{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T13:17:48Z","timestamp":1791206268304,"version":"4.1.0"},"reference-count":94,"publisher":"Elsevier BV","issue":"2","content-domain":{"domain":["cgfr.co.uk","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytokine &amp; Growth Factor Reviews"],"published-print":{"date-parts":[[2014,4]]},"DOI":"10.1016\/j.cytogfr.2014.01.004","type":"journal-article","created":{"date-parts":[[2014,1,23]],"date-time":"2014-01-23T22:10:05Z","timestamp":1390515005000},"page":"195-203","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":84,"title":["Ectodysplasin A (EDA) \u2013 EDA receptor signalling and its pharmacological modulation"],"prefix":"10.1016","volume":"25","author":[{"given":"Christine","family":"Kowalczyk-Quintas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0677-9409","authenticated-orcid":false,"given":"Pascal","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cytogfr.2014.01.004_bib0005","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1002\/ajmg.a.32864","article-title":"Ectodermal dysplasias: clinical and molecular review","volume":"149A","author":"Visinoni","year":"2009","journal-title":"Am J Med Genet A"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0010","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/ng0895-409","article-title":"X-linked anhidrotic (hypohidrotic) ectodermal dysplasia is caused by mutation in a novel transmembrane protein","volume":"13","author":"Kere","year":"1996","journal-title":"Nat Genet"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0015","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/ejhg.2009.127","article-title":"Functional analysis of ectodysplasin-A mutations causing selective tooth agenesis","volume":"18","author":"Mues","year":"2010","journal-title":"Eur J Hum Genet"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0020","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1038\/414913a","article-title":"Gene defect in ectodermal dysplasia implicates a death domain adapter in development","volume":"414","author":"Headon","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0025","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1038\/11943","article-title":"Involvement of a novel Tnf receptor homologue in hair follicle induction","volume":"22","author":"Headon","year":"1999","journal-title":"Nat Genet"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0030","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1093\/hmg\/7.11.1661","article-title":"The anhidrotic ectodermal dysplasia gene (EDA) undergoes alternative splicing and encodes ectodysplasin-A with deletion mutations in collagenous repeats","volume":"7","author":"Bayes","year":"1998","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0035","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.gene.2005.11.003","article-title":"Repertoire of mouse ectodysplasin-A (EDA-A) isoforms","volume":"371","author":"Hashimoto","year":"2006","journal-title":"Gene"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0040","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1126\/science.290.5491.523","article-title":"Two-amino acid molecular switch in an epithelial morphogen that regulates binding to two distinct receptors","volume":"290","author":"Yan","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0045","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.M113.535740","article-title":"Generation and characterization of function blocking anti-ectodysplasin A (EDA) monoclonal antibodies that induce ectodermal dysplasia","author":"Kowalczyk-Quintas","year":"2014","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0050","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1016\/j.febslet.2010.04.058","article-title":"p53-dependent transcriptional regulation of EDA2R and its involvement in chemotherapy-induced hair loss","volume":"584","author":"Brosh","year":"2010","journal-title":"FEBS Lett"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0055","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1128\/MCB.24.4.1608-1613.2004","article-title":"Myodegeneration in EDA-A2 transgenic mice is prevented by XEDAR deficiency","volume":"24","author":"Newton","year":"2004","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0060","doi-asserted-by":"crossref","first-page":"18819","DOI":"10.1074\/jbc.M101280200","article-title":"Mutations leading to X-linked hypohidrotic ectodermal dysplasia affect three major functional domains in the tumor necrosis factor family member ectodysplasin-A","volume":"276","author":"Schneider","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0065","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1126\/science.1107239","article-title":"Widespread parallel evolution in sticklebacks by repeated fixation of ectodysplasin alleles","volume":"307","author":"Colosimo","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0070","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1016\/j.str.2003.11.009","article-title":"The crystal structures of EDA-A1 and EDA-A2: splice variants with distinct receptor specificity","volume":"11","author":"Hymowitz","year":"2003","journal-title":"Structure"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0075","doi-asserted-by":"crossref","first-page":"27567","DOI":"10.1074\/jbc.M109.042259","article-title":"Biological activity of ectodysplasin A is conditioned by its collagen and heparan sulfate proteoglycan-binding domains","volume":"284","author":"Swee","year":"2009","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0080","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1002\/humu.20795","article-title":"Enhanced ectodysplasin-A receptor (EDAR) signaling alters multiple fiber characteristics to produce the East Asian hair form","volume":"29","author":"Mou","year":"2008","journal-title":"Hum Mutat"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0085","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1038\/nature06250","article-title":"Genome-wide detection and characterization of positive selection in human populations","volume":"449","author":"Sabeti","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0090","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1111\/bjd.12018","article-title":"Functional studies for the TRAF6 mutation associated with hypohidrotic ectodermal dysplasia","volume":"168","author":"Fujikawa","year":"2013","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0095","doi-asserted-by":"crossref","first-page":"8766","DOI":"10.1073\/pnas.132636999","article-title":"TRAF6-deficient mice display hypohidrotic ectodermal dysplasia","volume":"99","author":"Naito","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0100","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/j.1600-065X.2012.01108.x","article-title":"Ubiquitination in signaling to and activation of IKK","volume":"246","author":"Chen","year":"2012","journal-title":"Immunol Rev"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0105","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.1093\/hmg\/11.20.2371","article-title":"The NF-\u03baB signalling pathway in human diseases: from incontinentia pigmenti to ectodermal dysplasias and immune-deficiency syndromes","volume":"11","author":"Smahi","year":"2002","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0110","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1086\/316914","article-title":"A novel X-linked disorder of immune deficiency and hypohidrotic ectodermal dysplasia is allelic to incontinentia pigmenti and due to mutations in IKK-gamma (NEMO)","volume":"67","author":"Zonana","year":"2000","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0115","doi-asserted-by":"crossref","first-page":"3843","DOI":"10.1242\/dev.128.19.3843","article-title":"Requirement of NF-\u03baB\/Rel for the development of hair follicles and other epidermal appendices","volume":"128","author":"Schmidt-Ullrich","year":"2001","journal-title":"Development"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0120","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1242\/dev.02278","article-title":"NF-\u03baB transmits Eda A1\/EdaR signalling to activate Shh and cyclin D1 expression, and controls post-initiation hair placode down growth","volume":"133","author":"Schmidt-Ullrich","year":"2006","journal-title":"Development"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0125","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S0092-8674(01)00336-1","article-title":"Beta-catenin controls hair follicle morphogenesis and stem cell differentiation in the skin","volume":"105","author":"Huelsken","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0130","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1006\/dbio.2000.9955","article-title":"TNF signaling via the ligand\u2013receptor pair ectodysplasin and edar controls the function of epithelial signaling centers and is regulated by Wnt and activin during tooth organogenesis","volume":"229","author":"Laurikkala","year":"2001","journal-title":"Dev Biol"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0135","doi-asserted-by":"crossref","first-page":"2541","DOI":"10.1242\/dev.129.10.2541","article-title":"Regulation of hair follicle development by the TNF signal ectodysplasin and its receptor Edar","volume":"129","author":"Laurikkala","year":"2002","journal-title":"Development"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0140","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.devcel.2009.05.011","article-title":"Reciprocal requirements for EDA\/EDAR\/NF-\u03baB and Wnt\/beta-catenin signaling pathways in hair follicle induction","volume":"17","author":"Zhang","year":"2009","journal-title":"Dev Cell"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0145","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0378-1119(02)00407-9","article-title":"The EDA gene is a target of, but does not regulate Wnt signaling","volume":"285","author":"Durmowicz","year":"2002","journal-title":"Gene"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0150","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.semcdb.2007.01.007","article-title":"Genetic basis of skin appendage development","volume":"18","author":"Mikkola","year":"2007","journal-title":"Semin Cell Dev Biol"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0155","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1002\/bies.20184","article-title":"Molecular principles of hair follicle induction and morphogenesis","volume":"27","author":"Schmidt-Ullrich","year":"2005","journal-title":"Bioessays"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0160","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1046\/j.0022-202x.2001.01670.x","article-title":"Molecular mechanisms regulating hair follicle development","volume":"118","author":"Millar","year":"2002","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0165","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1006\/dbio.1998.9140","article-title":"WNT signaling in the control of hair growth and structure","volume":"207","author":"Millar","year":"1999","journal-title":"Dev Biol"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0170","doi-asserted-by":"crossref","first-page":"4775","DOI":"10.1242\/dev.127.22.4775","article-title":"Sonic hedgehog regulates growth and morphogenesis of the tooth","volume":"127","author":"Dassule","year":"2000","journal-title":"Development"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0175","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0925-4773(99)00322-6","article-title":"Reiterative signaling and patterning during mammalian tooth morphogenesis","volume":"92","author":"Jernvall","year":"2000","journal-title":"Mech Dev"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0180","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1111\/j.1469-7580.2008.01014.x","article-title":"Current knowledge of tooth development: patterning and mineralization of the murine dentition","volume":"214","author":"Caton","year":"2009","journal-title":"J Anat"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0185","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/S1534-5807(02)00167-3","article-title":"WNT signals are required for the initiation of hair follicle development","volume":"2","author":"Andl","year":"2002","journal-title":"Dev Cell"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0190","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.ydbio.2007.10.016","article-title":"Wnt\/beta-catenin signaling directs multiple stages of tooth morphogenesis","volume":"313","author":"Liu","year":"2008","journal-title":"Dev Biol"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0195","doi-asserted-by":"crossref","first-page":"2691","DOI":"10.1101\/gad.8.22.2691","article-title":"Development of several organs that require inductive epithelial\u2013mesenchymal interactions is impaired in LEF-1-deficient mice","volume":"8","author":"van Genderen","year":"1994","journal-title":"Genes Dev"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0200","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.devcel.2009.06.016","article-title":"Wnt\/beta-catenin signaling: components, mechanisms, and diseases","volume":"17","author":"MacDonald","year":"2009","journal-title":"Dev Cell"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0205","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1242\/dev.054668","article-title":"Inhibition of Wnt signaling by Wise (Sostdc1) and negative feedback from Shh controls tooth number and patterning","volume":"137","author":"Ahn","year":"2010","journal-title":"Development"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0210","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.ydbio.2012.01.026","article-title":"Sostdc1 defines the size and number of skin appendage placodes","volume":"364","author":"Narhi","year":"2012","journal-title":"Dev Biol"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0215","doi-asserted-by":"crossref","first-page":"4295","DOI":"10.1242\/dev.00674","article-title":"Wise, a context-dependent activator and inhibitor of Wnt signalling","volume":"130","author":"Itasaki","year":"2003","journal-title":"Development"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0220","doi-asserted-by":"crossref","first-page":"19883","DOI":"10.1074\/jbc.M413274200","article-title":"Sclerostin binds to LRP5\/6 and antagonizes canonical Wnt signaling","volume":"280","author":"Li","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0225","doi-asserted-by":"crossref","first-page":"23159","DOI":"10.1074\/jbc.M109.025478","article-title":"Characterization of wise protein and its molecular mechanism to interact with both Wnt and BMP signals","volume":"284","author":"Lintern","year":"2009","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0230","doi-asserted-by":"crossref","first-page":"23371","DOI":"10.1074\/jbc.M802376200","article-title":"Characterization of the Kremen-binding site on Dkk1 and elucidation of the role of Kremen in Dkk-mediated Wnt antagonism","volume":"283","author":"Wang","year":"2008","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0235","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.ydbio.2008.04.023","article-title":"Identification of dkk4 as a target of Eda-A1\/Edar pathway reveals an unexpected role of ectodysplasin as inhibitor of Wnt signalling in ectodermal placodes","volume":"320","author":"Fliniaux","year":"2008","journal-title":"Dev Biol"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0240","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ydbio.2003.08.011","article-title":"Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot","volume":"264","author":"Laurikkala","year":"2003","journal-title":"Dev Biol"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0245","doi-asserted-by":"crossref","first-page":"9075","DOI":"10.1073\/pnas.0600825103","article-title":"Generation of the primary hair follicle pattern","volume":"103","author":"Mou","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0250","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1126\/science.1116848","article-title":"Regulation of mammalian tooth cusp patterning by ectodin","volume":"309","author":"Kassai","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0255","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/11078","article-title":"Noggin is a mesenchymally derived stimulator of hair-follicle induction","volume":"1","author":"Botchkarev","year":"1999","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0260","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1083\/jcb.200309042","article-title":"Defining BMP functions in the hair follicle by conditional ablation of BMP receptor IA","volume":"163","author":"Kobielak","year":"2003","journal-title":"J Cell Biol"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0265","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1242\/dev.125.2.161","article-title":"The life history of an embryonic signaling center: BMP-4 induces p21 and is associated with apoptosis in the mouse tooth enamel knot","volume":"125","author":"Jernvall","year":"1998","journal-title":"Development"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0270","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.devcel.2004.09.012","article-title":"Follistatin regulates enamel patterning in mouse incisors by asymmetrically inhibiting BMP signaling and ameloblast differentiation","volume":"7","author":"Wang","year":"2004","journal-title":"Dev Cell"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0275","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1242\/dev.02708","article-title":"Ectodysplasin has a dual role in ectodermal organogenesis: inhibition of Bmp activity and induction of Shh expression","volume":"134","author":"Pummila","year":"2007","journal-title":"Development"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0280","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1242\/dev.01125","article-title":"Epithelial Bmpr1a regulates differentiation and proliferation in postnatal hair follicles and is essential for tooth development","volume":"131","author":"Andl","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0285","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1101\/gad.12.16.2636","article-title":"Activin is an essential early mesenchymal signal in tooth development that is required for patterning of the murine dentition","volume":"12","author":"Ferguson","year":"1998","journal-title":"Genes Dev"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0290","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1006\/mcne.1998.0710","article-title":"Defective whisker follicles and altered brainstem patterns in activin and follistatin knockout mice","volume":"12","author":"Jhaveri","year":"1998","journal-title":"Mol Cell Neurosci"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0295","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1038\/374360a0","article-title":"Multiple defects and perinatal death in mice deficient in follistatin","volume":"374","author":"Matzuk","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0300","doi-asserted-by":"crossref","first-page":"4605","DOI":"10.1242\/dev.128.22.4605","article-title":"The role of effectors of the activin signalling pathway, activin receptors IIA and IIB, and Smad2, in patterning of tooth development","volume":"128","author":"Ferguson","year":"2001","journal-title":"Development"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0305","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/dbio.1998.9103","article-title":"Essential role for Sonic hedgehog during hair follicle morphogenesis","volume":"205","author":"Chiang","year":"1999","journal-title":"Dev Biol"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0310","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1016\/S0960-9822(98)70443-9","article-title":"Sonic hedgehog signaling is essential for hair development","volume":"8","author":"St-Jacques","year":"1998","journal-title":"Curr Biol"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0315","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.1242\/dev.125.15.2803","article-title":"The Shh signalling pathway in tooth development: defects in Gli2 and Gli3 mutants","volume":"125","author":"Hardcastle","year":"1998","journal-title":"Development"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0320","doi-asserted-by":"crossref","first-page":"3173","DOI":"10.1101\/gad.1035602","article-title":"FGF4, a direct target of LEF1 and Wnt signaling, can rescue the arrest of tooth organogenesis in Lef1(\u2212\/\u2212) mice","volume":"16","author":"Kratochwil","year":"2002","journal-title":"Genes Dev"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0325","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1242\/dev.033803","article-title":"Apc inhibition of Wnt signaling regulates supernumerary tooth formation during embryogenesis and throughout adulthood","volume":"136","author":"Wang","year":"2009","journal-title":"Development"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0330","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1186\/1471-2164-13-257","article-title":"Genome-wide SNP scan of pooled DNA reveals nonsense mutation in FGF20 in the scaleless line of featherless chickens","volume":"13","author":"Wells","year":"2012","journal-title":"BMC Genomics"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0335","doi-asserted-by":"crossref","first-page":"3189","DOI":"10.1242\/dev.079558","article-title":"Ectodysplasin regulates activator\u2013inhibitor balance in murine tooth development through Fgf20 signaling","volume":"139","author":"Haara","year":"2012","journal-title":"Development"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0340","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1101\/gad.198945.112","article-title":"Fgf20 governs formation of primary and secondary dermal condensations in developing hair follicles","volume":"27","author":"Huh","year":"2013","journal-title":"Genes Dev"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0345","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.ydbio.2007.02.010","article-title":"Localization of Shh expression by Wnt and Eda affects axial polarity and shape of hairs","volume":"305","author":"Hammerschmidt","year":"2007","journal-title":"Dev Biol"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0350","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1006\/dbio.1999.9514","article-title":"Cusp patterning defect in Tabby mouse teeth and its partial rescue by FGF","volume":"216","author":"Pispa","year":"1999","journal-title":"Dev Biol"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0355","doi-asserted-by":"crossref","first-page":"5744","DOI":"10.1073\/pnas.1110627109","article-title":"Ectodysplasin regulates hormone-independent mammary ductal morphogenesis via NF-\u03baB","volume":"109","author":"Voutilainen","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0360","doi-asserted-by":"crossref","first-page":"2674","DOI":"10.1002\/dvdy.22406","article-title":"Recombinant EDA or Sonic Hedgehog rescue the branching defect in ectodysplasin A pathway mutant salivary glands in vitro","volume":"239","author":"Wells","year":"2010","journal-title":"Dev Dyn"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0365","first-page":"126","article-title":"Fine mapping of the EDA gene: a translocation breakpoint is associated with a CpG island that is transcribed","volume":"58","author":"Srivastava","year":"1996","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0370","doi-asserted-by":"crossref","first-page":"13069","DOI":"10.1073\/pnas.94.24.13069","article-title":"The Tabby phenotype is caused by mutation in a mouse homologue of the EDA gene that reveals novel mouse and human exons and encodes a protein (ectodysplasin-A) with collagenous domains","volume":"94","author":"Srivastava","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0375","first-page":"1","article-title":"The glandular aspects of the tabby syndrome in the mouse","volume":"25","author":"Gruneberg","year":"1971","journal-title":"J Embryol Exp Morphol"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0380","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1093\/oxfordjournals.jhered.a023146","article-title":"X-linked ectodermal dysplasia in the dog","volume":"88","author":"Casal","year":"1997","journal-title":"J Hered"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0385","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1007\/s00335-004-2463-4","article-title":"Mutation identification in a canine model of X-linked ectodermal dysplasia","volume":"16","author":"Casal","year":"2005","journal-title":"Mamm Genome"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0390","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1038\/nm861","article-title":"Permanent correction of an inherited ectodermal dysplasia with recombinant EDA","volume":"9","author":"Gaide","year":"2003","journal-title":"Nat Med"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0395","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1086\/521988","article-title":"Significant correction of disease after postnatal administration of recombinant ectodysplasin A in canine X-linked ectodermal dysplasia","volume":"81","author":"Casal","year":"2007","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0400","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1002\/ajmg.a.32916","article-title":"Neonatal treatment with recombinant ectodysplasin prevents respiratory disease in dogs with X-linked ectodermal dysplasia","volume":"149A","author":"Mauldin","year":"2009","journal-title":"Am J Med Genet A"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0405","doi-asserted-by":"crossref","first-page":"30769","DOI":"10.1074\/jbc.M111.267997","article-title":"Molecular and therapeutic characterization of anti-ectodysplasin A receptor (EDAR) agonist monoclonal antibodies","volume":"286","author":"Kowalczyk","year":"2011","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0410","doi-asserted-by":"crossref","first-page":"2931","DOI":"10.1093\/hmg\/ddg325","article-title":"Inducible mEDA-A1 transgene mediates sebaceous gland hyperplasia and differential formation of two types of mouse hair follicles","volume":"12","author":"Cui","year":"2003","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0415","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.2353\/ajpath.2006.060227","article-title":"Involvement of the Edar signaling in the control of hair follicle involution (catagen)","volume":"169","author":"Fessing","year":"2006","journal-title":"Am J Pathol"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0420","doi-asserted-by":"crossref","first-page":"18627","DOI":"10.1073\/pnas.0607289103","article-title":"Continuous tooth generation in mouse is induced by activated epithelial Wnt\/beta-catenin signaling","volume":"103","author":"Jarvinen","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0425","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1242\/dev.016550","article-title":"Sustained epithelial beta-catenin activity induces precocious hair development but disrupts hair follicle down-growth and hair shaft formation","volume":"135","author":"Narhi","year":"2008","journal-title":"Development"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0430","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1242\/dev.017459","article-title":"Activation of beta-catenin signaling programs embryonic epidermis to hair follicle fate","volume":"135","author":"Zhang","year":"2008","journal-title":"Development"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0435","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0012-1606(03)00157-X","article-title":"Stimulation of ectodermal organ development by ectodysplasin-A1","volume":"259","author":"Mustonen","year":"2003","journal-title":"Dev Biol"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0440","doi-asserted-by":"crossref","first-page":"e7591","DOI":"10.1371\/journal.pone.0007591","article-title":"Enhanced Edar signalling has pleiotropic effects on craniofacial and cutaneous glands","volume":"4","author":"Chang","year":"2009","journal-title":"PLoS ONE"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0445","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1007\/BF02996227","article-title":"The genetics and development of crinkled, a new mutant in the house mouse","volume":"50","author":"Falconer","year":"1951","journal-title":"J Genet"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0450","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S1534-5807(04)00024-3","article-title":"A dual role for Ikk alpha in tooth development","volume":"6","author":"Ohazama","year":"2004","journal-title":"Dev Cell"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0455","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1101\/gad.9.6.700","article-title":"Lymphoid enhancer factor 1 directs hair follicle patterning and epithelial cell fate","volume":"9","author":"Zhou","year":"1995","journal-title":"Genes Dev"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0460","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/S0002-9440(10)63197-5","article-title":"Morpho-regulation of ectodermal organs \u2013 integument pathology and phenotypic variations in K14-Noggin engineered mice through modulation of bone morphogenic protein pathway","volume":"164","author":"Plikus","year":"2004","journal-title":"Am J Pathol"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0465","doi-asserted-by":"crossref","first-page":"18166","DOI":"10.1073\/pnas.0608899103","article-title":"Bone morphogenetic protein signaling regulates the size of hair follicles and modulates the expression of cell cycle-associated genes","volume":"103","author":"Sharov","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.cytogfr.2014.01.004_bib0470","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1242\/dev.085118","article-title":"Lrp4 and Wise interplay controls the formation and patterning of mammary and other skin appendage placodes by modulating Wnt signaling","volume":"140","author":"Ahn","year":"2013","journal-title":"Development"}],"container-title":["Cytokine &amp; Growth Factor Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1359610114000057?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1359610114000057?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,3,24]],"date-time":"2022-03-24T10:32:44Z","timestamp":1648117964000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1359610114000057"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4]]},"references-count":94,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["S1359610114000057"],"URL":"https:\/\/doi.org\/10.1016\/j.cytogfr.2014.01.004","relation":{},"ISSN":["1359-6101"],"issn-type":[{"value":"1359-6101","type":"print"}],"subject":[],"published":{"date-parts":[[2014,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ectodysplasin A (EDA) \u2013 EDA receptor signalling and its pharmacological modulation","name":"articletitle","label":"Article Title"},{"value":"Cytokine & Growth Factor Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cytogfr.2014.01.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}