{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T19:51:27Z","timestamp":1792266687892,"version":"4.4.0"},"reference-count":21,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["874764"],"award-info":[{"award-number":["874764"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100029296","name":"Irvin Stern Family Foundation","doi-asserted-by":"publisher","award":["1870\/25"],"award-info":[{"award-number":["1870\/25"]}],"id":[{"id":"10.13039\/100029296","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["788194"],"award-info":[{"award-number":["788194"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["899224"],"award-info":[{"award-number":["899224"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001738","name":"Israel Ministry of Innovation Science & Technology","doi-asserted-by":"publisher","award":["0007196"],"award-info":[{"award-number":["0007196"]}],"id":[{"id":"10.13039\/501100001738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006245","name":"Ministry of Science and Technology, Israel","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006245","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003977","name":"ISF","doi-asserted-by":"publisher","award":["2214\/22"],"award-info":[{"award-number":["2214\/22"]}],"id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016882","name":"ERC","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016882","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytokine"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.cyto.2026.157221","type":"journal-article","created":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:12:04Z","timestamp":1792167124000},"page":"157221","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Glatiramer acetate attenuates the cytokine surge associated with acute decompensated heart failure"],"prefix":"10.1016","volume":"208","author":[{"given":"Gal","family":"Aviel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rabea","family":"Asleh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean","family":"Nachman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eldad","family":"Tzahor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Offer","family":"Amir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Sarig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cyto.2026.157221_bb0005","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.120.016782","article-title":"Trends of clinical outcomes and health care resource use in heart failure in the United States","volume":"9","author":"Khan","year":"2020","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.cyto.2026.157221_bb0010","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/S1053-2498(00)00083-8","article-title":"Prognostic value of serum cytokines in patients with congestive heart failure","volume":"19","author":"Orus","year":"2000","journal-title":"J. Heart Lung Transplant."},{"key":"10.1016\/j.cyto.2026.157221_bb0015","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1016\/j.jacc.2020.01.014","article-title":"Inflammation in heart failure: JACC state-of-the-art review","volume":"75","author":"Murphy","year":"2020","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.cyto.2026.157221_bb0020","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1161\/CIRCULATIONAHA.118.038010","article-title":"Anti-inflammatory therapy with canakinumab for the prevention of hospitalization for heart failure","volume":"139","author":"Everett","year":"2019","journal-title":"Circulation"},{"key":"10.1016\/j.cyto.2026.157221_bb0025","doi-asserted-by":"crossref","first-page":"3133","DOI":"10.1161\/01.CIR.0000077913.60364.D2","volume":"107","author":"Chung","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.cyto.2026.157221_bb0030","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1080\/14740338.2017.1274728","article-title":"Long-term safety and tolerability of glatiramer acetate 20 mg\/ml in the treatment of relapsing forms of multiple sclerosis","volume":"16","author":"Ziemssen","year":"2017","journal-title":"Expert Opin. Drug Saf."},{"key":"10.1016\/j.cyto.2026.157221_bb0035","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.autrev.2012.09.005","article-title":"The mechanism of action of glatiramer acetate in multiple sclerosis and beyond","volume":"12","author":"Aharoni","year":"2013","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.cyto.2026.157221_bb0040","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.imlet.2007.07.009","article-title":"The therapeutic effect of glatiramer acetate in a murine model of inflammatory bowel disease is mediated by anti-inflammatory T-cells","volume":"112","author":"Aharoni","year":"2007","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.cyto.2026.157221_bb0045","doi-asserted-by":"crossref","first-page":"G628","DOI":"10.1152\/ajpgi.00137.2006","article-title":"Beneficial effect of glatiramer acetate (Copaxone) on immune modulation of experimental hepatic fibrosis","volume":"292","author":"Horani","year":"2007","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.cyto.2026.157221_bb0050","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1038\/s44161-024-00524-x","article-title":"Repurposing of glatiramer acetate to treat cardiac ischemia in rodent models","volume":"3","author":"Aviel","year":"2024","journal-title":"Nat. Cardiovasc. Res."},{"key":"10.1016\/j.cyto.2026.157221_bb0055","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.1016\/j.jacc.2016.09.931","article-title":"Prognostic implications of changes in N-terminal pro-B-type natriuretic peptide in patients with heart failure","volume":"68","author":"Zile","year":"2016","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.cyto.2026.157221_bb0060","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.ejheart.2008.02.008","article-title":"Prognostic role of pro- and anti-inflammatory cytokines and their polymorphisms in acute decompensated heart failure","volume":"10","author":"Miettinen","year":"2008","journal-title":"Eur. J. Heart Fail."},{"key":"10.1016\/j.cyto.2026.157221_bb0065","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/s00392-010-0140-z","article-title":"Inflammation increases NT-proBNP and the NT-proBNP\/BNP ratio","volume":"99","author":"Jensen","year":"2010","journal-title":"Clin. Res. Cardiol."},{"key":"10.1016\/j.cyto.2026.157221_bb0070","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1161\/CIRCRESAHA.124.323659","article-title":"Myocardial inflammation in heart failure with reduced and preserved ejection fraction","volume":"134","author":"Alcaide","year":"2024","journal-title":"Circ. Res."},{"key":"10.1016\/j.cyto.2026.157221_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.jacadv.2024.101063","article-title":"Interleukin-6 and cardiovascular events in healthy adults: MESA","volume":"3","author":"Khan","year":"2024","journal-title":"JACC Adv."},{"key":"10.1016\/j.cyto.2026.157221_bb0080","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.molimm.2020.10.006","article-title":"High serum IL-6 values increase the risk of mortality and the severity of pneumonia in patients diagnosed with COVID-19","volume":"128","author":"Guirao","year":"2020","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.cyto.2026.157221_bb0085","article-title":"The role of pro-inflammatory cytokines in the pathogenesis of cardiovascular disease","volume":"25","author":"Zhang","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cyto.2026.157221_bb0090","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/s41569-019-0315-x","article-title":"Reappraising the role of inflammation in heart failure","volume":"17","author":"Adamo","year":"2020","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.cyto.2026.157221_bb0095","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1007\/s10741-025-10491-5","article-title":"Effects of anti-inflammatory therapy in acute heart failure: a systematic review and meta-analysis","volume":"30","author":"Davison","year":"2025","journal-title":"Heart Fail. Rev."},{"key":"10.1016\/j.cyto.2026.157221_bb0100","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2024.1356023","article-title":"Role of inflammation and evidence for the use of colchicine in patients with acute coronary syndrome","volume":"11","author":"Bulnes","year":"2024","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.cyto.2026.157221_bb0105","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.21873\/invivo.14001","article-title":"Glatiramer acetate reduces risk of cardiovascular disease and myocardial infarction","volume":"39","author":"Lehrer","year":"2025","journal-title":"In Vivo"}],"container-title":["Cytokine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S104346662600116X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S104346662600116X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T19:35:16Z","timestamp":1792265716000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S104346662600116X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":21,"alternative-id":["S104346662600116X"],"URL":"https:\/\/doi.org\/10.1016\/j.cyto.2026.157221","relation":{},"ISSN":["1043-4666"],"issn-type":[{"value":"1043-4666","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Glatiramer acetate attenuates the cytokine surge associated with acute decompensated heart failure","name":"articletitle","label":"Article Title"},{"value":"Cytokine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cyto.2026.157221","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"157221"}}