{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T21:49:05Z","timestamp":1793396945406,"version":"4.5.0"},"reference-count":110,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007166","name":"Jiangsu Province Department of Education","doi-asserted-by":"publisher","award":["24KJB180001"],"award-info":[{"award-number":["24KJB180001"]}],"id":[{"id":"10.13039\/501100007166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32400767"],"award-info":[{"award-number":["32400767"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytokine"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.cyto.2026.157192","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T22:18:35Z","timestamp":1784067515000},"page":"157192","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Adipose tissue macrophages in metabolic inflammation and disease: Insights from single-cell and multi-omics studies"],"prefix":"10.1016","volume":"205","author":[{"given":"Qining","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwen","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaozheng","family":"Shu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoliang","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cyto.2026.157192_bb0005","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.cell.2021.12.016","article-title":"Adipose-tissue plasticity in health and disease","volume":"185","author":"Sakers","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.cyto.2026.157192_bb0010","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1210\/endrev\/bnaf032","article-title":"Advances in adipose tissue biology","volume":"47","author":"Corvera","year":"2026","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.cyto.2026.157192_bb0015","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.it.2019.07.006","article-title":"Innate immune control of adipose tissue homeostasis","volume":"40","author":"Kane","year":"2019","journal-title":"Trends Immunol."},{"key":"10.1016\/j.cyto.2026.157192_bb0020","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1148188","article-title":"Capturing the multifaceted function of adipose tissue macrophages","volume":"14","author":"Matz","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cyto.2026.157192_bb0025","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1160\/TH12-09-0703","article-title":"The role of innate immune cells in obese adipose tissue inflammation and development of insulin resistance","volume":"109","author":"Chavakis","year":"2013","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.cyto.2026.157192_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111315","article-title":"Adipose tissue and insulin resistance in obese","volume":"137","author":"Ahmed","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.cyto.2026.157192_bb0035","doi-asserted-by":"crossref","first-page":"26602","DOI":"10.1074\/jbc.M601284200","article-title":"Overexpression of monocyte chemoattractant Protein-1 in adipose tissues causes macrophage recruitment and insulin resistance","volume":"281","author":"Kamei","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cyto.2026.157192_bb0040","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1002\/oby.21900","article-title":"Synergistic modulation of inflammatory but not metabolic effects of high-fat feeding by CCR2 and CX3CR1","volume":"25","author":"Zhang","year":"2017","journal-title":"Obesity"},{"key":"10.1016\/j.cyto.2026.157192_bb0045","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1172\/JCI29881","article-title":"Obesity induces a phenotypic switch in adipose tissue macrophage polarization","volume":"117","author":"Lumeng","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.cyto.2026.157192_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.mocell.2024.100031","article-title":"Adipose tissue macrophage heterogeneity in the single-cell genomics era","volume":"47","author":"Kang","year":"2024","journal-title":"Mol. Cells"},{"key":"10.1016\/j.cyto.2026.157192_bb0055","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/imr.12853","article-title":"Adipose tissue macrophages: unique polarization and bioenergetics in obesity","volume":"295","author":"Caslin","year":"2020","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.cyto.2026.157192_bb0060","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/imr.12218","article-title":"Macrophage phenotypes in atherosclerosis","volume":"262","author":"Colin","year":"2014","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.cyto.2026.157192_bb0065","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.977485","article-title":"Adipose tissue macrophage in obesity-associated metabolic diseases","volume":"13","author":"Yao","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cyto.2026.157192_bb0070","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.immuni.2014.07.009","article-title":"Macrophage activation and polarization: nomenclature and experimental guidelines","volume":"41","author":"Murray","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.cyto.2026.157192_bb0075","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1002\/JLB.3RU1018-378RR","article-title":"M2b macrophage polarization and its roles in diseases","volume":"106","author":"Wang","year":"2018","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.cyto.2026.157192_bb0080","doi-asserted-by":"crossref","DOI":"10.1038\/s41421-022-00466-3","article-title":"Single-cell sequencing unveils key contributions of immune cell populations in cancer-associated adipose wasting","volume":"8","author":"Han","year":"2022","journal-title":"Cell Discov."},{"key":"10.1016\/j.cyto.2026.157192_bb0085","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1007\/s11883-024-01229-z","article-title":"Targeting macrophage phenotypes and metabolism as novel therapeutic approaches in atherosclerosis and related cardiovascular diseases","volume":"26","author":"Wang","year":"2024","journal-title":"Curr. Atheroscler. Rep."},{"key":"10.1016\/j.cyto.2026.157192_bb0090","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.cell.2019.05.054","article-title":"Lipid-associated macrophages control metabolic homeostasis in a Trem2-dependent manner","volume":"178","author":"Jaitin","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.cyto.2026.157192_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2021.101232","article-title":"GPNMB plays a protective role against obesity-related metabolic disorders by reducing macrophage inflammatory capacity","volume":"297","author":"Prabata","year":"2021","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cyto.2026.157192_bb0100","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.cmet.2014.08.010","article-title":"Metabolic dysfunction drives a mechanistically distinct proinflammatory phenotype in adipose tissue macrophages","volume":"20","author":"Kratz","year":"2014","journal-title":"Cell Metab."},{"key":"10.1016\/j.cyto.2026.157192_bb0105","doi-asserted-by":"crossref","first-page":"3149","DOI":"10.1016\/j.celrep.2017.08.096","article-title":"Metabolically activated adipose tissue macrophages perform detrimental and beneficial functions during diet-induced obesity","volume":"20","author":"Coats","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.cyto.2026.157192_bb0110","doi-asserted-by":"crossref","first-page":"C319","DOI":"10.1152\/ajpcell.00103.2018","article-title":"MFehi adipose tissue macrophages compensate for tissue iron perturbations in mice","volume":"315","author":"Hubler","year":"2018","journal-title":"Am. J. Physiol.-Cell Physiol."},{"key":"10.1016\/j.cyto.2026.157192_bb0115","doi-asserted-by":"crossref","first-page":"421","DOI":"10.2337\/db13-0213","article-title":"Obesity alters adipose tissue macrophage Iron content and tissue Iron distribution","volume":"63","author":"Orr","year":"2014","journal-title":"Diabetes"},{"key":"10.1016\/j.cyto.2026.157192_bb0120","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/ni.3341","article-title":"The development and maintenance of resident macrophages","volume":"17","author":"Perdiguero","year":"2015","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.cyto.2026.157192_bb0125","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1038\/s41586-023-06002-x","article-title":"Physiology and diseases of tissue-resident macrophages","volume":"618","author":"Lazarov","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.cyto.2026.157192_bb0130","doi-asserted-by":"crossref","first-page":"3521","DOI":"10.1242\/dev.079210","article-title":"Immature hematopoietic stem cells undergo maturation in the fetal liver","volume":"139","author":"Kieusseian","year":"2012","journal-title":"Development"},{"key":"10.1016\/j.cyto.2026.157192_bb0135","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/nature13989","article-title":"Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors","volume":"518","author":"Gomez Perdiguero","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.cyto.2026.157192_bb0140","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.stem.2012.02.002","article-title":"Erythroid\/myeloid progenitors and hematopoietic stem cells originate from distinct populations of endothelial cells","volume":"10","author":"Chen","year":"2012","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.cyto.2026.157192_bb0145","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.immuni.2019.09.002","article-title":"Liver-derived signals sequentially reprogram myeloid enhancers to initiate and maintain Kupffer cell identity","volume":"51","author":"Sakai","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.cyto.2026.157192_bb0150","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1146\/annurev-immunol-032414-112220","article-title":"Macrophages: development and tissue specialization","volume":"33","author":"Varol","year":"2015","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.cyto.2026.157192_bb0155","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2014.00683","article-title":"Ontogeny and polarization of macrophages in inflammation: blood monocytes versus tissue macrophages","volume":"5","author":"Dey","year":"2015","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cyto.2026.157192_bb0160","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1802611115","article-title":"Distinct macrophage populations direct inflammatory versus physiological changes in adipose tissue","volume":"115","author":"Hill","year":"2018","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.cyto.2026.157192_bb0165","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1002\/JLB.1MA1219-275R","article-title":"Obesity retunes turnover kinetics of tissue-resident macrophages in fat","volume":"107","author":"Chen","year":"2020","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.cyto.2026.157192_bb0170","doi-asserted-by":"crossref","first-page":"3015","DOI":"10.1172\/JCI28898","article-title":"TLR4 links innate immunity and fatty acid\u2013induced insulin resistance","volume":"116","author":"Shi","year":"2006","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.cyto.2026.157192_bb0175","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1016\/j.cmet.2018.03.014","article-title":"Evidence that TLR4 is not a receptor for saturated fatty acids but mediates lipid-induced inflammation by reprogramming macrophage metabolism","volume":"27","author":"Lancaster","year":"2018","journal-title":"Cell Metab."},{"key":"10.1016\/j.cyto.2026.157192_bb0180","article-title":"Hypoxia signaling in the adipose tissue","volume":"16","author":"Huynh","year":"2024","journal-title":"J. Mol. Cell Biol."},{"key":"10.1016\/j.cyto.2026.157192_bb0185","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.171701","article-title":"A lipid-associated macrophage lineage rewires the spatial landscape of adipose tissue in early obesity","volume":"8","author":"Stansbury","year":"2023","journal-title":"JCI Insight"},{"key":"10.1016\/j.cyto.2026.157192_bb0190","doi-asserted-by":"crossref","first-page":"64","DOI":"10.14341\/2071-8713-5212","article-title":"Subcutaneous and visceral adipose tissue: structural and functional differences","volume":"7","author":"Ibrahim","year":"2010","journal-title":"Obes. Metab."},{"key":"10.1016\/j.cyto.2026.157192_bb0195","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.719979","article-title":"Single-cell proteomics reveals the defined heterogeneity of resident macrophages in white adipose tissue","volume":"12","author":"F\u00e9lix","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cyto.2026.157192_bb0200","doi-asserted-by":"crossref","first-page":"65","DOI":"10.24875\/RIC.23000231","article-title":"Adipose tissue immunometabolism: unveiling the intersection of metabolic and immune regulation","volume":"76","author":"Medina-Urrutia","year":"2024","journal-title":"Rev. Investig. Cl\u00ednica"},{"key":"10.1016\/j.cyto.2026.157192_bb0205","doi-asserted-by":"crossref","first-page":"7884","DOI":"10.1074\/jbc.M113.522037","article-title":"Metabolic reprogramming of macrophages","volume":"289","author":"Freemerman","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cyto.2026.157192_bb0210","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.cmet.2006.05.011","article-title":"Oxidative metabolism and PGC-1\u03b2 attenuate macrophage-mediated inflammation","volume":"4","author":"Vats","year":"2006","journal-title":"Cell Metab."},{"key":"10.1016\/j.cyto.2026.157192_bb0215","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1038\/ni.3796","article-title":"\u03b1-Ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming","volume":"18","author":"Liu","year":"2017","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.cyto.2026.157192_bb0220","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1080\/15548627.2025.2487035","article-title":"BNIP3-mediated mitophagy in macrophages regulates obesity-induced adipose tissue metaflammation","volume":"21","author":"Kim","year":"2025","journal-title":"Autophagy"},{"key":"10.1016\/j.cyto.2026.157192_bb0225","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1038\/s41467-025-57044-w","article-title":"Macrophage SUCLA2 coupled glutaminolysis manipulates obesity through AMPK","volume":"16","author":"Peng","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cyto.2026.157192_bb0230","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s13072-025-00575-9","article-title":"Crosstalk between metabolism and epigenetics during macrophage polarization","volume":"18","author":"Zhang","year":"2025","journal-title":"Epigenetics Chromatin"},{"key":"10.1016\/j.cyto.2026.157192_bb0235","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/j.imbio.2016.08.011","article-title":"Epigenetic mechanisms of macrophage activation in type 2 diabetes","volume":"222","author":"Ahmed","year":"2017","journal-title":"Immunobiology"},{"key":"10.1016\/j.cyto.2026.157192_bb0240","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1124\/mol.106.027029","article-title":"Hypoxia-inducible Factor-1 (HIF-1)","volume":"70","author":"Ke","year":"2006","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.cyto.2026.157192_bb0245","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.87748","article-title":"Epigenetic regulation of macrophage polarization and inflammation by DNA methylation in obesity","volume":"1","author":"Wang","year":"2016","journal-title":"JCI Insight"},{"key":"10.1016\/j.cyto.2026.157192_bb0250","doi-asserted-by":"crossref","DOI":"10.1186\/s13059-022-02702-1","article-title":"Epigenomic analysis reveals a dynamic and context-specific macrophage enhancer landscape associated with innate immune activation and tolerance","volume":"23","author":"Zhang","year":"2022","journal-title":"Genome Biol."},{"key":"10.1016\/j.cyto.2026.157192_bb0255","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1111\/imm.13002","article-title":"Properties and functions of adipose tissue macrophages in obesity","volume":"155","author":"Russo","year":"2018","journal-title":"Immunology"},{"key":"10.1016\/j.cyto.2026.157192_bb0260","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/s42255-024-00978-0","article-title":"Obesity causes mitochondrial fragmentation and dysfunction in white adipocytes due to RalA activation","volume":"6","author":"Xia","year":"2024","journal-title":"Nat. Metab."},{"key":"10.1016\/j.cyto.2026.157192_bb0265","doi-asserted-by":"crossref","DOI":"10.1177\/20420188241282707","article-title":"Excessive or sustained endoplasmic reticulum stress: one of the culprits of adipocyte dysfunction in obesity","volume":"15","author":"Jiang","year":"2024","journal-title":"Ther. Adv. Endocrinol. Metab."},{"key":"10.1016\/j.cyto.2026.157192_bb0270","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abe2480","article-title":"3D microscopy and deep learning reveal the heterogeneity of crown-like structure microenvironments in intact adipose tissue","volume":"7","author":"Geng","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.cyto.2026.157192_bb0275","doi-asserted-by":"crossref","DOI":"10.1186\/s12915-021-01181-3","article-title":"Adipoclast: a multinucleated fat-eating macrophage","volume":"19","author":"Olona","year":"2021","journal-title":"BMC Biol."},{"key":"10.1016\/j.cyto.2026.157192_bb0280","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2015.00637","article-title":"The macrophage switch in obesity development","volume":"6","author":"Castoldi","year":"2016","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cyto.2026.157192_bb0285","doi-asserted-by":"crossref","first-page":"2779","DOI":"10.1038\/s41467-024-47108-8","article-title":"TM4SF19-mediated control of lysosomal activity in macrophages contributes to obesity-induced inflammation and metabolic dysfunction","volume":"15","author":"Choi","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cyto.2026.157192_bb0290","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.tem.2024.04.009","article-title":"Lipid-associated macrophages between aggravation and alleviation of metabolic diseases","volume":"35","author":"Xu","year":"2024","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.cyto.2026.157192_bb0295","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1136\/gutjnl-2016-313654","article-title":"Adipose tissue macrophages induce hepatic neutrophil recruitment and macrophage accumulation in mice","volume":"67","author":"Bijnen","year":"2018","journal-title":"Gut"},{"key":"10.1016\/j.cyto.2026.157192_bb0300","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1002\/hep.30525","article-title":"Adipocyte death preferentially induces liver injury and inflammation through the activation of chemokine (C-C motif) receptor 2-positive macrophages and lipolysis","volume":"69","author":"Kim","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.cyto.2026.157192_bb0305","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1053\/j.gastro.2016.02.066","article-title":"Pathogenesis of nonalcoholic steatohepatitis","volume":"150","author":"Machado","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cyto.2026.157192_bb0310","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.atherosclerosis.2015.01.001","article-title":"A concise review of non-alcoholic fatty liver disease","volume":"239","author":"Than","year":"2015","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.cyto.2026.157192_bb0315","doi-asserted-by":"crossref","first-page":"77","DOI":"10.3350\/cmh.2022.0237","article-title":"Pathogenesis and treatment of non-alcoholic steatohepatitis and its fibrosis","volume":"29","author":"Lee","year":"2023","journal-title":"Clin. Mol. Hepatol."},{"key":"10.1016\/j.cyto.2026.157192_bb0320","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.freeradbiomed.2011.10.003","article-title":"Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitis","volume":"52","author":"Rolo","year":"2012","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.cyto.2026.157192_bb0325","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1016\/S0168-8278(03)00460-4","article-title":"Diet associated hepatic steatosis sensitizes to Fas mediated liver injury in mice","volume":"39","author":"Feldstein","year":"2003","journal-title":"J. Hepatol."},{"key":"10.1016\/j.cyto.2026.157192_bb0330","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.3748\/wjg.v16.i18.2223","article-title":"Understanding mechanisms of the pathogenesis of nonalcoholic fatty liver disease","volume":"16","author":"Basaranoglu","year":"2010","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.cyto.2026.157192_bb0335","doi-asserted-by":"crossref","first-page":"149","DOI":"10.5009\/gnl.2012.6.2.149","article-title":"NASH is an inflammatory disorder: pathogenic, prognostic and therapeutic implications","volume":"6","author":"Farrell","year":"2012","journal-title":"Gut Liver"},{"key":"10.1016\/j.cyto.2026.157192_bb0340","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1476-9255-7-15","article-title":"Elevated endotoxin levels in non-alcoholic fatty liver disease","volume":"7","author":"Harte","year":"2010","journal-title":"J. Inflamm."},{"key":"10.1016\/j.cyto.2026.157192_bb0345","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1053\/j.gastro.2021.05.008","article-title":"Associations among adipose tissue immunology, inflammation, exosomes and insulin sensitivity in people with obesity and nonalcoholic fatty liver disease","volume":"161","author":"Fuchs","year":"2021","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cyto.2026.157192_bb0350","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2019.01607","article-title":"Chronic adipose tissue inflammation linking obesity to insulin resistance and type 2 diabetes","volume":"10","author":"Zatterale","year":"2020","journal-title":"Front. Physiol."},{"key":"10.1016\/j.cyto.2026.157192_bb0355","doi-asserted-by":"crossref","first-page":"2596","DOI":"10.1096\/fj.09-151340","article-title":"JNK1 and IKK\u03b2: molecular links between obesity and metabolic dysfunction","volume":"24","author":"Solinas","year":"2010","journal-title":"FASEB J."},{"key":"10.1016\/j.cyto.2026.157192_bb0360","doi-asserted-by":"crossref","DOI":"10.33549\/physiolres.935046","article-title":"Research Progress into adipose tissue macrophages and insulin resistance","volume":"72","author":"Fu","year":"2023","journal-title":"Physiol. Res."},{"key":"10.1016\/j.cyto.2026.157192_bb0365","doi-asserted-by":"crossref","first-page":"13740","DOI":"10.1074\/jbc.M210689200","article-title":"Suppressor of cytokine Signaling-3 (SOCS-3), a potential mediator of Interleukin-6-dependent insulin resistance in hepatocytes","volume":"278","author":"Senn","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cyto.2026.157192_bb0370","doi-asserted-by":"crossref","first-page":"8762","DOI":"10.1128\/MCB.25.19.8762.2005","volume":"25","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.cyto.2026.157192_bb0375","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/s41392-025-02486-3","article-title":"Adipocytes orchestrate obesity-related chronic inflammation through \u03b22-microglobulin","volume":"10","author":"Li","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.cyto.2026.157192_bb0380","doi-asserted-by":"crossref","first-page":"7991","DOI":"10.1038\/s41467-024-52258-w","article-title":"Adipocyte inflammation is the primary driver of hepatic insulin resistance in a human iPSC-based microphysiological system","volume":"15","author":"Qi","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cyto.2026.157192_bb0385","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1038\/s42255-020-00311-5","article-title":"The PI3K pathway preserves metabolic health through MARCO-dependent lipid uptake by adipose tissue macrophages","volume":"2","author":"Brunner","year":"2020","journal-title":"Nat. Metab."},{"key":"10.1016\/j.cyto.2026.157192_bb0390","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.cmet.2008.08.015","article-title":"Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animals","volume":"8","author":"Patsouris","year":"2008","journal-title":"Cell Metab."},{"key":"10.1016\/j.cyto.2026.157192_bb0395","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1080\/13813450802181047","article-title":"Insulin resistance associated to obesity: the link TNF-alpha","volume":"114","author":"Nieto-Vazquez","year":"2008","journal-title":"Arch. Physiol. Biochem."},{"key":"10.1016\/j.cyto.2026.157192_bb0400","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1172\/JCI10583","article-title":"Cellular mechanisms of insulin resistance","volume":"106","author":"Shulman","year":"2000","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.cyto.2026.157192_bb0405","doi-asserted-by":"crossref","first-page":"5250","DOI":"10.2174\/13816128113199990344","article-title":"Pathophysiology of NASH: perspectives for a targeted treatment","volume":"19","author":"Marra","year":"2013","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.cyto.2026.157192_bb0410","doi-asserted-by":"crossref","first-page":"6153","DOI":"10.1074\/jbc.M109.088708","article-title":"Adiponectin promotes macrophage polarization toward an anti-inflammatory phenotype","volume":"285","author":"Ohashi","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cyto.2026.157192_bb0415","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/j.1748-1716.2010.02216.x","article-title":"Cross-talk between adipose tissue and vasculature: role of adiponectin","volume":"203","author":"Li","year":"2010","journal-title":"Acta Physiol."},{"key":"10.1016\/j.cyto.2026.157192_bb0420","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1210\/jcem.86.5.7463","article-title":"Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia","volume":"86","author":"Weyer","year":"2001","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.cyto.2026.157192_bb0425","doi-asserted-by":"crossref","first-page":"26850","DOI":"10.1074\/jbc.M802787200","article-title":"Suppression of lipopolysaccharide-stimulated tumor necrosis factor-\u03b1 production by adiponectin is mediated by transcriptional and post-transcriptional mechanisms","volume":"283","author":"Park","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cyto.2026.157192_bb0430","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.1161\/01.ATV.0000183883.72263.13","article-title":"A paracrine loop between adipocytes and macrophages aggravates inflammatory changes","volume":"25","author":"Suganami","year":"2005","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.cyto.2026.157192_bb0435","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2019.00841","article-title":"Leptin induces Proadipogenic and proinflammatory Signaling in adipocytes","volume":"10","author":"Palhinha","year":"2019","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.cyto.2026.157192_bb0440","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1111\/j.1440-1746.2010.06253.x","article-title":"A fresh look at NASH pathogenesis. Part 1: the metabolic movers","volume":"25","author":"Larter","year":"2010","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.cyto.2026.157192_bb0445","doi-asserted-by":"crossref","first-page":"6039","DOI":"10.3390\/ijms21176039","article-title":"There and Back again: leptin actions in white adipose tissue","volume":"21","author":"Mart\u00ednez-S\u00e1nchez","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cyto.2026.157192_bb0450","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s005920200027","article-title":"Insulin-resistant patients with type 2 diabetes mellitus have higher serum leptin levels independently of body fat mass","volume":"39","author":"Fischer","year":"2002","journal-title":"Acta Diabetol."},{"key":"10.1016\/j.cyto.2026.157192_bb0455","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20191869","article-title":"Tissue-resident macrophages in omentum promote metastatic spread of ovarian cancer","volume":"217","author":"Etzerodt","year":"2020","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.cyto.2026.157192_bb0460","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1084\/jem.20181616","article-title":"Metabolically activated adipose tissue macrophages link obesity to triple-negative breast cancer","volume":"216","author":"Tiwari","year":"2019","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.cyto.2026.157192_bb0465","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1038\/nm.2492","article-title":"Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth","volume":"17","author":"Nieman","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.cyto.2026.157192_bb0470","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1038\/s41388-018-0592-6","article-title":"Obesity-associated inflammation promotes angiogenesis and breast cancer via angiopoietin-like 4","volume":"38","author":"Kolb","year":"2018","journal-title":"Oncogene"},{"key":"10.1016\/j.cyto.2026.157192_bb0475","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.ccell.2021.05.006","article-title":"Tim-4+ cavity-resident macrophages impair anti-tumor CD8+ T cell immunity","volume":"39","author":"Chow","year":"2021","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cyto.2026.157192_bb0480","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1038\/s41586-024-07529-3","article-title":"Obesity induces PD-1 on macrophages to suppress anti-tumour immunity","volume":"630","author":"Bader","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.cyto.2026.157192_bb0485","doi-asserted-by":"crossref","DOI":"10.1016\/j.tranon.2025.102657","article-title":"Obesity and cancer: relevance of DNA damage response","volume":"65","author":"Deshmukh","year":"2026","journal-title":"Transl. Oncol."},{"key":"10.1016\/j.cyto.2026.157192_bb0490","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s00394-011-0188-1","article-title":"New mechanisms and the anti-inflammatory role of curcumin in obesity and obesity-related metabolic diseases","volume":"50","author":"Shehzad","year":"2011","journal-title":"Eur. J. Nutr."},{"key":"10.1016\/j.cyto.2026.157192_bb0495","doi-asserted-by":"crossref","unstructured":"Costa, G., Francisco, V., C. Lopes, M., Cruz, M. & Batista, M. Intracellular signaling pathways modulated by phenolic compounds: application for new anti-inflammatory drugs discovery. Curr. Med. Chem. 19, 2876\u20132900 (2012).","DOI":"10.2174\/092986712800672049"},{"key":"10.1016\/j.cyto.2026.157192_bb0500","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1016\/j.lfs.2006.11.030","article-title":"Active spice-derived components can inhibit inflammatory responses of adipose tissue in obesity by suppressing inflammatory actions of macrophages and release of monocyte chemoattractant protein-1 from adipocytes","volume":"80","author":"Woo","year":"2007","journal-title":"Life Sci."},{"key":"10.1016\/j.cyto.2026.157192_bb0505","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1002\/oby.22110","article-title":"Dietary curcumin intervention targets mouse white adipose tissue inflammation and Brown adipose tissue UCP1 expression","volume":"26","author":"Song","year":"2018","journal-title":"Obesity"},{"key":"10.1016\/j.cyto.2026.157192_bb0510","doi-asserted-by":"crossref","first-page":"10186","DOI":"10.1039\/D2FO01682F","article-title":"Nobiletin mitigates NAFLD via lipophagy and inflammation","volume":"13","author":"Yang","year":"2022","journal-title":"Food Funct."},{"key":"10.1016\/j.cyto.2026.157192_bb0515","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1093\/cvr\/cvs132","article-title":"The SDF-1\/CXCR4 axis in stem cell preconditioning","volume":"94","author":"Cencioni","year":"2012","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.cyto.2026.157192_bb0520","doi-asserted-by":"crossref","first-page":"3827","DOI":"10.3390\/ijms20153827","article-title":"Current strategies to enhance adipose stem cell function: An update","volume":"20","author":"Seo","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cyto.2026.157192_bb0525","doi-asserted-by":"crossref","first-page":"2743","DOI":"10.1038\/s41467-025-57444-y","article-title":"Adipose progenitor cell-derived extracellular vesicles suppress macrophage M1 program to alleviate midlife obesity","volume":"16","author":"Zhou","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cyto.2026.157192_bb0530","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1038\/ni.2639","article-title":"CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation","volume":"14","author":"Sheedy","year":"2013","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.cyto.2026.157192_bb0535","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1161\/CIRCRESAHA.119.315833","article-title":"Mitochondrial metabolic reprogramming by CD36 Signaling drives macrophage inflammatory responses","volume":"125","author":"Chen","year":"2019","journal-title":"Circ. Res."},{"key":"10.1016\/j.cyto.2026.157192_bb0540","doi-asserted-by":"crossref","first-page":"353","DOI":"10.2337\/db14-0582","article-title":"Regulation of AMPK activation by CD36 links fatty acid uptake to \u03b2-oxidation","volume":"64","author":"Samovski","year":"2014","journal-title":"Diabetes"},{"key":"10.1016\/j.cyto.2026.157192_bb0545","article-title":"CD36 restricts lipid-associated macrophages accumulation in white adipose tissues during atherogenesis","volume":"11","author":"Chen","year":"2024","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.cyto.2026.157192_bb0550","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1210\/me.2013-1293","article-title":"Epigenetic regulation of macrophage polarization by DNA methyltransferase 3b","volume":"28","author":"Yang","year":"2014","journal-title":"Mol. Endocrinol."}],"container-title":["Cytokine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466626000876?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466626000876?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T13:22:02Z","timestamp":1786022522000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043466626000876"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":110,"alternative-id":["S1043466626000876"],"URL":"https:\/\/doi.org\/10.1016\/j.cyto.2026.157192","relation":{},"ISSN":["1043-4666"],"issn-type":[{"value":"1043-4666","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Adipose tissue macrophages in metabolic inflammation and disease: Insights from single-cell and multi-omics studies","name":"articletitle","label":"Article Title"},{"value":"Cytokine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cyto.2026.157192","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"157192"}}