{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:10:09Z","timestamp":1790889009890,"version":"4.1.0"},"reference-count":87,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006602","name":"Air Force Research Laboratory","doi-asserted-by":"publisher","award":["FA8650-18-C-6898"],"award-info":[{"award-number":["FA8650-18-C-6898"]}],"id":[{"id":"10.13039\/100006602","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006602","name":"Air Force Research Laboratory","doi-asserted-by":"publisher","award":["P20 GM109089"],"award-info":[{"award-number":["P20 GM109089"]}],"id":[{"id":"10.13039\/100006602","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006602","name":"Air Force Research Laboratory","doi-asserted-by":"publisher","award":["P20 GM121176"],"award-info":[{"award-number":["P20 GM121176"]}],"id":[{"id":"10.13039\/100006602","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["1R01AI097202"],"award-info":[{"award-number":["1R01AI097202"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["P20 GM109089"],"award-info":[{"award-number":["P20 GM109089"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["P20 GM121176"],"award-info":[{"award-number":["P20 GM121176"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["P20 GM103451"],"award-info":[{"award-number":["P20 GM103451"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["RL5 GM118969"],"award-info":[{"award-number":["RL5 GM118969"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007179","name":"University of New Mexico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007179","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018091","name":"School of Medicine, University of New Mexico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018091","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000185","name":"Defense Advanced Research Projects Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000185","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006502","name":"Defense Advanced Research Projects Agency Defense Sciences Office","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006502","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Institutes of Health National Cancer Institute","doi-asserted-by":"publisher","award":["P30 CA119100"],"award-info":[{"award-number":["P30 CA119100"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytokine"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.cyto.2025.157105","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T09:59:03Z","timestamp":1767002343000},"page":"157105","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["IL-7 promotes na\u00efve T cell motility to enable T cell scanning of dendritic cells in the LN"],"prefix":"10.1016","volume":"198","author":[{"given":"Janie R.","family":"Byrum","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly A.","family":"Morrissey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sreenivasa Rao","family":"Oruganti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judy L.","family":"Cannon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.cyto.2025.157105_bb0005","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/80868","article-title":"Interleukin-7 mediates the homeostasis of naive and memory CD8 T cells in vivo","volume":"1","author":"Schluns","year":"2000","journal-title":"Nat. Immunol."},{"issue":"12","key":"10.1016\/j.cyto.2025.157105_bb0010","doi-asserted-by":"crossref","first-page":"6869","DOI":"10.4049\/jimmunol.167.12.6869","article-title":"IL-7 enhances the survival and maintains the size of naive T cells","volume":"167","author":"Rathmell","year":"2001","journal-title":"J. Immunol."},{"issue":"8","key":"10.1016\/j.cyto.2025.157105_bb0015","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/nri853","article-title":"Maintaining the norm: T-cell homeostasis","volume":"2","author":"Jameson","year":"2002","journal-title":"Nat. Rev. Immunol."},{"issue":"11","key":"10.1016\/j.cyto.2025.157105_bb0020","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1038\/ni1513","article-title":"Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells","volume":"8","author":"Link","year":"2007","journal-title":"Nat. Immunol."},{"issue":"24","key":"10.1016\/j.cyto.2025.157105_bb0025","doi-asserted-by":"crossref","first-page":"4675","DOI":"10.1182\/blood-2012-03-416859","article-title":"IL-7-producing stromal cells are critical for lymph node remodeling","volume":"120","author":"Onder","year":"2012","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.cyto.2025.157105_bb0030","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/j.1600-065X.2012.01160.x","article-title":"Structural insights into the common gamma-chain family of cytokines and receptors from the interleukin-7 pathway","volume":"250","author":"Walsh","year":"2012","journal-title":"Immunol. Rev."},{"issue":"47","key":"10.1016\/j.cyto.2025.157105_bb0035","doi-asserted-by":"crossref","first-page":"6724","DOI":"10.1038\/sj.onc.1210757","article-title":"Hematopoietic cytokine receptor signaling","volume":"26","author":"Baker","year":"2007","journal-title":"Oncogene"},{"issue":"1","key":"10.1016\/j.cyto.2025.157105_bb0040","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1189\/jlb.0313122","article-title":"Jak\/STAT and PI3K signaling pathways have both common and distinct roles in IL-7-mediated activities in human CD8+ T cells","volume":"95","author":"Crawley","year":"2014","journal-title":"J. Leukoc. Biol."},{"issue":"1","key":"10.1016\/j.cyto.2025.157105_bb0045","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/j.1600-065X.2008.00754.x","article-title":"Janus kinases in immune cell signaling","volume":"228","author":"Ghoreschi","year":"2009","journal-title":"Immunol. Rev."},{"issue":"5","key":"10.1016\/j.cyto.2025.157105_bb0050","doi-asserted-by":"crossref","first-page":"2623","DOI":"10.4049\/jimmunol.178.5.2623","article-title":"The JAK-STAT signaling pathway: input and output integration","volume":"178","author":"Murray","year":"2007","journal-title":"J. Immunol."},{"issue":"Pt 8","key":"10.1016\/j.cyto.2025.157105_bb0055","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1242\/jcs.00963","article-title":"The JAK\/STAT signaling pathway","volume":"117","author":"Rawlings","year":"2004","journal-title":"J. Cell Sci."},{"issue":"28","key":"10.1016\/j.cyto.2025.157105_bb0060","doi-asserted-by":"crossref","first-page":"20059","DOI":"10.1074\/jbc.R700016200","article-title":"JAK-STAT signaling: from interferons to cytokines","volume":"282","author":"Schindler","year":"2007","journal-title":"J. Biol. Chem."},{"issue":"11","key":"10.1016\/j.cyto.2025.157105_bb0065","doi-asserted-by":"crossref","first-page":"6571","DOI":"10.4049\/jimmunol.174.11.6571","article-title":"The many faces of IL-7: from lymphopoiesis to peripheral T cell maintenance","volume":"174","author":"Fry","year":"2005","journal-title":"J. Immunol."},{"issue":"43","key":"10.1016\/j.cyto.2025.157105_bb0070","doi-asserted-by":"crossref","first-page":"18505","DOI":"10.1073\/pnas.1010249107","article-title":"Coordination of IL-7 receptor and T-cell receptor signaling by cell-division cycle 42 in T-cell homeostasis","volume":"107","author":"Guo","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"7","key":"10.1016\/j.cyto.2025.157105_bb0075","doi-asserted-by":"crossref","first-page":"3461","DOI":"10.4049\/jimmunol.0902593","article-title":"IL-7 is essential for homeostatic control of T cell metabolism in vivo","volume":"184","author":"Jacobs","year":"2010","journal-title":"J. Immunol."},{"issue":"12","key":"10.1016\/j.cyto.2025.157105_bb0080","doi-asserted-by":"crossref","first-page":"5315","DOI":"10.4049\/jimmunol.157.12.5315","article-title":"Impaired survival and proliferation in IL-7 receptor-deficient peripheral T cells","volume":"157","author":"Maraskovsky","year":"1996","journal-title":"J. Immunol."},{"issue":"23","key":"10.1016\/j.cyto.2025.157105_bb0085","doi-asserted-by":"crossref","first-page":"5793","DOI":"10.1182\/blood-2008-12-192252","article-title":"Regulation of T cell-dendritic cell interactions by IL-7 governs T-cell activation and homeostasis","volume":"113","author":"Saini","year":"2009","journal-title":"Blood"},{"issue":"5","key":"10.1016\/j.cyto.2025.157105_bb0090","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/nri3198","article-title":"Regulation and function of mTOR signalling in T cell fate decisions","volume":"12","author":"Chi","year":"2012","journal-title":"Nat. Rev. Immunol."},{"issue":"20","key":"10.1016\/j.cyto.2025.157105_bb0095","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.261887","article-title":"cellPLATO - an unsupervised method for identifying cell behaviour in heterogeneous cell trajectory data","volume":"137","author":"Shannon","year":"2024","journal-title":"J. Cell Sci."},{"issue":"37","key":"10.1016\/j.cyto.2025.157105_bb0100","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2103444118","article-title":"IL-6 enhances CD4 cell motility by sustaining mitochondrial ca(2+) through the noncanonical STAT3 pathway","volume":"118","author":"Valenca-Pereira","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"10","key":"10.1016\/j.cyto.2025.157105_bb0105","doi-asserted-by":"crossref","first-page":"5256","DOI":"10.4049\/jimmunol.1201675","article-title":"The novel role of IL-7 ligation to IL-7 receptor in myeloid cells of rheumatoid arthritis and collagen-induced arthritis","volume":"190","author":"Chen","year":"2013","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.cyto.2025.157105_bb0110","article-title":"The involvement of JAK-STAT3 in cell motility, invasion, and metastasis","volume":"3","author":"Teng","year":"2014","journal-title":"JAKSTAT"},{"issue":"2","key":"10.1016\/j.cyto.2025.157105_bb0115","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0088014","article-title":"Jak3 enables chemokine-dependent actin cytoskeleton reorganization by regulating cofilin and Rac\/Rhoa GTPases activation","volume":"9","author":"Ambriz-Pena","year":"2014","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.cyto.2025.157105_bb0120","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/j.1365-2567.2007.02634.x","article-title":"Janus kinase 3-deficient T lymphocytes have an intrinsic defect in CCR7-mediated homing to peripheral lymphoid organs","volume":"122","author":"Garcia-Zepeda","year":"2007","journal-title":"Immunology"},{"issue":"5","key":"10.1016\/j.cyto.2025.157105_bb0125","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1002\/eji.200323897","article-title":"Chemokines integrate JAK\/STAT and G-protein pathways during chemotaxis and calcium flux responses","volume":"33","author":"Soriano","year":"2003","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.cyto.2025.157105_bb0130","doi-asserted-by":"crossref","first-page":"559","DOI":"10.3389\/fimmu.2015.00559","article-title":"T cell motility as modulator of interactions with dendritic cells","volume":"6","author":"Stein","year":"2015","journal-title":"Front. Immunol."},{"issue":"10","key":"10.1016\/j.cyto.2025.157105_bb0135","doi-asserted-by":"crossref","first-page":"2895","DOI":"10.1002\/eji.200425237","article-title":"Interleukin-6 is a direct mediator of T cell migration","volume":"34","author":"Weissenbach","year":"2004","journal-title":"Eur. J. Immunol."},{"issue":"5","key":"10.1016\/j.cyto.2025.157105_bb0140","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0126333","article-title":"Bringing statistics up to speed with data in analysis of lymphocyte motility","volume":"10","author":"Letendre","year":"2015","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.cyto.2025.157105_bb0145","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1004818","article-title":"Persistence and adaptation in immunity: T cells balance the extent and thoroughness of search","volume":"12","author":"Fricke","year":"2016","journal-title":"PLoS Comput. Biol."},{"issue":"11","key":"10.1016\/j.cyto.2025.157105_bb0150","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0078940","article-title":"PKCtheta regulates T cell motility via ezrin-radixin-moesin localization to the uropod","volume":"8","author":"Cannon","year":"2013","journal-title":"PLoS One"},{"issue":"44","key":"10.1016\/j.cyto.2025.157105_bb0155","doi-asserted-by":"crossref","first-page":"18036","DOI":"10.1073\/pnas.1211717109","article-title":"Quantification of lymph node transit times reveals differences in antigen surveillance strategies of naive CD4+ and CD8+ T cells","volume":"109","author":"Mandl","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"5","key":"10.1016\/j.cyto.2025.157105_bb0160","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/ni.2262","article-title":"Transcriptional profiling of stroma from inflamed and resting lymph nodes defines immunological hallmarks","volume":"13","author":"Malhotra","year":"2012","journal-title":"Nat. Immunol."},{"issue":"8","key":"10.1016\/j.cyto.2025.157105_bb0165","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1093\/intimm\/dxt012","article-title":"IL-7 production in murine lymphatic endothelial cells and induction in the setting of peripheral lymphopenia","volume":"25","author":"Miller","year":"2013","journal-title":"Int. Immunol."},{"issue":"5646","key":"10.1016\/j.cyto.2025.157105_bb0170","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1126\/science.1087061","article-title":"Prevention of organ allograft rejection by a specific Janus kinase 3 inhibitor","volume":"302","author":"Changelian","year":"2003","journal-title":"Science"},{"issue":"24","key":"10.1016\/j.cyto.2025.157105_bb0175","doi-asserted-by":"crossref","first-page":"8468","DOI":"10.1021\/jm1004286","article-title":"Discovery of CP-690,550: a potent and selective Janus kinase (JAK) inhibitor for the treatment of autoimmune diseases and organ transplant rejection","volume":"53","author":"Flanagan","year":"2010","journal-title":"J. Med. Chem."},{"issue":"38","key":"10.1016\/j.cyto.2025.157105_bb0180","doi-asserted-by":"crossref","first-page":"16601","DOI":"10.1073\/pnas.1003457107","article-title":"Differential effects of STAT5 and PI3K\/AKT signaling on effector and memory CD8 T-cell survival","volume":"107","author":"Hand","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1","key":"10.1016\/j.cyto.2025.157105_bb0185","doi-asserted-by":"crossref","first-page":"262","DOI":"10.4049\/jimmunol.178.1.262","article-title":"IL-7\/STAT5 cytokine signaling pathway is essential but insufficient for maintenance of naive CD4 T cell survival in peripheral lymphoid organs","volume":"178","author":"Seki","year":"2007","journal-title":"J. Immunol."},{"issue":"7","key":"10.1016\/j.cyto.2025.157105_bb0190","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/j.ejca.2008.02.043","article-title":"Blocking on the CXCR4\/mTOR signalling pathway induces the anti-metastatic properties and autophagic cell death in peritoneal disseminated gastric cancer cells","volume":"44","author":"Hashimoto","year":"2008","journal-title":"Eur. J. Cancer"},{"issue":"21","key":"10.1016\/j.cyto.2025.157105_bb0195","doi-asserted-by":"crossref","first-page":"3369","DOI":"10.1091\/mbc.e13-07-0405","article-title":"Mammalian target of rapamycin and Rictor control neutrophil chemotaxis by regulating Rac\/Cdc42 activity and the actin cytoskeleton","volume":"24","author":"He","year":"2013","journal-title":"Mol. Biol. Cell"},{"issue":"9","key":"10.1016\/j.cyto.2025.157105_bb0200","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0024667","article-title":"Involvement of mTOR in CXCL12 mediated T cell signaling and migration","volume":"6","author":"Munk","year":"2011","journal-title":"PLoS One"},{"issue":"10","key":"10.1016\/j.cyto.2025.157105_bb0205","doi-asserted-by":"crossref","first-page":"4892","DOI":"10.1182\/blood-2007-11-125039","article-title":"CCL5-mediated T-cell chemotaxis involves the initiation of mRNA translation through mTOR\/4E-BP1","volume":"111","author":"Murooka","year":"2008","journal-title":"Blood"},{"issue":"24","key":"10.1016\/j.cyto.2025.157105_bb0210","doi-asserted-by":"crossref","first-page":"10367","DOI":"10.1158\/0008-5472.CAN-08-2780","article-title":"CXCR6 induces prostate cancer progression by the AKT\/mammalian target of rapamycin signaling pathway","volume":"68","author":"Wang","year":"2008","journal-title":"Cancer Res."},{"issue":"4","key":"10.1016\/j.cyto.2025.157105_bb0215","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.cell.2015.03.021","article-title":"IL-7-induced glycerol transport and TAG synthesis promotes memory CD8+ T cell longevity","volume":"161","author":"Cui","year":"2015","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.cyto.2025.157105_bb0220","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1182\/blood-2007-06-096297","article-title":"IL-7 promotes Glut1 trafficking and glucose uptake via STAT5-mediated activation of Akt to support T-cell survival","volume":"111","author":"Wofford","year":"2008","journal-title":"Blood"},{"issue":"7","key":"10.1016\/j.cyto.2025.157105_bb0225","doi-asserted-by":"crossref","first-page":"3139","DOI":"10.4049\/jimmunol.1501389","article-title":"IL-7 abrogates the immunosuppressive function of human double-negative T cells by activating Akt\/mTOR signaling","volume":"195","author":"Allgauer","year":"2015","journal-title":"J. Immunol."},{"issue":"7","key":"10.1016\/j.cyto.2025.157105_bb0230","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1002202","article-title":"Lactate regulates metabolic and pro-inflammatory circuits in control of T cell migration and effector functions","volume":"13","author":"Haas","year":"2015","journal-title":"PLoS Biol."},{"issue":"5","key":"10.1016\/j.cyto.2025.157105_bb0235","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.immuni.2017.10.017","article-title":"Regulatory T cell migration is dependent on Glucokinase-mediated glycolysis","volume":"47","author":"Kishore","year":"2017","journal-title":"Immunity"},{"issue":"10","key":"10.1016\/j.cyto.2025.157105_bb0240","doi-asserted-by":"crossref","first-page":"2730","DOI":"10.1128\/MCB.01285-08","article-title":"Cdc42 and Rac family GTPases regulate mode and speed but not direction of primary fibroblast migration during platelet-derived growth factor-dependent chemotaxis","volume":"29","author":"Monypenny","year":"2009","journal-title":"Mol. Cell. Biol."},{"issue":"1","key":"10.1016\/j.cyto.2025.157105_bb0245","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1038\/s41467-017-01032-2","article-title":"ROCK regulates the intermittent mode of interstitial T cell migration in inflamed lungs","volume":"8","author":"Mrass","year":"2017","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.cyto.2025.157105_bb0250","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.autrev.2008.07.044","article-title":"Rho GTPase-mediated pathways in mature CD4+ T cells","volume":"8","author":"Pernis","year":"2009","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.cyto.2025.157105_bb0255","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.ceb.2015.08.005","article-title":"Rho GTPase signalling in cell migration","volume":"36","author":"Ridley","year":"2015","journal-title":"Curr. Opin. Cell Biol."},{"issue":"1","key":"10.1016\/j.cyto.2025.157105_bb0260","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S1074-7613(03)00350-9","article-title":"RhoA and zeta PKC control distinct modalities of LFA-1 activation by chemokines: critical role of LFA-1 affinity triggering in lymphocyte in vivo homing","volume":"20","author":"Giagulli","year":"2004","journal-title":"Immunity"},{"key":"10.1016\/j.cyto.2025.157105_bb0265","doi-asserted-by":"crossref","DOI":"10.4161\/sgtp.28208","article-title":"Rho-GTPases as key regulators of T lymphocyte biology","volume":"5","author":"Saoudi","year":"2014","journal-title":"Small GTPases"},{"issue":"4","key":"10.1016\/j.cyto.2025.157105_bb0270","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1128\/MCB.23.4.1316-1333.2003","article-title":"Rho family GTPases are required for activation of Jak\/STAT signaling by G protein-coupled receptors","volume":"23","author":"Pelletier","year":"2003","journal-title":"Mol. Cell. Biol."},{"issue":"12","key":"10.1016\/j.cyto.2025.157105_bb0275","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1038\/ni1139","article-title":"Visualizing dendritic cell networks in vivo","volume":"5","author":"Lindquist","year":"2004","journal-title":"Nat. Immunol."},{"issue":"4","key":"10.1016\/j.cyto.2025.157105_bb0280","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1073\/pnas.0306407101","article-title":"T cell repertoire scanning is promoted by dynamic dendritic cell behavior and random T cell motility in the lymph node","volume":"101","author":"Miller","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"5","key":"10.1016\/j.cyto.2025.157105_bb0285","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1084\/jem.20062079","article-title":"CCR7 ligands control basal T cell motility within lymph node slices in a phosphoinositide 3-kinase-independent manner","volume":"204","author":"Asperti-Boursin","year":"2007","journal-title":"J. Exp. Med."},{"issue":"6","key":"10.1016\/j.cyto.2025.157105_bb0290","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1189\/jlb.2MR0815-380R","article-title":"Common and biased signaling pathways of the chemokine receptor CCR7 elicited by its ligands CCL19 and CCL21 in leukocytes","volume":"99","author":"Hauser","year":"2016","journal-title":"J. Leukoc. Biol."},{"issue":"2","key":"10.1016\/j.cyto.2025.157105_bb0295","doi-asserted-by":"crossref","first-page":"617","DOI":"10.4049\/jimmunol.1400565","article-title":"Autotaxin produced by stromal cells promotes LFA-1-independent and rho-dependent interstitial T cell motility in the lymph node paracortex","volume":"193","author":"Katakai","year":"2014","journal-title":"J. Immunol."},{"issue":"7","key":"10.1016\/j.cyto.2025.157105_bb0300","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0101655","article-title":"Regulation of T cell motility in vitro and in vivo by LPA and LPA2","volume":"9","author":"Knowlden","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.cyto.2025.157105_bb0305","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.10561","article-title":"Fibroblastic reticular cell-derived lysophosphatidic acid regulates confined intranodal T-cell motility","volume":"5","author":"Takeda","year":"2016","journal-title":"Elife"},{"issue":"2","key":"10.1016\/j.cyto.2025.157105_bb0310","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1248\/bpb.33.204","article-title":"Regulatory effect of lysophosphatidic acid on lymphocyte migration","volume":"33","author":"Tanikawa","year":"2010","journal-title":"Biol. Pharm. Bull."},{"issue":"3","key":"10.1016\/j.cyto.2025.157105_bb0315","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1084\/jem.20061706","article-title":"CCR7 ligands stimulate the intranodal motility of T lymphocytes in vivo","volume":"204","author":"Worbs","year":"2007","journal-title":"J. Exp. Med."},{"issue":"8","key":"10.1016\/j.cyto.2025.157105_bb0320","doi-asserted-by":"crossref","first-page":"3914","DOI":"10.4049\/jimmunol.1201604","article-title":"Autotaxin through lysophosphatidic acid stimulates polarization, motility, and transendothelial migration of naive T cells","volume":"189","author":"Zhang","year":"2012","journal-title":"J. Immunol."},{"issue":"3","key":"10.1016\/j.cyto.2025.157105_bb0325","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.immuni.2025.02.009","article-title":"Collaboration between IL-7 and IL-15 enables adaptation of tissue-resident and circulating memory CD8(+) T cells to cytokine deficiency","volume":"58","author":"Jarjour","year":"2025","journal-title":"Immunity"},{"issue":"5","key":"10.1016\/j.cyto.2025.157105_bb0330","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1084\/jem.180.5.1955","article-title":"Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice","volume":"180","author":"Peschon","year":"1994","journal-title":"J. Exp. Med."},{"issue":"1\u20132","key":"10.1016\/j.cyto.2025.157105_bb0335","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.imlet.2012.05.002","article-title":"Involvement of the MAPK and RhoA\/ROCK pathways in PGE2-mediated CCR7-dependent monocyte migration","volume":"146","author":"Allaire","year":"2012","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.cyto.2025.157105_bb0340","doi-asserted-by":"crossref","first-page":"528","DOI":"10.3389\/fimmu.2020.00528","article-title":"The chemokine receptor CCR7 uses distinct signaling modules with biased functionality to regulate dendritic cells","volume":"11","author":"Rodriguez-Fernandez","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cyto.2025.157105_bb0345","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.99373","article-title":"Endosomal chemokine receptor signalosomes regulate central mechanisms underlying cell migration","volume":"13","author":"Hahn","year":"2025","journal-title":"Elife"},{"issue":"50","key":"10.1016\/j.cyto.2025.157105_bb0350","doi-asserted-by":"crossref","first-page":"38781","DOI":"10.1074\/jbc.M110.152173","article-title":"CCR7\/CCL21 migration on fibronectin is mediated by phospholipase Cgamma1 and ERK1\/2 in primary T lymphocytes","volume":"285","author":"Shannon","year":"2010","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.cyto.2025.157105_bb0355","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.immuni.2015.12.010","article-title":"Inflammation-induced CCR7 oligomers form scaffolds to integrate distinct signaling pathways for efficient cell migration","volume":"44","author":"Hauser","year":"2016","journal-title":"Immunity"},{"issue":"9","key":"10.1016\/j.cyto.2025.157105_bb0360","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0007066","article-title":"Jak3 is involved in dendritic cell maturation and CCR7-dependent migration","volume":"4","author":"Rivas-Caicedo","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.cyto.2025.157105_bb0365","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/415375","article-title":"CCR7 regulates cell migration and invasion through JAK2\/STAT3 in metastatic squamous cell carcinoma of the head and neck","volume":"2014","author":"Liu","year":"2014","journal-title":"Biomed. Res. Int."},{"issue":"12","key":"10.1016\/j.cyto.2025.157105_bb0370","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1038\/sj.bjc.6605068","article-title":"Alternative implication of CXCR4 in JAK2\/STAT3 activation in small cell lung cancer","volume":"100","author":"Pfeiffer","year":"2009","journal-title":"Br. J. Cancer"},{"issue":"1","key":"10.1016\/j.cyto.2025.157105_bb0375","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1182\/blood-2002-03-0841","article-title":"CCR7-mediated physiological lymphocyte homing involves activation of a tyrosine kinase pathway","volume":"101","author":"Stein","year":"2003","journal-title":"Blood"},{"issue":"5935","key":"10.1016\/j.cyto.2025.157105_bb0380","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1126\/science.1171721","article-title":"Mitochondrial STAT3 supports Ras-dependent oncogenic transformation","volume":"324","author":"Gough","year":"2009","journal-title":"Science"},{"issue":"10","key":"10.1016\/j.cyto.2025.157105_bb0385","doi-asserted-by":"crossref","first-page":"3550","DOI":"10.1158\/0008-5472.CAN-03-3959","article-title":"Activated signal transducer and activator of transcription (STAT) 3: localization in focal adhesions and function in ovarian cancer cell motility","volume":"64","author":"Silver","year":"2004","journal-title":"Cancer Res."},{"issue":"18","key":"10.1016\/j.cyto.2025.157105_bb0390","doi-asserted-by":"crossref","first-page":"12349","DOI":"10.1074\/jbc.M807761200","article-title":"STAT3-stathmin interactions control microtubule dynamics in migrating T-cells","volume":"284","author":"Verma","year":"2009","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.cyto.2025.157105_bb0395","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/0092-8674(94)90235-6","article-title":"Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway","volume":"77","author":"Akira","year":"1994","journal-title":"Cell"},{"issue":"11","key":"10.1016\/j.cyto.2025.157105_bb0400","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.it.2012.07.003","article-title":"Interleukin-6: from an inflammatory marker to a target for inflammatory diseases","volume":"33","author":"Rincon","year":"2012","journal-title":"Trends Immunol."},{"issue":"9","key":"10.1016\/j.cyto.2025.157105_bb0405","doi-asserted-by":"crossref","first-page":"5315","DOI":"10.4049\/jimmunol.1001948","article-title":"Differential localization of effector and memory CD8 T cell subsets in lymphoid organs during acute viral infection","volume":"185","author":"Jung","year":"2010","journal-title":"J. Immunol."},{"issue":"4","key":"10.1016\/j.cyto.2025.157105_bb0410","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1084\/jem.20170518","article-title":"IL-7-dependent maintenance of ILC3s is required for normal entry of lymphocytes into lymph nodes","volume":"215","author":"Yang","year":"2018","journal-title":"J. Exp. Med."},{"issue":"7","key":"10.1016\/j.cyto.2025.157105_bb0415","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.4049\/jimmunol.1901480","article-title":"Regulatory T cell stability and migration are dependent on mTOR","volume":"205","author":"Vallion","year":"2020","journal-title":"J. Immunol."},{"issue":"2","key":"10.1016\/j.cyto.2025.157105_bb0420","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/JLB.1MR1117-472R","article-title":"Metabolic regulation of leukocyte motility and migration","volume":"104","author":"Marelli-Berg","year":"2018","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.cyto.2025.157105_bb0425","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbior.2022.100940","article-title":"IL-7 and IL-7R in health and disease: an update through COVID times","volume":"87","author":"Fernandes","year":"2023","journal-title":"Adv. Biol. Regul."},{"issue":"1","key":"10.1016\/j.cyto.2025.157105_bb0430","doi-asserted-by":"crossref","first-page":"7268","DOI":"10.1038\/s41467-021-27197-5","article-title":"Interleukin-7 receptor alpha mutational activation can initiate precursor B-cell acute lymphoblastic leukemia","volume":"12","author":"Almeida","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cyto.2025.157105_bb0435","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.jbior.2018.09.012","article-title":"IL-7R-mediated signaling in T-cell acute lymphoblastic leukemia: an update","volume":"71","author":"Oliveira","year":"2019","journal-title":"Adv. Biol. Regul."}],"container-title":["Cytokine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466625002522?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466625002522?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T15:02:38Z","timestamp":1773932558000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043466625002522"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":87,"alternative-id":["S1043466625002522"],"URL":"https:\/\/doi.org\/10.1016\/j.cyto.2025.157105","relation":{},"ISSN":["1043-4666"],"issn-type":[{"value":"1043-4666","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"IL-7 promotes na\u00efve T cell motility to enable T cell scanning of dendritic cells in the LN","name":"articletitle","label":"Article Title"},{"value":"Cytokine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cyto.2025.157105","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"157105"}}