{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T02:33:13Z","timestamp":1793241193374,"version":"4.5.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001409","name":"India Ministry of Science &amp; Technology Department of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001501","name":"University Grants Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001501","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100024586","name":"Human Resource Development Centre, Council of Scientific And Industrial Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100024586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008812","name":"Defence Science and Technology Group","doi-asserted-by":"publisher","award":["SRG\/2023\/001857"],"award-info":[{"award-number":["SRG\/2023\/001857"]}],"id":[{"id":"10.13039\/501100008812","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytokine"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.cyto.2026.157185","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T12:12:35Z","timestamp":1783080755000},"page":"157185","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["The multifaceted role of acetamide derivative of chalcone: Anti-inflammatory action and impact on osteoclastogenesis, insights on NF-\u03baB and MAPK pathway"],"prefix":"10.1016","volume":"205","author":[{"given":"Sobia","family":"Anjum","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tazeem","family":"Akram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Unnatti","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omesh","family":"Manhas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasha Momo H.","family":"Anal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gurleen","family":"Kour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zabeer","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.cyto.2026.157185_bb0005","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.cell.2010.03.006","article-title":"Inflammation 2010: new adventures of an old flame","volume":"140","author":"Medzhitov","year":"2010","journal-title":"Cell"},{"issue":"7203","key":"10.1016\/j.cyto.2026.157185_bb0010","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1038\/nature07201","article-title":"Origin and physiological roles of inflammation","volume":"454","author":"Medzhitov","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.cyto.2026.157185_bb0015","doi-asserted-by":"crossref","unstructured":"Chen, Shanze et al. \u201cMacrophages in immunoregulation and therapeutics.\u201d Signal Transduct. Target. Ther. vol. 8,1 207. 22 May. 2023, doi:https:\/\/doi.org\/10.1038\/s41392-023-01452-1.","DOI":"10.1038\/s41392-023-01452-1"},{"issue":"5","key":"10.1016\/j.cyto.2026.157185_bb0020","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1111\/j.1462-5822.2007.00914.x","article-title":"Intracellular signalling cascades regulating innate immune responses to mycobacteria: branching out from toll-like receptors","volume":"9","author":"Jo","year":"2007","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.cyto.2026.157185_bb0025","doi-asserted-by":"crossref","unstructured":"Yamaguchi, Adriana et al. \u201cEicosanoids in inflammation in the blood and the vessel.\u201d Front. Pharmacol. vol. 13 997403. 27 Sep. 2022, doi:https:\/\/doi.org\/10.3389\/fphar.2022.997403.","DOI":"10.3389\/fphar.2022.997403"},{"issue":"7","key":"10.1016\/j.cyto.2026.157185_bb0030","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1089\/ars.2012.5149","article-title":"Reactive oxygen species in inflammation and tissue injury","volume":"20","author":"Mittal","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.cyto.2026.157185_bb0035","doi-asserted-by":"crossref","unstructured":"Li, Danyang, and Minghua Wu. \u201cPattern recognition receptors in health and diseases.\u201d Signal Transduct. Target. Ther. vol. 6,1 291. 4 Aug. 2021, doi:https:\/\/doi.org\/10.1038\/s41392-021-00687-0.","DOI":"10.1038\/s41392-021-00687-0"},{"issue":"5","key":"10.1016\/j.cyto.2026.157185_bb0040","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1002\/jcb.21553","article-title":"The osteoclast: a multinucleated, hematopoietic-origin, bone-resorbing osteoimmune cell","volume":"102","author":"Bar-Shavit","year":"2007","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.cyto.2026.157185_bb0045","series-title":"Myeloid Cells in Health and Disease: A Synthesis","first-page":"235","article-title":"Osteoclasts\u2014key players in skeletal health and disease","author":"Novack","year":"2017"},{"issue":"6937","key":"10.1016\/j.cyto.2026.157185_bb0050","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature01658","article-title":"Osteoclast differentiation and activation","volume":"423","author":"Boyle","year":"2003","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.cyto.2026.157185_bb0055","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/S8756-3282(99)00210-0","article-title":"Osteoblasts\/stromal cells stimulate osteoclast activation through expression of osteoclast differentiation factor\/RANKL but not macrophage colony-stimulating factor: receptor activator of NF-kappa B ligand","volume":"25","author":"Udagawa","year":"1999","journal-title":"Bone"},{"issue":"5484","key":"10.1016\/j.cyto.2026.157185_bb0060","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1126\/science.289.5484.1504","article-title":"Bone resorption by osteoclasts","volume":"289","author":"Teitelbaum","year":"2000","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.cyto.2026.157185_bb0065","doi-asserted-by":"crossref","unstructured":"Wijayanti, Lucia Wiwid et al. \u201cSynthesis and Evaluation of Chalcone Derivatives as Novel Sunscreen Agent.\u201d Molecules (Basel, Switzerland) vol. 26,9 2698. 4 May. 2021, doi:https:\/\/doi.org\/10.3390\/molecules26092698.","DOI":"10.3390\/molecules26092698"},{"key":"10.1016\/j.cyto.2026.157185_bb0070","doi-asserted-by":"crossref","unstructured":"Ouyang, Yang et al. \u201cChalcone derivatives: role in anticancer therapy.\u201d Biomolecules vol. 11,6 894. 16 Jun. 2021, doi:https:\/\/doi.org\/10.3390\/biom11060894.","DOI":"10.3390\/biom11060894"},{"key":"10.1016\/j.cyto.2026.157185_bb0075","doi-asserted-by":"crossref","unstructured":"Dhaliwal, Jagjit Singh et al. \u201cPharmacotherapeutics applications and chemistry of chalcone derivatives.\u201d Molecules vol. 27,20 7062. 19 Oct. 2022, doi:https:\/\/doi.org\/10.3390\/molecules27207062.","DOI":"10.3390\/molecules27207062"},{"key":"10.1016\/j.cyto.2026.157185_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmcl.2024.129795","article-title":"Design, synthesis, and biological evaluation of chalcone acetamide derivatives against triple negative breast cancer","volume":"107","author":"Kumar","year":"2024","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"6","key":"10.1016\/j.cyto.2026.157185_bb0085","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1007\/s10787-007-0013-x","article-title":"Role of nitric oxide in inflammatory diseases","volume":"15","author":"Sharma","year":"2007","journal-title":"Inflammopharmacology"},{"issue":"9","key":"10.1016\/j.cyto.2026.157185_bb0090","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/1043-2760(94)90105-8","article-title":"Multifunctional role of nitric oxide in inflammation","volume":"5","author":"Laskin","year":"1994","journal-title":"Trends Endocrinol Metab"},{"issue":"1\u20132","key":"10.1016\/j.cyto.2026.157185_bb0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.imlet.2008.07.008","article-title":"Regulation of autoimmune inflammation by pro-inflammatory cytokines","volume":"120","author":"Kim","year":"2008","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.cyto.2026.157185_bb0100","doi-asserted-by":"crossref","unstructured":"Da, Wacili et al. \u201cROS\/MMP-9 mediated CS degradation in BMSC inhibits citric acid metabolism participating in the dual regulation of bone remodelling.\u201d Cell Death Discov. vol. 10,1 77. 14 Feb. 2024, doi:https:\/\/doi.org\/10.1038\/s41420-024-01835-5.","DOI":"10.1038\/s41420-024-01835-5"},{"issue":"2","key":"10.1016\/j.cyto.2026.157185_bb0105","doi-asserted-by":"crossref","DOI":"10.1111\/sji.12970","article-title":"An inflammation classification system using cytokine parameters","volume":"93","author":"Roe","year":"2021","journal-title":"Scand. J. Immunol."},{"issue":"10275","key":"10.1016\/j.cyto.2026.157185_bb0110","first-page":"1023","article-title":"RA pathogenesis","volume":"397","author":"McInnes","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.cyto.2026.157185_bb0115","article-title":"Inflammation and bone erosion","volume":"11","author":"Crotti","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cyto.2026.157185_bb0120","doi-asserted-by":"crossref","unstructured":"Day, Richard O, and Garry G Graham. \u201cNon-steroidal anti-inflammatory drugs (NSAIDs).\u201d BMJ (Clinical research ed.) vol. 346 f3195. 11 Jun. 2013, doi:https:\/\/doi.org\/10.1136\/bmj.f3195.","DOI":"10.1136\/bmj.f3195"},{"issue":"5","key":"10.1016\/j.cyto.2026.157185_bb0125","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1007\/s00774-015-0702-2","article-title":"Methotrexate inhibits osteoclastogenesis by decreasing RANKL-induced calcium influx into osteoclast progenitors","volume":"34","author":"Kanagawa","year":"2016","journal-title":"J. Bone Miner. Metab."},{"issue":"12","key":"10.1016\/j.cyto.2026.157185_bb0130","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1080\/17460441.2024.2436908","article-title":"Advances in chalcone-based anticancer therapy: mechanisms, preclinical advances, and future perspectives","volume":"19","author":"Chowdhary","year":"2024","journal-title":"Expert Opin. Drug Discov."},{"issue":"4","key":"10.1016\/j.cyto.2026.157185_bb0135","article-title":"Chalcones suppress NF-\u03baB\/MAPK","volume":"21","author":"Hsieh","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cyto.2026.157185_bb0140","article-title":"Chalcone inhibits osteoclastogenesis","volume":"201","author":"Zhang","year":"2022","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.cyto.2026.157185_bb0145","doi-asserted-by":"crossref","unstructured":"Yu, Yajie et al. \u201cMacrophages play a key role in tissue repair and regeneration.\u201d PeerJ vol. 10 e14053. 29 Sep. 2022, doi:https:\/\/doi.org\/10.7717\/peerj.14053.","DOI":"10.7717\/peerj.14053"},{"key":"10.1016\/j.cyto.2026.157185_bb0150","doi-asserted-by":"crossref","unstructured":"Chen, Linlin et al. \u201cInflammatory responses and inflammation-associated diseases in organs.\u201d Oncotarget vol. 9,6 7204\u20137218. 14 Dec. 2017, doi:10.18632\/oncotarget.23208.","DOI":"10.18632\/oncotarget.23208"},{"key":"10.1016\/j.cyto.2026.157185_bb0155","doi-asserted-by":"crossref","unstructured":"Sun, Yang et al. \u201cMacrophage-osteoclast associations: origin, polarization, and subgroups.\u201d Front. Immunol. vol. 12 778078. 1 Dec. 2021, doi:https:\/\/doi.org\/10.3389\/fimmu.2021.778078.","DOI":"10.3389\/fimmu.2021.778078"},{"issue":"3","key":"10.1016\/j.cyto.2026.157185_bb0160","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1111\/j.1574-695X.2007.00329.x","article-title":"The role of nitric oxide in inflammatory reactions","volume":"51","author":"Tripathi","year":"2007","journal-title":"FEMS Immunol. Med. Microbiol."},{"issue":"5","key":"10.1016\/j.cyto.2026.157185_bb0165","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1161\/ATVBAHA.110.207449","article-title":"Prostaglandins and inflammation","volume":"31","author":"Ricciotti","year":"2011","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"1","key":"10.1016\/j.cyto.2026.157185_bb0170","doi-asserted-by":"crossref","first-page":"13612","DOI":"10.1038\/s41598-023-37729-2","article-title":"Phytochemical mediated modulation of COX-3 and NF\u03baB for the management and treatment of arthritis","volume":"13","author":"Biswas","year":"2023","journal-title":"Sci. Rep."},{"issue":"12","key":"10.1016\/j.cyto.2026.157185_bb0175","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1111\/ijcp.12022","article-title":"Denosumab: mechanism of action and clinical outcomes","volume":"66","author":"Hanley","year":"2012","journal-title":"Int. J. Clin. Pract."},{"key":"10.1016\/j.cyto.2026.157185_bb0180","doi-asserted-by":"crossref","unstructured":"Everts-Graber, Judith et al. \u201cIncidence of atypical femoral fractures in patients on osteoporosis therapy-a registry-based cohort study.\u201d JBMR Plus vol. 6,10 e10681. 22 Sep. 2022, doi:https:\/\/doi.org\/10.1002\/jbm4.10681.","DOI":"10.1002\/jbm4.10681"},{"issue":"35","key":"10.1016\/j.cyto.2026.157185_bb0185","first-page":"27","article-title":"RANKL-RANK signaling regulates osteoblast differentiation and bone formation","volume":"6","author":"Cao","year":"2018","journal-title":"Bone Res."},{"issue":"5","key":"10.1016\/j.cyto.2026.157185_bb0190","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.392","article-title":"A novel RANKL-targeted flavonoid glycoside prevents osteoporosis through inhibiting NFATc1 and reactive oxygen species","volume":"11","author":"Hong","year":"2021","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.cyto.2026.157185_bb0195","first-page":"457","article-title":"Osteoclast biology","volume":"15","author":"Novack","year":"2020","journal-title":"Annu. Rev. Pathol."},{"issue":"12","key":"10.1016\/j.cyto.2026.157185_bb0200","doi-asserted-by":"crossref","first-page":"8355","DOI":"10.1111\/jcmm.14713","article-title":"Astilbin prevents bone loss in ovariectomized mice through the inhibition of RANKL-induced osteoclastogenesis","volume":"23","author":"Jin","year":"2019","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.cyto.2026.157185_bb0205","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.freeradbiomed.2025.06.043","article-title":"Idebenone attenuates RANKL-induced osteoclastogenesis and improves bone mass in ovariectomized mice","volume":"238","author":"Yu","year":"2025","journal-title":"Free Radic. Biol. Med."},{"issue":"1","key":"10.1016\/j.cyto.2026.157185_bb0210","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1111\/jcmm.13955","article-title":"Evodiamine inhibits RANKL-induced osteoclastogenesis and prevents ovariectomy-induced bone loss in mice","volume":"23","author":"Jin","year":"2019","journal-title":"J. Cell. Mol. Med."},{"issue":"9","key":"10.1016\/j.cyto.2026.157185_bb0215","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.2174\/1389450118666170321105425","article-title":"Therapeutic potential and outlook of alternative medicine for osteoporosis","volume":"18","author":"Wang","year":"2017","journal-title":"Curr. Drug Targets"}],"container-title":["Cytokine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466626000803?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466626000803?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:36:56Z","timestamp":1785890216000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043466626000803"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":43,"alternative-id":["S1043466626000803"],"URL":"https:\/\/doi.org\/10.1016\/j.cyto.2026.157185","relation":{},"ISSN":["1043-4666"],"issn-type":[{"value":"1043-4666","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The multifaceted role of acetamide derivative of chalcone: Anti-inflammatory action and impact on osteoclastogenesis, insights on NF-\u03baB and MAPK pathway","name":"articletitle","label":"Article Title"},{"value":"Cytokine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cyto.2026.157185","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"157185"}}