{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T08:55:18Z","timestamp":1766048118440},"reference-count":53,"publisher":"Elsevier BV","issue":"5-6","license":[{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytokine & Growth Factor Reviews"],"published-print":{"date-parts":[[2008,10]]},"DOI":"10.1016\/j.cytogfr.2008.08.002","type":"journal-article","created":{"date-parts":[[2008,10,20]],"date-time":"2008-10-20T08:26:01Z","timestamp":1224491161000},"page":"405-413","source":"Crossref","is-referenced-by-count":61,"title":["Pivotal role for TGF-\u03b2 in infectious heart disease: The case of Trypanosoma cruzi infection and consequent Chagasic myocardiopathy"],"prefix":"10.1016","volume":"19","author":[{"given":"Tania C.","family":"Ara\u00fajo-Jorge","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana C.","family":"Waghabi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria de Nazar\u00e9 C.","family":"Soeiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Keramidas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine","family":"Bailly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Jacques","family":"Feige","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cytogfr.2008.08.002_bib1","series-title":"Peptide growth factors and their receptors","first-page":"419","article-title":"The transforming growth factor-\u03b2s","author":"Roberts","year":"1991"},{"key":"10.1016\/j.cytogfr.2008.08.002_bib2","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1146\/annurev.biochem.67.1.753","article-title":"TGF-beta signal transduction","volume":"67","author":"Massague","year":"1998","journal-title":"Annu Rev Biochem"},{"key":"10.1016\/j.cytogfr.2008.08.002_bib3","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S1359-6101(99)00025-8","article-title":"TGF-beta signaling by Smad proteins","volume":"11","author":"Miyazono","year":"2000","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1016\/j.cytogfr.2008.08.002_bib4","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1038\/labinvest.3700669","article-title":"Pathobiology of transforming growth factor beta in cancer, fibrosis and immunologic disease, and therapeutic considerations","volume":"87","author":"Prud\u2019homme","year":"2007","journal-title":"Lab Invest"},{"key":"10.1016\/j.cytogfr.2008.08.002_bib5","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/S0169-4758(99)01562-8","article-title":"Maintaining the immunological balance in parasitic infections: a role for TGF-beta?","volume":"16","author":"Omer","year":"2000","journal-title":"Parasitol Today"},{"key":"10.1016\/j.cytogfr.2008.08.002_bib6","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1016\/S1286-4579(99)00252-X","article-title":"TGF-beta in infections and infectious diseases","volume":"1","author":"Reed","year":"1999","journal-title":"Microbes Infect"},{"key":"10.1016\/j.cytogfr.2008.08.002_bib7","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.cytogfr.2007.01.010","article-title":"Cytokines and cell adhesion receptors in the regulation of immunity to Trypanosoma cruzi","volume":"18","author":"Savino","year":"2007","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1016\/j.cytogfr.2008.08.002_bib8","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1002\/stem.150190","article-title":"TGF-beta latency: biological significance and mechanisms of activation","volume":"15","author":"Gleizes","year":"1997","journal-title":"Stem Cells"},{"key":"10.1016\/j.cytogfr.2008.08.002_bib9","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1002\/j.1460-2075.1996.tb00355.x","article-title":"Association of the small latent transforming growth factor-beta with an eight cysteine repeat of its binding protein LTBP-1","volume":"15","author":"Saharinen","year":"1996","journal-title":"Embo J"},{"key":"10.1016\/j.cytogfr.2008.08.002_bib10","doi-asserted-by":"crossref","first-page":"2691","DOI":"10.1091\/mbc.11.8.2691","article-title":"Specific sequence motif of 8-Cys repeats of TGF-beta binding proteins, LTBPs, creates a hydrophobic interaction surface for binding of small latent TGF-beta","volume":"11","author":"Saharinen","year":"2000","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.cytogfr.2008.08.002_bib11","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1038\/nrm2262","article-title":"Extracellular control of TGFbeta signalling in vascular development and disease","volume":"8","author":"ten Dijke","year":"2007","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.cytogfr.2008.08.002_bib12","doi-asserted-by":"crossref","first-page":"14090","DOI":"10.1016\/S0021-9258(18)47909-4","article-title":"Latent transforming growth factor-beta in serum: a specific complex with alpha 2-macroglobulin","volume":"262","author":"O\u2019Connor-McCourt","year":"1987","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cytogfr.2008.08.002_bib13","doi-asserted-by":"crossref","first-page":"5118","DOI":"10.1210\/en.136.11.5118","article-title":"Thrombospondins selectively activate one of the two latent forms of transforming growth factor-beta present in adrenocortical cell-conditioned medium","volume":"136","author":"Souchelnitskiy","year":"1995","journal-title":"Endocrinology"},{"key":"10.1016\/j.cytogfr.2008.08.002_bib14","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/370341a0","article-title":"Mechanism of activation of the TGF-beta receptor","volume":"370","author":"Wrana","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.cytogfr.2008.08.002_bib15","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.1101\/gad.1350705","article-title":"Smad transcription factors","volume":"19","author":"Massague","year":"2005","journal-title":"Genes Dev"},{"key":"10.1016\/j.cytogfr.2008.08.002_bib16","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1242\/jcs.02554","article-title":"Non-Smad TGF-beta signals","volume":"118","author":"Moustakas","year":"2005","journal-title":"J Cell Sci"},{"key":"10.1016\/j.cytogfr.2008.08.002_bib17","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/nature02006","article-title":"Smad-dependent and Smad-independent pathways in TGF-beta family signalling","volume":"425","author":"Derynck","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.cytogfr.2008.08.002_bib18","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.cardiores.2005.07.007","article-title":"The complex pattern of SMAD signaling in the cardiovascular system","volume":"69","author":"Euler-Taimor","year":"2006","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.cytogfr.2008.08.002_bib19","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1161\/hy0202.103268","article-title":"Stimulation of collagen production by transforming growth factor-beta1 during differentiation of cardiac fibroblasts to myofibroblasts","volume":"39","author":"Petrov","year":"2002","journal-title":"Hypertension"},{"key":"10.1016\/j.cytogfr.2008.08.002_bib20","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1159\/000236708","article-title":"Immunophenotype of lymphocytes in pericardial fluid from patients with different forms of heart disease","volume":"104","author":"Riemann","year":"1994","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.cytogfr.2008.08.002_bib21","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1006\/jmcc.1999.1055","article-title":"Autocrine regulation of TGF beta expression in adult cardiomyocytes","volume":"31","author":"Taimor","year":"1999","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.cytogfr.2008.08.002_bib22","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.exppara.2007.06.002","article-title":"Schistosoma mansoni: TGF-beta signaling pathways","volume":"117","author":"Loverde","year":"2007","journal-title":"Exp Parasitol"},{"key":"10.1016\/j.cytogfr.2008.08.002_bib23","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/j.1365-2567.2006.02336.x","article-title":"Fibrosis in heart disease: understanding the role of transforming growth factor-beta in cardiomyopathy, valvular disease and arrhythmia","volume":"118","author":"Khan","year":"2006","journal-title":"Immunology"},{"issue":"Suppl. 1","key":"10.1016\/j.cytogfr.2008.08.002_bib24","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1590\/S0074-02762007000900018","article-title":"Chagas disease: what is known and what is needed\u2014a background article","volume":"102","author":"Coura","year":"2007","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"10.1016\/j.cytogfr.2008.08.002_bib25","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1002\/clc.4960231205","article-title":"Chagas\u2019 heart disease","volume":"23","author":"Rassi","year":"2000","journal-title":"Clin Cardiol"},{"key":"10.1016\/j.cytogfr.2008.08.002_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000176822","article-title":"The challenge of Chagasic cardiomyopathy: the pathologic roles of autonomic abnormalities, autoimmune mechanisms and microvascular changes, and therapeutic implications","volume":"86","author":"Rossi","year":"1995","journal-title":"Cardiology"},{"key":"10.1016\/j.cytogfr.2008.08.002_bib27","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/S1473-3099(01)00065-2","article-title":"Clinical epidemiological aspects of Chagas disease","volume":"1","author":"Prata","year":"2001","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.cytogfr.2008.08.002_bib28","doi-asserted-by":"crossref","first-page":"485","DOI":"10.4269\/ajtmh.1997.56.485","article-title":"Association of an increase in CD8+T cells with the presence of Trypanosoma cruzi antigens in chronic, human, Chagasic myocarditis","volume":"56","author":"Higuchi","year":"1997","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.cytogfr.2008.08.002_bib29","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1084\/jem.174.3.539","article-title":"Regulation of Trypanosoma cruzi infections in vitro and in vivo by transforming growth factor beta (TGF-beta)","volume":"174","author":"Silva","year":"1991","journal-title":"J Exp Med"},{"key":"10.1016\/j.cytogfr.2008.08.002_bib30","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1080\/08916930410001713115","article-title":"Innate and acquired immunity in the pathogenesis of Chagas disease","volume":"37","author":"Golgher","year":"2004","journal-title":"Autoimmunity"},{"key":"10.1016\/j.cytogfr.2008.08.002_bib31","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1590\/S0074-02762006000500001","article-title":"Evolution and pathology in Chagas disease\u2014a review","volume":"101","author":"Teixeira","year":"2006","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"10.1016\/j.cytogfr.2008.08.002_bib32","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1046\/j.1365-3024.1999.00242.x","article-title":"Local and systemic cytokine expression during experimental chronic Trypanosoma cruzi infection in a Cebus monkey model","volume":"21","author":"Samudio","year":"1999","journal-title":"Parasite Immunol"},{"key":"10.1016\/j.cytogfr.2008.08.002_bib33","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1002\/eji.1830260116","article-title":"Characterization of cytokine production in murine Trypanosoma cruzi infection by in situ immunocytochemistry: lack of association between susceptibility and type 2 cytokine production","volume":"26","author":"Zhang","year":"1996","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.cytogfr.2008.08.002_bib34","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1086\/345882","article-title":"Implication of transforming growth factor-beta1 in Chagas disease myocardiopathy","volume":"186","author":"Ara\u00fajo-Jorge","year":"2002","journal-title":"J Infect Dis"},{"key":"10.1016\/j.cytogfr.2008.08.002_bib35","doi-asserted-by":"crossref","first-page":"s314","DOI":"10.2741\/1012","article-title":"The role of nitric oxide in the pathogenesis of Chagas disease","volume":"8","author":"Silva","year":"2003","journal-title":"Front Biosci"},{"key":"10.1016\/j.cytogfr.2008.08.002_bib36","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/0092-8674(95)90316-X","article-title":"Trypanosome invasion of mammalian cells requires activation of the TGF beta signaling pathway","volume":"82","author":"Ming","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.cytogfr.2008.08.002_bib37","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1111\/j.1462-5822.2004.00481.x","article-title":"Activation of transforming growth factor \u03b2 by Trypanosoma cruzi","volume":"7","author":"Waghabi","year":"2005","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.cytogfr.2008.08.002_bib38","doi-asserted-by":"crossref","first-page":"4975","DOI":"10.1093\/emboj\/17.17.4975","article-title":"Oligopeptidase B-dependent signaling mediates host cell invasion by Trypanosoma cruzi","volume":"17","author":"Caler","year":"1998","journal-title":"Embo J"},{"key":"10.1016\/j.cytogfr.2008.08.002_bib39","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/0166-6851(92)90050-T","article-title":"Inhibitors of the major cysteinyl proteinase (GP57\/51) impair host cell invasion and arrest the intracellular development of Trypanosoma cruzi in vitro","volume":"52","author":"Meirelles","year":"1992","journal-title":"Mol Biochem Parasitol"},{"key":"10.1016\/j.cytogfr.2008.08.002_bib40","doi-asserted-by":"crossref","first-page":"2905","DOI":"10.1128\/AAC.00022-07","article-title":"SB-431542, a transforming growth factor beta inhibitor, impairs Trypanosoma cruzi infection in cardiomyocytes and parasite cycle completion","volume":"51","author":"Waghabi","year":"2007","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.cytogfr.2008.08.002_bib41","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/S0002-9440(10)61189-3","article-title":"Uptake of host cell transforming growth factor-beta by Trypanosoma cruzi amastigotes in cardiomyocytes: potential role in parasite cycle completion","volume":"167","author":"Waghabi","year":"2005","journal-title":"Am J Pathol"},{"key":"10.1016\/j.cytogfr.2008.08.002_bib42","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/0014-4894(73)90088-X","article-title":"Trypanosoma cruzi: interaction with vertebrate cells in vitro 2: quantitative analysis of the penetration phase","volume":"34","author":"Hyde","year":"1973","journal-title":"Exp Parasitol"},{"key":"10.1016\/j.cytogfr.2008.08.002_bib43","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1247\/csf.24.139","article-title":"A cardiomyocyte mannose receptor system is involved in Trypanosoma cruzi invasion and is down-modulated after infection","volume":"24","author":"Soeiro Mde","year":"1999","journal-title":"Cell Struct Funct"},{"key":"10.1016\/j.cytogfr.2008.08.002_bib44","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1590\/S0074-02762003000400010","article-title":"Characterization of [Ca2+]i responses in primary cultures of mouse cardiomyocytes induced by Trypanosoma cruzi trypomastigotes","volume":"98","author":"Garzoni","year":"2003","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"10.1016\/j.cytogfr.2008.08.002_bib45","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1083\/jcb.200205110","article-title":"Lysosomes and the plasma membrane: trypanosomes reveal a secret relationship","volume":"158","author":"Andrews","year":"2002","journal-title":"J Cell Biol"},{"key":"10.1016\/j.cytogfr.2008.08.002_bib46","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1111\/j.1550-7408.1979.tb04203.x","article-title":"Trypanosoma cruzi: interaction with vertebrate cells DNA synthesis and growth of intracellular amastigotes and their relationship to host cell DNA synthesis and growth","volume":"26","author":"Crane","year":"1979","journal-title":"J Protozool"},{"key":"10.1016\/j.cytogfr.2008.08.002_bib47","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s00441-003-0782-5","article-title":"Host and parasite apoptosis following Trypanosoma cruzi infection in in vitro and in vivo models","volume":"314","author":"de Souza","year":"2003","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.cytogfr.2008.08.002_bib48","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1136\/hrt.82.3.279","article-title":"Different microcirculatory and interstitial matrix patterns in idiopathic dilated cardiomyopathy and Chagas\u2019 disease: a three dimensional confocal microscopy study","volume":"82","author":"Higuchi","year":"1999","journal-title":"Heart"},{"key":"10.1016\/j.cytogfr.2008.08.002_bib49","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/0002-8703(86)90144-4","article-title":"Right ventricular endomyocardial biopsy in chronic Chagas disease","volume":"111","author":"Pereira Barretto","year":"1986","journal-title":"Am Heart J"},{"key":"10.1016\/j.cytogfr.2008.08.002_bib50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1590\/S0037-86822006000100001","article-title":"Reinfections with strains of Trypanosoma cruzi, of different biodemes as a factor of aggravation of myocarditis and myositis in mice","volume":"39","author":"Andrade","year":"2006","journal-title":"Rev Soc Bras Med Trop"},{"key":"10.1016\/j.cytogfr.2008.08.002_bib51","doi-asserted-by":"crossref","first-page":"252","DOI":"10.4269\/ajtmh.1989.40.252","article-title":"Sequential changes of the connective matrix components of the myocardium (fibronectin and laminin) and evolution of cardiac fibrosis in mice infected with Trypanosoma cruzi","volume":"40","author":"Andrade","year":"1989","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.cytogfr.2008.08.002_bib52","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1590\/S0037-86822000000600001","article-title":"Growth factors in the myocardium of patients with chronic Chagasic cardiomyopathy","volume":"33","author":"Reis","year":"2000","journal-title":"Rev Soc Bras Med Trop"},{"key":"10.1016\/j.cytogfr.2008.08.002_bib53","doi-asserted-by":"crossref","first-page":"5115","DOI":"10.1128\/IAI.70.9.5115-5123.2002","article-title":"Increased Trypanosoma cruzi invasion and heart fibrosis associated with high transforming growth factor beta levels in mice deficient in alpha(2)-macroglobulin","volume":"70","author":"Waghabi","year":"2002","journal-title":"Infect Immun"}],"container-title":["Cytokine & Growth Factor Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S135961010800066X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S135961010800066X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,9,19]],"date-time":"2021-09-19T04:58:28Z","timestamp":1632027508000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S135961010800066X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10]]},"references-count":53,"journal-issue":{"issue":"5-6","published-print":{"date-parts":[[2008,10]]}},"alternative-id":["S135961010800066X"],"URL":"https:\/\/doi.org\/10.1016\/j.cytogfr.2008.08.002","relation":{},"ISSN":["1359-6101"],"issn-type":[{"value":"1359-6101","type":"print"}],"subject":[],"published":{"date-parts":[[2008,10]]}}}