{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T22:40:45Z","timestamp":1785451245660,"version":"3.56.0"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007289","name":"Nanjing Medical University","doi-asserted-by":"publisher","award":["2023LX098"],"award-info":[{"award-number":["2023LX098"]}],"id":[{"id":"10.13039\/501100007289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007289","name":"Nanjing Medical University","doi-asserted-by":"publisher","award":["CMCC202408"],"award-info":[{"award-number":["CMCC202408"]}],"id":[{"id":"10.13039\/501100007289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82103752"],"award-info":[{"award-number":["82103752"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytokine"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.cyto.2026.157123","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:37:57Z","timestamp":1770079077000},"page":"157123","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Oxidative stress activates HIF-1\u03b1 to mediate the secretion of CXCL9 and CXCL10 in keratinocytes and trigger the abnormal immune response in vitiligo"],"prefix":"10.1016","volume":"200","author":[{"given":"Ruolin","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxue","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyuan","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duo","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinpeng","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.cyto.2026.157123_bb0005","doi-asserted-by":"crossref","DOI":"10.3390\/cimb47030191","article-title":"Emerging therapeutic innovations for vitiligo treatment","volume":"47","author":"Li","year":"2025","journal-title":"Curr. Issues Mol. Biol."},{"issue":"4","key":"10.1016\/j.cyto.2026.157123_bb0010","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/exd.12103","article-title":"Vitiligo: interplay between oxidative stress and immune system","volume":"22","author":"Laddha","year":"2013","journal-title":"Exp. Dermatol."},{"issue":"4","key":"10.1016\/j.cyto.2026.157123_bb0015","doi-asserted-by":"crossref","DOI":"10.1002\/eji.202250281","article-title":"The IFN-\u03b3-CXCL9\/CXCL10-CXCR3 axis in vitiligo: pathological mechanism and treatment","volume":"54","author":"Liu","year":"2024","journal-title":"Eur. J. Immunol."},{"issue":"1","key":"10.1016\/j.cyto.2026.157123_bb0020","first-page":"9","article-title":"Differential expression of serum CXCL9 and CXCL10 levels in vitiligo patients and their correlation with disease severity and stability: a cross-sectional study","volume":"91","author":"Aulakh","year":"2025","journal-title":"Indian J. Dermatol. Venereol. Leprol."},{"key":"10.1016\/j.cyto.2026.157123_bb0025","article-title":"Melanocyte-keratinocyte cross-talk in vitiligo","volume":"10","author":"Touni","year":"2023","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.cyto.2026.157123_bb0030","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.freeradbiomed.2019.05.011","article-title":"Oxidative stress-induced IL-15 trans-presentation in keratinocytes contributes to CD8(+) T cells activation via JAK-STAT pathway in vitiligo","volume":"139","author":"Chen","year":"2019","journal-title":"Free Radic. Biol. Med."},{"issue":"223","key":"10.1016\/j.cyto.2026.157123_bb0035","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3007811","article-title":"CXCL10 is critical for the progression and maintenance of depigmentation in a mouse model of vitiligo","volume":"6","author":"Rashighi","year":"2014","journal-title":"Sci Transl Med"},{"issue":"9","key":"10.1016\/j.cyto.2026.157123_bb0040","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/s41581-022-00587-8","article-title":"The effect of HIF on metabolism and immunity","volume":"18","author":"Taylor","year":"2022","journal-title":"Nat. Rev. Nephrol."},{"issue":"1","key":"10.1016\/j.cyto.2026.157123_bb0045","doi-asserted-by":"crossref","first-page":"6858","DOI":"10.1038\/s41467-023-42634-3","article-title":"Mitochondrial dysfunction promotes the transition of precursor to terminally exhausted T cells through HIF-1\u03b1-mediated glycolytic reprogramming","volume":"14","author":"Wu","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cyto.2026.157123_bb0050","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/2503924","article-title":"Transcriptome analysis and emerging driver identification of CD8+ T cells in patients with vitiligo","volume":"2019","author":"Deng","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.cyto.2026.157123_bb0055","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/6732972","article-title":"Occludin promotes adhesion of CD8(+) T cells and melanocytes in vitiligo via the HIF-1\u03b1 Signaling pathway","volume":"2022","author":"Zou","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.cyto.2026.157123_bb0060","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1435306","article-title":"The role of hypoxic microenvironment in autoimmune diseases","volume":"15","author":"Gong","year":"2024","journal-title":"Front. Immunol."},{"issue":"8","key":"10.1016\/j.cyto.2026.157123_bb0065","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1111\/febs.16752","article-title":"Take a breath: oxygen sensing of epidermal differentiation","volume":"290","author":"Smirnov","year":"2023","journal-title":"FEBS J."},{"issue":"8","key":"10.1016\/j.cyto.2026.157123_bb0070","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1111\/febs.16707","article-title":"Involvement of hypoxia-inducible factor activity in inevitable air-exposure treatment upon differentiation in a three-dimensional keratinocyte culture","volume":"290","author":"Teshima","year":"2023","journal-title":"FEBS J."},{"issue":"4","key":"10.1016\/j.cyto.2026.157123_bb0075","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1016\/j.jid.2021.07.185","article-title":"Keratinocytes counteract UVB-induced immunosuppression in mice through HIF-1a Signaling","volume":"142","author":"Fa\u00dfbender","year":"2022","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.cyto.2026.157123_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.106689","article-title":"Hypoxia-inducible factor-1: a potential pharmacological target to manage psoriasis","volume":"86","author":"Zhu","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.cyto.2026.157123_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.omtn.2023.102036","article-title":"The decoy oligodeoxynucleotide against HIF-1\u03b1 and STAT5 ameliorates atopic dermatitis-like mouse model","volume":"34","author":"Gwon","year":"2023","journal-title":"Mol Ther Nucleic Acids"},{"issue":"7","key":"10.1016\/j.cyto.2026.157123_bb0090","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1007\/s13555-023-00952-w","article-title":"Hypoxia-inducible factor-1\u03b1 (HIF-1\u03b1) as a biomarker for changes in microcirculation in individuals with systemic sclerosis","volume":"13","author":"Maciejewska","year":"2023","journal-title":"Dermatol. Ther. (Heidelb.)"},{"issue":"2","key":"10.1016\/j.cyto.2026.157123_bb0095","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1002\/med.21754","article-title":"Mechanisms of melanocyte death in vitiligo","volume":"41","author":"Chen","year":"2021","journal-title":"Med. Res. Rev."},{"issue":"1","key":"10.1016\/j.cyto.2026.157123_bb0100","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.jaci.2016.10.013","article-title":"Oxidative stress drives CD8(+) T-cell skin trafficking in patients with vitiligo through CXCL16 upregulation by activating the unfolded protein response in keratinocytes","volume":"140","author":"Li","year":"2017","journal-title":"J. Allergy Clin. Immunol."},{"issue":"1","key":"10.1016\/j.cyto.2026.157123_bb0105","doi-asserted-by":"crossref","DOI":"10.1111\/pcmr.13202","article-title":"LL37-DNA complex drives vitiligo progression through TLR9-MyD88 Signaling pathways","volume":"38","author":"Wang","year":"2025","journal-title":"Pigment Cell Melanoma Res."},{"issue":"2","key":"10.1016\/j.cyto.2026.157123_bb0110","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.jid.2016.09.016","article-title":"Keratinocyte-derived chemokines orchestrate T-cell positioning in the epidermis during vitiligo and may serve as biomarkers of disease","volume":"137","author":"Richmond","year":"2017","journal-title":"J. Invest. Dermatol."},{"issue":"7891","key":"10.1016\/j.cyto.2026.157123_bb0115","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/s41586-021-04221-8","article-title":"Anatomically distinct fibroblast subsets determine skin autoimmune patterns","volume":"601","author":"Xu","year":"2022","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.cyto.2026.157123_bb0120","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22020843","article-title":"The effect of hypoxia on the expression of CXC chemokines and CXC chemokine receptors-a review of literature","volume":"22","author":"Korbecki","year":"2021","journal-title":"Int. J. Mol. Sci."}],"container-title":["Cytokine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466626000189?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466626000189?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T21:40:41Z","timestamp":1778794841000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043466626000189"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":24,"alternative-id":["S1043466626000189"],"URL":"https:\/\/doi.org\/10.1016\/j.cyto.2026.157123","relation":{},"ISSN":["1043-4666"],"issn-type":[{"value":"1043-4666","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Oxidative stress activates HIF-1\u03b1 to mediate the secretion of CXCL9 and CXCL10 in keratinocytes and trigger the abnormal immune response in vitiligo","name":"articletitle","label":"Article Title"},{"value":"Cytokine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cyto.2026.157123","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"157123"}}