{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T17:06:19Z","timestamp":1778864779742,"version":"3.51.4"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100010256","name":"Guangzhou Municipal Science and Technology Project","doi-asserted-by":"publisher","award":["2024A03J0876"],"award-info":[{"award-number":["2024A03J0876"]}],"id":[{"id":"10.13039\/501100010256","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2304800"],"award-info":[{"award-number":["2022YFC2304800"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytokine"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.cyto.2025.157074","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T16:43:38Z","timestamp":1764089018000},"page":"157074","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Dysregulated inflammatory cytokines in MSM living with HIV who exhibited suboptimal immune reconstitution despite antiretroviral therapy (ART)"],"prefix":"10.1016","volume":"197","author":[{"given":"Heping","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fenqi","family":"Da","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anping","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanshan","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuemei","family":"Ling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huachun","family":"Zou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linghua","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.cyto.2025.157074_bb0005","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1097\/COH.0000000000000761","article-title":"Update on treatment as prevention of HIV illness, death, and transmission: sub-Saharan Africa HIV financing and progress towards the 95-95-95 target","volume":"17","author":"Gupta","year":"2022","journal-title":"Curr. Opin. HIV AIDS"},{"issue":"4","key":"10.1016\/j.cyto.2025.157074_bb0010","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1002\/JLB.4MR1019-189R","article-title":"Incomplete immune reconstitution in HIV\/AIDS patients on antiretroviral therapy: challenges of immunological non-responders","volume":"107","author":"Yang","year":"2020","journal-title":"J. Leukoc. Biol."},{"issue":"3","key":"10.1016\/j.cyto.2025.157074_bb0015","first-page":"155","article-title":"Failure of CD4+ T-cell recovery upon virally-effective cART: an enduring gap in the understanding of HIV+ immunological non-responders","volume":"45","author":"Bono","year":"2022","journal-title":"New Microbiol."},{"issue":"3","key":"10.1016\/j.cyto.2025.157074_bb0020","article-title":"Characteristics of suboptimal immune response after initiating antiretroviral therapy among people living with HIV with a pre-treatment CD4 T cell count <200 cells\/mm3 in Thailand","volume":"6","author":"Han","year":"2020","journal-title":"J. Virus Erad."},{"issue":"5","key":"10.1016\/j.cyto.2025.157074_bb0025","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1097\/QAI.0000000000002157","article-title":"Definition of immunological nonresponse to antiretroviral therapy: a systematic review","volume":"82","author":"Rb-Silva","year":"2019","journal-title":"J. Acquir. Immune Defic. Syndr."},{"issue":"1","key":"10.1016\/j.cyto.2025.157074_bb0030","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1186\/s12879-024-09683-5","article-title":"Mortality and associated factors among patients with TB-HIV co-infection in Ethiopia: a systematic review and meta-analysis","volume":"24","author":"Moges","year":"2024","journal-title":"BMC Infect. Dis."},{"issue":"13","key":"10.1016\/j.cyto.2025.157074_bb0035","article-title":"Worldwide occurrence of HIV-associated neurocognitive disorders and its associated factors: a systematic review and Meta-analysis","volume":"31","author":"Zenebe","year":"2022","journal-title":"Front. Psychol."},{"issue":"1","key":"10.1016\/j.cyto.2025.157074_bb0040","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1186\/s12885-025-13516-2","article-title":"The impact of HPV\/HIV co-infection on immunosuppression, HPV genotype, and cervical cancer biomarkers","volume":"25","author":"Swase","year":"2025","journal-title":"BMC Cancer"},{"issue":"5","key":"10.1016\/j.cyto.2025.157074_bb0045","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/j.jmii.2023.06.005","article-title":"Effect of immunological non-response on incidence of non-AIDS events in people living with HIV: a retrospective multicenter cohort study in Taiwan","volume":"56","author":"Wen","year":"2023","journal-title":"J. Microbiol. Immunol. Infect."},{"issue":"1","key":"10.1016\/j.cyto.2025.157074_bb0050","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1186\/s12879-022-07113-y","article-title":"Determinants of suboptimal immune recovery among a Chinese Yi ethnicity population with sustained HIV suppression","volume":"22","author":"Chen","year":"2022","journal-title":"BMC Infect. Dis."},{"issue":"1","key":"10.1016\/j.cyto.2025.157074_bb0055","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1186\/s12879-021-06206-4","article-title":"Immunological and virological discordance among people living with HIV on highly active antiretroviral therapy in Tigray, northern Ethiopia","volume":"21","author":"Hailu","year":"2021","journal-title":"BMC Infect. Dis."},{"issue":"10","key":"10.1016\/j.cyto.2025.157074_bb0060","doi-asserted-by":"crossref","first-page":"4975","DOI":"10.1002\/jmv.27944","article-title":"Suboptimal immune recovery and associated factors among people living with HIV\/AIDS on second-line antiretroviral therapy in Central China: a retrospective cohort study","volume":"94","author":"Zhu","year":"2022","journal-title":"J. Med. Virol."},{"issue":"2","key":"10.1016\/j.cyto.2025.157074_bb0065","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0148915","article-title":"The factors related to CD4+ T-cell recovery and viral suppression in patients who have low CD4+ T cell counts at the initiation of HAART: a retrospective study of the national HIV treatment sub-database of Zhejiang Province, China, 2014","volume":"11","author":"He","year":"2016","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.cyto.2025.157074_bb0070","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1186\/s12879-024-09021-9","article-title":"Factors associated with immunological non-response after ART initiation: a retrospective observational cohort study","volume":"24","author":"Zhao","year":"2024","journal-title":"BMC Infect. Dis."},{"key":"10.1016\/j.cyto.2025.157074_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2022.104037","article-title":"Variation in blood microbial lipopolysaccharide (LPS) contributes to immune reconstitution in response to suppressive antiretroviral therapy in HIV","volume":"80","author":"Luo","year":"2022","journal-title":"EBioMedicine"},{"issue":"6","key":"10.1016\/j.cyto.2025.157074_bb0080","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1097\/QAD.0000000000000596","article-title":"Association of microbial translocation biomarkers with clinical outcome in controllers HIV-infected patients","volume":"29","author":"Le\u00f3n","year":"2015","journal-title":"AIDS"},{"issue":"9","key":"10.1016\/j.cyto.2025.157074_bb0085","doi-asserted-by":"crossref","DOI":"10.1002\/jia2.25585","article-title":"Determinants of suboptimal CD4+ T cell recovery after antiretroviral therapy initiation in a prospective cohort of acute HIV-1 infection","volume":"23","author":"Handoko","year":"2020","journal-title":"J. Int. AIDS Soc."},{"issue":"7","key":"10.1016\/j.cyto.2025.157074_bb0090","first-page":"614","article-title":"Stimulation of PBMC and monocyte-derived macrophages via toll-like receptor activates innate immune pathways in HIV-infected patients on virally suppressive combination antiretroviral therapy","volume":"19","author":"Merlini","year":"2016","journal-title":"Front. Immunol."},{"issue":"11","key":"10.1016\/j.cyto.2025.157074_bb0095","doi-asserted-by":"crossref","DOI":"10.1002\/jmv.70081","article-title":"Profiles of lymphocyte subtypes in HIV-infected people with different immunologic responses to antiretroviral therapy","volume":"96","author":"Zhao","year":"2024","journal-title":"J. Med. Virol."},{"issue":"3","key":"10.1016\/j.cyto.2025.157074_bb0100","doi-asserted-by":"crossref","DOI":"10.1002\/jmv.28674","article-title":"Altered gut microbiota is associated with different immunologic responses to antiretroviral therapy in HIV-infected men who have sex with men","volume":"95","author":"Zhao","year":"2023","journal-title":"J. Med. Virol."},{"issue":"1","key":"10.1016\/j.cyto.2025.157074_bb0105","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000041222","article-title":"Influence of cytokines on the recovery trajectory of HIV patients on antiretroviral therapy: a review","volume":"104","author":"Obeagu","year":"2025","journal-title":"Medicine (Baltimore)"},{"issue":"1","key":"10.1016\/j.cyto.2025.157074_bb0110","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1007\/s00018-025-05685-x","article-title":"Targeting inflammasomes as a therapeutic potential for HIV\/AIDS","volume":"82","author":"Zhang","year":"2025","journal-title":"Cell. Mol. Life Sci."},{"issue":"15","key":"10.1016\/j.cyto.2025.157074_bb0115","article-title":"HIV immunological non-responders are characterized by extensive immunosenescence and impaired lymphocyte cytokine production capacity","volume":"8","author":"Vos","year":"2024","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.cyto.2025.157074_bb0120","first-page":"727","article-title":"PD-1\/PD-L1 pathway: current researches in cancer","volume":"10","author":"Han","year":"2020","journal-title":"Am. J. Cancer Res."},{"issue":"21","key":"10.1016\/j.cyto.2025.157074_bb0125","doi-asserted-by":"crossref","first-page":"3682","DOI":"10.1200\/JCO.23.00737","article-title":"Treating Cancer in people with HIV","volume":"41","author":"Lurain","year":"2023","journal-title":"J. Clin. Oncol."},{"issue":"5","key":"10.1016\/j.cyto.2025.157074_bb0130","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1097\/QAI.0b013e318271c2c7","article-title":"Reduced levels of serum FGF19 and impaired expression of receptors for endocrine FGFs in adipose tissue from HIV-infected patients","volume":"61","author":"Gallego-Escuredo","year":"2012","journal-title":"J. Acquir. Immune Defic. Syndr."},{"issue":"1","key":"10.1016\/j.cyto.2025.157074_bb0135","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.jhep.2023.02.036","article-title":"FGF19\/FGFR4-mediated elevation of ETV4 facilitates hepatocellular carcinoma metastasis by upregulating PD-L1 and CCL2","volume":"79","author":"Xie","year":"2023","journal-title":"J. Hepatol."},{"issue":"1","key":"10.1016\/j.cyto.2025.157074_bb0140","doi-asserted-by":"crossref","DOI":"10.1080\/22221751.2022.2150566","article-title":"Distinct inflammation-related proteins associated with T cell immune recovery during chronic HIV-1 infection","author":"Wan","year":"2023","journal-title":"Emerg. Microbes Infect."},{"issue":"6","key":"10.1016\/j.cyto.2025.157074_bb0145","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1080\/15384101.2016.1151581","article-title":"4E-BP1, a multifactor regulated multifunctional protein","volume":"15","author":"Qin","year":"2016","journal-title":"Cell Cycle"},{"issue":"10","key":"10.1016\/j.cyto.2025.157074_bb0150","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.3389\/fimmu.2019.01965","article-title":"Systemic inflammation and the increased risk of Inflamm-aging and age-associated diseases in people living with HIV on long term suppressive antiretroviral therapy","volume":"27","author":"Babu","year":"2019","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.cyto.2025.157074_bb0155","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1096\/fj.201600813r","article-title":"Hyperactivation of mammalian target of rapamycin complex 1 by HIV-1 is necessary for virion production and latent viral reactivation","volume":"31","author":"Kumar","year":"2017","journal-title":"FASEB J."}],"container-title":["Cytokine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466625002212?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466625002212?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T11:37:05Z","timestamp":1766144225000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043466625002212"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":31,"alternative-id":["S1043466625002212"],"URL":"https:\/\/doi.org\/10.1016\/j.cyto.2025.157074","relation":{},"ISSN":["1043-4666"],"issn-type":[{"value":"1043-4666","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dysregulated inflammatory cytokines in MSM living with HIV who exhibited suboptimal immune reconstitution despite antiretroviral therapy (ART)","name":"articletitle","label":"Article Title"},{"value":"Cytokine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cyto.2025.157074","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"157074"}}