{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T12:10:02Z","timestamp":1789560602233,"version":"build-2803163510"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:00:00Z","timestamp":1788480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004809","name":"Financiadora de Estudos e Projetos","doi-asserted-by":"publisher","award":["6205283B-BB28-4F9C-AA65-808FE4450542"],"award-info":[{"award-number":["6205283B-BB28-4F9C-AA65-808FE4450542"]}],"id":[{"id":"10.13039\/501100004809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["88881.507175\/2020-01"],"award-info":[{"award-number":["88881.507175\/2020-01"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007374","name":"Universidade Federal de Minas Gerais","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007374","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["APQ-02618-23"],"award-info":[{"award-number":["APQ-02618-23"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["APQ-04983-24"],"award-info":[{"award-number":["APQ-04983-24"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["RED-00202-22"],"award-info":[{"award-number":["RED-00202-22"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["APQ-04650-23"],"award-info":[{"award-number":["APQ-04650-23"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["APQ-00473-23"],"award-info":[{"award-number":["APQ-00473-23"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytokine"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.cyto.2026.157209","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:32:25Z","timestamp":1788309145000},"page":"157209","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Obesity exacerbates cardiac oxidative stress and fibrosis upon coronavirus infection"],"prefix":"10.1016","volume":"207","author":[{"given":"Aline Borges","family":"BarbosaTeles","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larisse","family":"de Souza Barbosa Lacerda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael Ferreira","family":"Calil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celso Martins","family":"Queiroz-Junior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Fl\u00e1via Santos","family":"Linhares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro Martins","family":"Teixeira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina Gomes Miranda E","family":"Castor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian Vasconcelos","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefany","family":"Cau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.cyto.2026.157209_bb0005","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/s41579-018-0118-9","article-title":"Origin and evolution of pathogenic coronaviruses","volume":"17","author":"Cui","year":"2019","journal-title":"Nat. Rev. Microbiol."},{"issue":"5","key":"10.1016\/j.cyto.2026.157209_bb0015","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.jacbts.2020.04.002","article-title":"COVID-19 for the cardiologist: basic virology, epidemiology, cardiac manifestations, and potential therapeutic strategies","volume":"5","author":"Atri","year":"2020","journal-title":"JACC Basic Transl. Sci."},{"issue":"11","key":"10.1016\/j.cyto.2026.157209_bb0020","article-title":"Cardiovascular complications of COVID-19: a scoping review of evidence","volume":"15","author":"Ntchana","year":"2023","journal-title":"Cureus"},{"issue":"3","key":"10.1016\/j.cyto.2026.157209_bb0025","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41591-022-01689-3","article-title":"Long-term cardiovascular outcomes of COVID-19","volume":"28","author":"Xie","year":"2022","journal-title":"Nat. Med."},{"issue":"1","key":"10.1016\/j.cyto.2026.157209_bb0030","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-025-66270-1","article-title":"COVID-19 and cardiovascular disease in a total population-study of long-term effects, social factors and COVID-19-vaccination","volume":"16","author":"Spetz","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cyto.2026.157209_bb0035","article-title":"Covid-19: most patients require mechanical ventilation in first 24 hours of critical care","volume":"368","author":"Mahase","year":"2020","journal-title":"BMJ"},{"issue":"7","key":"10.1016\/j.cyto.2026.157209_bb0040","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1002\/oby.22831","article-title":"High prevalence of obesity in severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) requiring invasive mechanical ventilation","volume":"28","author":"Simonnet","year":"2020","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.cyto.2026.157209_bb0045","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.780872","article-title":"Association of Obesity with COVID-19 severity and mortality: an updated systemic review, Meta-analysis, and Meta-regression","volume":"13","author":"Singh","year":"2022","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.cyto.2026.157209_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2024.155812","article-title":"Mortality risk in patients with obesity and COVID-19 infection: a systematic review and meta-analysis","volume":"155","author":"Haber","year":"2024","journal-title":"Metabolism"},{"issue":"3","key":"10.1016\/j.cyto.2026.157209_bb0055","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1002\/oby.70093","article-title":"Adipose tissue in SARS-CoV-2 viral tropism, viral replication, and the concept of a viral reservoir: an update","volume":"34","author":"Maher","year":"2026","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.cyto.2026.157209_bb0060","doi-asserted-by":"crossref","first-page":"1433531","DOI":"10.3389\/fimmu.2024.1433531","article-title":"Obesity-compromised immunity in post-COVID-19 condition: a critical control point of chronicity","volume":"15","author":"Jang","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cyto.2026.157209_bb0065","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.649359","article-title":"COVID-19 severity in obesity: leptin and inflammatory cytokine interplay in the link between high morbidity and mortality","volume":"12","author":"Maurya","year":"2021","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.cyto.2026.157209_bb0070","doi-asserted-by":"crossref","first-page":"7217","DOI":"10.1038\/s41598-021-86747-5","article-title":"Low HDL and high triglycerides predict COVID-19 severity","volume":"11","author":"Masana","year":"2021","journal-title":"Sci. Rep."},{"issue":"11","key":"10.1016\/j.cyto.2026.157209_bb0075","doi-asserted-by":"crossref","first-page":"2174","DOI":"10.1016\/j.cmet.2021.09.009","article-title":"Hyperglycemia in acute COVID-19 is characterized by insulin resistance and adipose tissue infectivity by SARS-CoV-2","volume":"33","author":"Reiterer","year":"2021","journal-title":"Cell Metab."},{"issue":"8","key":"10.1016\/j.cyto.2026.157209_bb0080","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1177\/08850666241232362","article-title":"Association of Body mass Index with multiple organ failure in hospitalized patients with COVID-19: a multicenter retrospective cohort study","volume":"39","author":"Phillips","year":"2024","journal-title":"J. Intensive Care Med."},{"issue":"2","key":"10.1016\/j.cyto.2026.157209_bb0085","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1161\/CIRCULATIONAHA.120.051936","article-title":"Association of Body Mass Index and age with Morbidity and mortality in patients hospitalized with COVID-19: results from the American Heart Association COVID-19 cardiovascular disease registry","volume":"143","author":"Hendren","year":"2021","journal-title":"Circulation"},{"key":"10.1016\/j.cyto.2026.157209_bb0090","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.bbi.2025.03.022","article-title":"Neuropsychiatric sequelae in an experimental model of post-COVID syndrome in mice","volume":"128","author":"Pimenta","year":"2025","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.cyto.2026.157209_bb0095","series-title":"Guia Brasileiro de Produ\u00e7\u00e3o, Manuten\u00e7\u00e3o ou Utiliza\u00e7\u00e3o de Animais para Atividades de Ensino ou Pesquisa Cient\u00edfica","year":"2023"},{"key":"10.1016\/j.cyto.2026.157209_bb0100","article-title":"Contribution of RAS, ROS and COX-1-derived prostanoids to the contractile profile of perivascular adipose tissue in cafeteria diet-induced obesity","volume":"309","author":"Costa","year":"2022","journal-title":"Life Sci."},{"key":"10.1016\/j.cyto.2026.157209_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2023.156192","article-title":"Cardiac disturbances and changes in tissue cytokine levels in mice fed with a high-refined carbohydrate diet","volume":"166","author":"Bruno","year":"2023","journal-title":"Cytokine"},{"key":"10.1016\/j.cyto.2026.157209_bb0110","doi-asserted-by":"crossref","unstructured":"E.C.R.G. Miranda, A.S. Bruno, C.A. Pereira, F.L.M. Bello, Y.B. Rodrigues, M.G. Silva, S.S. Bernardes, E.C. MGM, A.J. Ferreira, R.C. Tostes, S. Cau, Glibenclamide reverses cardiac damage and NLRP3 inflammasome activation associated with a high refined sugar diet, Eur. J. Pharmacol. 984 (2024) 177035.","DOI":"10.1016\/j.ejphar.2024.177035"},{"key":"10.1016\/j.cyto.2026.157209_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2025.123928","article-title":"NOX2-induced oxidative stress triggers cardiac hypercontractility during severe malaria","volume":"380","author":"de Oliveira","year":"2025","journal-title":"Life Sci."},{"issue":"2","key":"10.1016\/j.cyto.2026.157209_bb0120","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/aps.2011.203","article-title":"Laboratory animals as surrogate models of human obesity","volume":"33","author":"Nilsson","year":"2012","journal-title":"Acta Pharmacol. Sin."},{"issue":"7","key":"10.1016\/j.cyto.2026.157209_bb0125","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1007\/s00011-015-0831-z","article-title":"Cafeteria diet-fed mice is a pertinent model of obesity-induced organ damage: a potential role of inflammation","volume":"64","author":"Zeeni","year":"2015","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.cyto.2026.157209_bb0130","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.568197","article-title":"Proteomic and structural manifestations of cardiomyopathy in rat models of obesity and weight loss","volume":"12","author":"Liskiewicz","year":"2021","journal-title":"Front. Endocrinol. (Lausanne)"},{"issue":"8","key":"10.1016\/j.cyto.2026.157209_bb0135","doi-asserted-by":"crossref","DOI":"10.3390\/v12080880","article-title":"Of mice and men: the coronavirus MHV and mouse models as a translational approach to understand SARS-CoV-2","volume":"12","author":"Korner","year":"2020","journal-title":"Viruses"},{"issue":"22","key":"10.1016\/j.cyto.2026.157209_bb0140","doi-asserted-by":"crossref","DOI":"10.1128\/jvi.01276-21","article-title":"A Biosafety Level 2 mouse model for studying Betacoronavirus-induced acute lung damage and systemic manifestations","volume":"95","author":"Andrade","year":"2021","journal-title":"J. Virol."},{"issue":"7","key":"10.1016\/j.cyto.2026.157209_bb0145","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1042\/CS20220663","article-title":"TNF\/iNOS\/NO pathway mediates host susceptibility to endothelial-dependent circulatory failure and death induced by betacoronavirus infection","volume":"137","author":"Vieira-Alves","year":"2023","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.cyto.2026.157209_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2023.105567","article-title":"Neuromuscular defects after infection with a beta coronavirus in mice","volume":"169","author":"Rossi","year":"2023","journal-title":"Neurochem. Int."},{"issue":"10\u221211","key":"10.1016\/j.cyto.2026.157209_bb0155","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1007\/s00011-023-01798-w","article-title":"A suitable model to investigate acute neurological consequences of coronavirus infection","volume":"72","author":"Pimenta","year":"2023","journal-title":"Inflamm. Res."},{"issue":"12","key":"10.1016\/j.cyto.2026.157209_bb0160","doi-asserted-by":"crossref","DOI":"10.3390\/v15122434","article-title":"Dietary vitamin D mitigates coronavirus-induced lung inflammation and damage in mice","volume":"15","author":"Campolina-Silva","year":"2023","journal-title":"Viruses"},{"issue":"7","key":"10.1016\/j.cyto.2026.157209_bb0165","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1097\/HJH.0000000000003110","article-title":"Cardiovascular outcome 6 months after severe coronavirus disease 2019 infection","volume":"40","author":"Raafs","year":"2022","journal-title":"J. Hypertens."},{"key":"10.1016\/j.cyto.2026.157209_bb0170","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.748417","article-title":"The pathogenesis of COVID-19 myocardial injury: an immunohistochemical study of postmortem biopsies","volume":"12","author":"Hartmann","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cyto.2026.157209_bb0175","doi-asserted-by":"crossref","first-page":"1470953","DOI":"10.3389\/fmicb.2024.1470953","article-title":"Possible mechanisms of SARS-CoV-2-associated myocardial fibrosis: reflections in the post-pandemic era","volume":"15","author":"Wang","year":"2024","journal-title":"Front. Microbiol."},{"issue":"6","key":"10.1016\/j.cyto.2026.157209_bb0180","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.virs.2023.10.005","article-title":"Myocardial injury and related mortality in hospitalized patients with COVID-19 during the omicron pandemic: new perspectives and insights","volume":"38","author":"He","year":"2023","journal-title":"Virol. Sin."},{"issue":"12","key":"10.1016\/j.cyto.2026.157209_bb0185","doi-asserted-by":"crossref","DOI":"10.3390\/antiox11122371","article-title":"Oxidative stress as a therapeutic target of cardiac remodeling","volume":"11","author":"Martins","year":"2022","journal-title":"Antioxidants"},{"issue":"4","key":"10.1016\/j.cyto.2026.157209_bb0190","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1002\/ejhf.1320","article-title":"Treating oxidative stress in heart failure: past, present and future","volume":"21","author":"van der Pol","year":"2019","journal-title":"Eur. J. Heart Fail."},{"issue":"5","key":"10.1016\/j.cyto.2026.157209_bb0195","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1093\/infdis\/jiaa159","article-title":"A high-fat diet increases influenza a virus-associated cardiovascular damage","volume":"222","author":"Siegers","year":"2020","journal-title":"J Infect Dis"},{"issue":"5","key":"10.1016\/j.cyto.2026.157209_bb0200","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1016\/j.yjmcc.2011.02.005","article-title":"Role of reactive oxygen species in the regulation of cardiac contractility","volume":"50","author":"Kubin","year":"2011","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"8","key":"10.1016\/j.cyto.2026.157209_bb0205","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19082404","article-title":"NOX inhibition improves beta-adrenergic stimulated contractility and intracellular calcium handling in the aged rat heart","volume":"19","author":"Valdes","year":"2018","journal-title":"Int. J. Mol. Sci."}],"container-title":["Cytokine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466626001043?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466626001043?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T11:48:34Z","timestamp":1789559314000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043466626001043"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":40,"alternative-id":["S1043466626001043"],"URL":"https:\/\/doi.org\/10.1016\/j.cyto.2026.157209","relation":{},"ISSN":["1043-4666"],"issn-type":[{"value":"1043-4666","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Obesity exacerbates cardiac oxidative stress and fibrosis upon coronavirus infection","name":"articletitle","label":"Article Title"},{"value":"Cytokine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cyto.2026.157209","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"157209"}}