{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T10:29:54Z","timestamp":1794479394342,"version":"4.9.1"},"reference-count":130,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["81072398"],"award-info":[{"award-number":["81072398"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytokine"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.cyto.2026.157214","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T13:23:18Z","timestamp":1790688198000},"page":"157214","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Interleukin-35 and pancreatic cancer: research progress from tumor-promoting mechanisms to treatment resistance"],"prefix":"10.1016","volume":"208","author":[{"given":"Yuanzhen","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luoyang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiying","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningjing","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cyto.2026.157214_bb0005","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1001\/jama.2021.13027","article-title":"Pancreatic cancer: A review","volume":"326","author":"Park","year":"2021","journal-title":"JAMA"},{"key":"10.1016\/j.cyto.2026.157214_bb0010","doi-asserted-by":"crossref","unstructured":"Mannucci, A. & Goel, A. Advances in pancreatic cancer early diagnosis, prevention, and treatment: The past, the present, and the future. CA. Cancer J. Clin. https:\/\/doi.org\/10.3322\/caac.70035 (2025) doi:https:\/\/doi.org\/10.3322\/caac.70035.","DOI":"10.3322\/caac.70035"},{"key":"10.1016\/j.cyto.2026.157214_bb0015","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1001\/jamaoncol.2022.3829","article-title":"Five-year outcomes of FOLFIRINOX vs gemcitabine as adjuvant therapy for pancreatic cancer: A randomized clinical trial","volume":"8","author":"Conroy","year":"2022","journal-title":"JAMA Oncol."},{"key":"10.1016\/j.cyto.2026.157214_bb0020","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/s41575-019-0245-4","article-title":"Role of oncogenic KRAS in the diagnosis, prognosis and treatment of pancreatic cancer","volume":"17","author":"Buscail","year":"2020","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.cyto.2026.157214_bb0025","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1002\/ijc.34367","article-title":"Crosstalk between tumor acidosis, p53 and extracellular matrix regulates pancreatic cancer aggressiveness","volume":"152","author":"Czaplinska","year":"2023","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.cyto.2026.157214_bb0030","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s40170-024-00354-2","article-title":"PAF1\/HIF1\u03b1 axis rewires the glycolytic metabolism to fuel aggressiveness of pancreatic cancer","volume":"12","author":"Ogunleye","year":"2024","journal-title":"Cancer Metab."},{"key":"10.1016\/j.cyto.2026.157214_bb0035","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1136\/gutjnl-2024-332782","article-title":"TPX2 serves as a novel target for expanding the utility of PARPi in pancreatic cancer through conferring synthetic lethality","volume":"74","author":"Xiao","year":"2025","journal-title":"Gut"},{"key":"10.1016\/j.cyto.2026.157214_bb0040","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/nature21052","article-title":"Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer","volume":"542","author":"Dey","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.cyto.2026.157214_bb0045","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/s41420-025-02382-3","article-title":"Investigating synthetic lethality and PARP inhibitor resistance in pancreatic cancer through enantiomer differential activity","volume":"11","author":"Masi","year":"2025","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.cyto.2026.157214_bb0050","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1136\/gutjnl-2023-330480","article-title":"Enhanced antitumour immunity following neoadjuvant chemoradiotherapy mediates a favourable prognosis in women with resected pancreatic cancer","volume":"73","author":"van Eijck","year":"2024","journal-title":"Gut"},{"key":"10.1016\/j.cyto.2026.157214_bb0055","doi-asserted-by":"crossref","first-page":"6645","DOI":"10.1038\/s41467-025-61890-z","article-title":"Cell-free DNA testing for the detection and prognosis prediction of pancreatic cancer","volume":"16","author":"Wu","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cyto.2026.157214_bb0060","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.ajpath.2024.11.009","article-title":"IL-35 may prevent the exacerbation of aspiration pneumonia involving porphyromonas gingivalis by suppressing IL-17 production","volume":"195","author":"Kawamura","year":"2025","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.cyto.2026.157214_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.107642","article-title":"Interleukin-35 regulates peripheral T cell activity in patients with kawasaki disease","volume":"96","author":"Sun","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.cyto.2026.157214_bb0070","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.humimm.2013.09.018","article-title":"Circulating IL-35 in pancreatic ductal adenocarcinoma patients","volume":"75","author":"Jin","year":"2014","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.cyto.2026.157214_bb0075","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.874823","article-title":"The molecular role of IL-35 in non-small cell lung cancer","volume":"12","author":"Hao","year":"2022","journal-title":"Front. Oncol."},{"key":"10.1016\/j.cyto.2026.157214_bb0080","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.cyto.2018.07.006","article-title":"Serum concentration of interleukin-35 and its association with tumor stages and FOXP3 gene polymorphism in patients with prostate cancer","volume":"113","author":"Chatrabnous","year":"2019","journal-title":"Cytokine"},{"key":"10.1016\/j.cyto.2026.157214_bb0085","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.cyto.2016.09.012","article-title":"Increased interleukin-35 expression in tumor-infiltrating lymphocytes correlates with poor prognosis in patients with breast cancer","volume":"89","author":"Zhao","year":"2017","journal-title":"Cytokine"},{"key":"10.1016\/j.cyto.2026.157214_bb0090","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1038\/bjc.2016.47","article-title":"Overexpression of interleukin-35 associates with hepatocellular carcinoma aggressiveness and recurrence after curative resection","volume":"114","author":"Fu","year":"2016","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.cyto.2026.157214_bb0095","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.309","article-title":"A novel potential target of IL-35-regulated JAK\/STAT signaling pathway in lupus nephritis","volume":"11","author":"Cai","year":"2021","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.cyto.2026.157214_bb0100","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.autrev.2018.01.017","article-title":"Emerging role of IL-35 in inflammatory autoimmune diseases","volume":"17","author":"Su","year":"2018","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.cyto.2026.157214_bb0105","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.bbi.2024.07.043","article-title":"Interleukin-35 alleviates neuropathic pain and induces an anti-inflammatory shift in spinal microglia in nerve-injured male mice","volume":"122","author":"Fiore","year":"2024","journal-title":"Brain. Behav. Immun."},{"key":"10.1016\/j.cyto.2026.157214_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2025.103594","article-title":"Interleukin-35 inhibits NETs to ameliorate Th17\/treg immune imbalance during the exacerbation of cigarette smoke exposed-asthma via gp130\/STAT3\/ferroptosis axis","volume":"82","author":"Tao","year":"2025","journal-title":"Redox Biol."},{"key":"10.1016\/j.cyto.2026.157214_bb0115","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1038\/nature06306","article-title":"The inhibitory cytokine IL-35 contributes to regulatory T-cell function","volume":"450","author":"Collison","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.cyto.2026.157214_bb0120","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1002\/eji.201546095","article-title":"A novel IL-23p19\/Ebi3 (IL-39) cytokine mediates inflammation in lupus-like mice","volume":"46","author":"Wang","year":"2016","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.cyto.2026.157214_bb0125","doi-asserted-by":"crossref","first-page":"214","DOI":"10.5114\/ceji.2020.97911","article-title":"Interleukin 39: A new member of interleukin 12 family","volume":"45","author":"Lu","year":"2020","journal-title":"Cent.-Eur. J. Immunol."},{"key":"10.1016\/j.cyto.2026.157214_bb0130","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s12016-015-8468-9","article-title":"IL-35 and autoimmunity: A comprehensive perspective","volume":"49","author":"Choi","year":"2015","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"10.1016\/j.cyto.2026.157214_bb0135","doi-asserted-by":"crossref","first-page":"969","DOI":"10.3389\/fonc.2019.00969","article-title":"IL-27, IL-30, and IL-35: A cytokine triumvirate in cancer","volume":"9","author":"Kourko","year":"2019","journal-title":"Front. Oncol."},{"key":"10.1016\/j.cyto.2026.157214_bb0140","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/nature12979","article-title":"IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases","volume":"507","author":"Shen","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.cyto.2026.157214_bb0145","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/nm.3554","article-title":"Interleukin-35 induces regulatory B cells that suppress autoimmune disease","volume":"20","author":"Wang","year":"2014","journal-title":"Nat. Med."},{"key":"10.1016\/j.cyto.2026.157214_bb0150","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1002\/eji.201445217","article-title":"Human tolerogenic dendritic cells produce IL-35 in the absence of other IL-12 family members","volume":"45","author":"Dixon","year":"2015","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.cyto.2026.157214_bb0155","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.cyto.2014.06.020","article-title":"IL-35 promotes pancreas cancer growth through enhancement of proliferation and inhibition of apoptosis: Evidence for a role as an autocrine growth factor","volume":"70","author":"Nicholl","year":"2014","journal-title":"Cytokine"},{"issue":"190","key":"10.1016\/j.cyto.2026.157214_bb0160","first-page":"2415","article-title":"Tumor-derived IL-35 promotes tumor growth by enhancing myeloid cell accumulation and angiogenesis","volume":"1950","author":"Wang","year":"2013","journal-title":"J. Immunol. Baltim. Md"},{"key":"10.1016\/j.cyto.2026.157214_bb0165","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/ni.2227","article-title":"The composition and signaling of the IL-35 receptor are unconventional","volume":"13","author":"Collison","year":"2012","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.cyto.2026.157214_bb0170","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.cytogfr.2012.04.001","article-title":"Plasticity and cross-talk of interleukin 6-type cytokines","volume":"23","author":"Garbers","year":"2012","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.cyto.2026.157214_bb0175","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1038\/ni.2366","article-title":"IL-12 family cytokines: Immunological playmakers","volume":"13","author":"Vignali","year":"2012","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.cyto.2026.157214_bb0180","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S1074-7613(00)80614-7","article-title":"IL-12 acts directly on DC to promote nuclear localization of NF-kappaB and primes DC for IL-12 production","volume":"9","author":"Grohmann","year":"1998","journal-title":"Immunity"},{"key":"10.1016\/j.cyto.2026.157214_bb0185","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1038\/gt.2011.37","article-title":"Oncolytic adenovirus co-expressing IL-12 and IL-18 improves tumor-specific immunity via differentiation of T cells expressing IL-12R\u03b22 or IL-18R\u03b1","volume":"18","author":"Choi","year":"2011","journal-title":"Gene Ther."},{"key":"10.1016\/j.cyto.2026.157214_bb0190","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.3390\/cells10081955","article-title":"Implications of a \u2018third signal\u2019 in NK cells","volume":"10","author":"Khalil","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.cyto.2026.157214_bb0195","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.ccr.2011.03.009","article-title":"Stat3\/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer","volume":"19","author":"Lesina","year":"2011","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cyto.2026.157214_bb0200","doi-asserted-by":"crossref","first-page":"5001","DOI":"10.1002\/cam4.4823","article-title":"Interleukin 6\/gp130 axis promotes neural invasion in pancreatic cancer","volume":"11","author":"Suzuki","year":"2022","journal-title":"Cancer Med."},{"key":"10.1016\/j.cyto.2026.157214_bb0205","doi-asserted-by":"crossref","first-page":"2845","DOI":"10.7314\/APJCP.2015.16.7.2845","article-title":"IL-35 over-expression is associated with genesis of gastric cancer","volume":"16","author":"Fan","year":"2015","journal-title":"Asian Pac. J. Cancer Prev. APJCP"},{"key":"10.1016\/j.cyto.2026.157214_bb0210","doi-asserted-by":"crossref","first-page":"3214105","DOI":"10.1155\/2016\/3214105","article-title":"Epstein-barr virus-induced gene 3 (EBI3) blocking leads to induce antitumor cytotoxic T lymphocyte response and suppress tumor growth in colorectal cancer by bidirectional reciprocal-regulation STAT3 signaling pathway","volume":"2016","author":"Liang","year":"2016","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.cyto.2026.157214_bb0215","doi-asserted-by":"crossref","first-page":"6293","DOI":"10.1038\/s41598-025-89015-y","article-title":"IL35 modulates HBV-related HCC progression via IL6-STAT3 signaling","volume":"15","author":"Zhou","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cyto.2026.157214_bb0220","doi-asserted-by":"crossref","first-page":"2384","DOI":"10.1002\/ijc.29563","article-title":"Regulatory T cells-derived IL-35 promotes the growth of adult acute myeloid leukemia blasts","volume":"137","author":"Tao","year":"2015","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.cyto.2026.157214_bb0225","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.immuni.2015.04.005","article-title":"Regulatory B cells: Origin, phenotype, and function","volume":"42","author":"Rosser","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.cyto.2026.157214_bb0230","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1158\/2159-8290.CD-15-0843","article-title":"IL35-producing B cells promote the development of pancreatic neoplasia","volume":"6","author":"Pylayeva-Gupta","year":"2016","journal-title":"Cancer Discov."},{"key":"10.1016\/j.cyto.2026.157214_bb0235","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1158\/2326-6066.CIR-17-0710","article-title":"IL35 hinders endogenous antitumor T-cell immunity and responsiveness to immunotherapy in pancreatic cancer","volume":"6","author":"Mirlekar","year":"2018","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.cyto.2026.157214_bb0240","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/s41467-017-00838-4","article-title":"IL-12p35 induces expansion of IL-10 and IL-35-expressing regulatory B cells and ameliorates autoimmune disease","volume":"8","author":"Dambuza","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cyto.2026.157214_bb0245","article-title":"B cell receptor signaling and protein kinase D2 support regulatory B cell function in pancreatic cancer","volume":"12","author":"Michaud","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cyto.2026.157214_bb0250","article-title":"Balance between immunoregulatory B cells and plasma cells drives pancreatic tumor immunity","volume":"3","author":"Mirlekar","year":"2022","journal-title":"Cell Rep. Med."},{"key":"10.1016\/j.cyto.2026.157214_bb0255","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1158\/2326-6066.CIR-20-0272","article-title":"Antitumor T-cell immunity contributes to pancreatic cancer immune resistance","volume":"9","author":"Ajina","year":"2021","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.cyto.2026.157214_bb0260","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1158\/2326-6066.CIR-19-0349","article-title":"B cell-derived IL35 drives STAT3-dependent CD8+ T-cell exclusion in pancreatic cancer","volume":"8","author":"Mirlekar","year":"2020","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.cyto.2026.157214_bb0265","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1136\/gutjnl-2019-319912","article-title":"Interleukin-1\u03b2-induced pancreatitis promotes pancreatic ductal adenocarcinoma via B lymphocyte-mediated immune suppression","volume":"70","author":"Takahashi","year":"2021","journal-title":"Gut"},{"key":"10.1016\/j.cyto.2026.157214_bb0270","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.immuni.2016.01.013","article-title":"Interleukin-35 limits anti-tumor immunity","volume":"44","author":"Turnis","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.cyto.2026.157214_bb0275","doi-asserted-by":"crossref","first-page":"4579","DOI":"10.1158\/0008-5472.CAN-13-0529","article-title":"Neuropilin-2 promotes extravasation and metastasis by interacting with endothelial \u03b15 integrin","volume":"73","author":"Cao","year":"2013","journal-title":"Cancer Res."},{"key":"10.1016\/j.cyto.2026.157214_bb0280","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1158\/1078-0432.CCR-12-2940","article-title":"Increased circulation of galectin-3 in cancer induces secretion of metastasis-promoting cytokines from blood vascular endothelium","volume":"19","author":"Chen","year":"2013","journal-title":"Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res."},{"key":"10.1016\/j.cyto.2026.157214_bb0285","doi-asserted-by":"crossref","first-page":"14035","DOI":"10.1038\/ncomms14035","article-title":"Tumour-derived interleukin 35 promotes pancreatic ductal adenocarcinoma cell extravasation and metastasis by inducing ICAM1 expression","volume":"8","author":"Huang","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cyto.2026.157214_bb0290","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1158\/2159-8290.CD-14-0474","article-title":"Mutant KRAS-induced expression of ICAM-1 in pancreatic acinar cells causes attraction of macrophages to expedite the formation of precancerous lesions","volume":"5","author":"Liou","year":"2015","journal-title":"Cancer Discov."},{"key":"10.1016\/j.cyto.2026.157214_bb0295","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s12943-018-0927-5","article-title":"Tumor-stromal crosstalk in pancreatic cancer and tissue fibrosis","volume":"18","author":"Thomas","year":"2019","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.cyto.2026.157214_bb0300","doi-asserted-by":"crossref","first-page":"3579","DOI":"10.1111\/cas.15495","article-title":"Tumor microenvironmental 15-PGDH depletion promotes fibrotic tumor formation and angiogenesis in pancreatic cancer","volume":"113","author":"Bu","year":"2022","journal-title":"Cancer Sci."},{"key":"10.1016\/j.cyto.2026.157214_bb0305","doi-asserted-by":"crossref","first-page":"2562","DOI":"10.1007\/s12033-024-01219-1","article-title":"TGF\u03b22 promotes the construction of fibrotic and immunosuppressive tumor microenvironment in pancreatic adenocarcinoma: A comprehensive analysis","volume":"67","author":"Yu","year":"2025","journal-title":"Mol. Biotechnol."},{"key":"10.1016\/j.cyto.2026.157214_bb0310","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.jconrel.2024.03.041","article-title":"Targeting ROCK2 improves macromolecular permeability in a 3D fibrotic pancreatic cancer microenvironment model","volume":"369","author":"Tanaka","year":"2024","journal-title":"J. Control. Release Off. J. Control. Release Soc."},{"key":"10.1016\/j.cyto.2026.157214_bb0315","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1038\/s41556-025-01697-8","article-title":"Durotaxis is a driver and potential therapeutic target in lung fibrosis and metastatic pancreatic cancer","volume":"27","author":"Al-Hilal","year":"2025","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cyto.2026.157214_bb0320","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1038\/s41563-024-01908-x","article-title":"Engineered matrices reveal stiffness-mediated chemoresistance in patient-derived pancreatic cancer organoids","volume":"23","author":"LeSavage","year":"2024","journal-title":"Nat. Mater."},{"key":"10.1016\/j.cyto.2026.157214_bb0325","article-title":"Tumor-derived interleukin 35 promotes fibrosis in the tumor microenvironment of pancreatic cancer by activating pancreatic stellate cells","volume":"e09074","author":"Li","year":"2025","journal-title":"Adv. Sci. Weinh. Baden-Wurtt. Ger."},{"key":"10.1016\/j.cyto.2026.157214_bb0330","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1016\/j.biopha.2018.09.136","article-title":"Role of angiogenesis in pancreatic cancer biology and therapy","volume":"108","author":"Zhang","year":"2018","journal-title":"Biomed. Pharmacother. Biomedecine Pharmacother."},{"key":"10.1016\/j.cyto.2026.157214_bb0335","doi-asserted-by":"crossref","first-page":"7504","DOI":"10.18632\/oncotarget.3233","article-title":"TCGA data and patient-derived orthotopic xenografts highlight pancreatic cancer-associated angiogenesis","volume":"6","author":"Gore","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.cyto.2026.157214_bb0340","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.2174\/0115680096284588240105051402","article-title":"Angiogenesis and pancreatic cancer: Novel approaches to overcome treatment resistance","volume":"24","author":"Grobbelaar","year":"2024","journal-title":"Curr. Cancer Drug Targets"},{"key":"10.1016\/j.cyto.2026.157214_bb0345","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1186\/s12935-020-01583-3","article-title":"Interleukin-35 promotes progression of prostate cancer and inhibits anti-tumour immunity","volume":"20","author":"Zhu","year":"2020","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.cyto.2026.157214_bb0350","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0018534","article-title":"Rgs2 mediates pro-angiogenic function of myeloid derived suppressor cells in the tumor microenvironment via upregulation of MCP-1","volume":"6","author":"Boelte","year":"2011","journal-title":"PloS One"},{"key":"10.1016\/j.cyto.2026.157214_bb0355","doi-asserted-by":"crossref","first-page":"3356","DOI":"10.1172\/JCI80005","article-title":"Myeloid-derived suppressor cells in the tumor microenvironment: Expect the unexpected","volume":"125","author":"Marvel","year":"2015","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.cyto.2026.157214_bb0360","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1053\/j.gastro.2017.09.039","article-title":"Interleukin 35 expression correlates with microvessel density in pancreatic ductal adenocarcinoma, recruits monocytes, and promotes growth and angiogenesis of xenograft tumors in mice","volume":"154","author":"Huang","year":"2018","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cyto.2026.157214_bb0365","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1007\/s12029-025-01381-y","article-title":"The Vascular Density\/Angiogenesis Marker CD31\/PECAM1 does not Correlate with Overall Survival in Neuroendocrine Tumors","volume":"57","author":"Skill","year":"2026","journal-title":"J. Gastrointest. Cancer"},{"key":"10.1016\/j.cyto.2026.157214_bb0370","doi-asserted-by":"crossref","first-page":"37","DOI":"10.11152\/mu-1234","article-title":"Correlation between Contrast-Enhanced Ultrasound and Microvessel Density via CD31 and CD34 in a rabbit VX2 lung peripheral tumor model","volume":"1","author":"Xing","year":"2018","journal-title":"Med. Ultrason."},{"key":"10.1016\/j.cyto.2026.157214_bb0375","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1158\/1078-0432.CCR-20-3141","article-title":"Composition, Spatial Characteristics, and Prognostic Significance of Myeloid Cell Infiltration in Pancreatic Cancer. Clin. Cancer Res","volume":"27","author":"V\u00e4yrynen","year":"2021","journal-title":"Off. J. Am. Assoc. Cancer Res."},{"key":"10.1016\/j.cyto.2026.157214_bb0380","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1186\/s12943-024-02128-2","article-title":"Sulindac (K-80003) with nab-paclitaxel and gemcitabine overcomes drug-resistant pancreatic cancer","volume":"23","author":"Xie","year":"2024","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.cyto.2026.157214_bb0385","doi-asserted-by":"crossref","first-page":"3034","DOI":"10.1002\/1878-0261.13279","article-title":"Systematic exploration of the underlying mechanism of gemcitabine resistance in pancreatic adenocarcinoma","volume":"16","author":"Liu","year":"2022","journal-title":"Mol. Oncol."},{"key":"10.1016\/j.cyto.2026.157214_bb0390","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1053\/j.gastro.2023.02.025","article-title":"Targeting UBE2T potentiates gemcitabine efficacy in pancreatic cancer by regulating pyrimidine metabolism and replication stress","volume":"164","author":"Jiang","year":"2023","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cyto.2026.157214_bb0395","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/s41388-024-02938-0","article-title":"Tumor-derived interleukin 35 mediates the dissemination of gemcitabine resistance in pancreatic adenocarcinoma","volume":"43","author":"Sun","year":"2024","journal-title":"Oncogene"},{"key":"10.1016\/j.cyto.2026.157214_bb0400","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1158\/1535-7163.MCT-23-0242","article-title":"IL-35: New Target for Immunotherapy Targeting the Tumor Microenvironment","volume":"23","author":"Yi","year":"2024","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.cyto.2026.157214_bb0405","unstructured":"STING agonist therapy in combination with PD-1 immune checkpoint blockade enhances response to carboplatin chemotherapy in high-grade serous ovarian cancer - PubMed. https:\/\/pubmed.ncbi.nlm.nih.gov\/30046165\/."},{"key":"10.1016\/j.cyto.2026.157214_bb0410","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.immuni.2020.06.009","article-title":"Interferon-independent activities of mammalian STING mediate antiviral response and tumor immune evasion","volume":"53","author":"Wu","year":"2020","journal-title":"Immunity"},{"key":"10.1016\/j.cyto.2026.157214_bb0415","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2020-001182","article-title":"Overcoming resistance to STING agonist therapy to incite durable protective antitumor immunity","volume":"8","author":"Lemos","year":"2020","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.cyto.2026.157214_bb0420","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/s41586-022-05254-3","article-title":"STING-induced regulatory B cells compromise NK function in cancer immunity","volume":"610","author":"Li","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.cyto.2026.157214_bb0425","doi-asserted-by":"crossref","first-page":"3316","DOI":"10.1038\/s41388-018-0668-3","article-title":"BTK signaling drives CD1dhiCD5+ regulatory B-cell differentiation to promote pancreatic carcinogenesis","volume":"38","author":"Das","year":"2019","journal-title":"Oncogene"},{"key":"10.1016\/j.cyto.2026.157214_bb0430","doi-asserted-by":"crossref","first-page":"2160","DOI":"10.3390\/biomedicines13092160","article-title":"STING-Activating Nanoparticles Combined with PD-1\/PD-L1 Blockade: A Synergistic Approach in Cancer Immunotherapy","volume":"13","author":"Bartusik-Aebisher","year":"2025","journal-title":"Biomedicines"},{"key":"10.1016\/j.cyto.2026.157214_bb0435","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s13045-019-0721-x","article-title":"Activating cGAS-STING pathway for the optimal effect of cancer immunotherapy. J. Hematol. Oncol","volume":"12","author":"Li","year":"2019","journal-title":"J Hematol Oncol"},{"key":"10.1016\/j.cyto.2026.157214_bb0440","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1111\/febs.14801","article-title":"IL-35 ameliorates collagen-induced arthritis by promoting TNF-\u03b1-induced apoptosis of synovial fibroblasts and stimulating M2 macrophages polarization","volume":"286","author":"Peng","year":"2019","journal-title":"FEBS J."},{"key":"10.1016\/j.cyto.2026.157214_bb0445","doi-asserted-by":"crossref","DOI":"10.1002\/jcp.31231","article-title":"Interleukin-35 protein inhibits osteoclastogenesis and attenuates collagen-induced arthritis in mice","volume":"239","author":"Yuan","year":"2024","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.cyto.2026.157214_bb0450","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.309","article-title":"A novel potential target of IL-35-regulated JAK\/STAT signaling pathway in lupus nephritis","volume":"11","author":"Cai","year":"2021","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.cyto.2026.157214_bb0455","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/s41467-017-00838-4","article-title":"IL-12p35 induces expansion of IL-10 and IL-35-expressing regulatory B cells and ameliorates autoimmune disease","volume":"8","author":"Dambuza","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cyto.2026.157214_bb0460","article-title":"Decreased expression of IL-35 and its receptor contributes to impaired megakaryopoiesis in the pathogenesis of immune thrombocytopenia","volume":"11","author":"Cai","year":"2024","journal-title":"Adv. Sci. Weinh. Baden-Wurtt. Ger."},{"key":"10.1016\/j.cyto.2026.157214_bb0465","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1002\/alr.22438","article-title":"Probiotic extracts ameliorate nasal allergy by inducing interleukin-35-producing dendritic cells in mice","volume":"9","author":"Xue","year":"2019","journal-title":"Int. Forum Allergy Rhinol."},{"key":"10.1016\/j.cyto.2026.157214_bb0470","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/j.jaci.2018.06.041","article-title":"Role of IL-35 in sublingual allergen immunotherapy","volume":"143","author":"Shamji","year":"2019","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.cyto.2026.157214_bb0475","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.4168\/aair.2020.12.6.1029","article-title":"Aberrant TH2 immune responses are associated with a reduced frequency of IL-35-induced regulatory T cells after allergen exposure in patients with allergic asthma","volume":"12","author":"Wang","year":"2020","journal-title":"Allergy Asthma Immunol. Res."},{"key":"10.1016\/j.cyto.2026.157214_bb0480","doi-asserted-by":"crossref","DOI":"10.1016\/j.ygeno.2023.110639","article-title":"Interleukin-35 expression promotes hepatocellular carcinogenesis by inducing \u03b3\u03b4 T-cell exhaustion","volume":"115","author":"Ren","year":"2023","journal-title":"Genomics"},{"key":"10.1016\/j.cyto.2026.157214_bb0485","article-title":"Gut microbiota derived indole-3-acetic acid ameliorates precancerous inflammatory intestinal milieu to inhibit tumorigenesis through IL-35","volume":"13","author":"Wang","year":"2025","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.cyto.2026.157214_bb0490","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1161\/CIRCRESAHA.118.314569","article-title":"Interleukin-35 promotes macrophage survival and improves wound healing after myocardial infarction in mice","volume":"124","author":"Jia","year":"2019","journal-title":"Circ. Res."},{"key":"10.1016\/j.cyto.2026.157214_bb0495","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1161\/ATVBAHA.117.310626","article-title":"IL-35 (interleukin-35) suppresses endothelial cell activation by inhibiting mitochondrial reactive oxygen species-mediated site-specific acetylation of H3K14 (histone 3 lysine 14)","volume":"38","author":"Li","year":"2018","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.cyto.2026.157214_bb0500","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1097\/TP.0000000000004707","article-title":"IL-35 stabilizes treg phenotype to protect cardiac allografts in mice","volume":"108","author":"Huang","year":"2024","journal-title":"Transplantation"},{"key":"10.1016\/j.cyto.2026.157214_bb0505","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1038\/ni.1952","article-title":"IL-35-mediated induction of a potent regulatory T cell population","volume":"11","author":"Collison","year":"2010","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.cyto.2026.157214_bb0510","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1111\/jcpe.13282","article-title":"Interleukin-35 inhibits alveolar bone resorption by modulating the Th17\/treg imbalance during periodontitis","volume":"47","author":"Cafferata","year":"2020","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.cyto.2026.157214_bb0515","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/978-1-0716-1237-8_8","article-title":"IL-35 detection in B cells at the mRNA and protein level","volume":"2270","author":"Mirlekar","year":"2021","journal-title":"Methods Mol. Biol. Clifton NJ"},{"key":"10.1016\/j.cyto.2026.157214_bb0520","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1172\/JCI38019","article-title":"Epithelial-mesenchymal transitions: The importance of changing cell state in development and disease","volume":"119","author":"Acloque","year":"2009","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.cyto.2026.157214_bb0525","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.tcb.2020.07.003","article-title":"EMT, MET, plasticity, and tumor metastasis","volume":"30","author":"Bakir","year":"2020","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.cyto.2026.157214_bb0530","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/nrc3447","article-title":"Regulatory networks defining EMT during cancer initiation and progression","volume":"13","author":"De Craene","year":"2013","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.cyto.2026.157214_bb0535","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.bbrc.2021.04.050","article-title":"IL-35 promotes EMT through STAT3 activation and induces MET by promoting M2 macrophage polarization in HCC","volume":"559","author":"He","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.cyto.2026.157214_bb0540","doi-asserted-by":"crossref","first-page":"3763","DOI":"10.1038\/s41467-018-06268-0","article-title":"Macrophage-secreted interleukin-35 regulates cancer cell plasticity to facilitate metastatic colonization","volume":"9","author":"Lee","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cyto.2026.157214_bb0545","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/j.ccell.2015.04.011","article-title":"Dysfunction of the reciprocal feedback loop between GATA3- and ZEB2-nucleated repression programs contributes to breast cancer metastasis","volume":"27","author":"Si","year":"2015","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cyto.2026.157214_bb0550","first-page":"775","article-title":"Preliminary mechanisms of regulating PD-L1 expression in non-small cell lung cancer during the EMT process","volume":"40","author":"Li","year":"2018","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.cyto.2026.157214_bb0555","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/s41388-018-0454-2","article-title":"Epithelial-mesenchymal transition (EMT) beyond EGFR mutations per se is a common mechanism for acquired resistance to EGFR TKI","volume":"38","author":"Weng","year":"2019","journal-title":"Oncogene"},{"key":"10.1016\/j.cyto.2026.157214_bb0560","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.lungcan.2019.10.012","article-title":"Gene signatures of tumor inflammation and epithelial-to-mesenchymal transition (EMT) predict responses to immune checkpoint blockade in lung cancer with high accuracy","volume":"139","author":"Thompson","year":"2020","journal-title":"Lung Cancer Amst. Neth."},{"key":"10.1016\/j.cyto.2026.157214_bb0565","doi-asserted-by":"crossref","unstructured":"Tieftrunk, E., Demir, I. E., Friess, H. & Ceyhan, G. O. Back pain as a potential indicator of local recurrence in pancreatic cancer. J. Surg. Case Rep. 2015, rjv127 (2015).","DOI":"10.1093\/jscr\/rjv127"},{"key":"10.1016\/j.cyto.2026.157214_bb0570","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/S1499-3872(13)60086-7","article-title":"The relationship between multiple clinicopathological features and nerve invasion in pancreatic cancer","volume":"12","author":"Wang","year":"2013","journal-title":"Hepatobiliary Pancreat. Dis. Int. HBPD INT"},{"key":"10.1016\/j.cyto.2026.157214_bb0575","doi-asserted-by":"crossref","first-page":"5901","DOI":"10.1111\/jcmm.15265","article-title":"NGF from pancreatic stellate cells induces pancreatic cancer proliferation and invasion by PI3K\/AKT\/GSK signal pathway","volume":"24","author":"Jiang","year":"2020","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.cyto.2026.157214_bb0580","doi-asserted-by":"crossref","first-page":"2326","DOI":"10.1523\/JNEUROSCI.1815-18.2019","article-title":"Regulatory T cells and their derived cytokine, interleukin-35, reduce pain in experimental autoimmune encephalomyelitis","volume":"39","author":"Duffy","year":"2019","journal-title":"J. Neurosci. Off. J. Soc. Neurosci."},{"key":"10.1016\/j.cyto.2026.157214_bb0585","article-title":"Distinct small molecule inhibitors of kras specifically prime CTLA4 blockade therapy to transcriptionally reprogram tregs and overcome resistance to suppress pancreas cancer","volume":"2025.02.28.640711","author":"Mahadevan","year":"2025","journal-title":"BioRxiv Prepr. Serv. Biol."},{"key":"10.1016\/j.cyto.2026.157214_bb0590","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s12950-017-0164-5","article-title":"Interleukin-35 on B cell and T cell induction and regulation","volume":"14","author":"Huang","year":"2017","journal-title":"J. Inflamm. Lond. Engl."},{"key":"10.1016\/j.cyto.2026.157214_bb0595","doi-asserted-by":"crossref","first-page":"12041","DOI":"10.1073\/pnas.94.22.12041","article-title":"Epstein-barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin","volume":"94","author":"Devergne","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cyto.2026.157214_bb0600","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1128\/jvi.70.2.1143-1153.1996","article-title":"A novel interleukin-12 p40-related protein induced by latent epstein-barr virus infection in B lymphocytes","volume":"70","author":"Devergne","year":"1996","journal-title":"J. Virol."},{"key":"10.1016\/j.cyto.2026.157214_bb0605","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1007\/s10238-025-01838-1","article-title":"Unlocking the therapeutic potential of the STING signaling pathway in anti-tumor treatment","volume":"25","author":"Li","year":"2025","journal-title":"Clin. Exp. Med."},{"key":"10.1016\/j.cyto.2026.157214_bb0610","doi-asserted-by":"crossref","first-page":"5590","DOI":"10.4049\/jimmunol.1201744","article-title":"Human prostate tumor antigen-specific CD8+ regulatory T cells are inhibited by CTLA-4 or IL-35 blockade","volume":"189","author":"Olson","year":"2012","journal-title":"J. Immunol."},{"key":"10.1016\/j.cyto.2026.157214_bb0615","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1097\/PAS.0000000000002398","article-title":"Clinicopathologic Characteristics of Immune Checkpoint Inhibitor-related Pancreatitis","volume":"49","author":"Chen","year":"2025","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1016\/j.cyto.2026.157214_bb0620","doi-asserted-by":"crossref","DOI":"10.1016\/j.esmoop.2024.103489","article-title":"Circulating immune-related proteins associated with immune checkpoint inhibitor efficacy in patients with pancreatic ductal adenocarcinoma","volume":"9","author":"Christensen","year":"2024","journal-title":"ESMO Open"},{"key":"10.1016\/j.cyto.2026.157214_bb0625","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1186\/s12885-019-6372-z","article-title":"Fatal myositis and spontaneous haematoma induced by combined immune checkpoint inhibitor treatment in a patient with pancreatic adenocarcinoma","volume":"19","author":"Liu","year":"2019","journal-title":"BMC Cancer"},{"key":"10.1016\/j.cyto.2026.157214_bb0630","doi-asserted-by":"crossref","first-page":"327","DOI":"10.20517\/cdr.2022.142","article-title":"Major hurdles of immune-checkpoint inhibitors in pancreatic ductal adenocarcinoma","volume":"6","author":"Akhuba","year":"2023","journal-title":"Cancer Drug Resist."},{"key":"10.1016\/j.cyto.2026.157214_bb0635","doi-asserted-by":"crossref","first-page":"1196970","DOI":"10.3389\/fimmu.2023.1196970","article-title":"Bispecific antibody targeting TGF-\u03b2 and PD-L1 for synergistic cancer immunotherapy","volume":"14","author":"Li","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cyto.2026.157214_bb0640","doi-asserted-by":"crossref","first-page":"2182","DOI":"10.7150\/thno.53102","article-title":"Silencing PCBP2 normalizes desmoplastic stroma and improves the antitumor activity of chemotherapy in pancreatic cancer","volume":"11","author":"Li","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.cyto.2026.157214_bb0645","article-title":"Recent advances in nanoparticles-based sonodynamic and immune checkpoint blockade synergistic therapy for pancreatic ductal adenocarcinoma","volume":"35","author":"Li","year":"2025","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.cyto.2026.157214_bb0650","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1053\/j.gastro.2011.07.040","article-title":"Interleukin-35 mediates mucosal immune responses that protect against T-cell-dependent colitis","volume":"141","author":"Wirtz","year":"2011","journal-title":"Gastroenterology"}],"container-title":["Cytokine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466626001092?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466626001092?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T09:55:48Z","timestamp":1794477348000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043466626001092"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":130,"alternative-id":["S1043466626001092"],"URL":"https:\/\/doi.org\/10.1016\/j.cyto.2026.157214","relation":{},"ISSN":["1043-4666"],"issn-type":[{"value":"1043-4666","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Interleukin-35 and pancreatic cancer: research progress from tumor-promoting mechanisms to treatment resistance","name":"articletitle","label":"Article Title"},{"value":"Cytokine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cyto.2026.157214","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"157214"}}