{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T10:30:53Z","timestamp":1794479453848,"version":"4.9.1"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T00:00:00Z","timestamp":1789776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"publisher","award":["2025ZD01903901"],"award-info":[{"award-number":["2025ZD01903901"]}],"id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004000","name":"Guangzhou Science and Technology Program Key Projects","doi-asserted-by":"publisher","award":["2025B01J3002"],"award-info":[{"award-number":["2025B01J3002"]}],"id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004000","name":"Guangzhou Science and Technology Program Key Projects","doi-asserted-by":"publisher","award":["2024A04J10019"],"award-info":[{"award-number":["2024A04J10019"]}],"id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013091","name":"Science and Technology Major Project of Guangxi","doi-asserted-by":"publisher","award":["GuikeAA24206008"],"award-info":[{"award-number":["GuikeAA24206008"]}],"id":[{"id":"10.13039\/501100013091","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017691","name":"Guangxi Key Research and Development Program","doi-asserted-by":"publisher","award":["GuikeAB24010081"],"award-info":[{"award-number":["GuikeAB24010081"]}],"id":[{"id":"10.13039\/501100017691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Guangdong Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2022A1515010506"],"award-info":[{"award-number":["2022A1515010506"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Guangdong Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2023B1111040004"],"award-info":[{"award-number":["2023B1111040004"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020084","name":"Guangzhou Municipal Science and Technology Bureau","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020084","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013804","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013804","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82020108009"],"award-info":[{"award-number":["82020108009"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171766"],"award-info":[{"award-number":["82171766"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["23ptpy107"],"award-info":[{"award-number":["23ptpy107"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002402","name":"Sun Yat-sen University","doi-asserted-by":"publisher","award":["2023WST01"],"award-info":[{"award-number":["2023WST01"]}],"id":[{"id":"10.13039\/501100002402","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytokine"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.cyto.2026.157212","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:47:08Z","timestamp":1790232428000},"page":"157212","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["MUC13 enhances IL-17 signaling pathway activity in nasal epithelial cells"],"prefix":"10.1016","volume":"208","author":[{"given":"Jiewen","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuwen","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengqi","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiping","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nianzhen","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.cyto.2026.157212_bb0005","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1183\/09031936.00141514","article-title":"The innate immune function of airway epithelial cells in inflammatory lung disease","volume":"45","author":"Hiemstra","year":"2015","journal-title":"Eur. Respir. J."},{"issue":"6","key":"10.1016\/j.cyto.2026.157212_bb0010","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/s41577-020-00477-9","article-title":"Regulation of immune responses by the airway epithelial cell landscape","volume":"21","author":"Hewitt","year":"2021","journal-title":"Nat. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.cyto.2026.157212_bb0015","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1128\/CMR.00014-10","article-title":"The airway epithelium: soldier in the fight against respiratory viruses","volume":"24","author":"Vareille","year":"2011","journal-title":"Clin. Microbiol. Rev."},{"issue":"3","key":"10.1016\/j.cyto.2026.157212_bb0020","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.mucimm.2025.03.003","article-title":"Airway epithelial cells as drivers of severe asthma pathogenesis","volume":"18","author":"Dorscheid","year":"2025","journal-title":"Mucosal Immunol."},{"issue":"5","key":"10.1016\/j.cyto.2026.157212_bb0025","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1016\/j.jaci.2022.02.016","article-title":"Mechanisms and pathogenesis of chronic rhinosinusitis","volume":"149","author":"Kato","year":"2022","journal-title":"J. Allergy Clin. Immunol."},{"issue":"12","key":"10.1016\/j.cyto.2026.157212_bb0030","doi-asserted-by":"crossref","first-page":"3192","DOI":"10.1111\/all.16318","article-title":"The epithelial barrier theory and its associated diseases","volume":"79","author":"Sun","year":"2024","journal-title":"Allergy"},{"issue":"6","key":"10.1016\/j.cyto.2026.157212_bb0035","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/nrgastro.2013.35","article-title":"The gastrointestinal mucus system in health and disease","volume":"10","author":"Johansson","year":"2013","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"5","key":"10.1016\/j.cyto.2026.157212_bb0040","doi-asserted-by":"crossref","DOI":"10.3390\/cancers15051491","article-title":"The mucin family of proteins: candidates as potential biomarkers for colon cancer","volume":"15","author":"Cox","year":"2023","journal-title":"Cancers (Basel)"},{"issue":"5","key":"10.1016\/j.cyto.2026.157212_bb0045","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1158\/1541-7786.MCR-10-0443","article-title":"Mucin 13: structure, function, and potential roles in cancer pathogenesis","volume":"9","author":"Maher","year":"2011","journal-title":"Mol. Cancer Res."},{"issue":"3","key":"10.1016\/j.cyto.2026.157212_bb0050","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1007\/s10555-024-10177-8","article-title":"Deciphering cellular and molecular mechanism of MUC13 mucin involved in cancer cell plasticity and drug resistance","volume":"43","author":"Malik","year":"2024","journal-title":"Cancer Metastasis Rev."},{"issue":"21","key":"10.1016\/j.cyto.2026.157212_bb0055","doi-asserted-by":"crossref","first-page":"18327","DOI":"10.1074\/jbc.M008850200","article-title":"Muc13, a novel human cell surface mucin expressed by epithelial and hemopoietic cells","volume":"276","author":"Williams","year":"2001","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.cyto.2026.157212_bb0060","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.jcmgh.2023.08.011","article-title":"MUC13 cell surface mucin limits Salmonella typhimurium infection by protecting the mucosal epithelial barrier","volume":"16","author":"McGuckin","year":"2023","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"issue":"5","key":"10.1016\/j.cyto.2026.157212_bb0065","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/onc.2016.241","article-title":"MUC13 protects colorectal cancer cells from death by activating the NF-\u03baB pathway and is a potential therapeutic target","volume":"36","author":"Sheng","year":"2017","journal-title":"Oncogene"},{"issue":"1","key":"10.1016\/j.cyto.2026.157212_bb0070","doi-asserted-by":"crossref","first-page":"8778","DOI":"10.1038\/s41598-025-92125-2","article-title":"Probiotic Bifidobacterium bifidum strains desialylate MUC13 and increase intestinal epithelial barrier function","volume":"15","author":"Segui-Perez","year":"2025","journal-title":"Sci. Rep."},{"issue":"9","key":"10.1016\/j.cyto.2026.157212_bb0075","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1016\/j.dld.2024.01.198","article-title":"GCNT3 regulated MUC13 to promote the development of hepatocellular carcinoma through the GSK3\u03b2\/\u03b2-catenin pathway","volume":"56","author":"Kang","year":"2024","journal-title":"Dig. Liver Dis."},{"issue":"12","key":"10.1016\/j.cyto.2026.157212_bb0080","doi-asserted-by":"crossref","DOI":"10.26508\/lsa.202301975","article-title":"MUC13 drives cancer aggressiveness and metastasis through the YAP1-dependent pathway","volume":"6","author":"Doxtater","year":"2023","journal-title":"Life Sci Alliance"},{"issue":"4","key":"10.1016\/j.cyto.2026.157212_bb0085","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.jhep.2019.11.021","article-title":"MUC13 promotes intrahepatic cholangiocarcinoma progression via EGFR\/PI3K\/AKT pathways","volume":"72","author":"Tiemin","year":"2020","journal-title":"J. Hepatol."},{"issue":"1","key":"10.1016\/j.cyto.2026.157212_bb0090","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3892\/ol.2021.13155","article-title":"MUC13 promotes lung cancer development and progression by activating ERK signaling","volume":"23","author":"Pang","year":"2022","journal-title":"Oncol. Lett."},{"issue":"48","key":"10.1016\/j.cyto.2026.157212_bb0095","doi-asserted-by":"crossref","first-page":"7294","DOI":"10.1038\/s41388-019-0951-y","article-title":"MUC13 promotes the development of colitis-associated colorectal tumors via \u03b2-catenin activity","volume":"38","author":"Sheng","year":"2019","journal-title":"Oncogene"},{"issue":"3","key":"10.1016\/j.cyto.2026.157212_bb0100","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/mi.2012.98","article-title":"MUC1 and MUC13 differentially regulate epithelial inflammation in response to inflammatory and infectious stimuli","volume":"6","author":"Sheng","year":"2013","journal-title":"Mucosal Immunol."},{"issue":"3","key":"10.1016\/j.cyto.2026.157212_bb0105","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.jaci.2025.06.023","article-title":"S aureus upregulation of MUC13 modulates mucosal remodeling in chronic rhinosinusitis via MEK1\/2 and WNT2B","volume":"156","author":"Feng","year":"2025","journal-title":"J. Allergy Clin. Immunol."},{"issue":"12","key":"10.1016\/j.cyto.2026.157212_bb0110","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"issue":"1","key":"10.1016\/j.cyto.2026.157212_bb0115","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/75556","article-title":"Gene ontology: tool for the unification of biology. The Gene Ontology Consortium","volume":"25","author":"Ashburner","year":"2000","journal-title":"Nat. Genet."},{"issue":"D1","key":"10.1016\/j.cyto.2026.157212_bb0120","doi-asserted-by":"crossref","first-page":"D545","DOI":"10.1093\/nar\/gkaa970","article-title":"KEGG: integrating viruses and cellular organisms","volume":"49","author":"Kanehisa","year":"2021","journal-title":"Nucleic Acids Res."},{"issue":"43","key":"10.1016\/j.cyto.2026.157212_bb0125","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"10.1016\/j.cyto.2026.157212_bb0130","article-title":"clusterProfiler 4.0: a universal enrichment tool for interpreting omics data","volume":"2","author":"Wu","year":"2021","journal-title":"Innovation (Camb)"},{"issue":"5","key":"10.1016\/j.cyto.2026.157212_bb0135","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00732-2019","article-title":"Whole-transcriptome sequencing reveals heightened inflammation and defective host defence responses in chronic rhinosinusitis with nasal polyps","volume":"54","author":"Peng","year":"2019","journal-title":"Eur. Respir. J."},{"issue":"9","key":"10.1016\/j.cyto.2026.157212_bb0140","doi-asserted-by":"crossref","DOI":"10.3390\/cells12091224","article-title":"IL-22-activated MUC13 impacts on colonic barrier function through JAK1\/STAT3, SNAI1\/ZEB1 and ROCK2\/MAPK Signaling","volume":"12","author":"Breugelmans","year":"2023","journal-title":"Cells"},{"issue":"10","key":"10.1016\/j.cyto.2026.157212_bb0145","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1007\/s00535-013-0885-z","article-title":"Functions and regulation of MUC13 mucin in colon cancer cells","volume":"49","author":"Gupta","year":"2014","journal-title":"J. Gastroenterol."},{"issue":"3","key":"10.1016\/j.cyto.2026.157212_bb0150","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1159\/000453594","article-title":"Transmembrane mucins: signaling receptors at the intersection of inflammation and cancer","volume":"9","author":"van Putten","year":"2017","journal-title":"J. Innate Immun."},{"issue":"3","key":"10.1016\/j.cyto.2026.157212_bb0155","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/mi.2017.97","article-title":"Mucocutaneous IL-17 immunity in mice and humans: host defense vs. excessive inflammation","volume":"11","author":"Li","year":"2018","journal-title":"Mucosal Immunol."},{"issue":"4","key":"10.1016\/j.cyto.2026.157212_bb0160","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/j.immuni.2019.03.021","article-title":"The IL-17 family of cytokines in health and disease","volume":"50","author":"McGeachy","year":"2019","journal-title":"Immunity"},{"issue":"1","key":"10.1016\/j.cyto.2026.157212_bb0165","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/s41392-023-01620-3","article-title":"The IL-17 family in diseases: from bench to bedside","volume":"8","author":"Huangfu","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.cyto.2026.157212_bb0170","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2017.01373","article-title":"T(H)17 cell and epithelial cell crosstalk during inflammatory bowel disease and carcinogenesis","volume":"8","author":"Kempski","year":"2017","journal-title":"Front. Immunol."},{"issue":"6","key":"10.1016\/j.cyto.2026.157212_bb0175","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0098915","article-title":"Interleukin-17A promotes MUC5AC expression and goblet cell hyperplasia in nasal polyps via the Act1-mediated pathway","volume":"9","author":"Xia","year":"2014","journal-title":"PloS One"},{"issue":"1","key":"10.1016\/j.cyto.2026.157212_bb0180","doi-asserted-by":"crossref","first-page":"11110","DOI":"10.1038\/s41598-022-15393-2","article-title":"Function-specific IL-17A and dexamethasone interactions in primary human airway epithelial cells","volume":"12","author":"Rahmawati","year":"2022","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.cyto.2026.157212_bb0185","article-title":"NF-\u03baB signaling in inflammation","volume":"2","author":"Liu","year":"2017","journal-title":"Signal Transduct. Target. Ther."},{"issue":"1","key":"10.1016\/j.cyto.2026.157212_bb0190","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1172\/JCI11830","article-title":"NF-kappaB: a key role in inflammatory diseases","volume":"107","author":"Tak","year":"2001","journal-title":"J. Clin. Invest."},{"issue":"10","key":"10.1016\/j.cyto.2026.157212_bb0195","doi-asserted-by":"crossref","first-page":"6676","DOI":"10.4049\/jimmunol.175.10.6676","article-title":"Up-regulation of CC chemokine ligand 20 expression in human airway epithelium by IL-17 through a JAK-independent but MEK\/NF-kappaB-dependent signaling pathway","volume":"175","author":"Kao","year":"2005","journal-title":"J. Immunol."},{"issue":"3","key":"10.1016\/j.cyto.2026.157212_bb0200","doi-asserted-by":"crossref","first-page":"507","DOI":"10.4168\/aair.2020.12.3.507","article-title":"Role of IL-17A in chronic rhinosinusitis with nasal polyp","volume":"12","author":"Ryu","year":"2020","journal-title":"Allergy Asthma Immunol. Res."}],"container-title":["Cytokine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466626001079?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466626001079?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T09:56:06Z","timestamp":1794477366000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043466626001079"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":40,"alternative-id":["S1043466626001079"],"URL":"https:\/\/doi.org\/10.1016\/j.cyto.2026.157212","relation":{},"ISSN":["1043-4666"],"issn-type":[{"value":"1043-4666","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MUC13 enhances IL-17 signaling pathway activity in nasal epithelial cells","name":"articletitle","label":"Article Title"},{"value":"Cytokine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cyto.2026.157212","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"157212"}}