{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:56:16Z","timestamp":1791327376811,"version":"4.3.1"},"reference-count":199,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytokine &amp; Growth Factor Reviews"],"published-print":{"date-parts":[[2010,8]]},"DOI":"10.1016\/j.cytogfr.2010.06.001","type":"journal-article","created":{"date-parts":[[2010,8,3]],"date-time":"2010-08-03T10:31:02Z","timestamp":1280831462000},"page":"287-298","source":"Crossref","is-referenced-by-count":137,"title":["BMP signaling in vascular development and disease"],"prefix":"10.1016","volume":"21","author":[{"given":"Jonathan W.","family":"Lowery","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark P.","family":"de Caestecker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cytogfr.2010.06.001_bib1","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1126\/science.3201241","article-title":"Novel regulators of bone formation: molecular clones and activities","volume":"242","author":"Wozney","year":"1988","journal-title":"Science"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib2","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.cytogfr.2005.04.002","article-title":"BMP signaling and early embryonic patterning","volume":"16","author":"Kishigami","year":"2005","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib3","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1002\/gene.10167","article-title":"Consequences of knocking out BMP signaling in the mouse","volume":"35","author":"Zhao","year":"2003","journal-title":"Genesis"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib4","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.ydbio.2007.08.060","article-title":"Distinct and cooperative roles of mammalian Vg1 homologs GDF1 and GDF3 during early embryonic development","volume":"311","author":"Andersson","year":"2007","journal-title":"Dev Biol"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib5","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1038\/sj.embor.7400752","article-title":"Growth differentiation factor 11 signals through the transforming growth factor-beta receptor ALK5 to regionalize the anterior\u2013posterior axis","volume":"7","author":"Andersson","year":"2006","journal-title":"EMBO Rep"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib6","doi-asserted-by":"crossref","first-page":"7230","DOI":"10.1128\/MCB.23.20.7230-7242.2003","article-title":"Myostatin signals through a transforming growth factor beta-like signaling pathway to block adipogenesis","volume":"23","author":"Rebbapragada","year":"2003","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib7","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.ydbio.2005.06.012","article-title":"BMP-3 is a novel inhibitor of both activin and BMP-4 signaling in Xenopus embryos","volume":"285","author":"Gamer","year":"2005","journal-title":"Dev Biol"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib8","doi-asserted-by":"crossref","first-page":"7934","DOI":"10.1074\/jbc.M209710200","article-title":"Inhibin is an antagonist of bone morphogenetic protein signaling","volume":"278","author":"Wiater","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib9","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.cytogfr.2009.10.011","article-title":"Control of BMP gene expression by long-range regulatory elements","volume":"20","author":"Pregizer","year":"2009","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib10","doi-asserted-by":"crossref","first-page":"4735","DOI":"10.1093\/emboj\/17.16.4735","article-title":"BMP-4 is proteolytically activated by furin and\/or PC6 during vertebrate embryonic development","volume":"17","author":"Cui","year":"1998","journal-title":"EMBO J"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib11","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1083\/jcb.144.1.139","article-title":"Regulation of bone morphogenetic protein activity by pro domains and proprotein convertases","volume":"144","author":"Constam","year":"1999","journal-title":"J Cell Biol"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib12","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1242\/dev.02368","article-title":"Mutation of an upstream cleavage site in the BMP4 prodomain leads to tissue-specific loss of activity","volume":"133","author":"Goldman","year":"2006","journal-title":"Development"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib13","doi-asserted-by":"crossref","first-page":"27970","DOI":"10.1074\/jbc.M504270200","article-title":"The prodomain of BMP-7 targets the BMP-7 complex to the extracellular matrix","volume":"280","author":"Gregory","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib14","doi-asserted-by":"crossref","first-page":"25111","DOI":"10.1074\/jbc.M503328200","article-title":"Crystal structure of BMP-9 and functional interactions with pro-region and receptors","volume":"280","author":"Brown","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib15","doi-asserted-by":"crossref","first-page":"3715","DOI":"10.1242\/dev.031534","article-title":"The extracellular regulation of bone morphogenetic protein signaling","volume":"136","author":"Umulis","year":"2009","journal-title":"Development"},{"issue":"11","key":"10.1016\/j.cytogfr.2010.06.001_bib16","doi-asserted-by":"crossref","first-page":"e1000747","DOI":"10.1371\/journal.pgen.1000747","article-title":"Mutations in GDF5 reveal a key residue mediating BMP inhibition by NOGGIN","volume":"5","author":"Seemann","year":"2009","journal-title":"PLoS Genet"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib17","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/S0092-8674(00)80133-6","article-title":"The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4","volume":"86","author":"Zimmerman","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib18","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/S0092-8674(00)80132-4","article-title":"Dorsoventral patterning in Xenopus: inhibition of ventral signals by direct binding of chordin to BMP-4","volume":"86","author":"Piccolo","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib19","doi-asserted-by":"crossref","first-page":"4439","DOI":"10.1242\/dev.128.22.4439","article-title":"Proteolytic cleavage of chordin as a switch for the dual activities of twisted gastrulation in BMP signaling","volume":"128","author":"Larrain","year":"2001","journal-title":"Development"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib20","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1093\/jb\/mvp148","article-title":"Bone morphogenetic protein receptors and signal transduction","volume":"147","author":"Miyazono","year":"2010","journal-title":"J Biochem"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib21","doi-asserted-by":"crossref","first-page":"3699","DOI":"10.1242\/dev.030338","article-title":"The regulation of TGFbeta signal transduction","volume":"136","author":"Moustakas","year":"2009","journal-title":"Development"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib22","doi-asserted-by":"crossref","first-page":"5776","DOI":"10.1128\/MCB.00218-07","article-title":"A novel regulatory mechanism of the bone morphogenetic protein (BMP) signaling pathway involving the carboxyl-terminal tail domain of BMP type II receptor","volume":"27","author":"Chan","year":"2007","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib23","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1038\/emboj.2009.103","article-title":"Novel crosstalk to BMP signalling: cGMP-dependent kinase I modulates BMP receptor and Smad activity","volume":"28","author":"Schwappacher","year":"2009","journal-title":"EMBO J"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib24","doi-asserted-by":"crossref","first-page":"4792","DOI":"10.1038\/sj.emboj.7600418","article-title":"Activation of LIMK1 by binding to the BMP receptor, BMPRII, regulates BMP-dependent dendritogenesis","volume":"23","author":"Lee-Hoeflich","year":"2004","journal-title":"EMBO J"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib25","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.cytogfr.2009.10.022","article-title":"Intricacies of BMP receptor assembly","volume":"20","author":"Nickel","year":"2009","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib26","doi-asserted-by":"crossref","first-page":"13198","DOI":"10.1016\/S0021-9258(19)38285-7","article-title":"Bovine osteogenic protein is composed of dimers of OP-1 and BMP-2A, two members of the transforming growth factor-beta superfamily","volume":"265","author":"Sampath","year":"1990","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib27","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1006\/bbrc.1995.1578","article-title":"Efficient expression of a heterodimer of bone morphogenetic protein subunits using a baculovirus expression system","volume":"209","author":"Hazama","year":"1995","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib28","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1038\/ncb1870","article-title":"Bone morphogenetic protein heterodimers assemble heteromeric type I receptor complexes to pattern the dorsoventral axis","volume":"11","author":"Little","year":"2009","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib29","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1210\/me.2003-0393","article-title":"Growth differentiation factor-9 signaling is mediated by the type I receptor, activin receptor-like kinase 5","volume":"18","author":"Mazerbourg","year":"2004","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib30","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1095\/biolreprod67.2.473","article-title":"Bone morphogenetic protein receptor type II is a receptor for growth differentiation factor-9","volume":"67","author":"Vitt","year":"2002","journal-title":"Biol Reprod"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib31","doi-asserted-by":"crossref","first-page":"6889","DOI":"10.1128\/MCB.01192-08","article-title":"Transforming growth factor beta-induced Smad1\/5 phosphorylation in epithelial cells is mediated by novel receptor complexes and is essential for anchorage-independent growth","volume":"28","author":"Daly","year":"2008","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib32","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/S1097-2765(03)00386-1","article-title":"Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFbeta\/ALK5 signaling","volume":"12","author":"Goumans","year":"2003","journal-title":"Mol Cell"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib33","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1093\/emboj\/21.7.1743","article-title":"Balancing the activation state of the endothelium via two distinct TGF-beta type I receptors","volume":"21","author":"Goumans","year":"2002","journal-title":"EMBO J"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib34","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1002\/(SICI)1097-4652(199908)180:2<141::AID-JCP1>3.0.CO;2-I","article-title":"Functional antagonism between activin and osteogenic protein-1 in human embryonal carcinoma cells","volume":"180","author":"Piek","year":"1999","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib35","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.tibs.2005.09.003","article-title":"Cell-surface co-receptors: emerging roles in signaling and human disease","volume":"30","author":"Kirkbride","year":"2005","journal-title":"Trends Biochem Sci"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib36","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1083\/jcb.124.4.557","article-title":"Betaglycan can act as a dual modulator of TGF-beta access to signaling receptors: mapping of ligand binding and GAG attachment sites","volume":"124","author":"Lopez-Casillas","year":"1994","journal-title":"J Cell Biol"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib37","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1038\/nm1429","article-title":"Soluble endoglin contributes to the pathogenesis of preeclampsia","volume":"12","author":"Venkatesha","year":"2006","journal-title":"Nat Med"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib38","doi-asserted-by":"crossref","first-page":"7628","DOI":"10.1074\/jbc.M704883200","article-title":"Bone morphogenetic proteins signal through the transforming growth factor-beta type III receptor","volume":"283","author":"Kirkbride","year":"2008","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib39","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/35006129","article-title":"Betaglycan binds inhibin and can mediate functional antagonism of activin signalling","volume":"404","author":"Lewis","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib40","doi-asserted-by":"crossref","first-page":"7628","DOI":"10.1074\/jbc.M704883200","article-title":"Bone morphogenetic proteins signal through the transforming growth factor-\u03b2 type III receptor","volume":"283","author":"Kirkbride","year":"2008","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib41","doi-asserted-by":"crossref","first-page":"4362","DOI":"10.1091\/mbc.E09-07-0539","article-title":"The transforming growth factor-beta type III receptor mediates distinct subcellular trafficking and downstream signaling of activin-like kinase (ALK)3 and ALK6 receptors","volume":"20","author":"Lee","year":"2009","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib42","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1074\/jbc.274.2.584","article-title":"Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-\u03b2 superfamily","volume":"274","author":"Barbara","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib43","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1242\/jcs.002949","article-title":"BMP-9 signals via ALK1 and inhibits bFGF-induced endothelial cell proliferation and VEGF-stimulated angiogenesis","volume":"120","author":"Scharpfenecker","year":"2007","journal-title":"J Cell Sci"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib44","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1182\/blood-2006-07-034124","article-title":"Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells","volume":"109","author":"David","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib45","doi-asserted-by":"crossref","first-page":"13934","DOI":"10.1074\/jbc.M611062200","article-title":"Endoglin differentially modulates antagonistic transforming growth factor-beta1 and BMP-7 signaling","volume":"282","author":"Scherner","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib46","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1074\/jbc.274.2.584","article-title":"Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-beta superfamily","volume":"274","author":"Barbara","year":"1999","journal-title":"J Biol Chem"},{"issue":"3","key":"10.1016\/j.cytogfr.2010.06.001_bib47","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1093\/carcin\/bgp327","article-title":"ALK5 phosphorylation of the endoglin cytoplasmic domain regulates Smad1\/5\/8 signaling and endothelial cell migration","volume":"31","author":"Ray","year":"2009","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib48","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.biocel.2007.09.006","article-title":"How the Smads regulate transcription","volume":"40","author":"Ross","year":"2008","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib49","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0092-8674(03)00432-X","article-title":"Mechanisms of TGF-beta signaling from cell membrane to the nucleus","volume":"113","author":"Shi","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib50","doi-asserted-by":"crossref","first-page":"9755","DOI":"10.1074\/jbc.M809223200","article-title":"Transforming growth factor {beta} can stimulate smad1 phosphorylation independently of bone morphogenic protein receptors","volume":"284","author":"Wrighton","year":"2009","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib51","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/emboj.2008.266","article-title":"TGFbeta-stimulated Smad1\/5 phosphorylation requires the ALK5 L45 loop and mediates the pro-migratory TGFbeta switch","volume":"28","author":"Liu","year":"2009","journal-title":"EMBO J"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib52","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1002\/jcp.21968","article-title":"Endoglin is involved in BMP-2-induced osteogenic differentiation of periodontal ligament cells through a pathway independent of Smad-1\/5\/8 phosphorylation","volume":"222","author":"Ishibashi","year":"2010","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib53","doi-asserted-by":"crossref","first-page":"15794","DOI":"10.1074\/jbc.M109.002881","article-title":"Bone morphogenetic protein (BMP) and activin type II receptors balance BMP9 signals mediated by activin receptor-like kinase-1 in human pulmonary artery endothelial cells","volume":"284","author":"Upton","year":"2009","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib54","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/cr.2008.308","article-title":"Regulating the stability of TGFbeta receptors and Smads","volume":"19","author":"Lonn","year":"2009","journal-title":"Cell Res"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib55","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/cr.2008.327","article-title":"Phospho-control of TGF-beta superfamily signaling","volume":"19","author":"Wrighton","year":"2009","journal-title":"Cell Res"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib56","doi-asserted-by":"crossref","first-page":"41361","DOI":"10.1074\/jbc.M204597200","article-title":"Modulation of Smad2-mediated signaling by extracellular signal-regulated kinase","volume":"277","author":"Funaba","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib57","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1101\/gad.12.11.1587","article-title":"Smad2 transduces common signals from receptor serine-threonine and tyrosine kinases","volume":"12","author":"de Caestecker","year":"1998","journal-title":"Genes Dev"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib58","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1096\/fj.08-127910","article-title":"Serotonin induces Rho\/ROCK-dependent activation of Smads 1\/5\/8 in pulmonary artery smooth muscle cells","volume":"23","author":"Liu","year":"2009","journal-title":"FASEB J"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib59","doi-asserted-by":"crossref","first-page":"48805","DOI":"10.1074\/jbc.M305472200","article-title":"Smad4 and beta-catenin co-activators functionally interact with lymphoid-enhancing factor to regulate graded expression of Msx2","volume":"278","author":"Hussein","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib60","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/sj.emboj.7600065","article-title":"Synergy and antagonism between Notch and BMP receptor signaling pathways in endothelial cells","volume":"23","author":"Itoh","year":"2004","journal-title":"EMBO J"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib61","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/nature07086","article-title":"SMAD proteins control DROSHA-mediated microRNA maturation","volume":"454","author":"Davis","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib62","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/nature07242","article-title":"The impact of microRNAs on protein output","volume":"455","author":"Baek","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib63","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/nature07228","article-title":"Widespread changes in protein synthesis induced by microRNAs","volume":"455","author":"Selbach","year":"2008","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.cytogfr.2010.06.001_bib64","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/emboj.2009.370","article-title":"Molecular basis for antagonism between PDGF and the TGFbeta family of signalling pathways by control of miR-24 expression","volume":"29","author":"Chan","year":"2010","journal-title":"EMBO J"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib65","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/cr.2008.328","article-title":"Non-Smad pathways in TGF-beta signaling","volume":"19","author":"Zhang","year":"2009","journal-title":"Cell Res"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib66","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1091\/mbc.11.3.1023","article-title":"Bone morphogenetic protein receptor complexes on the surface of live cells: a new oligomerization mode for serine\/threonine kinase receptors","volume":"11","author":"Gilboa","year":"2000","journal-title":"Mol Biol Cell"},{"issue":"Suppl. 3","key":"10.1016\/j.cytogfr.2010.06.001_bib67","doi-asserted-by":"crossref","first-page":"44","DOI":"10.2106\/00004623-200300003-00009","article-title":"Initiation of Smad-dependent and Smad-independent signaling via distinct BMP-receptor complexes","volume":"85A","author":"Hassel","year":"2003","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib68","doi-asserted-by":"crossref","first-page":"5330","DOI":"10.1074\/jbc.M102750200","article-title":"The mode of bone morphogenetic protein (BMP) receptor oligomerization determines different BMP-2 signaling pathways","volume":"277","author":"Nohe","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib69","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1093\/emboj\/18.1.179","article-title":"XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1-TAK1 in the BMP signaling pathway","volume":"18","author":"Yamaguchi","year":"1999","journal-title":"EMBO J"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib70","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1126\/science.272.5265.1179","article-title":"TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction","volume":"272","author":"Shibuya","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib71","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1126\/science.270.5244.2008","article-title":"Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction","volume":"270","author":"Yamaguchi","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib72","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1038\/emboj.2009.162","article-title":"TAK1 is an essential regulator of BMP signalling in cartilage","volume":"28","author":"Shim","year":"2009","journal-title":"EMBO J"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib73","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.jss.2007.03.077","article-title":"Endothelial Bmp4 is induced during arterial remodeling: effects on smooth muscle cell migration and proliferation","volume":"145","author":"Corriere","year":"2008","journal-title":"J Surg Res"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib74","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1172\/JCI116391","article-title":"Bone morphogenetic protein expression in human atherosclerotic lesions","volume":"91","author":"Bostrom","year":"1993","journal-title":"J Clin Invest"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib75","doi-asserted-by":"crossref","first-page":"31128","DOI":"10.1074\/jbc.M300703200","article-title":"Bone morphogenic protein 4 produced in endothelial cells by oscillatory shear stress stimulates an inflammatory response","volume":"278","author":"Sorescu","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib76","doi-asserted-by":"crossref","first-page":"2364","DOI":"10.1161\/01.CIR.0000164201.40634.1D","article-title":"Regulation of bone morphogenetic protein-2 expression in endothelial cells: role of nuclear factor-kappaB activation by tumor necrosis factor-alpha, H2O2, and high intravascular pressure","volume":"111","author":"Csiszar","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib77","doi-asserted-by":"crossref","first-page":"2824","DOI":"10.1172\/JCI119830","article-title":"Inhibition of rat vascular smooth muscle proliferation in vitro and in vivo by bone morphogenetic protein-2","volume":"100","author":"Nakaoka","year":"1997","journal-title":"J Clin Invest"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib78","doi-asserted-by":"crossref","first-page":"2818","DOI":"10.1161\/CIRCULATIONAHA.106.611822","article-title":"Bone morphogenic protein-4 induces hypertension in mice: role of noggin, vascular NADPH oxidases, and impaired vasorelaxation","volume":"113","author":"Miriyala","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib79","doi-asserted-by":"crossref","first-page":"629","DOI":"10.2353\/ajpath.2006.050284","article-title":"Bone morphogenetic protein-2 induces proinflammatory endothelial phenotype","volume":"168","author":"Csiszar","year":"2006","journal-title":"Am J Pathol"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib80","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1161\/01.RES.0000145728.22878.45","article-title":"Bone morphogenic protein 4 produced in endothelial cells by oscillatory shear stress induces monocyte adhesion by stimulating reactive oxygen species production from a nox1-based NADPH oxidase","volume":"95","author":"Sorescu","year":"2004","journal-title":"Circ Res"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib81","doi-asserted-by":"crossref","first-page":"H569","DOI":"10.1152\/ajpheart.00180.2008","article-title":"Differential proinflammatory and prooxidant effects of bone morphogenetic protein-4 in coronary and pulmonary arterial endothelial cells","volume":"295","author":"Csiszar","year":"2008","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib82","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1161\/01.RES.0000181152.65534.07","article-title":"Bone morphogenetic protein 4 promotes pulmonary vascular remodeling in hypoxic pulmonary hypertension","volume":"97","author":"Frank","year":"2005","journal-title":"Circ Res"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib83","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0272-5231(21)00199-4","article-title":"Pulmonary hypertension. Anatomic and physiologic correlates","volume":"4","author":"Meyrick","year":"1983","journal-title":"Clin Chest Med"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib84","doi-asserted-by":"crossref","first-page":"R833","DOI":"10.1152\/ajpregu.00534.2009","article-title":"Bmp2 and Bmp4 exert opposing effects in hypoxic pulmonary hypertension","volume":"298","author":"Anderson","year":"2010","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib85","doi-asserted-by":"crossref","first-page":"L1059","DOI":"10.1152\/ajplung.00180.2006","article-title":"BMP-dependent activation of caspase-9 and caspase-8 mediates apoptosis in pulmonary artery smooth muscle cells","volume":"291","author":"Lagna","year":"2006","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib86","doi-asserted-by":"crossref","first-page":"4344","DOI":"10.1210\/en.2004-0234","article-title":"Characterization of the bone morphogenetic protein (BMP) system in human pulmonary arterial smooth muscle cells isolated from a sporadic case of primary pulmonary hypertension: roles of BMP type IB receptor (activin receptor-like kinase-6) in the mitotic action","volume":"145","author":"Takeda","year":"2004","journal-title":"Endocrinology"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib87","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1161\/01.RES.0000166926.54293.68","article-title":"Dysfunctional Smad signaling contributes to abnormal smooth muscle cell proliferation in familial pulmonary arterial hypertension","volume":"96","author":"Yang","year":"2005","journal-title":"Circ Res"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib88","doi-asserted-by":"crossref","first-page":"L98","DOI":"10.1152\/ajplung.00034.2007","article-title":"Increased susceptibility to hypoxic pulmonary hypertension in Bmpr2 mutant mice is associated with endothelial dysfunction in the pulmonary vasculature","volume":"294","author":"Frank","year":"2008","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib89","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1471-2121-10-20","article-title":"A rapid and sensitive bioassay for the simultaneous measurement of multiple bone morphogenetic proteins. Identification and quantification of BMP4, BMP6 and BMP9 in bovine and human serum","volume":"10","author":"Herrera","year":"2009","journal-title":"BMC Cell Biol"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib90","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1161\/CIRCRESAHA.107.165530","article-title":"Bone morphogenetic protein-9 is a circulating vascular quiescence factor","volume":"102","author":"David","year":"2008","journal-title":"Circ Res"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib91","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1161\/CIRCRESAHA.108.178434","article-title":"BMPER is an endothelial cell regulator and controls bone morphogenetic protein-4-dependent angiogenesis","volume":"103","author":"Heinke","year":"2008","journal-title":"Circ Res"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib92","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.1182\/blood-2006-08-039743","article-title":"Gene expression profiles identify a role for cyclooxygenase 2-dependent prostanoid generation in BMP6-induced angiogenic responses","volume":"109","author":"Ren","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib93","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.yjmcc.2007.10.021","article-title":"Gremlin promotes vascular smooth muscle cell proliferation and migration","volume":"44","author":"Maciel","year":"2008","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib94","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1093\/ndt\/gfn611","article-title":"Expression of gremlin, a bone morphogenetic protein antagonist,is associated with vascular calcification in uraemia","volume":"24","author":"Jara","year":"2009","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib95","doi-asserted-by":"crossref","first-page":"L272","DOI":"10.1152\/ajplung.00358.2007","article-title":"Lung-selective gene responses to alveolar hypoxia: potential role for the bone morphogenetic antagonist gremlin in pulmonary hypertension","volume":"295","author":"Costello","year":"2008","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib96","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1161\/CIRCULATIONAHA.106.683227","article-title":"Bone morphogenic protein antagonists are coexpressed with bone morphogenic protein 4 in endothelial cells exposed to unstable flow in vitro in mouse aortas and in human coronary arteries: role of bone morphogenic protein antagonists in inflammation and atherosclerosis","volume":"116","author":"Chang","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib97","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.yjmcc.2007.05.008","article-title":"BMPER is a conserved regulator of hematopoietic and vascular development in zebrafish","volume":"43","author":"Moser","year":"2007","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib98","doi-asserted-by":"crossref","first-page":"4388","DOI":"10.1074\/jbc.M109683200","article-title":"Matrix GLA protein, a regulatory protein for bone morphogenetic protein-2","volume":"277","author":"Zebboudj","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib99","doi-asserted-by":"crossref","first-page":"33921","DOI":"10.1074\/jbc.M604239200","article-title":"Regulation of bone morphogenetic protein-4 by matrix GLA protein in vascular endothelial cells involves activin-like kinase receptor 1","volume":"281","author":"Yao","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib100","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/386078a0","article-title":"Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein","volume":"386","author":"Luo","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib101","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1002\/ajmg.a.30680","article-title":"A novel MGP mutation in a consanguineous family: review of the clinical and molecular characteristics of Keutel syndrome","volume":"135","author":"Hur","year":"2005","journal-title":"Am J Med Genet A"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib102","doi-asserted-by":"crossref","first-page":"30131","DOI":"10.1074\/jbc.M704297200","article-title":"Matrix GLA protein, an inhibitory morphogen in pulmonary vascular development","volume":"282","author":"Yao","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib103","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/humu.20285","article-title":"Mutations of the TGF-beta type II receptor BMPR2 in pulmonary arterial hypertension","volume":"27","author":"Machado","year":"2006","journal-title":"Hum Mutat"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib104","doi-asserted-by":"crossref","first-page":"S32","DOI":"10.1016\/j.jacc.2009.04.015","article-title":"Genetics and genomics of pulmonary arterial hypertension","volume":"54","author":"Machado","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib105","doi-asserted-by":"crossref","first-page":"5S","DOI":"10.1016\/j.jacc.2004.02.037","article-title":"Clinical classification of pulmonary hypertension","volume":"43","author":"Simonneau","year":"2004","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib106","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1056\/NEJMoa021650","article-title":"Signaling molecules in nonfamilial pulmonary hypertension","volume":"348","author":"Du","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib107","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1161\/01.CIR.0000012754.72951.3D","article-title":"Primary pulmonary hypertension is associated with reduced pulmonary vascular expression of type II bone morphogenetic protein receptor","volume":"105","author":"Atkinson","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib108","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1182\/blood-2006-11-058594","article-title":"Dosage-dependent requirement of BMP type II receptor for maintenance of vascular integrity","volume":"110","author":"Liu","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib109","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1161\/CIRCULATIONAHA.107.736801","article-title":"Genetic ablation of the Bmpr2 gene in pulmonary endothelium is sufficient to predispose to pulmonary arterial hypertension","volume":"118","author":"Hong","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib110","doi-asserted-by":"crossref","first-page":"L744","DOI":"10.1152\/ajplung.90255.2008","article-title":"Mice expressing BMPR2R899X transgene in smooth muscle develop pulmonary vascular lesions","volume":"295","author":"West","year":"2008","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib111","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1016\/j.jacc.2009.04.006","article-title":"Inflammation, growth factors, and pulmonary vascular remodeling","volume":"54","author":"Hassoun","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib112","doi-asserted-by":"crossref","first-page":"H677","DOI":"10.1152\/ajpheart.91519.2007","article-title":"Inflammation, endothelial injury, and persistent pulmonary hypertension in heterozygous BMPR2-mutant mice","volume":"295","author":"Song","year":"2008","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib113","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1161\/CIRCULATIONAHA.104.492488","article-title":"Increased susceptibility to pulmonary hypertension in heterozygous BMPR2-mutant mice","volume":"112","author":"Song","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib114","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1161\/01.RES.0000215809.47923.fd","article-title":"Serotonin increases susceptibility to pulmonary hypertension in BMPR2-deficient mice","volume":"98","author":"Long","year":"2006","journal-title":"Circ Res"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib115","doi-asserted-by":"crossref","first-page":"L1241","DOI":"10.1152\/ajplung.00239.2004","article-title":"BMPR-II heterozygous mice have mild pulmonary hypertension and an impaired pulmonary vascular remodeling response to prolonged hypoxia","volume":"287","author":"Beppu","year":"2004","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib116","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1172\/JCI11144","article-title":"Hypoxia-induced pulmonary vascular remodeling: a model for what human disease?","volume":"106","author":"Voelkel","year":"2000","journal-title":"J Clin Invest"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib117","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1111\/j.1538-7836.2007.02531.x","article-title":"Hereditary hemorrhagic telangiectasia: clinical features in ENG and ALK1 mutation carriers","volume":"5","author":"Sabba","year":"2007","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib118","doi-asserted-by":"crossref","first-page":"2626","DOI":"10.1073\/pnas.97.6.2626","article-title":"Activin receptor-like kinase 1 modulates transforming growth factor-beta 1 signaling in the regulation of angiogenesis","volume":"97","author":"Oh","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib119","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/81634","article-title":"Arteriovenous malformations in mice lacking activin receptor-like kinase-1","volume":"26","author":"Urness","year":"2000","journal-title":"Nat Genet"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib120","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1006\/dbio.1999.9534","article-title":"Endoglin, an ancillary TGF[beta] receptor, is required for extraembryonic angiogenesis and plays a key role in heart development","volume":"217","author":"Arthur","year":"2000","journal-title":"Dev Biol"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib121","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1093\/hmg\/ddg050","article-title":"A mouse model for hereditary hemorrhagic telangiectasia (HHT) type 2","volume":"12","author":"Srinivasan","year":"2003","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib122","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1182\/blood-2007-08-107359","article-title":"ALK5- and TGFBR2-independent role of ALK1 in the pathogenesis of hereditary hemorrhagic telangiectasia type 2","volume":"111","author":"Park","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib123","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1136\/jmg.40.12.865","article-title":"Molecular and functional analysis identifies ALK-1 as the predominant cause of pulmonary hypertension related to hereditary haemorrhagic telangiectasia","volume":"40","author":"Harrison","year":"2003","journal-title":"J Med Genet"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib124","doi-asserted-by":"crossref","first-page":"3473","DOI":"10.1242\/dev.02499","article-title":"Bone morphogenetic protein receptor 1A signaling is dispensable for hematopoietic development but essential for vessel and atrioventricular endocardial cushion formation","volume":"133","author":"Park","year":"2006","journal-title":"Development"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib125","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1161\/CIRCRESAHA.107.161059","article-title":"Smooth muscle protein 22alpha-mediated patchy deletion of Bmpr1a impairs cardiac contractility but protects against pulmonary vascular remodeling","volume":"102","author":"El-Bizri","year":"2008","journal-title":"Circ Res"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib126","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/ng1294-345","article-title":"Endoglin, a TGF-beta binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1","volume":"8","author":"McAllister","year":"1994","journal-title":"Nat Genet"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib127","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S1050-1738(01)00062-7","article-title":"Endoglin-deficient mice, a unique model to study hereditary hemorrhagic telangiectasia","volume":"10","author":"Bourdeau","year":"2000","journal-title":"Trends Cardiovasc Med"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib128","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1161\/ATVBAHA.109.200121","article-title":"Spontaneous adult-onset pulmonary arterial hypertension attributable to increased endothelial oxidative stress in a murine model of hereditary hemorrhagic telangiectasia","volume":"30","author":"Toporsian","year":"2010","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib129","doi-asserted-by":"crossref","first-page":"L1170","DOI":"10.1152\/ajplung.00168.2009","article-title":"Age-dependent endothelial nitric oxide synthase uncoupling in pulmonary arteries of endoglin heterozygous mice","volume":"297","author":"Belik","year":"2009","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib130","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1152\/physiol.00043.2008","article-title":"Preeclampsia: the role of angiogenic factors in its pathogenesis","volume":"24","author":"Wang","year":"2009","journal-title":"Physiology (Bethesda)"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib131","doi-asserted-by":"crossref","first-page":"2340","DOI":"10.1002\/eji.1830230943","article-title":"Identification and expression of two forms of the human transforming growth factor-beta-binding protein endoglin with distinct cytoplasmic regions","volume":"23","author":"Bellon","year":"1993","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib132","doi-asserted-by":"crossref","first-page":"4450","DOI":"10.1038\/sj.onc.1208644","article-title":"Characterization of murine S-endoglin isoform and its effects on tumor development","volume":"24","author":"Perez-Gomez","year":"2005","journal-title":"Oncogene"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib133","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1161\/CIRCRESAHA.108.176552","article-title":"S-endoglin expression is induced in senescent endothelial cells and contributes to vascular pathology","volume":"103","author":"Blanco","year":"2008","journal-title":"Circ Res"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib134","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s10456-008-9101-9","article-title":"Endoglin in angiogenesis and vascular diseases","volume":"11","author":"ten Dijke","year":"2008","journal-title":"Angiogenesis"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib135","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.ydbio.2006.04.442","article-title":"Dose-dependent Smad1, Smad5 and Smad8 signaling in the early mouse embryo","volume":"296","author":"Arnold","year":"2006","journal-title":"Dev Biol"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib136","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1242\/dev.126.8.1631","article-title":"Smad5 knockout mice die at mid-gestation due to multiple embryonic and extraembryonic defects","volume":"126","author":"Chang","year":"1999","journal-title":"Development"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib137","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1242\/dev.126.8.1571","article-title":"Angiogenesis defects and mesenchymal apoptosis in mice lacking SMAD5","volume":"126","author":"Yang","year":"1999","journal-title":"Development"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib138","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.2353\/ajpath.2007.060839","article-title":"Inactivation of Smad5 in endothelial cells and smooth muscle cells demonstrates that Smad5 is required for cardiac homeostasis","volume":"170","author":"Umans","year":"2007","journal-title":"Am J Pathol"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib139","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1006\/dbio.2001.0469","article-title":"Targeted mutagenesis of Smad1 reveals an essential role in chorioallantoic fusion","volume":"240","author":"Lechleider","year":"2001","journal-title":"Dev Biol"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib140","doi-asserted-by":"crossref","first-page":"2791","DOI":"10.1093\/hmg\/ddp214","article-title":"Defective pulmonary vascular remodeling in Smad8 mutant mice","volume":"18","author":"Huang","year":"2009","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib141","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1136\/jmg.2008.062703","article-title":"A new nonsense mutation of SMAD8 associated with pulmonary arterial hypertension","volume":"46","author":"Shintani","year":"2009","journal-title":"J Med Genet"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib142","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1136\/jmg.2004.018598","article-title":"The prevalence of MADH4 and BMPR1A mutations in juvenile polyposis and absence of BMPR2, BMPR1B, and ACVR1 mutations","volume":"41","author":"Howe","year":"2004","journal-title":"J Med Genet"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib143","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1101\/gad.12.1.107","article-title":"The tumor suppressor gene Smad4\/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo","volume":"12","author":"Sirard","year":"1998","journal-title":"Genes Dev"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib144","doi-asserted-by":"crossref","first-page":"3667","DOI":"10.1073\/pnas.95.7.3667","article-title":"The tumor suppressor SMAD4\/DPC4 is essential for epiblast proliferation and mesoderm induction in mice","volume":"95","author":"Yang","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib145","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1126\/science.284.5419.1534","article-title":"Defective angiogenesis in mice lacking endoglin","volume":"284","author":"Li","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib146","doi-asserted-by":"crossref","first-page":"7683","DOI":"10.1128\/MCB.00577-07","article-title":"Essential role of endothelial Smad4 in vascular remodeling and integrity","volume":"27","author":"Lan","year":"2007","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib147","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/72835","article-title":"A role for smad6 in development and homeostasis of the cardiovascular system","volume":"24","author":"Galvin","year":"2000","journal-title":"Nat Genet"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib148","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1242\/dev.02333","article-title":"The TGF beta activated kinase TAK1 regulates vascular development in vivo","volume":"133","author":"Jadrich","year":"2006","journal-title":"Development"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib149","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.cytogfr.2009.10.021","article-title":"Applications of small molecule BMP inhibitors in physiology and disease","volume":"20","author":"Hong","year":"2009","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib150","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1182\/blood-2009-01-199166","article-title":"Expression of vascular endothelial growth factor is coordinately regulated by the activin-like kinase receptors 1 and 5 in endothelial cells","volume":"114","author":"Shao","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib151","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1182\/blood-2006-07-034124","article-title":"Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells","volume":"109","author":"David","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib152","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1158\/1535-7163.MCT-09-0650","article-title":"ALK1-Fc inhibits multiple mediators of angiogenesis and suppresses tumor growth","volume":"9","author":"Mitchell","year":"2010","journal-title":"Mol Cancer Ther"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib153","doi-asserted-by":"crossref","first-page":"3519","DOI":"10.1242\/jcs.112.20.3519","article-title":"Characterization of bone morphogenetic protein-6 signaling pathways in osteoblast differentiation","volume":"112","author":"Ebisawa","year":"1999","journal-title":"J Cell Sci"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib154","doi-asserted-by":"crossref","first-page":"16985","DOI":"10.1016\/S0021-9258(17)32506-1","article-title":"Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4","volume":"269","author":"ten Dijke","year":"1994","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib155","doi-asserted-by":"crossref","first-page":"25628","DOI":"10.1074\/jbc.273.40.25628","article-title":"Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2","volume":"273","author":"Mac\u0131\u0301as-Silva","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib156","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1083\/jcb.130.1.217","article-title":"Osteogenic protein-1 binds to activin type II receptors and induces certain activin-like effects","volume":"130","author":"Yamashita","year":"1995","journal-title":"J Cell Biol"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib157","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nsmb756","article-title":"Molecular recognition of BMP-2 and BMP receptor IA","volume":"11","author":"Keller","year":"2004","journal-title":"Nat Struct Mol Biol"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib158","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.2106\/00004623-200100001-00002","article-title":"The crystal structure of the BMP-2:BMPR-IA complex and the generation of BMP-2 antagonists","volume":"83","author":"Nickel","year":"2001","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib159","doi-asserted-by":"crossref","first-page":"5961","DOI":"10.1128\/MCB.14.9.5961","article-title":"Characterization and cloning of a receptor for BMP-2 and BMP-4 from NIH 3T3 cells","volume":"14","author":"Koenig","year":"1994","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib160","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1038\/75903","article-title":"Crystal structure of the BMP-2-BRIA ectodomain complex","volume":"7","author":"Kirsch","year":"2000","journal-title":"Nat Struct Biol"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib161","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0014-5793(00)01214-X","article-title":"Isolation of recombinant BMP receptor IA ectodomain and its 2:1 complex with BMP-2","volume":"468","author":"Kirsch","year":"2000","journal-title":"FEBS Lett"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib162","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1006\/bbrc.1994.2898","article-title":"A mammalian serine\/threonine kinase receptor specifically binds BMP-2 and BMP-4","volume":"205","author":"Yamaji","year":"1994","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib163","doi-asserted-by":"crossref","first-page":"7643","DOI":"10.1073\/pnas.0602558103","article-title":"Structure of the ternary signaling complex of a TGF-beta superfamily member","volume":"103","author":"Allendorph","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib164","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1002\/1097-0282(2000)55:5<399::AID-BIP1014>3.0.CO;2-9","article-title":"Identification of the ligand-binding site of the BMP type IA receptor for BMP-4","volume":"55","author":"Hatta","year":"2000","journal-title":"Pept Sci"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib165","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1471-2202-2-12","article-title":"Bone morphogenetic protein-5 (BMP-5) promotes dendritic growth in cultured sympathetic neurons","volume":"2","author":"Beck","year":"2001","journal-title":"BMC Neurosci"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib166","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1093\/humupd\/dml014","article-title":"Genomic analyses facilitate identification of receptors and signalling pathways for growth differentiation factor 9 and related orphan bone morphogenetic protein\/growth differentiation factor ligands","volume":"12","author":"Mazerbourg","year":"2006","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib167","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1359\/jbmr.1998.13.3.383","article-title":"Cartilage-derived morphogenetic proteins and osteogenic protein-1 differentially regulate osteogenesis","volume":"13","author":"Erlacher","year":"1998","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib168","doi-asserted-by":"crossref","first-page":"21345","DOI":"10.1074\/jbc.271.35.21345","article-title":"Identification of type I and type II serine\/threonine kinase receptors for growth\/differentiation factor-5","volume":"271","author":"Nishitoh","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib169","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1074\/jbc.M207362200","article-title":"Molecular basis of bone morphogenetic protein-15 signaling in granulosa cells","volume":"278","author":"Moore","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib170","doi-asserted-by":"crossref","first-page":"3314","DOI":"10.1093\/emboj\/19.13.3314","article-title":"BMP-2 antagonists emerge from alterations in the low-affinity binding epitope for receptor BMPR-II","volume":"19","author":"Kirsch","year":"2000","journal-title":"EMBO J"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib171","doi-asserted-by":"crossref","first-page":"3479","DOI":"10.1128\/MCB.15.7.3479","article-title":"Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs","volume":"15","author":"Liu","year":"1995","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib172","doi-asserted-by":"crossref","first-page":"7632","DOI":"10.1073\/pnas.92.17.7632","article-title":"Cloning and characterization of a human type II receptor for bone morphogenetic proteins","volume":"92","author":"Rosenzweig","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib173","doi-asserted-by":"crossref","first-page":"18129","DOI":"10.1074\/jbc.M701679200","article-title":"Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4","volume":"282","author":"Xia","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib174","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/S1097-2765(03)00094-7","article-title":"The BMP7\/ActRII extracellular domain complex provides new insights into the cooperative nature of receptor assembly","volume":"11","author":"Greenwald","year":"2003","journal-title":"Mol Cell"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib175","doi-asserted-by":"crossref","first-page":"29820","DOI":"10.1074\/jbc.M503511200","article-title":"Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor","volume":"280","author":"Babitt","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib176","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1750-2187-2-4","article-title":"Role of RGM coreceptors in bone morphogenetic protein signaling","volume":"2","author":"Halbrooks","year":"2007","journal-title":"J Mol Signal"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib177","doi-asserted-by":"crossref","first-page":"14122","DOI":"10.1074\/jbc.M410034200","article-title":"DRAGON, a bone morphogenetic protein co-receptor","volume":"280","author":"Samad","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib178","doi-asserted-by":"crossref","first-page":"C994","DOI":"10.1152\/ajpcell.00563.2007","article-title":"Selective binding of RGMc\/hemojuvelin, a key protein in systemic iron metabolism, to BMP-2 and neogenin","volume":"294","author":"Kuns-Hashimoto","year":"2008","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib179","doi-asserted-by":"crossref","first-page":"4237","DOI":"10.1021\/bi800036h","article-title":"Neogenin interacts with hemojuvelin through its two membrane-proximal fibronectin type III domains","volume":"47","author":"Yang","year":"2008","journal-title":"Biochemistry"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib180","doi-asserted-by":"crossref","first-page":"5195","DOI":"10.1182\/blood-2007-09-111567","article-title":"Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin","volume":"111","author":"Xia","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib181","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/ng1777","article-title":"Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression","volume":"38","author":"Babitt","year":"2006","journal-title":"Nat Genet"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib182","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/ng.335","article-title":"BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism","volume":"41","author":"Andriopoulos","year":"2009","journal-title":"Nat Genet"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib183","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1038\/46794","article-title":"Silencing of TGF-beta signalling by the pseudoreceptor BAMBI","volume":"401","author":"Onichtchouk","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib184","doi-asserted-by":"crossref","first-page":"9869","DOI":"10.1158\/0008-5472.CAN-07-0436","article-title":"TrkC binds to the bone morphogenetic protein type II receptor to suppress bone morphogenetic protein signaling","volume":"67","author":"Jin","year":"2007","journal-title":"Cancer Res"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib185","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbrc.2008.12.162","article-title":"Biochemical and functional characterization of the Ror2\/BRIb receptor complex","volume":"381","author":"Sammar","year":"2009","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib186","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1111\/j.1365-2443.2004.00799.x","article-title":"Modulation of GDF5\/BRI-b signalling through interaction with the tyrosine kinase receptor Ror2","volume":"9","author":"Sammar","year":"2004","journal-title":"Genes Cells"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib187","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.1002\/ajmg.a.32468","article-title":"BMPR2 mutation in a patient with pulmonary arterial hypertension and suspected hereditary hemorrhagic telangiectasia","volume":"146A","author":"Rigelsky","year":"2008","journal-title":"Am J Med Genet A"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib188","first-page":"3487","article-title":"Real-time imaging of de novo arteriovenous malformation in a mouse model of hereditary hemorrhagic telangiectasia","volume":"119","author":"Park","year":"2009","journal-title":"J Clin Invest"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib189","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1253\/circj.72.127","article-title":"Implications of mutations of activin receptor-like kinase 1 gene (ALK1) in addition to bone morphogenetic protein receptor II gene (BMPR2) in children with pulmonary arterial hypertension","volume":"72","author":"Fujiwara","year":"2008","journal-title":"Circ J"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib190","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/ng0696-189","article-title":"Mutations in the activin receptor-like kinase 1 gene in hereditary haemorrhagic telangiectasia type 2","volume":"13","author":"Johnson","year":"1996","journal-title":"Nat Genet"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib191","doi-asserted-by":"crossref","first-page":"2981","DOI":"10.1242\/dev.017863","article-title":"SM22alpha-targeted deletion of bone morphogenetic protein receptor 1A in mice impairs cardiac and vascular development, and influences organogenesis","volume":"135","author":"El-Bizri","year":"2008","journal-title":"Development"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib192","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/S0002-9440(10)64960-7","article-title":"Endoglin expression is reduced in normal vessels but still detectable in arteriovenous malformations of patients with hereditary hemorrhagic telangiectasia type 1","volume":"156","author":"Bourdeau","year":"2000","journal-title":"Am J Pathol"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib193","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1161\/CIRCRESAHA.109.211037","article-title":"Pathogenesis of arteriovenous malformations in the absence of endoglin","volume":"106","author":"Mahmoud","year":"2010","journal-title":"Circ Res"},{"issue":"6","key":"10.1016\/j.cytogfr.2010.06.001_bib194","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1002\/humu.9421","article-title":"Distribution of ENG and ACVRL1 (ALK1) mutations in French HHT patients","volume":"27","author":"Lesca","year":"2006","journal-title":"Hum Mutat"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib195","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1002\/ajmg.a.33206","article-title":"Overlapping spectra of SMAD4 mutations in juvenile polyposis (JP) and JP-HHT syndrome","volume":"152A","author":"Gallione","year":"2010","journal-title":"Am J Med Genet A"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib196","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1136\/jmg.2006.041517","article-title":"SMAD4 mutations found in unselected HHT patients","volume":"43","author":"Gallione","year":"2006","journal-title":"J Med Genet"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib197","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1210\/er.2002-0003","article-title":"Genetic analysis of the mammalian transforming growth factor-beta superfamily","volume":"23","author":"Chang","year":"2002","journal-title":"Endocr Rev"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib198","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1093\/molbev\/msm092","article-title":"MEGA4: molecular evolutionary genetics analysis (MEGA) software version 4.0","volume":"24","author":"Tamura","year":"2007","journal-title":"Mol Biol Evol"},{"key":"10.1016\/j.cytogfr.2010.06.001_bib199","first-page":"406","article-title":"The neighbor-joining method: a new method for reconstructing phylogenetic trees","volume":"4","author":"Saitou","year":"1987","journal-title":"Mol Biol Evol"}],"container-title":["Cytokine &amp; Growth Factor Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S135961011000047X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S135961011000047X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,11,2]],"date-time":"2021-11-02T23:19:23Z","timestamp":1635895163000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S135961011000047X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8]]},"references-count":199,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,8]]}},"alternative-id":["S135961011000047X"],"URL":"https:\/\/doi.org\/10.1016\/j.cytogfr.2010.06.001","relation":{},"ISSN":["1359-6101"],"issn-type":[{"value":"1359-6101","type":"print"}],"subject":[],"published":{"date-parts":[[2010,8]]}}}