{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T13:24:59Z","timestamp":1786886699000,"version":"build-2736575974"},"reference-count":120,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100009104","name":"Department of Health Research","doi-asserted-by":"publisher","award":["SUG-2024-1119"],"award-info":[{"award-number":["SUG-2024-1119"]}],"id":[{"id":"10.13039\/501100009104","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100030887","name":"Central Council for Research in Unani Medicine","doi-asserted-by":"publisher","award":["TECH-21013\/8\/2024-CCRUM-HQ"],"award-info":[{"award-number":["TECH-21013\/8\/2024-CCRUM-HQ"]}],"id":[{"id":"10.13039\/100030887","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytokine"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.cyto.2026.157148","type":"journal-article","created":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T18:05:52Z","timestamp":1775585152000},"page":"157148","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["CSF3R signalling beyond granulopoiesis: new paradigms in female reproductive biology"],"prefix":"10.1016","volume":"202","author":[{"given":"Rashid","family":"Ansari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay N.","family":"Awathale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sameer N.","family":"Goyal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cyto.2026.157148_bb0005","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0955-2235(05)80004-3","article-title":"Granulocyte colony-stimulating factor and its receptor","volume":"3","author":"Nagata","year":"1991","journal-title":"Prog. Growth Factor Res."},{"key":"10.1016\/j.cyto.2026.157148_bb0010","first-page":"169","article-title":"CSF-1 as a regulator of macrophage activation and immune responses","volume":"51","author":"Sweet","year":"2003","journal-title":"Arch. Immunol. Ther. Exp. Sciendo"},{"key":"10.1016\/j.cyto.2026.157148_bb0015","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.cyto.2008.03.002","article-title":"Granulocyte colony-stimulating factor: molecular mechanisms of action during steady state and \u2018emergency\u2019 hematopoiesis","volume":"42","author":"Panopoulos","year":"2008","journal-title":"Cytokine"},{"key":"10.1016\/j.cyto.2026.157148_bb0020","doi-asserted-by":"crossref","DOI":"10.1002\/jgm.3508","article-title":"Integrated transcriptome, proteome and single-cell sequencing uncover the prognostic and immunological features of colony-stimulating factor 3 receptor in pan-cancer","volume":"25","author":"Song","year":"2023","journal-title":"J. Gene Med."},{"key":"10.1016\/j.cyto.2026.157148_bb0025","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.932608","article-title":"A review of granulocyte colony-stimulating factor receptor signaling and regulation with implications for cancer","author":"Park","year":"2022","journal-title":"Front. Oncol."},{"key":"10.1016\/j.cyto.2026.157148_bb0030","doi-asserted-by":"crossref","first-page":"7387","DOI":"10.1074\/jbc.RA118.002417","article-title":"Gain-of-function mutations in granulocyte colony\u2013stimulating factor receptor (CSF3R) reveal distinct mechanisms of CSF3R activation","volume":"293","author":"Zhang","year":"2018","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cyto.2026.157148_bb0035","doi-asserted-by":"crossref","DOI":"10.1007\/s10565-024-09934-w","article-title":"G-CSFR-induced leukocyte transendothelial migration during the inflammatory response is regulated by the ICAM1-PKCa axis: based on multiomics integration analysis","volume":"40","author":"Zhu","year":"2024","journal-title":"Cell Biol. Toxicol."},{"key":"10.1016\/j.cyto.2026.157148_bb0040","doi-asserted-by":"crossref","first-page":"14483","DOI":"10.1073\/pnas.0605245103","article-title":"Granulocyte colony-stimulating factor preferentially stimulates proliferation of monosomy 7 cells bearing the isoform IV receptor","volume":"103","author":"Sloand","year":"2006","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.cyto.2026.157148_bb0045","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1186\/s12935-025-03941-5","article-title":"Research progress on the mechanisms of CSF3R mutations in leukemogenesis and treatment strategies","volume":"25","author":"Wang","year":"2025","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.cyto.2026.157148_bb0050","first-page":"263","article-title":"Distribution of different classes of CSF3R mutations and co-mutational pattern in 360 myeloid neoplasia","volume":"104","author":"Maffei","year":"2025","journal-title":"Ann. Hematol."},{"key":"10.1016\/j.cyto.2026.157148_bb0055","article-title":"Systematic identification of hub genes in placenta accreta spectrum based on integrated transcriptomic and proteomic analysis","author":"Chen","year":"2020","journal-title":"Front. Genet."},{"key":"10.1016\/j.cyto.2026.157148_bb0060","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/bjc.2013.673","article-title":"Granulocyte colony-stimulating factor receptor signalling via janus kinase 2\/signal transducer and activator of transcription 3 in ovarian cancer","volume":"110","author":"Kumar","year":"2014","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.cyto.2026.157148_bb0065","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.186133","article-title":"Neutrophils initiate proinflammatory immune responses in early endometriosis lesion development","author":"Wilson","year":"2025","journal-title":"JCI Insight"},{"key":"10.1016\/j.cyto.2026.157148_bb0070","article-title":"Deciphering the cellular and molecular landscape of cervical cancer progression through single-cell and spatial transcriptomics","volume":"9","author":"Xia","year":"2025","journal-title":"NPJ Precis. Oncol."},{"key":"10.1016\/j.cyto.2026.157148_bb0075","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s12958-023-01082-w","article-title":"Granulocyte colony-stimulating factor priming improves embryos and pregnancy rate in patients with poor ovarian reserve: a randomized controlled trial","volume":"21","author":"Jinno","year":"2023","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.cyto.2026.157148_bb0080","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1159\/000363239","article-title":"The protective effect of granulocyte Colony-stimulating factor on endometrium and ovary in a rat model of diabetes mellitus","volume":"78","author":"Pala","year":"2014","journal-title":"Gynecol. Obstet. Investig."},{"key":"10.1016\/j.cyto.2026.157148_bb0085","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1055\/s-0028-1108011","article-title":"The role of growth factors and cytokines during implantation: endocrine and paracrine interactions","volume":"27","author":"Guzeloglu-Kayisli","year":"2009","journal-title":"Semin. Reprod. Med."},{"key":"10.1016\/j.cyto.2026.157148_bb0090","first-page":"107","article-title":"G-CSF intrauterine for thin endometrium, and pregnancy outcome","volume":"9","author":"Tehraninejad","year":"2015","journal-title":"J. Family Reprod. Health"},{"key":"10.1016\/j.cyto.2026.157148_bb0095","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/s41594-023-00960-6","article-title":"Regulation of human trophoblast gene expression by endogenous retroviruses","volume":"30","author":"Frost","year":"2023","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.cyto.2026.157148_bb0100","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1095\/biolreprod.110.085167","article-title":"Lactobacillus rhamnosus GR-1 stimulates Colony-stimulating factor 3 (granulocyte) (CSF3) output in placental trophoblast cells in a fetal sex-dependent manner","volume":"84","author":"Yeganegi","year":"2011","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.cyto.2026.157148_bb0105","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1080\/09513590.2017.1370644","article-title":"Therapeutic approach for metabolic disorders and infertility in women with PCOS","volume":"34","author":"Morgante","year":"2018","journal-title":"Gynecol. Endocrinol."},{"key":"10.1016\/j.cyto.2026.157148_bb0110","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.cyto.2014.09.002","article-title":"Granulocyte colony-stimulating factor: a relation between serum and follicular fluid levels and in-vitro fertilization outcome in patients with polycystic ovary syndrome","volume":"74","author":"Kahyaoglu","year":"2015","journal-title":"Cytokine"},{"key":"10.1016\/j.cyto.2026.157148_bb0115","series-title":"Use of Granulocyte Colony-Stimulating Factor for the Treatment of Unexplained Recurrent Miscarriage: A Randomised Controlled Trial","author":"Scarpellini","year":"2009"},{"key":"10.1016\/j.cyto.2026.157148_bb0120","series-title":"Role of Granulocyte Colony Stimulating Factor in Reproductive Medicine- Case Series from UAE","author":"Alhmoudi","year":"2025"},{"key":"10.1016\/j.cyto.2026.157148_bb0125","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241411489","article-title":"The role of miRNAs in the development, proliferation, and progression of endometrial cancer","volume":"24","author":"Bogaczyk","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cyto.2026.157148_bb0130","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1097\/BS9.0000000000000078","article-title":"Colony-stimulating factor 3 receptor (CSF3R) M696T mutation does not impact on clinical outcomes of a Ph+ acute lymphoblastic leukemia patient","volume":"3","author":"Chen","year":"2021","journal-title":"Blood Sci"},{"key":"10.1016\/j.cyto.2026.157148_bb0135","doi-asserted-by":"crossref","first-page":"227","DOI":"10.3390\/cancers17020227","article-title":"Chronic neutrophilic leukemia: advances in diagnosis, genetic insights, and management strategies","volume":"17","author":"Elbaz Younes","year":"2025","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.cyto.2026.157148_bb0140","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.exphem.2016.10.008","article-title":"Granulocyte colony-stimulating factor receptor signaling in severe congenital neutropenia, chronic neutrophilic leukemia, and related malignancies","volume":"46","author":"Dwivedi","year":"2017","journal-title":"Exp. Hematol."},{"key":"10.1016\/j.cyto.2026.157148_bb0145","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1182\/blood-2020-143107","article-title":"Complex CSF3R protein isoform interactions dictate cytokine responsiveness","volume":"136","author":"Seegers","year":"2020","journal-title":"Blood"},{"key":"10.1016\/j.cyto.2026.157148_bb0150","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-017-01881-x","article-title":"Granulocyte-colony stimulating factor controls neural and behavioral plasticity in response to cocaine","volume":"9","author":"Calipari","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cyto.2026.157148_bb0155","doi-asserted-by":"crossref","first-page":"5269","DOI":"10.1182\/bloodadvances.2020002013","article-title":"Heterozygous germ line CSF3R variants as risk alleles for development of hematologic malignancies","volume":"4","author":"Trottier","year":"2020","journal-title":"Blood Adv."},{"key":"10.1016\/j.cyto.2026.157148_bb0160","doi-asserted-by":"crossref","first-page":"3667","DOI":"10.1182\/blood-2021-152546","article-title":"Germline and somatic variants of CSF3R define distinct myeloid neoplasia syndromes","volume":"138","author":"Kewan","year":"2021","journal-title":"Blood"},{"key":"10.1016\/j.cyto.2026.157148_bb0165","doi-asserted-by":"crossref","first-page":"3378","DOI":"10.3390\/cancers17203378","article-title":"Colony-stimulating factor 3 receptor mutations and variants in hematological malignancies","volume":"17","author":"Liongue","year":"2025","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.cyto.2026.157148_bb0170","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/bjc.2013.673","article-title":"Granulocyte colony-stimulating factor receptor signalling via janus kinase 2\/signal transducer and activator of transcription 3 in ovarian cancer","volume":"110","author":"Kumar","year":"2014","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.cyto.2026.157148_bb0175","doi-asserted-by":"crossref","first-page":"3171","DOI":"10.62347\/MUKD2745","article-title":"Increased blood CSF3R+ myeloid-derived suppressor cell is a predictor for breast cancer recurrence","volume":"14","author":"Li","year":"2024","journal-title":"Am. J. Cancer Res."},{"key":"10.1016\/j.cyto.2026.157148_bb0180","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1182\/blood.V88.4.1234.bloodjournal8841234","article-title":"PU.1 (spi-1) and C\/EBP\u03b1 regulate the granulocyte Colony-stimulating factor receptor promoter in myeloid cells","volume":"88","author":"Smith","year":"1996","journal-title":"Blood"},{"key":"10.1016\/j.cyto.2026.157148_bb0185","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1042\/CS20170238","article-title":"Transcriptional mechanisms that control expression of the macrophage colony-stimulating factor receptor locus","volume":"131","author":"Rojo","year":"2017","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.cyto.2026.157148_bb0190","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/imm.12641","article-title":"Protein kinase a inhibition of macrophage maturation is accompanied by an increase in DNA methylation of the colony-stimulating factor 1 receptor gene","volume":"149","author":"Zas\u0142ona","year":"2016","journal-title":"Immunology"},{"key":"10.1016\/j.cyto.2026.157148_bb0195","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1203\/00006450-199909000-00015","article-title":"Distribution of granulocyte Colony-stimulating factor (G-CSF) and G-CSF-receptor mRNA and protein in the human fetus","volume":"46","author":"Calhoun","year":"1999","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.cyto.2026.157148_bb0200","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1016\/j.fertnstert.2013.10.042","article-title":"MicroRNA: key gene expression regulators","volume":"101","author":"Moreno-Moya","year":"2014","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.cyto.2026.157148_bb0205","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1182\/hematology.2024000555","article-title":"The spectrum of ph-negative disease: CNL and CSF3R-related disorders","volume":"2024","author":"Hasserjian","year":"2024","journal-title":"Hematology Am. Soc. Hematol. Educ. Program"},{"key":"10.1016\/j.cyto.2026.157148_bb0210","doi-asserted-by":"crossref","first-page":"2372","DOI":"10.1016\/j.biocel.2009.08.011","article-title":"Granulocyte colony-stimulating factor receptor: stimulating granulopoiesis and much more","volume":"41","author":"Liongue","year":"2009","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.cyto.2026.157148_bb0215","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1007\/s00018-019-03351-7","article-title":"Tumor angiogenesis: causes, consequences, challenges and opportunities","volume":"77","author":"Lugano","year":"2019","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.cyto.2026.157148_bb0220","doi-asserted-by":"crossref","first-page":"10154","DOI":"10.1038\/s41598-022-14307-6","article-title":"Integrated bioinformatics analysis reveals marker genes and immune infiltration for pulmonary arterial hypertension","volume":"12","author":"Tang","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cyto.2026.157148_bb0225","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1084\/jem.20101059","article-title":"G-CSF influences mouse skeletal muscle development and regeneration by stimulating myoblast proliferation","volume":"208","author":"Hara","year":"2011","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.cyto.2026.157148_bb0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2025.115843","article-title":"SETDB1 promotes mammalian liver regeneration by stimulating cytokine CSF3 in hepatocytes","volume":"44","author":"Huang","year":"2025","journal-title":"Cell Rep."},{"key":"10.1016\/j.cyto.2026.157148_bb0235","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26094440","article-title":"The effect of reduced dietary protein on adipose tissue in local kr\u0161kopolje pigs","volume":"26","author":"Poklukar","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cyto.2026.157148_bb0240","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25053020","article-title":"Gene expression of CSF3R\/CD114 is associated with poorer patient survival in glioma","volume":"25","author":"Bark","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cyto.2026.157148_bb0245","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.jri.2015.01.010","article-title":"Treatment with granulocyte colony-stimulating factor in patients with repetitive implantation failures and\/or recurrent spontaneous abortions","volume":"108","author":"W\u00fcrfel","year":"2015","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.cyto.2026.157148_bb0250","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.69603","article-title":"Modelling the impact of decidual senescence on embryo implantation in human endometrial assembloids","volume":"10","author":"Rawlings","year":"2021","journal-title":"eLife"},{"key":"10.1016\/j.cyto.2026.157148_bb0255","doi-asserted-by":"crossref","first-page":"4258","DOI":"10.1158\/0008-5472.CAN-17-1052","article-title":"Unpaired extracellular cysteine mutations of CSF3R mediate gain or loss of function","volume":"77","author":"Zhang","year":"2017","journal-title":"Cancer Res."},{"key":"10.1016\/j.cyto.2026.157148_bb0260","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.str.2011.12.010","article-title":"The WSXWS motif in cytokine receptors is a molecular switch involved in receptor activation: insight from structures of the prolactin receptor","volume":"20","author":"Dagil","year":"2012","journal-title":"Structure"},{"key":"10.1016\/j.cyto.2026.157148_bb0265","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1146\/annurev.immunol.24.021605.090616","article-title":"Structural biology of shared cytokine receptors","volume":"27","author":"Wang","year":"2009","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.cyto.2026.157148_bb0270","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.3324\/haematol.2022.281828","article-title":"A novel colony stimulating factor 3 receptor activating mutation identified in a patient with chronic neutrophilic leukemia","volume":"108","author":"Maniaci","year":"2023","journal-title":"Haematologica"},{"key":"10.1016\/j.cyto.2026.157148_bb0275","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1158\/1078-0432.CCR-14-3100","article-title":"The Colony-stimulating factor 3 receptor T640N mutation is oncogenic, sensitive to JAK inhibition, and mimics T618I","volume":"22","author":"Maxson","year":"2016","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.cyto.2026.157148_bb0280","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1186\/s12935-025-03941-5","article-title":"Research progress on the mechanisms of CSF3R mutations in leukemogenesis and treatment strategies","volume":"25","author":"Wang","year":"2025","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.cyto.2026.157148_bb0285","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1084\/jem.20132496","article-title":"The Src family kinases Hck, Fgr, and Lyn are critical for the generation of the in vivo inflammatory environment without a direct role in leukocyte recruitment","volume":"211","author":"Kov\u00e1cs","year":"2014","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.cyto.2026.157148_bb0290","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1080\/16078454.2021.1965725","article-title":"New insight into the mechanism of granulocyte colony-stimulating factor (G-CSF) that induces the mobilization of neutrophils","volume":"26","author":"Theyab","year":"2021","journal-title":"Hematology"},{"key":"10.1016\/j.cyto.2026.157148_bb0295","doi-asserted-by":"crossref","first-page":"2752","DOI":"10.1038\/leu.2017.126","article-title":"Characterization of the leukemogenic potential of distal cytoplasmic CSF3R truncation and missense mutations","volume":"31","author":"Zhang","year":"2017","journal-title":"Leukemia"},{"key":"10.1016\/j.cyto.2026.157148_bb0300","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1111\/j.1600-0854.2009.00928.x","article-title":"Site-specific ubiquitination determines lysosomal sorting and signal attenuation of the granulocyte Colony-stimulating factor receptor","volume":"10","author":"W\u00f6lfler","year":"2009","journal-title":"Traffic"},{"key":"10.1016\/j.cyto.2026.157148_bb0305","doi-asserted-by":"crossref","first-page":"3811","DOI":"10.1182\/blood-2013-11-535419","article-title":"Inherited biallelic CSF3R mutations in severe congenital neutropenia","volume":"123","author":"Triot","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.cyto.2026.157148_bb0310","doi-asserted-by":"crossref","first-page":"6762","DOI":"10.1158\/0008-5472.CAN-18-1638","article-title":"A novel germline variant in CSF3R reduces n-glycosylation and exerts potent oncogenic effects in leukemia","volume":"78","author":"Spiciarich","year":"2018","journal-title":"Cancer Res."},{"key":"10.1016\/j.cyto.2026.157148_bb0315","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13081930","article-title":"Current methods of post-translational modification analysis and their applications in blood cancers","volume":"13","author":"Dunphy","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.cyto.2026.157148_bb0320","series-title":"G-CSFR Ubiquitination Critically Regulates Myeloid Cell Survival and Proliferation \u2013 CORE","author":"Hemar","year":"2008"},{"key":"10.1016\/j.cyto.2026.157148_bb0325","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2023.104755","article-title":"Mutational screens highlight glycosylation as a modulator of colony-stimulating factor 3 receptor (CSF3R) activity","volume":"299","author":"Hollander","year":"2023","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cyto.2026.157148_bb0330","article-title":"Effects of human recombinant granulocyte-colony stimulating factor treatment during in vitro culture on porcine pre-implantation embryos","author":"Cai","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.cyto.2026.157148_bb0335","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.131018","article-title":"Cellular and molecular architecture of hematopoietic stem cells and progenitors in genetic models of bone marrow failure","volume":"5","author":"Heidemann","year":"2020","journal-title":"JCI Insight"},{"key":"10.1016\/j.cyto.2026.157148_bb0340","doi-asserted-by":"crossref","DOI":"10.1038\/bcj.2015.105","article-title":"RUNX1 haploinsufficiency results in granulocyte colony-stimulating factor hypersensitivity","volume":"6","author":"Chin","year":"2016","journal-title":"Blood Cancer J."},{"key":"10.1016\/j.cyto.2026.157148_bb0345","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1073\/pnas.0811466106","article-title":"A regulatory interplay between miR-27a and runx1 during megakaryopoiesis","volume":"106","author":"Ben-Ami","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cyto.2026.157148_bb0350","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.7150\/ijbs.59876","article-title":"MiR-223: an effective regulator of immune cell differentiation and inflammation","volume":"17","author":"Jiao","year":"2021","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.cyto.2026.157148_bb0355","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1038\/leu.2017.229","article-title":"C\/EBP\u03b1 deregulation as a paradigm for leukemogenesis","volume":"31","author":"Pulikkan","year":"2017","journal-title":"Leukemia"},{"key":"10.1016\/j.cyto.2026.157148_bb0360","article-title":"G-CSF in tumors: aggressiveness, tumor microenvironment and immune cell regulation","volume":"142","author":"Ioannis","year":"2021","journal-title":"Cytokine"},{"key":"10.1016\/j.cyto.2026.157148_bb0365","doi-asserted-by":"crossref","first-page":"50642","DOI":"10.18632\/oncotarget.16892","article-title":"Upregulation of microRNA-125b by G-CSF promotes metastasis in colorectal cancer","volume":"8","author":"Zhang","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.cyto.2026.157148_bb0370","doi-asserted-by":"crossref","first-page":"4338","DOI":"10.1182\/blood-2010-06-289058","article-title":"Enforced expression of miR-125b affects myelopoiesis by targeting multiple signaling pathways","volume":"117","author":"Surdziel","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.cyto.2026.157148_bb0375","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.leukres.2011.09.027","article-title":"MiR-590-5p, miR-219-5p, miR-15b and miR-628-5p are commonly regulated by IL-3, GM-CSF and G-CSF in acute myeloid leukemia","volume":"36","author":"Favreau","year":"2012","journal-title":"Leuk. Res."},{"key":"10.1016\/j.cyto.2026.157148_bb0380","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.exphem.2018.09.002","article-title":"Upregulated microRNA-146a expression induced by granulocyte colony-stimulating factor enhanced low-dosage chemotherapy response in aged acute myeloid leukemia patients","volume":"68","author":"Li","year":"2018","journal-title":"Exp. Hematol."},{"key":"10.1016\/j.cyto.2026.157148_bb0385","doi-asserted-by":"crossref","first-page":"243","DOI":"10.3324\/haematol.2013.086959","article-title":"Granulocyte colony-stimulating factor produces long-term changes in gene and microRNA expression profiles in CD34+ cells from healthy donors","volume":"99","author":"B\u00e1ez","year":"2014","journal-title":"Haematologica"},{"key":"10.1016\/j.cyto.2026.157148_bb0390","doi-asserted-by":"crossref","DOI":"10.1016\/j.tranon.2025.102310","article-title":"CSF3 promotes colorectal cancer progression by activating p65\/NF-\u03baB signaling pathway and inducing an immunosuppressive microenvironment","volume":"53","author":"Xu","year":"2025","journal-title":"Transl. Oncol."},{"key":"10.1016\/j.cyto.2026.157148_bb0395","doi-asserted-by":"crossref","first-page":"7","DOI":"10.4103\/jrms.JRMS_628_17","article-title":"Role of granulocyte colony-stimulating factor in human reproduction","volume":"23","author":"Eftekhar","year":"2018","journal-title":"J. Res. Med. Sci."},{"key":"10.1016\/j.cyto.2026.157148_bb0400","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.3324\/haematol.2015.132142","article-title":"JAK kinase targeting in hematologic malignancies: a sinuous pathway from identification of genetic alterations towards clinical indications","volume":"100","author":"Springuel","year":"2015","journal-title":"Haematologica"},{"key":"10.1016\/j.cyto.2026.157148_bb0405","article-title":"Evolving cognition of the JAK-STAT signaling pathway: autoimmune disorders and cancer","volume":"8","author":"Xue","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.cyto.2026.157148_bb0410","series-title":"Frontiers | JAK\/STAT Pathway: Extracellular Signals, Diseases, Immunity, and Therapeutic Regimens","author":"Hu","year":"2023"},{"key":"10.1016\/j.cyto.2026.157148_bb0415","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1128\/MMBR.00031-10","article-title":"Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases","volume":"75","author":"Cargnello","year":"2011","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1016\/j.cyto.2026.157148_bb0420","article-title":"ERK1\/2 MAP kinases promote cell cycle entry by rapid, kinase-independent disruption of retinoblastoma\u2013lamin A complexes","author":"(PDF)","year":"2025","journal-title":"ResearchGate"},{"key":"10.1016\/j.cyto.2026.157148_bb0425","doi-asserted-by":"crossref","first-page":"1","DOI":"10.26502\/jbb.2642-91280066","article-title":"The ERK signaling cascade inhibits gonadotropin-stimulated steroidogenesis","volume":"6","author":"Seger","year":"2023","journal-title":"J. Biotechnol. Biomed."},{"key":"10.1016\/j.cyto.2026.157148_bb0430","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-34015-4","article-title":"ERK1\/2-dependent gene expression in the bovine ovulating follicle","volume":"8","author":"Schuermann","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cyto.2026.157148_bb0435","doi-asserted-by":"crossref","first-page":"5820","DOI":"10.1074\/jbc.M113.508440","article-title":"Ligand independence of the T618I mutation in the colony-stimulating factor 3 receptor (CSF3R) protein results from loss of O-linked glycosylation and increased receptor dimerization*","volume":"289","author":"Maxson","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cyto.2026.157148_bb0440","first-page":"722","article-title":"An update on physiopathological roles of akt in the ReprodAKTive mammalian ovary","volume":"14","author":"Giaccari","year":"2024","journal-title":"Life (Basel)"},{"key":"10.1016\/j.cyto.2026.157148_bb0445","doi-asserted-by":"crossref","first-page":"27179","DOI":"10.1074\/jbc.M414361200","article-title":"Involvement of NADPH oxidase isoforms and src family kinases in CD95-dependent hepatocyte apoptosis*","volume":"280","author":"Reinehr","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cyto.2026.157148_bb0450","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1182\/blood-2003-08-2913","article-title":"G-CSF receptor truncations found in SCN\/AML relieve SOCS3-controlled inhibition of STAT5 but leave suppression of STAT3 intact","volume":"104","author":"van de Geijn","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.cyto.2026.157148_bb0455","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1006\/bbrc.1998.9441","article-title":"The src-like tyrosine kinase hck is activated by granulocyte Colony-stimulating factor (G-CSF) and docks to the activated G-CSF receptor","volume":"251","author":"Ward","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.cyto.2026.157148_bb0460","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.lfs.2016.05.036","article-title":"Novel roles of src in cancer cell epithelial-to-mesenchymal transition, vascular permeability, microinvasion and metastasis","volume":"157","author":"Patel","year":"2016","journal-title":"Life Sci."},{"key":"10.1016\/j.cyto.2026.157148_bb0465","doi-asserted-by":"crossref","first-page":"17023","DOI":"10.1038\/sigtrans.2017.23","article-title":"NF-\u03baB signaling in inflammation","volume":"2","author":"Liu","year":"2017","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.cyto.2026.157148_bb0470","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2021.155632","article-title":"MIF-mediated NF-\u03baB signaling pathway regulates the pathogenesis of polycystic ovary syndrome in rats","volume":"146","author":"He","year":"2021","journal-title":"Cytokine"},{"key":"10.1016\/j.cyto.2026.157148_bb0475","article-title":"Effects of human recombinant granulocyte-colony stimulating factor treatment during in vitro culture on porcine pre-implantation embryos","author":"Cai","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.cyto.2026.157148_bb0480","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/s41375-019-0567-9","article-title":"Altered expression of CSF3R splice variants impacts signal response and is associated with SRSF2 mutations","volume":"34","author":"Lance","year":"2020","journal-title":"Leukemia"},{"key":"10.1016\/j.cyto.2026.157148_bb0485","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s44342-025-00051-6","article-title":"Unravelling the molecular landscape of polycystic ovary syndrome (PCOS) and role of inflammation through transcriptomics analysis of human ovarian granulosa cells","volume":"23","author":"Mahra","year":"2025","journal-title":"Genomics Inform"},{"key":"10.1016\/j.cyto.2026.157148_bb0490","doi-asserted-by":"crossref","DOI":"10.1002\/adbi.202400279","article-title":"Granulocyte colony stimulating factor enhances decidualization process of endometrial stromal cells through STAT3\/HOXA10 axis","volume":"9","author":"Zhang","year":"2025","journal-title":"Adv. Biol."},{"key":"10.1016\/j.cyto.2026.157148_bb0495","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2024.1370114","article-title":"The value of G-CSF in women experienced at least one implantation failure: a systematic review and meta-analysis","volume":"15","author":"Su","year":"2024","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.cyto.2026.157148_bb0500","doi-asserted-by":"crossref","first-page":"2703","DOI":"10.1093\/humrep\/dep240","article-title":"Use of granulocyte colony-stimulating factor for the treatment of unexplained recurrent miscarriage: a randomised controlled trial","volume":"24","author":"Scarpellini","year":"2009","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.cyto.2026.157148_bb0505","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1093\/humupd\/dmz018","article-title":"The endometrial immune environment of women with endometriosis","volume":"25","author":"Vallv\u00e9-Juanico","year":"2019","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.cyto.2026.157148_bb0510","doi-asserted-by":"crossref","DOI":"10.1016\/j.fertnstert.2017.03.013","article-title":"Peritoneal fluid cytokines related to endometriosis in patients evaluated for infertility","volume":"107","author":"J\u00f8rgensen","year":"2017","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.cyto.2026.157148_bb0515","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/bjh.18477","article-title":"Truncated CSF3 receptors induce pro-inflammatory responses in severe congenital neutropenia","volume":"200","author":"Olofsen","year":"2023","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.cyto.2026.157148_bb0520","doi-asserted-by":"crossref","first-page":"2901","DOI":"10.3390\/ijms24032901","article-title":"The role of NF-\u03baB in endometrial diseases in humans and animals: a review","volume":"24","author":"Zdrojkowski","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cyto.2026.157148_bb0525","doi-asserted-by":"crossref","first-page":"3171","DOI":"10.62347\/MUKD2745","article-title":"Increased blood CSF3R+ myeloid-derived suppressor cell is a predictor for breast cancer recurrence","volume":"14","author":"Li","year":"2024","journal-title":"Am. J. Cancer Res."},{"key":"10.1016\/j.cyto.2026.157148_bb0530","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1002\/vms3.694","article-title":"Neutrophilic leucocytosis induced by granulocyte colony-stimulating factor and interleukin-6 in canine primary lung adenocarcinoma","volume":"8","author":"Tamura","year":"2021","journal-title":"Vet Med Sci"},{"key":"10.1016\/j.cyto.2026.157148_bb0535","article-title":"Colony-stimulating factor 3 and its receptor promote leukocyte immunoglobulin-like receptor b2 expression and ligands in gastric cancer","volume":"17","author":"Wang","year":"2025","journal-title":"World J. Gastrointest. Oncol."},{"key":"10.1016\/j.cyto.2026.157148_bb0540","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.ccell.2015.11.005","article-title":"Neutrophils oppose uterine epithelial carcinogenesis via debridement of hypoxic tumor cells","volume":"28","author":"Blaisdell","year":"2015","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cyto.2026.157148_bb0545","article-title":"Crosstalk between trophoblasts and decidual immune cells: the cornerstone of maternal-fetal immunotolerance","volume":"12","author":"Xu","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cyto.2026.157148_bb0550","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2020.109545","article-title":"Crosstalk between the m1 muscarinic acetylcholine receptor and the endocannabinoid system: a relevance for alzheimers disease?","volume":"70","author":"Thompson","year":"2020","journal-title":"Cell. Signal."},{"key":"10.1016\/j.cyto.2026.157148_bb0555","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.1111\/jcmm.16191","article-title":"M2 macrophage-derived G-CSF promotes trophoblasts EMT, invasion and migration via activating PI3K\/Akt\/Erk1\/2 pathway to mediate normal pregnancy","volume":"25","author":"Ding","year":"2021","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.cyto.2026.157148_bb0560","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/s12958-025-01414-y","article-title":"The mechanisms and therapeutic effects of granulocyte colony-stimulating factor in reproduction","volume":"23","author":"Zhou","year":"2025","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.cyto.2026.157148_bb0565","series-title":"Twenty Years of G-CSF","first-page":"395","article-title":"The safety profile of filgrastim and pegfilgrastim","author":"Neumann","year":"2011"},{"key":"10.1016\/j.cyto.2026.157148_bb0570","article-title":"Treatment of G-CSF in unexplained, repeated implantation failure: a systematic review and meta-analysis","volume":"49","author":"Jiang","year":"2020","journal-title":"J. Gynecol. Obstet. Hum. Reprod."},{"key":"10.1016\/j.cyto.2026.157148_bb0575","article-title":"The role of granulocyte Colony-stimulating factor in endometrial preparation for embryo implantation in in vitro fertilization","volume":"16","author":"Voros","year":"2026","journal-title":"Life (Basel)"},{"key":"10.1016\/j.cyto.2026.157148_bb0580","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.3390\/ijms23042262","article-title":"Cytokine-induced JAK2-STAT3 activates tissue regeneration under systemic or local inflammation","volume":"23","author":"Kim","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cyto.2026.157148_bb0585","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1326281","article-title":"Potential applications of JAK inhibitors, clinically approved drugs against autoimmune diseases, in cancer therapy","volume":"14","author":"Wei","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.cyto.2026.157148_bb0590","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1038\/sj.bjc.6605381","article-title":"Activity of the multikinase inhibitor dasatinib against ovarian cancer cells","volume":"101","author":"Konecny","year":"2009","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.cyto.2026.157148_bb0595","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1007\/s11912-022-01326-9","article-title":"Targeting the PI3K pathway in gynecologic malignancies","volume":"24","author":"Avila","year":"2022","journal-title":"Curr. Oncol. Rep."},{"issue":"11","key":"10.1016\/j.cyto.2026.157148_bb0600","doi-asserted-by":"crossref","first-page":"4392","DOI":"10.4049\/jimmunol.1600121","article-title":"Therapeutic targeting of the G-CSF receptor reduces neutrophil trafficking and joint inflammation in antibody-mediated inflammatory arthritis","volume":"197","author":"Campbell","year":"2016","journal-title":"J. Immunol."}],"container-title":["Cytokine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466626000438?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466626000438?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T12:37:50Z","timestamp":1786883870000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043466626000438"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":120,"alternative-id":["S1043466626000438"],"URL":"https:\/\/doi.org\/10.1016\/j.cyto.2026.157148","relation":{},"ISSN":["1043-4666"],"issn-type":[{"value":"1043-4666","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CSF3R signalling beyond granulopoiesis: new paradigms in female reproductive biology","name":"articletitle","label":"Article Title"},{"value":"Cytokine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cyto.2026.157148","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"157148"}}