceptive neurons","volume":"30","author":"Gascon","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.cyto.2025.156985_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.mcn.2022.103767","article-title":"Gabapentin inhibits the analgesic effects and nerve regeneration process induced by hepatocyte growth factor (HGF) in a peripheral nerve injury model: implication for the use of VM202 and gabapentinoids for peripheral neuropathy","volume":"122","author":"Lee","year":"2022","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.cyto.2025.156985_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155867","article-title":"Xiaoke Bitong capsule alleviates inflammatory impairment via inhibition of the TNF signaling pathway to against diabetic peripheral neuropathy","volume":"132","author":"Tian","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.cyto.2025.156985_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110991","article-title":"An update on potential biomarkers for diagnosing diabetic foot ulcer at early stage","volume":"133","author":"Wang","year":"2021","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.cyto.2025.156985_bb0205","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1186\/s13287-022-02927-8","article-title":"Human umbilical cord-derived mesenchymal stem cells not only ameliorate blood glucose but also protect vascular endothelium from diabetic damage through a paracrine mechanism mediated by MAPK\/ERK signaling","volume":"13","author":"Liu","year":"2022","journal-title":"Stem Cell Res Ther"},{"issue":"Suppl. 1","key":"10.1016\/j.cyto.2025.156985_bb0210","doi-asserted-by":"crossref","first-page":"S121","DOI":"10.1016\/j.diabres.2004.05.010","article-title":"Possible contribution of adipocytokines on diabetic neuropathy","volume":"66","author":"Matsuda","year":"2004","journal-title":"Diabetes Res. Clin. Pract."},{"issue":"19","key":"10.1016\/j.cyto.2025.156985_bb0215","doi-asserted-by":"crossref","DOI":"10.3390\/ijms221910647","article-title":"TNFSF14-derived molecules as a novel treatment for obesity and type 2 diabetes","volume":"22","author":"Agostino","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.cyto.2025.156985_bb0220","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1186\/s12951-022-01516-4","article-title":"MiR-21 regulating PVT1\/PTEN\/IL-17 axis towards the treatment of infectious diabetic wound healing by modified GO-derived biomaterial in mouse models","volume":"20","author":"Chen","year":"2022","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.cyto.2025.156985_bb0225","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.746151","article-title":"Meta-inflammation and metabolic reprogramming of macrophages in diabetes and obesity: the importance of metabolites","volume":"12","author":"Russo","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cyto.2025.156985_bb0230","article-title":"Characterization of the microenvironment of diabetic foot ulcers and potential drug identification based on scRNA-seq","volume":"13","author":"Li","year":"2022","journal-title":"Front. Endocrinol. (Lausanne)."}],"container-title":["Cytokine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466625001322?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466625001322?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T14:41:45Z","timestamp":1762353705000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043466625001322"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":46,"alternative-id":["S1043466625001322"],"URL":"https:\/\/doi.org\/10.1016\/j.cyto.2025.156985","relation":{},"ISSN":["1043-4666"],"issn-type":[{"value":"1043-4666","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exploring the role of immune cell traits and circulating inflammatory cytokines in the development of diabetic neuropathy","name":"articletitle","label":"Article Title"},{"value":"Cytokine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cyto.2025.156985","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"156985"}}