{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:18:27Z","timestamp":1791310707322,"version":"4.3.1"},"reference-count":110,"publisher":"Elsevier BV","issue":"3-4","license":[{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytokine &amp; Growth Factor Reviews"],"published-print":{"date-parts":[[2008,6]]},"DOI":"10.1016\/j.cytogfr.2008.04.006","type":"journal-article","created":{"date-parts":[[2008,6,3]],"date-time":"2008-06-03T11:46:25Z","timestamp":1212493585000},"page":"263-276","source":"Crossref","is-referenced-by-count":144,"title":["TACI, an enigmatic BAFF\/APRIL receptor, with new unappreciated biochemical and biological properties"],"prefix":"10.1016","volume":"19","author":[{"given":"Fabienne","family":"Mackay","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cytogfr.2008.04.006_bib1","doi-asserted-by":"crossref","DOI":"10.1038\/nri844","article-title":"BAFF and APRIL: a tutorial on B cell survival","author":"Mackay","year":"2002","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib2","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1097\/BOR.0b013e328277ef4c","article-title":"An important role for B-cell activation factor and B cells in the pathogenesis of Sjogren's syndrome","volume":"19","author":"Mackay","year":"2007","journal-title":"Curr Opin Rheumatol"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib3","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.coi.2007.04.008","article-title":"B cells and the BAFF\/APRIL axis: fast-forward on autoimmunity and signaling","volume":"19","author":"Mackay","year":"2007","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib4","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/nri844","article-title":"BAFF: a fundamental survival factor for B cells","volume":"2","author":"Mackay","year":"2002","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib5","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1084\/jem.190.11.1697","article-title":"Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations","volume":"190","author":"Mackay","year":"1999","journal-title":"J Exp Med"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib6","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1172\/JCI0214121","article-title":"Association of BAFF\/BLyS overexpression and altered B cell differentiation with Sjogren's syndrome","volume":"109","author":"Groom","year":"2002","journal-title":"J Clin Invest"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib7","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1159\/000082106","article-title":"The BAFF\/APRIL system: an important player in systemic rheumatic diseases","volume":"8","author":"Mackay","year":"2005","journal-title":"Curr Dir Autoimmun"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib8","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S1074-7613(01)00130-3","article-title":"Regulation of the T-independent humoral response by TACI","volume":"14","author":"von Bulow","year":"2001","journal-title":"Immunity"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib9","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1038\/89790","article-title":"Activation and accumulation of B cells in TACI-deficient mice","volume":"2","author":"Yan","year":"2001","journal-title":"Nat Immunol"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib10","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1002\/eji.200635956","article-title":"BAFF costimulation of Toll-like receptor-activated B-1 cells","volume":"36","author":"Ng","year":"2006","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib11","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S1074-7613(03)00025-6","article-title":"Loss of TACI causes fatal lymphoproliferation and autoimmunity, establishing TACI as an inhibitory BLyS receptor","volume":"18","author":"Seshasayee","year":"2003","journal-title":"Immunity"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib12","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1093\/embo-reports\/kve198","article-title":"Biologically active APRIL is secreted following intracellular processing in the Golgi apparatus by furin convertase","volume":"2","author":"Lopez-Fraga","year":"2001","journal-title":"EMBO Rep"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib13","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1084\/jem.189.11.1747","article-title":"BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth","volume":"189","author":"Schneider","year":"1999","journal-title":"J Exp Med"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib14","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0092-8674(02)00631-1","article-title":"Crystal structure of sTALL-1 reveals a virus-like assembly of TNF family ligands","volume":"108","author":"Liu","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib15","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1038\/sj.cdd.4401647","article-title":"Heparan sulfate proteoglycan binding promotes APRIL-induced tumor cell proliferation","volume":"12","author":"Hendriks","year":"2005","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib16","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1084\/jem.20042309","article-title":"Identification of proteoglycans as the APRIL-specific binding partners","volume":"201","author":"Ingold","year":"2005","journal-title":"J Exp Med"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib17","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.smim.2006.04.006","article-title":"BAFF, APRIL and their receptors: structure, function and signaling","volume":"18","author":"Bossen","year":"2006","journal-title":"Semin Immunol"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib18","doi-asserted-by":"crossref","first-page":"3235","DOI":"10.1182\/blood-2005-01-0256","article-title":"Selective activation of TACI by syndecan-2","volume":"107","author":"Bischof","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib19","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1021\/bi048227k","article-title":"Selectivity of BAFF\/BLyS and APRIL for binding to the TNF family receptors BAFFR\/BR3 and BCMA","volume":"44","author":"Day","year":"2005","journal-title":"Biochemistry"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib20","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1126\/science.1061965","article-title":"BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF","volume":"293","author":"Thompson","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib21","doi-asserted-by":"crossref","first-page":"13964","DOI":"10.1074\/jbc.M601553200","article-title":"Interactions of tumor necrosis factor (TNF) and TNF receptor family members in the mouse and human","volume":"281","author":"Bossen","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib22","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1126\/science.1062677","article-title":"Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway","volume":"293","author":"Senftleben","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib23","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/S1074-7613(02)00425-9","article-title":"BAFF\/BLyS receptor 3 binds the B cell survival factor BAFF ligand through a discrete surface loop and promotes processing of NF-kappaB2","volume":"17","author":"Kayagaki","year":"2002","journal-title":"Immunity"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib24","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1038\/ni842","article-title":"BAFF-induced NEMO-independent processing of NF-kappa B2 in maturing B cells","volume":"3","author":"Claudio","year":"2002","journal-title":"Nat Immunol"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib25","doi-asserted-by":"crossref","first-page":"804","DOI":"10.4049\/jimmunol.165.2.804","article-title":"Abnormal immune function of hemopoietic cells from alymphoplasia (aly) mice, a natural strain with mutant NF-kappa B-inducing kinase","volume":"165","author":"Yamada","year":"2000","journal-title":"J Immunol"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib26","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.immuni.2006.07.010","article-title":"Alternative and classical NF-kappa B signaling retain autoreactive B cells in the splenic marginal zone and result in lupus-like disease","volume":"25","author":"Enzler","year":"2006","journal-title":"Immunity"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib27","doi-asserted-by":"crossref","first-page":"6359","DOI":"10.1073\/pnas.0700296104","article-title":"Regulation of late B cell differentiation by intrinsic IKKalpha-dependent signals","volume":"104","author":"Mills","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib28","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1084\/jem.186.7.999","article-title":"Gastric hyperplasia and increased proliferative responses of lymphocytes in mice lacking the COOH-terminal ankyrin domain of NF-kappaB2","volume":"186","author":"Ishikawa","year":"1997","journal-title":"J Exp Med"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib29","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/j.immuni.2006.04.005","article-title":"Canonical NF-kappaB activity, dispensable for B cell development, replaces BAFF-receptor signals and promotes B cell proliferation upon activation","volume":"24","author":"Sasaki","year":"2006","journal-title":"Immunity"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib30","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1002\/eji.200324692","article-title":"The anti-apoptotic factor Bcl-2 can functionally substitute for the B cell survival but not for the marginal zone B cell differentiation activity of BAFF","volume":"34","author":"Tardivel","year":"2004","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib31","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.immuni.2004.09.011","article-title":"TRAF2 differentially regulates the canonical and noncanonical pathways of NF-kappaB activation in mature B cells","volume":"21","author":"Grech","year":"2004","journal-title":"Immunity"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib32","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.immuni.2007.07.012","article-title":"Tumor necrosis factor receptor-associated factor 3 is a critical regulator of B cell homeostasis in secondary lymphoid organs","volume":"27","author":"Xie","year":"2007","journal-title":"Immunity"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib33","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.1084\/jem.20061166","article-title":"Rescue of TRAF3-null mice by p100 NF-kappa B deficiency","volume":"203","author":"He","year":"2006","journal-title":"J Exp Med"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib34","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.immuni.2004.09.001","article-title":"Act1, a negative regulator in CD40- and BAFF-mediated B cell survival","volume":"21","author":"Qian","year":"2004","journal-title":"Immunity"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib35","doi-asserted-by":"crossref","first-page":"10018","DOI":"10.1074\/jbc.M413634200","article-title":"An atypical tumor necrosis factor (TNF) receptor-associated factor-binding motif of B cell-activating factor belonging to the TNF family (BAFF) receptor mediates induction of the noncanonical NF-kappaB signaling pathway","volume":"280","author":"Morrison","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib36","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/nrc842","article-title":"Roles of heparan-sulphate glycosaminoglycans in cancer","volume":"2","author":"Sasisekharan","year":"2002","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib37","doi-asserted-by":"crossref","first-page":"2687","DOI":"10.1182\/blood-2005-12-017319","article-title":"A role for BLyS in the activation of innate immune cells","volume":"108","author":"Chang","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib38","doi-asserted-by":"crossref","DOI":"10.1182\/blood-2007-09-110874","article-title":"TACI, unlike BAFF-R, is solely activated by oligomeric BAFF and APRIL to support survival of activated B cells and plasmablasts","author":"Bossen","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib39","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1002\/eji.200636623","article-title":"TACI attenuates antibody production costimulated by BAFF-R and CD40","volume":"37","author":"Sakurai","year":"2007","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib40","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/79802","article-title":"APRIL and TALL-I and receptors BCMA and TACI: system for regulating humoral immunity","volume":"1","author":"Yu","year":"2000","journal-title":"Nat Immunol"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib41","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/0092-8674(95)90192-2","article-title":"The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80kDa tumor necrosis factor receptor","volume":"83","author":"Grell","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib42","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1128\/MCB.23.4.1428-1440.2003","article-title":"Two adjacent trimeric Fas ligands are required for Fas signaling and formation of a death-inducing signaling complex","volume":"23","author":"Holler","year":"2003","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib43","doi-asserted-by":"crossref","first-page":"3094","DOI":"10.1002\/1521-4141(2001010)31:10<3094::AID-IMMU3094>3.0.CO;2-F","article-title":"Analysis of the oligomeric requirement for signaling by CD40 using soluble multimeric forms of its ligand, CD154","volume":"31","author":"Haswell","year":"2001","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib44","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1093\/intimm\/dxm011","article-title":"The role of BLyS\/BLyS receptors in anti-chromatin B cell regulation","volume":"19","author":"Hondowicz","year":"2007","journal-title":"Int Immunol"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib45","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1038\/sj.leu.2404228","article-title":"BAFF and APRIL as osteoclast-derived survival factors for myeloma cells: a rationale for TACI-Fc treatment in patients with multiple myeloma","volume":"20","author":"Abe","year":"2006","journal-title":"Leukemia"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib46","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1365-2141.2007.06747.x","article-title":"Targeting MEK1\/2 blocks osteoclast differentiation, function and cytokine secretion in multiple myeloma","volume":"139","author":"Breitkreutz","year":"2007","journal-title":"Br J Haematol"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib47","first-page":"447","article-title":"Novel function of TNF cytokines in regulating bone marrow B cell survival","volume":"1","author":"Zhang","year":"2004","journal-title":"Cell Mol Immunol"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib48","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1038\/sj.leu.2404627","article-title":"Paracrine promotion of tumor development by the TNF ligand APRIL in Hodgkin's disease","volume":"21","author":"Schwaller","year":"2007","journal-title":"Leukemia"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib49","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1126\/science.278.5335.138","article-title":"NF-AT activation induced by a CAML-interacting member of the tumor necrosis factor receptor superfamily","volume":"278","author":"von Bulow","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib50","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1084\/jem.192.1.137","article-title":"TACI is a TRAF-interacting receptor for TALL-1, a tumor necrosis factor family member involved in B cell regulation","volume":"192","author":"Xia","year":"2000","journal-title":"J Exp Med"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib51","doi-asserted-by":"crossref","first-page":"807","DOI":"10.4049\/jimmunol.173.2.807","article-title":"B cell-activating factor belonging to the TNF family (BAFF)-R is the principal BAFF receptor facilitating BAFF costimulation of circulating T and B cells","volume":"173","author":"Ng","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib52","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.smim.2006.04.005","article-title":"The role of the BAFF\/APRIL system on T cell function","volume":"18","author":"Mackay","year":"2006","journal-title":"Semin Immunol"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib53","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1084\/jem.20062567","article-title":"BAFF and MyD88 signals promote a lupuslike disease independent of T cells","volume":"204","author":"Groom","year":"2007","journal-title":"J Exp Med"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib54","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1002\/eji.200636800","article-title":"Synthetic CpG oligodeoxynucleotides augment BAFF- and APRIL-mediated immunoglobulin secretion","volume":"37","author":"Katsenelson","year":"2007","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib55","doi-asserted-by":"crossref","first-page":"7531","DOI":"10.4049\/jimmunol.178.12.7531","article-title":"TLR stimulation modifies BLyS receptor expression in follicular and marginal zone B cells","volume":"178","author":"Treml","year":"2007","journal-title":"J Immunol"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib56","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1002\/eji.200636698","article-title":"BAFF and LPS cooperate to induce B cells to become susceptible to CD95\/Fas-mediated cell death","volume":"37","author":"Acosta-Rodriguez","year":"2007","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib57","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/S1074-7613(01)00129-7","article-title":"Marginal zone and B1 B cells unite in the early response against T-independent blood-borne particulate antigens","volume":"14","author":"Martin","year":"2001","journal-title":"Immunity"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib58","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1046\/j.1365-2249.2002.01953.x","article-title":"The dual function of the splenic marginal zone: essential for initiation of anti-TI-2 responses but also vital in the general first-line defense against blood-borne antigens","volume":"130","author":"Zandvoort","year":"2002","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib59","doi-asserted-by":"crossref","first-page":"2282","DOI":"10.4049\/jimmunol.179.4.2282","article-title":"TACI is required for efficient plasma cell differentiation in response to T-independent type 2 antigens","volume":"179","author":"Mantchev","year":"2007","journal-title":"J Immunol"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib60","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1084\/jem.184.3.1149","article-title":"A tumor-suppressor function for Fas (CD95) revealed in T cell-deficient mice","volume":"184","author":"Peng","year":"1996","journal-title":"J Exp Med"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib61","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1182\/blood-2004-12-4708","article-title":"TACI-BLyS signaling via B-cell-dendritic cell cooperation is required for naive CD8+ T-cell priming in vivo","volume":"107","author":"Diaz-de-Durana","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib62","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1084\/jem.194.11.1691","article-title":"Maturation of marginal zone and follicular B cells requires B cell activating factor of the tumor necrosis factor family and is independent of B cell maturation antigen","volume":"194","author":"Schneider","year":"2001","journal-title":"J Exp Med"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib63","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.jaci.2007.06.012","article-title":"Transmembrane activator and calcium modulator and cyclophilin ligand interactor enhances CD40-driven plasma cell differentiation","volume":"120","author":"Castigli","year":"2007","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib64","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.smim.2006.07.001","article-title":"BLyS receptor signatures resolve homeostatically independent compartments among naive and antigen-experienced B cells","volume":"18","author":"Treml","year":"2006","journal-title":"Semin Immunol"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib65","doi-asserted-by":"crossref","first-page":"3903","DOI":"10.1073\/pnas.0307348101","article-title":"Impaired IgA class switching in APRIL-deficient mice","volume":"101","author":"Castigli","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib66","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1128\/MCB.24.3.997-1006.2004","article-title":"APRIL-deficient mice have normal immune system development","volume":"24","author":"Varfolomeev","year":"2004","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib67","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.3324\/haematol.10317","article-title":"APRIL but not BLyS serum levels are increased in chronic lymphocytic leukemia: prognostic relevance of APRIL for survival","volume":"92","author":"Planelles","year":"2007","journal-title":"Haematologica"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib68","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1084\/jem.20031330","article-title":"BCMA is essential for the survival of long-lived bone marrow plasma cells","volume":"199","author":"O\u2019Connor","year":"2004","journal-title":"J Exp Med"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib69","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1038\/ni829","article-title":"DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL","volume":"3","author":"Litinskiy","year":"2002","journal-title":"Nat Immunol"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib70","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1084\/jem.20032000","article-title":"TACI and BAFF-R mediate isotype switching in B cells","volume":"201","author":"Castigli","year":"2005","journal-title":"J Exp Med"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib71","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1126\/science.1061964","article-title":"An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway","volume":"293","author":"Schiemann","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib72","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S1074-7613(01)00183-2","article-title":"TACI-Ig neutralizes molecules critical for B cell development and autoimmune disease. Impaired B cell maturation in mice lacking BLyS","volume":"15","author":"Gross","year":"2001","journal-title":"Immunity"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib73","doi-asserted-by":"crossref","DOI":"10.1182\/blood-2006-08-041772","article-title":"TACI regulates IgA production by APRIL in collaboration with HSPG","author":"Sakurai","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib74","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1002\/eji.200636645","article-title":"Stimuli that enhance IgA class switching increase histone 3 acetylation at S alpha, but poorly stimulate sequential switching from IgG2b","volume":"37","author":"Kaminski","year":"2007","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib75","doi-asserted-by":"crossref","first-page":"20","DOI":"10.4049\/jimmunol.172.1.20","article-title":"Cutting edge: an endogenous pathway to systemic inflammatory response syndrome (SIRS)-like reactions through Toll-like receptor 4","volume":"172","author":"Johnson","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib76","doi-asserted-by":"crossref","first-page":"5233","DOI":"10.4049\/jimmunol.168.10.5233","article-title":"Receptor-mediated monitoring of tissue well-being via detection of soluble heparan sulfate by Toll-like receptor 4","volume":"168","author":"Johnson","year":"2002","journal-title":"J Immunol"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib77","doi-asserted-by":"crossref","first-page":"2504","DOI":"10.1002\/eji.200636270","article-title":"Development of nephritis but not sialadenitis in autoimmune-prone BAFF transgenic mice lacking marginal zone B cells","volume":"36","author":"Fletcher","year":"2006","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib78","doi-asserted-by":"crossref","first-page":"812","DOI":"10.4049\/jimmunol.172.2.812","article-title":"TNF deficiency fails to protect BAFF transgenic mice against autoimmunity and reveals a predisposition to B cell lymphoma","volume":"172","author":"Batten","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib79","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1146\/annurev.immunol.21.120601.141152","article-title":"BAFF AND APRIL: a tutorial on B cell survival","volume":"21","author":"Mackay","year":"2003","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib80","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.immuni.2004.05.010","article-title":"Excess BAFF rescues self-reactive B cells from peripheral deletion and allows them to enter forbidden follicular and marginal zone niches","volume":"20","author":"Thien","year":"2004","journal-title":"Immunity"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib81","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.smim.2006.04.003","article-title":"Regulation of B cell self-tolerance by BAFF","volume":"18","author":"Brink","year":"2006","journal-title":"Semin Immunol"},{"issue":"Suppl. 4","key":"10.1016\/j.cytogfr.2008.04.006_bib82","doi-asserted-by":"crossref","first-page":"S22","DOI":"10.1186\/ar1009","article-title":"B cell abnormalities in systemic lupus erythematosus","volume":"5","author":"Grammer","year":"2003","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib83","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1080\/08916930500123983","article-title":"T cell abnormalities in systemic lupus erythematosus","volume":"38","author":"Takeuchi","year":"2005","journal-title":"Autoimmunity"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib84","first-page":"468","article-title":"Pathogenesis and treatment of systemic lupus erythematosus nephritis","volume":"18","author":"Davidson","year":"2006","journal-title":"Curr Opin Rheumatol"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib85","doi-asserted-by":"crossref","first-page":"803","DOI":"10.4049\/jimmunol.172.2.803","article-title":"Marginal zone, but not follicular B cells, are potent activators of naive CD4 T cells","volume":"172","author":"Attanavanich","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib86","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/S1074-7613(04)00112-8","article-title":"Pathogenic roles of B cells in human autoimmunity; insights from the clinic","volume":"20","author":"Martin","year":"2004","journal-title":"Immunity"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib87","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/3-540-29714-6_1","article-title":"B cell tolerance\u2014how to make it and how to break it","volume":"305","author":"Melchers","year":"2006","journal-title":"Curr Top Microbiol Immunol"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib88","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1038\/nri1957","article-title":"Toll-like receptors in systemic autoimmune disease","volume":"6","author":"Marshak-Rothstein","year":"2006","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib89","doi-asserted-by":"crossref","first-page":"5537","DOI":"10.4049\/jimmunol.174.9.5537","article-title":"BAFF augments certain Th1-associated inflammatory responses","volume":"174","author":"Sutherland","year":"2005","journal-title":"J Immunol"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib90","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.coi.2007.04.002","article-title":"Toll-like receptors and innate immunity in B-cell activation and antibody responses","volume":"19","author":"Lanzavecchia","year":"2007","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib91","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/nri799","article-title":"Marginal-zone B cells","volume":"2","author":"Martin","year":"2002","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib92","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1159\/000082100","article-title":"Marginal zone B cell physiology and disease","volume":"8","author":"Lopes-Carvalho","year":"2005","journal-title":"Curr Dir Autoimmun"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib93","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0952-7915(00)00204-1","article-title":"B1 cells: similarities and differences with other B cell subsets","volume":"13","author":"Martin","year":"2001","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib94","doi-asserted-by":"crossref","first-page":"3943","DOI":"10.1002\/art.21489","article-title":"Expression and occupancy of BAFF-R on B cells in systemic lupus erythematosus","volume":"52","author":"Carter","year":"2005","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib95","doi-asserted-by":"crossref","first-page":"7276","DOI":"10.4049\/jimmunol.179.11.7276","article-title":"Regulated expression of BAFF-binding receptors during human B cell differentiation","volume":"179","author":"Darce","year":"2007","journal-title":"J Immunol"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib96","doi-asserted-by":"crossref","first-page":"5612","DOI":"10.4049\/jimmunol.178.9.5612","article-title":"Divergent effects of BAFF on human memory B cell differentiation into Ig-secreting cells","volume":"178","author":"Darce","year":"2007","journal-title":"J Immunol"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib97","doi-asserted-by":"crossref","first-page":"3148","DOI":"10.1182\/blood-2003-06-1984","article-title":"BAFF and APRIL protect myeloma cells from apoptosis induced by interleukin 6 deprivation and dexamethasone","volume":"103","author":"Moreaux","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib98","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1182\/blood-2004-11-4512","article-title":"The level of TACI gene expression in myeloma cells is associated with a signature of microenvironment dependence versus a plasmablastic signature","volume":"106","author":"Moreaux","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib99","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1182\/blood-2003-06-2043","article-title":"Expression of BCMA, TACI, and BAFF-R in multiple myeloma: a mechanism for growth and survival","volume":"103","author":"Novak","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib100","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1182\/blood-2006-04-015958","article-title":"Hodgkin lymphoma cells express TACI and BCMA receptors and generate survival and proliferation signals in response to BAFF and APRIL","volume":"109","author":"Chiu","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib101","doi-asserted-by":"crossref","first-page":"3268","DOI":"10.4049\/jimmunol.172.5.3268","article-title":"Lymphoma B cells evade apoptosis through the TNF family members BAFF\/BLyS and APRIL","volume":"172","author":"He","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib102","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1182\/blood-2004-02-0762","article-title":"Expression of BLyS and its receptors in B-cell non-Hodgkin lymphoma: correlation with disease activity and patient outcome","volume":"104","author":"Novak","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib103","doi-asserted-by":"crossref","first-page":"803","DOI":"10.3324\/haematol.10574","article-title":"TACI expression is associated with a mature bone marrow plasma cell signature and C-MAF overexpression in human myeloma cell lines","volume":"92","author":"Moreaux","year":"2007","journal-title":"Haematologica"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib104","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/j.1365-2249.2007.03461.x","article-title":"Translational mini-review series on immunodeficiency: molecular defects in common variable immunodeficiency","volume":"149","author":"Bacchelli","year":"2007","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib105","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/ng0407-430","article-title":"Reexamining the role of TACI coding variants in common variable immunodeficiency and selective IgA deficiency","volume":"39","author":"Castigli","year":"2007","journal-title":"Nat Genet"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib106","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/ng1601","article-title":"TACI is mutant in common variable immunodeficiency and IgA deficiency","volume":"37","author":"Castigli","year":"2005","journal-title":"Nat Genet"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib107","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/ng0407-429","article-title":"Reexamining the role of TACI coding variants in common variable immunodeficiency and selective IgA deficiency","volume":"39","author":"Pan-Hammarstrom","year":"2007","journal-title":"Nat Genet"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib108","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1038\/ng1600","article-title":"Mutations in TNFRSF13B encoding TACI are associated with common variable immunodeficiency in humans","volume":"37","author":"Salzer","year":"2005","journal-title":"Nat Genet"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib109","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1172\/JCI31023","article-title":"Dominant-negative effect of the heterozygous C104R TACI mutation in common variable immunodeficiency (CVID)","volume":"117","author":"Garibyan","year":"2007","journal-title":"J Clin Invest"},{"key":"10.1016\/j.cytogfr.2008.04.006_bib110","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.4049\/jimmunol.173.4.2245","article-title":"TNF family member B cell-activating factor (BAFF) receptor-dependent and -independent roles for BAFF in B cell physiology","volume":"173","author":"Sasaki","year":"2004","journal-title":"J Immunol"}],"container-title":["Cytokine &amp; Growth Factor Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1359610108000397?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1359610108000397?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,11]],"date-time":"2019-05-11T17:30:38Z","timestamp":1557595838000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1359610108000397"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6]]},"references-count":110,"journal-issue":{"issue":"3-4","published-print":{"date-parts":[[2008,6]]}},"alternative-id":["S1359610108000397"],"URL":"https:\/\/doi.org\/10.1016\/j.cytogfr.2008.04.006","relation":{},"ISSN":["1359-6101"],"issn-type":[{"value":"1359-6101","type":"print"}],"subject":[],"published":{"date-parts":[[2008,6]]}}}