{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T09:23:15Z","timestamp":1762593795261,"version":"build-2065373602"},"reference-count":94,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005669","name":"Research Support Foundation of Para\u00edba State","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005669","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018802","name":"Universidade Federal da Para\u00edba","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018802","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordination for the improvement of Higher Education Personnel","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytokine"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.cyto.2025.157047","type":"journal-article","created":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T06:59:25Z","timestamp":1759993165000},"page":"157047","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Quercetin enhances amphotericin B activity and regulates ROS and cytokine production in human monocytes infected by Leishmania infantum"],"prefix":"10.1016","volume":"196","author":[{"given":"Leonardo Lima","family":"Cardoso","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Delva Fonseca Lamec","family":"Thyares","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Let\u00edcia Monteiro","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ros\u00e1lia Santos","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shayenne Eduarda Ramos","family":"Vanderley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando C\u00e9zar","family":"Comberlang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda Silva","family":"Almeida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatjana","family":"de Souza Lima Keesen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"author":"Pan American Health Organization (PAHO)","key":"10.1016\/j.cyto.2025.157047_bb0005"},{"key":"10.1016\/j.cyto.2025.157047_bb0010","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.pt.2021.07.003","article-title":"Leishmaniasis: the act of transmission","volume":"37","author":"Serafim","year":"2021","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.cyto.2025.157047_bb0015","doi-asserted-by":"crossref","first-page":"8965","DOI":"10.1007\/s00253-020-10856-w","article-title":"Recent advances and new strategies on leishmaniasis treatment","volume":"104","author":"Roatt","year":"2020","journal-title":"Appl. Microbiol. Biotechnol."},{"author":"World Health Organization (WHO)","key":"10.1016\/j.cyto.2025.157047_bb0020"},{"key":"10.1016\/j.cyto.2025.157047_bb0025","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1093\/qjmed\/hct116","article-title":"Leishmaniasis: clinical syndromes and treatment","volume":"107","author":"Mcgwire","year":"2014","journal-title":"QJM"},{"key":"10.1016\/j.cyto.2025.157047_bb0030","first-page":"11","article-title":"Lipsosomal amphotericin B: a review of its properties, function, and use for treatment of cutaneous leishmaniasis","volume":"10","author":"Shirzadi","year":"2019","journal-title":"Res. Rep. Trop. Med."},{"key":"10.1016\/j.cyto.2025.157047_bb0035","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1039\/D0MO00043D","article-title":"Protein glycosylation in Leishmania spp","volume":"16","author":"Mule","year":"2020","journal-title":"Mol. Omics."},{"key":"10.1016\/j.cyto.2025.157047_bb0040","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1345\/aph.18181","article-title":"Hepatotoxicity possibly caused by amphotericin B","volume":"33","author":"Gill","year":"1999","journal-title":"Ann. Pharmacother."},{"key":"10.1016\/j.cyto.2025.157047_bb0045","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1186\/s12882-022-02770-2","article-title":"Tolerability and epidemiology of nephrotoxicity associated with conventional amphotericin B therapy: a retrospective study in tertiary care centers in Palestine","volume":"23","author":"Abdel-Hafez","year":"2022","journal-title":"BMC Nephrol."},{"key":"10.1016\/j.cyto.2025.157047_bb0050","article-title":"Effect of amphotericin B on the thermodynamic stability, aggregation state, hemolysis, and antifungal activity of amphotericin B-nonionic surfactant micellar","volume":"377","author":"Liu","year":"2023","journal-title":"J. Mol. Liq."},{"key":"10.1016\/j.cyto.2025.157047_bb0055","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1128\/AAC.50.4.1352-1364.2006","article-title":"Antitrypanosomal and antileishmanial activities of flavonoids and their analogues: in vitro, in vivo, structure-activity relationship, and quantitative structure-activity","volume":"50","author":"Tasdemir","year":"2006","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.cyto.2025.157047_bb0060","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.foodchem.2009.12.097","article-title":"Flavonoid\u2013flavonoid interaction and its effect on their antioxidant activity","volume":"121","author":"Hidalgo","year":"2010","journal-title":"Food Chem."},{"key":"10.1016\/j.cyto.2025.157047_bb0065","first-page":"753","article-title":"Quercetin promotes antipromastigote effect by increasing the ROS production and anti-amastigote by upregulating Nrf2\/HO-1 expression, affecting iron","volume":"111","author":"Cataneo","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.cyto.2025.157047_bb0070","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.archoralbio.2018.11.005","article-title":"Activity of quercetin and kaemferol against Streptococcus mutans biofilm","volume":"98","author":"Zeng","year":"2019","journal-title":"Arch. Oral Biol."},{"key":"10.1016\/j.cyto.2025.157047_bb0075","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1007\/s00894-020-04356-x","article-title":"Mechanism of antioxidant properties of quercetin and quercetin-DNA complex","volume":"26","author":"Song","year":"2020","journal-title":"J. Mol. Model."},{"key":"10.1016\/j.cyto.2025.157047_bb0080","doi-asserted-by":"crossref","first-page":"421","DOI":"10.2147\/JIR.S228361","article-title":"Modulation of chronic inflammation by quercetin: the beneficial effects on obesity","volume":"13","author":"Sato","year":"2020","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.cyto.2025.157047_bb0085","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.703985","article-title":"Antileishmanial activity of flavones-rich fraction from Arrabidaea chica Verlot (Bignoniaceae)","volume":"12","author":"Silva-Silva","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.cyto.2025.157047_bb0090","doi-asserted-by":"crossref","first-page":"4625","DOI":"10.1007\/s00436-015-4708-4","article-title":"Antileishmanial activity and evaluation of the mechanism of action of strychnobiflavone flavonoid isolated from Strychnos pseudoquina against Leishmania infantum","volume":"114","author":"Lage","year":"2015","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.cyto.2025.157047_bb0095","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.canlet.2008.03.046","article-title":"Multitargeted cancer prevention by quercetin","volume":"269","author":"Murakami","year":"2008","journal-title":"Cancer Lett."},{"key":"10.1016\/j.cyto.2025.157047_bb0100","doi-asserted-by":"crossref","first-page":"167","DOI":"10.3390\/nu8030167","article-title":"Quercetin, inflammation and immunity","volume":"8","author":"Li","year":"2016","journal-title":"Nutrients"},{"key":"10.1016\/j.cyto.2025.157047_bb0105","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.3390\/nu7042345","article-title":"Estimated daily intake and seasonal food sources of quercetin in Japan","volume":"7","author":"Nishimuro","year":"2015","journal-title":"Nutrients"},{"key":"10.1016\/j.cyto.2025.157047_bb0110","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.plaphy.2021.05.023","article-title":"The role of quercetin in plants","volume":"166","author":"Singh","year":"2021","journal-title":"Plant Physiol. Biochem."},{"key":"10.1016\/j.cyto.2025.157047_bb0115","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1021\/np400193m","article-title":"Reactive oxygen species production by quercetin causes the death of Leishmania amazonensis intracellular amastigotes","volume":"76","author":"Fonseca-Silva","year":"2013","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.cyto.2025.157047_bb0120","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.apjtb.2017.01.022","article-title":"Caffeic acid and quercetin exert caspase-independent apoptotic effects on Leishmania major promastigotes, and reactivate the death of infected phagocytes derived from BALB\/c mice","volume":"7","author":"Belkhelfa-Slimani","year":"2017","journal-title":"Asian Pac. J. Trop. Biomed."},{"key":"10.1016\/j.cyto.2025.157047_bb0125","article-title":"Therapeutic effect of oral quercetin in hamsters infected with Leishmania Viannia braziliensis","volume":"12","author":"Dos Santos","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.cyto.2025.157047_bb0130","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1093\/jac\/dkn053","article-title":"Quercetin interferes with iron metabolism in Leishmania donovani and targets ribonucleotide reductase to exert leishmanicidal activity","volume":"61","author":"Sen","year":"2008","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.cyto.2025.157047_bb0135","first-page":"296","article-title":"The leishmanicidal flavonols quercetin and quercitrin target Leishmania (Leishmania) amazonensis arginase","volume":"131","author":"da Silva","year":"2012","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.cyto.2025.157047_bb0140","doi-asserted-by":"crossref","first-page":"64","DOI":"10.4103\/abr.abr_76_17","article-title":"Synthesis and in vitro leishmanicidal activities of six quercetin derivatives","volume":"7","author":"Mohajeri","year":"2018","journal-title":"Adv. Biomed. Res."},{"key":"10.1016\/j.cyto.2025.157047_bb0145","doi-asserted-by":"crossref","first-page":"3067","DOI":"10.1007\/s00436-019-06403-w","article-title":"Biological activity of Morita-Baylis-Hillman adduct homodimers in L. infantum and L. amazonensis: anti-Leishmania activity and cytotoxicity","volume":"118","author":"da C\u00e2mara Rocha","year":"2019","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.cyto.2025.157047_bb0150","doi-asserted-by":"crossref","first-page":"141","DOI":"10.3390\/tropicalmed8030141","article-title":"Leishmanicidal activity of guanidine derivatives against Leishmania infantum","volume":"8","author":"Almeida","year":"2023","journal-title":"Trop. Med. Infect. Dis."},{"key":"10.1016\/j.cyto.2025.157047_bb0155","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1128\/IAI.00914-06","article-title":"Oxidant generation by single infected monocytes after short-term fluorescence labeling of a protozoan parasite","volume":"75","author":"Chang","year":"2007","journal-title":"Infect. Immun."},{"key":"10.1016\/j.cyto.2025.157047_bb0160","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2022.788196","article-title":"Leishmania infantum defective in Lipophosphoglycan biosynthesis interferes with activation of human neutrophils","volume":"12","author":"Quintela-Carvalho","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.cyto.2025.157047_bb0165","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0187186","article-title":"Arginase expression modulates nitric oxide production in Leishmania (Leishmania) amazonensis","volume":"12","author":"Acuna","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.cyto.2025.157047_bb0170","doi-asserted-by":"crossref","DOI":"10.1155\/2024\/7632408","article-title":"Quercetin as a promising antiprotozoan phytochemical: current knowledge and future research avenues","volume":"2024","author":"Memariani","year":"2024","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.cyto.2025.157047_bb0175","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3390\/antibiotics9020045","article-title":"Antifungal efficacy and mechanisms of flavonoids","volume":"9","author":"Al Aboody","year":"2020","journal-title":"Antibiotics (Basel)"},{"key":"10.1016\/j.cyto.2025.157047_bb0180","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1111\/mve.12181","article-title":"Synergism of thymol, carvacrol and eugenol in larvae of the cattle tick, Rhipicephalus microplus, and brown dog tick, Rhipicephalus sanguineus","volume":"30","author":"Ara\u00fajo","year":"2016","journal-title":"Med. Vet. Entomol."},{"key":"10.1016\/j.cyto.2025.157047_bb0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.crphar.2022.100110","article-title":"Evaluation of synergism in drug combinations and reference models for future orientations in oncology","volume":"3","author":"Duarte","year":"2022","journal-title":"Curr. Res. Pharmacol. Drug Discov."},{"key":"10.1016\/j.cyto.2025.157047_bb0190","doi-asserted-by":"crossref","first-page":"321","DOI":"10.3390\/jof6040321","article-title":"Amphotericin B and other polyenes\u2014discovery, clinical use, mode of action and drug resistance","volume":"6","author":"Carolus","year":"2020","journal-title":"J. Fungi."},{"key":"10.1016\/j.cyto.2025.157047_bb0195","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.ijpharm.2013.02.038","article-title":"Hemolytic and pharmacokinetic studies of liposomal and particulate amphotericin B formulations","volume":"447","author":"Serrano","year":"2013","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.cyto.2025.157047_bb0200","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2021.685296","article-title":"Mechanisms of immunopathogenesis in cutaneous leishmaniasis and post kala-azar dermal leishmaniasis (PKDL)","volume":"11","author":"Volpedo","year":"2021","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.cyto.2025.157047_bb0205","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.748325","article-title":"Determinants of innate immunity in visceral leishmaniasis and their implication in vaccine development","volume":"12","author":"Volpedo","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cyto.2025.157047_bb0210","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2021.624009","article-title":"Role of cytokines in experimental and human visceral leishmaniasis","volume":"11","author":"Samant","year":"2021","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.cyto.2025.157047_bb0215","doi-asserted-by":"crossref","first-page":"3367","DOI":"10.1021\/acs.molpharmaceut.2c00492","article-title":"Therapeutic potential of quercetin-loaded nanoemulsion against experimental visceral leishmaniasis: In vitro\/ex vivo studies and mechanistic insights","volume":"19","author":"Das","year":"2022","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.cyto.2025.157047_bb0220","doi-asserted-by":"crossref","first-page":"4","DOI":"10.4103\/2221-1691.367689","article-title":"Anti-leishmanial, immunomodulatory and anti-oxidative activity of quercetin against cutaneous leishmaniasis caused by Leishmania major","volume":"13","author":"Oryan","year":"2023","journal-title":"Asian Pac. J. Trop. Biomed."},{"key":"10.1016\/j.cyto.2025.157047_bb0225","article-title":"Probing the molecular mechanism of aggressive infection by antimony resistant Leishmania donovani","volume":"137","author":"Mukherjee","year":"2021","journal-title":"Cytokine"},{"year":"2024","series-title":"Antimony Toxicity, in: StatPearls","author":"Martin","key":"10.1016\/j.cyto.2025.157047_bb0230"},{"key":"10.1016\/j.cyto.2025.157047_bb0235","doi-asserted-by":"crossref","first-page":"5412","DOI":"10.1021\/acs.molpharmaceut.4c00485","article-title":"Formulation strategies to overcome amphotericin B induced toxicity","volume":"21","author":"Dash","year":"2024","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.cyto.2025.157047_bb0240","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/3157867","article-title":"Quercetin as a novel therapeutic approach for lymphoma","volume":"2021","author":"Soofiyani","year":"2021","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.cyto.2025.157047_bb0245","doi-asserted-by":"crossref","first-page":"22959","DOI":"10.1038\/s41598-021-02248-5","article-title":"Mechanism of quercetin therapeutic targets for Alzheimer disease and type 2 diabetes mellitus","volume":"11","author":"Zu","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cyto.2025.157047_bb0250","doi-asserted-by":"crossref","first-page":"2494","DOI":"10.3390\/molecules27082494","article-title":"Antimicrobial activity of quercetin: an approach to its mechanistic principle","volume":"27","author":"Nguyen","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.cyto.2025.157047_bb0255","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1080\/14756366.2019.1616182","article-title":"Leishmania infantum arginase: biochemical characterization and inhibition by naturally occurring phenolic substances","volume":"34","author":"Garcia","year":"2019","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.cyto.2025.157047_bb0260","doi-asserted-by":"crossref","first-page":"5843","DOI":"10.3390\/molecules26195843","article-title":"Bioflavonoid-induced apoptosis and DNA damage in amastigotes and promastigotes of Leishmania donovani: deciphering the mode of action","volume":"26","author":"Mehwish","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.cyto.2025.157047_bb0265","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s00436-024-08199-w","article-title":"Piperine, quercetin, and curcumin identified as promising natural products for topical treatment of cutaneous leishmaniasis","volume":"123","author":"Clemente","year":"2024","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.cyto.2025.157047_bb0270","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1039\/d0mt00125b","article-title":"Iron in parasitic protists\u2013from uptake to storage and where we can interfere","volume":"12","author":"Mach","year":"2020","journal-title":"Metallomics"},{"key":"10.1016\/j.cyto.2025.157047_bb0275","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1488590","article-title":"Cutaneous leishmaniasis and iron metabolism: current insights and challenges","volume":"15","author":"Assouab","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cyto.2025.157047_bb0280","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.3390\/ijms24021635","article-title":"Miltefosine and Nifuratel combination: a promising therapy for the treatment of Leishmania donovani visceral Leishmaniasis","volume":"24","author":"Melcon-Fernandez","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cyto.2025.157047_bb0285","first-page":"152","article-title":"Combination therapy with nitazoxanide and amphotericin B, Glucantime\u00ae, miltefosine and sitamaquine against Leishmania (Leishmania) infantum intracellular amastigotes","volume":"132","author":"Mesquita","year":"2014","journal-title":"Acta Trop."},{"key":"10.1016\/j.cyto.2025.157047_bb0290","doi-asserted-by":"crossref","first-page":"6197","DOI":"10.1128\/AAC.00093-14","article-title":"Resveratrol Is Active against Leishmania amazonensis: In Vitro Effect of Its Association with Amphotericin B","volume":"58","author":"Ferreira","year":"2014","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.cyto.2025.157047_bb0295","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.108274","article-title":"In vitro and in vivo therapeutic potentials of 6-gingerol in combination with amphotericin B for treatment of Leishmania major infection: powerful synergistic and multifunctional effects","volume":"101","author":"Keyhani","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.cyto.2025.157047_bb0300","first-page":"108","article-title":"Antileishmanial activity of Moringa oleifera leaf extracts and potential synergy with amphotericin B","volume":"130","author":"Hammi","year":"2020","journal-title":"S. Afr. J. Bot."},{"key":"10.1016\/j.cyto.2025.157047_bb0305","doi-asserted-by":"crossref","first-page":"151","DOI":"10.3390\/biom15010151","article-title":"The role of quercetin, a flavonoid in the Management of Pathogenesis through Regulation of oxidative stress, Inflammation, and Biological Activities","volume":"15","author":"Alharbi","year":"2025","journal-title":"Biomolecules"},{"key":"10.1016\/j.cyto.2025.157047_bb0310","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1002\/tox.22096","article-title":"Quercetin protects human peripheral blood mononuclear cells from OTA-induced oxidative stress, genotoxicity, and inflammation","volume":"31","author":"Periasamy","year":"2016","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.cyto.2025.157047_bb0315","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/14786419.2024.2401499","article-title":"In vitro and in silico evaluation of the anti-leishmania activity of synthetic chalcones","author":"Leite","year":"2024","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.cyto.2025.157047_bb0320","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2022.1044665","article-title":"In vitro anti-Leishmania activity of triclabendazole and its synergic effect with amphotericin B","volume":"12","author":"Borges","year":"2023","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.cyto.2025.157047_bb0325","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1093\/jac\/dky014","article-title":"Pharmacodynamics and cellular accumulation of amphotericin B and miltefosine in Leishmania donovani-infected primary macrophages","volume":"73","author":"Voak","year":"2018","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.cyto.2025.157047_bb0330","doi-asserted-by":"crossref","first-page":"72","DOI":"10.3389\/fcimb.2012.00072","article-title":"Impact of Leishmania metalloprotease GP63 on macrophage signaling","volume":"2","author":"Isnard","year":"2012","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.cyto.2025.157047_bb0335","first-page":"1","article-title":"Extracellular vesicles and leishmaniasis: current knowledge and promising avenues for future development","volume":"138","author":"Dong","year":"2021","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.cyto.2025.157047_bb0340","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0014666","article-title":"Reactive oxygen species production and mitochondrial dysfunction contribute to quercetin induced death in Leishmania amazonensis","volume":"6","author":"Fonseca-Silva","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.cyto.2025.157047_bb0345","doi-asserted-by":"crossref","DOI":"10.3390\/ijms231911746","article-title":"A comprehensive analysis and anti-cancer activities of quercetin in ROS-mediated cancer and cancer stem cells","volume":"23","author":"Biswas","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cyto.2025.157047_bb0350","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/s10863-017-9733-9","article-title":"Plants of Brazilian restingas with tripanocide activity against Trypanosoma cruzi strains","volume":"49","author":"Faria","year":"2017","journal-title":"J. Bioenerg. Biomembr."},{"key":"10.1016\/j.cyto.2025.157047_bb0355","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1093\/infdis\/jiu013","article-title":"Human classical monocytes control the intracellular stage of Leishmania braziliensis by reactive oxygen species","volume":"209","author":"Novais","year":"2014","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.cyto.2025.157047_bb0360","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1128\/AAC.00030-11","article-title":"Mechanism of amphotericin B resistance in clinical isolates of Leishmania donovani","volume":"56","author":"Purkait","year":"2012","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.cyto.2025.157047_bb0365","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1128\/AAC.02834-14","article-title":"Ascorbate peroxidase, a key molecule regulating amphotericin B resistance in clinical isolates of Leishmania donovani","volume":"58","author":"Kumar","year":"2014","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.cyto.2025.157047_bb0370","doi-asserted-by":"crossref","first-page":"6239","DOI":"10.1021\/acsabm.4c00835","article-title":"Development of amphotericin B decorated gold nanoparticles as a promising Antileishmanial Nanoconjugate","volume":"7","author":"Sharma","year":"2024","journal-title":"ACS Appl. Bio Mater."},{"key":"10.1016\/j.cyto.2025.157047_bb0375","article-title":"Synergic effect of eugenol oleate with amphotericin B augments anti-leishmanial immune response in experimental visceral leishmaniasis in vitro and in vivo","volume":"90","author":"Kar","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.cyto.2025.157047_bb0380","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2020.155319","article-title":"Lupeol and amphotericin B mediate synergistic anti-leishmanial immunomodulatory effects in Leishmania donovani-infected BALB\/c mice","volume":"137","author":"Das","year":"2021","journal-title":"Cytokine"},{"key":"10.1016\/j.cyto.2025.157047_bb0385","article-title":"The importance of T cell-derived cytokines in post-kala-azar dermal leishmaniasis","volume":"138","author":"Jafarzadeh","year":"2021","journal-title":"Cytokine"},{"key":"10.1016\/j.cyto.2025.157047_bb0390","article-title":"Role of Treg, Breg and other cytokine sets in host protection and immunopathology during human leishmaniasis: are they potential valuable markers in clinical settings and vaccine evaluation?","volume":"242","author":"Divenuto","year":"2023","journal-title":"Acta Trop."},{"key":"10.1016\/j.cyto.2025.157047_bb0395","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1486407","article-title":"The development and maintenance of immunity against visceral leishmaniasis","volume":"15","author":"Tiwari","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cyto.2025.157047_bb0400","doi-asserted-by":"crossref","first-page":"409","DOI":"10.3390\/pathogens11040409","article-title":"The dangerous liaisons in the oxidative stress response to Leishmania infection","volume":"11","author":"Reverte","year":"2022","journal-title":"Pathogens"},{"key":"10.1016\/j.cyto.2025.157047_bb0405","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/j.pt.2023.07.005","article-title":"Immune dysregulation and inflammation causing hypopigmentation in post kala-azar dermal leishmaniasis: partners in crime?","volume":"39","author":"Sengupta","year":"2023","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.cyto.2025.157047_bb0410","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1277557","article-title":"CD4+ Th1 and Th17 responses and multifunctional CD8 T lymphocytes associated with cure or disease worsening in human visceral leishmaniasis","volume":"15","author":"de Franca","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cyto.2025.157047_bb0415","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.3390\/vaccines12101179","article-title":"Immunotherapeutic strategies as potential treatment options for cutaneous Leishmaniasis","volume":"12","author":"Lafleur","year":"2024","journal-title":"Vaccines (Basel)"},{"key":"10.1016\/j.cyto.2025.157047_bb0420","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S1471-4906(02)00013-3","article-title":"IL-6: a regulator of the transition from neutrophil to monocyte recruitment during inflammation","volume":"24","author":"Kaplanski","year":"2003","journal-title":"Trends Immunol."},{"key":"10.1016\/j.cyto.2025.157047_bb0425","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.yexcr.2012.02.017","article-title":"Quercetin abrogates IL-6\/STAT3 signaling and inhibits glioblastoma cell line growth and migration","volume":"318","author":"Michaud-Levesque","year":"2012","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.cyto.2025.157047_bb0430","article-title":"Study on the effect and mechanism of quercetin in treating gout arthritis","volume":"113","author":"Feng","year":"2022","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.cyto.2025.157047_bb0435","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.cyto.2018.07.001","article-title":"The impact of IL-10 dynamic modulation on host immune response against visceral leishmaniasis","volume":"112","author":"In\u00eas","year":"2018","journal-title":"Cytokine"},{"issue":"11","key":"10.1016\/j.cyto.2025.157047_bb0440","article-title":"Malnutrition disrupts adaptive immunity during visceral leishmaniasis by enhancing IL-10 production","volume":"20","author":"La\u00eds","year":"2024","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.cyto.2025.157047_bb0445","article-title":"Higher levels of IL-6 and IL-10 cytokines in visceral leishmaniasis-HIV co-infected patients from Brazilian high endemic area","volume":"185","author":"Nogueira","year":"2025","journal-title":"Cytokine"},{"key":"10.1016\/j.cyto.2025.157047_bb0450","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.molimm.2021.06.014","article-title":"IL-10 receptor blockade controls the in vitro infectivity of Leishmania infantum and promotes a Th1 activation in PBMC of dogs with visceral leishmaniasis","volume":"137","author":"Cardoso","year":"2021","journal-title":"Mol. Immunol."},{"author":"Cataneo","key":"10.1016\/j.cyto.2025.157047_bb0455"},{"key":"10.1016\/j.cyto.2025.157047_bb0460","first-page":"255","article-title":"The flavonoid, quercetin, differentially regulates Th-1 (IFN\u03b3) and Th-2 (IL4) cytokine gene expression by normal peripheral blood mononuclear cells","volume":"1588","author":"Nair","year":"2002","journal-title":"Biochim. Biophys. Acta, Mol. Cell Res."},{"key":"10.1016\/j.cyto.2025.157047_bb0465","doi-asserted-by":"crossref","DOI":"10.1093\/mmy\/myac011","article-title":"Paeonol enhances treatment of fluconazole and amphotericin B against oropharyngeal candidiasis through HIF-1\u03b1 related IL-17 signaling","volume":"60","author":"Pan","year":"2022","journal-title":"Med. Mycol."},{"key":"10.1016\/j.cyto.2025.157047_bb0470","doi-asserted-by":"crossref","DOI":"10.1016\/j.imbio.2021.152148","article-title":"Immunomodulatory role of Th17 pathway in experimental visceral leishmaniasis","volume":"226","author":"Khatonier","year":"2021","journal-title":"Immunobiology"}],"container-title":["Cytokine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466625001942?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466625001942?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T09:20:19Z","timestamp":1762593619000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043466625001942"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":94,"alternative-id":["S1043466625001942"],"URL":"https:\/\/doi.org\/10.1016\/j.cyto.2025.157047","relation":{},"ISSN":["1043-4666"],"issn-type":[{"type":"print","value":"1043-4666"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Quercetin enhances amphotericin B activity and regulates ROS and cytokine production in human monocytes infected by Leishmania infantum","name":"articletitle","label":"Article Title"},{"value":"Cytokine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cyto.2025.157047","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"157047"}}