{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,8]],"date-time":"2026-11-08T03:24:28Z","timestamp":1794108268823,"version":"4.8.0"},"reference-count":160,"publisher":"Elsevier BV","issue":"3","content-domain":{"domain":["cgfr.co.uk","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytokine & Growth Factor Reviews"],"published-print":{"date-parts":[[2014,6]]},"DOI":"10.1016\/j.cytogfr.2014.03.003","type":"journal-article","created":{"date-parts":[[2014,3,22]],"date-time":"2014-03-22T02:51:28Z","timestamp":1395456688000},"page":"273-283","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":228,"title":["PDGF receptor signaling networks in normal and cancer cells"],"prefix":"10.1016","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8016-6689","authenticated-orcid":false,"given":"Jean-Baptiste","family":"Demoulin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3415-7340","authenticated-orcid":false,"given":"Ahmed","family":"Essaghir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cytogfr.2014.03.003_bib0005","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1073\/pnas.71.4.1207","article-title":"A platelet-dependent serum factor that stimulates the proliferation of arterial smooth muscle cells in vitro","volume":"71","author":"Ross","year":"1974","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0010","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/0014-4827(76)90476-6","article-title":"A platelet factor stimulating human normal glial cells","volume":"98","author":"Westermark","year":"1976","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0015","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/0014-4827(74)90484-4","article-title":"Platelets as a source of fibroblast growth-promoting activity","volume":"87","author":"Kohler","year":"1974","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0020","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/304035a0","article-title":"Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus","volume":"304","author":"Waterfield","year":"1983","journal-title":"Nature"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0025","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/323226a0","article-title":"Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors","volume":"323","author":"Yarden","year":"1986","journal-title":"Nature"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0030","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1038\/295419a0","article-title":"Stimulation of tyrosine-specific phosphorylation by platelet-derived growth factor","volume":"295","author":"Ek","year":"1982","journal-title":"Nature"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0035","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0065-230X(06)97011-0","article-title":"PDGF receptors as targets in tumor treatment","volume":"97","author":"Ostman","year":"2007","journal-title":"Adv Cancer Res"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0040","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1101\/gad.1653708","article-title":"Role of platelet-derived growth factors in physiology and medicine","volume":"22","author":"Andrae","year":"2008","journal-title":"Genes Dev"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0045","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.cytogfr.2004.03.007","article-title":"The PDGF family: four gene products form five dimeric isoforms","volume":"15","author":"Fredriksson","year":"2004","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0050","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1101\/gad.266803","article-title":"Endothelial PDGF-B retention is required for proper investment of pericytes in the microvessel wall","volume":"17","author":"Lindblom","year":"2003","journal-title":"Genes Dev"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0055","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/35074588","article-title":"PDGF-D is a specific, protease-activated ligand for the PDGF beta-receptor","volume":"3","author":"Bergsten","year":"2001","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0060","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/35010579","article-title":"PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor","volume":"2","author":"Li","year":"2000","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0065","doi-asserted-by":"crossref","first-page":"3793","DOI":"10.1038\/sj.emboj.7600397","article-title":"Tissue plasminogen activator is a potent activator of PDGF-CC","volume":"23","author":"Fredriksson","year":"2004","journal-title":"Embo J"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0070","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/nm1787","article-title":"Activation of PDGF-CC by tissue plasminogen activator impairs blood-brain barrier integrity during ischemic stroke","volume":"14","author":"Su","year":"2008","journal-title":"Nat Med"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0075","doi-asserted-by":"crossref","first-page":"15926","DOI":"10.1074\/jbc.M909616199","article-title":"Angiotensin II induces transactivation of two different populations of the platelet-derived growth factor beta receptor. Key role for the p66 adaptor protein Shc","volume":"275","author":"Heeneman","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0080","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.cellsig.2009.09.031","article-title":"The dopamine D4 receptor activates intracellular platelet-derived growth factor receptor beta to stimulate ERK1\/2","volume":"22","author":"Gill","year":"2010","journal-title":"Cell Signal"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0085","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1161\/ATVBAHA.107.155754","article-title":"TF\/FVIIa transactivate PDGFRbeta to regulate PDGF-BB-induced chemotaxis in different cell types: involvement of Src and PLC","volume":"28","author":"Siegbahn","year":"2008","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0090","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1042\/BJ20060095","article-title":"Angiotensin II stimulates phosphorylation of an ectodomain-truncated platelet-derived growth factor receptor-beta and its binding to class IA PI3K in vascular smooth muscle cells","volume":"397","author":"Gao","year":"2006","journal-title":"Biochem J"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0095","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1083\/jcb.200608093","article-title":"Vascular endothelial growth factor can signal through platelet-derived growth factor receptors","volume":"177","author":"Ball","year":"2007","journal-title":"J Cell Biol"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0100","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1128\/MCB.06668-11","article-title":"Vascular endothelial growth factor A competitively inhibits platelet-derived growth factor (PDGF)-dependent activation of PDGF receptor and subsequent signaling events and cellular responses","volume":"32","author":"Pennock","year":"2012","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0105","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1126\/science.277.5323.242","article-title":"Pericyte loss and microaneurysm formation in PDGF-B-deficient mice","volume":"277","author":"Lindahl","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0110","doi-asserted-by":"crossref","first-page":"2691","DOI":"10.1242\/dev.124.14.2691","article-title":"The PDGF alpha receptor is required for neural crest cell development and for normal patterning of the somites","volume":"124","author":"Soriano","year":"1997","journal-title":"Development"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0115","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1038\/ng1415","article-title":"A specific requirement for PDGF-C in palate formation and PDGFR-alpha signaling","volume":"36","author":"Ding","year":"2004","journal-title":"Nat Genet"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0120","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S1097-2765(01)00182-4","article-title":"The two PDGF receptors maintain conserved signaling in vivo despite divergent embryological functions","volume":"7","author":"Klinghoffer","year":"2001","journal-title":"Mol Cell"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0125","doi-asserted-by":"crossref","first-page":"233","DOI":"10.2147\/CIA.S1106","article-title":"Becaplermin gel in the treatment of diabetic neuropathic foot ulcers","volume":"3","author":"Papanas","year":"2008","journal-title":"Clin Interv Aging"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0130","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1016\/S0002-9440(10)63033-7","article-title":"Platelet-derived growth factor B-chain of hematopoietic origin is not necessary for granulation tissue formation and its absence enhances vascularization","volume":"159","author":"Buetow","year":"2001","journal-title":"Am J Pathol"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0135","doi-asserted-by":"crossref","first-page":"11410","DOI":"10.1073\/pnas.96.20.11410","article-title":"Platelet-derived growth factor beta receptor regulates interstitial fluid homeostasis through phosphatidylinositol-3\u2032 kinase signaling","volume":"96","author":"Heuchel","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0140","doi-asserted-by":"crossref","first-page":"2429","DOI":"10.1182\/blood-2010-04-279752","article-title":"New insights into the mechanisms of hematopoietic cell transformation by activated receptor tyrosine kinases","volume":"116","author":"Toffalini","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0145","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/1478-811X-11-97","article-title":"Targeting the PDGF signaling pathway in tumor treatment","volume":"11","author":"Heldin","year":"2013","journal-title":"Cell Commun Signal"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0150","doi-asserted-by":"crossref","DOI":"10.1038\/onc.2013.218","article-title":"PDGFRA alterations in cancer: characterization of a gain-of-function V536E transmembrane mutant as well as loss-of-function and passenger mutations","author":"Velghe","year":"2014","journal-title":"Oncogene"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0155","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/j.1582-4934.2011.01415.x","article-title":"Tyrosine kinase gene fusions in cancer: translating mechanisms into targeted therapies","volume":"16","author":"Medves","year":"2012","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0160","first-page":"44","article-title":"Platelet-derived growth factors and their receptors in normal and malignant hematopoiesis","volume":"2","author":"Demoulin","year":"2012","journal-title":"Am J Blood Res"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0165","first-page":"111","article-title":"Review of current classification, molecular alterations, and tyrosine kinase inhibitor therapies in myeloproliferative disorders with hypereosinophilia","volume":"4","author":"Havelange","year":"2013","journal-title":"J Blood Med"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0170","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.1056\/NEJMoa052955","article-title":"Stimulatory autoantibodies to the PDGF receptor in systemic sclerosis","volume":"354","author":"Baroni","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0175","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1002\/art.24381","article-title":"Lack of evidence of stimulatory autoantibodies to platelet-derived growth factor receptor in patients with systemic sclerosis","volume":"60","author":"Classen","year":"2009","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0180","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1056\/NEJMc091209","volume":"361","author":"Demoulin","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0185","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1002\/art.24365","article-title":"Lack of detection of agonist activity by antibodies to platelet-derived growth factor receptor alpha in a subset of normal and systemic sclerosis patient sera","volume":"60","author":"Loizos","year":"2009","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0190","doi-asserted-by":"crossref","first-page":"4070","DOI":"10.1182\/blood-2011-03-341693","article-title":"A phase 1 study of imatinib for corticosteroid-dependent\/refractory chronic graft-versus-host disease: response does not correlate with anti-PDGFRA antibodies","volume":"118","author":"Chen","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0195","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1038\/sj.onc.1209152","article-title":"Bovine papillomavirus E5 oncoprotein binds to the activated form of the platelet-derived growth factor beta receptor in naturally occurring bovine urinary bladder tumours","volume":"25","author":"Borzacchiello","year":"2006","journal-title":"Oncogene"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0200","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/nature07209","article-title":"Platelet-derived growth factor-alpha receptor activation is required for human cytomegalovirus infection","volume":"455","author":"Soroceanu","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0205","doi-asserted-by":"crossref","first-page":"e1002905","DOI":"10.1371\/journal.ppat.1002905","article-title":"PDGF receptor-alpha does not promote HCMV entry into epithelial and endothelial cells but increased quantities stimulate entry by an abnormal pathway","volume":"8","author":"Vanarsdall","year":"2012","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0210","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1038\/nm929","article-title":"Identification of PDGFR as a receptor for AAV-5 transduction","volume":"9","author":"Di Pasquale","year":"2003","journal-title":"Nat Med"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0215","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.virol.2012.03.004","article-title":"Mutation in the platelet-derived growth factor receptor alpha inhibits adeno-associated virus type 5 transduction","volume":"428","author":"Pilz","year":"2012","journal-title":"Virology"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0220","doi-asserted-by":"crossref","first-page":"e1000021","DOI":"10.1371\/journal.ppat.1000021","article-title":"RNA interference screen identifies Abl kinase and PDGFR signaling in Chlamydia trachomatis entry","volume":"4","author":"Elwell","year":"2008","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0225","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.1038\/leu.2012.162","article-title":"Long-term follow-up of FIP1L1-PDGFRA-mutated patients with eosinophilia: survival and clinical outcome","volume":"26","author":"Pardanani","year":"2012","journal-title":"Leukemia"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0230","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/leu.2009.2","article-title":"FIP1L1-PDGFRalpha D842V, a novel panresistant mutant, emerging after treatment of FIP1L1-PDGFRalpha T674I eosinophilic leukemia with single agent sorafenib","volume":"23","author":"Lierman","year":"2009","journal-title":"Leukemia"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0235","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1038\/sj.bjc.6605411","article-title":"Multicentre phase II studies evaluating imatinib plus hydroxyurea in patients with progressive glioblastoma","volume":"101","author":"Reardon","year":"2009","journal-title":"Br J Cancer"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0240","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s11481-013-9484-2","article-title":"Targeting the PDGF signaling pathway in the treatment of non-malignant diseases","volume":"9","author":"Heldin","year":"2014","journal-title":"J Neuroimmun Pharmacol"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0245","doi-asserted-by":"crossref","first-page":"12676","DOI":"10.1074\/jbc.272.19.12676","article-title":"Immunoglobulin-like domain 4-mediated receptor\u2013receptor interactions contribute to platelet-derived growth factor-induced receptor dimerization","volume":"272","author":"Omura","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0250","doi-asserted-by":"crossref","first-page":"19732","DOI":"10.1074\/jbc.M314070200","article-title":"Autoinhibition of the platelet-derived growth factor beta-receptor tyrosine kinase by its C-terminal tail","volume":"279","author":"Chiara","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0255","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1016\/j.cellsig.2010.05.004","article-title":"Mutation of tyrosine residue 857 in the PDGF beta-receptor affects cell proliferation but not migration","volume":"22","author":"Wardega","year":"2010","journal-title":"Cell Signal"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0260","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.1128\/MCB.18.4.2014","article-title":"Activation of Src family members is not required for the platelet-derived growth factor beta receptor to initiate mitogenesis","volume":"18","author":"DeMali","year":"1998","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0265","doi-asserted-by":"crossref","first-page":"2459","DOI":"10.1093\/emboj\/18.9.2459","article-title":"Src family kinases are required for integrin but not PDGFR signal transduction","volume":"18","author":"Klinghoffer","year":"1999","journal-title":"EMBO J"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0270","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.1038\/sj.onc.1203608","article-title":"No requirement for src family kinases for PDGF signaling in fibroblasts expressing SV40 large T antigen","volume":"19","author":"Broome","year":"2000","journal-title":"Oncogene"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0275","doi-asserted-by":"crossref","first-page":"3906","DOI":"10.1182\/blood-2006-07-036335","article-title":"Myeloproliferative disease induced by TEL-PDGFRB displays dynamic range sensitivity to Stat5 gene dosage","volume":"109","author":"Cain","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0280","doi-asserted-by":"crossref","first-page":"9018","DOI":"10.1128\/MCB.20.23.9018-9027.2000","article-title":"SU6656, a selective src family kinase inhibitor, used to probe growth factor signaling","volume":"20","author":"Blake","year":"2000","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0285","doi-asserted-by":"crossref","first-page":"5299","DOI":"10.1002\/j.1460-2075.1996.tb00915.x","article-title":"Mutation of a Src phosphorylation site in the PDGF beta-receptor leads to increased PDGF-stimulated chemotaxis but decreased mitogenesis","volume":"15","author":"Hansen","year":"1996","journal-title":"EMBO J"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0290","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.molonc.2009.07.001","article-title":"Identification of c-Src tyrosine kinase substrates in platelet-derived growth factor receptor signaling","volume":"3","author":"Amanchy","year":"2009","journal-title":"Mol Oncol"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0295","doi-asserted-by":"crossref","first-page":"2400","DOI":"10.1101\/gad.13.18.2400","article-title":"c-Abl is activated by growth factors and Src family kinases and has a role in the cellular response to PDGF","volume":"13","author":"Plattner","year":"1999","journal-title":"Genes Dev"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0300","doi-asserted-by":"crossref","first-page":"2573","DOI":"10.1128\/MCB.24.6.2573-2583.2004","article-title":"Bidirectional signaling links the Abelson kinases to the platelet-derived growth factor receptor","volume":"24","author":"Plattner","year":"2004","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0305","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1093\/emboj\/21.4.514","article-title":"c-Abl is an effector of Src for growth factor-induced c-myc expression and DNA synthesis","volume":"21","author":"Furstoss","year":"2002","journal-title":"EMBO J"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0310","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/ncb949","article-title":"A new link between the c-Abl tyrosine kinase and phosphoinositide signalling through PLC-gamma1","volume":"5","author":"Plattner","year":"2003","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0315","doi-asserted-by":"crossref","first-page":"3717","DOI":"10.1242\/jcs.02491","article-title":"Abl tyrosine kinase regulates a Rac\/JNK and a Rac\/Nox pathway for DNA synthesis and Myc expression induced by growth factors","volume":"118","author":"Boureux","year":"2005","journal-title":"J Cell Sci"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0320","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/35078555","article-title":"Regulation of c-myc expression by PDGF through Rho GTPases","volume":"3","author":"Chiariello","year":"2001","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0325","doi-asserted-by":"crossref","first-page":"4670","DOI":"10.1172\/JCI58559","article-title":"Activation of Rac1 by Src-dependent phosphorylation of Dock180(Y1811) mediates PDGFRalpha-stimulated glioma tumorigenesis in mice and humans","volume":"121","author":"Feng","year":"2011","journal-title":"J Clin Invest"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0330","doi-asserted-by":"crossref","first-page":"7319","DOI":"10.1073\/pnas.131568898","article-title":"Stat3-mediated Myc expression is required for Src transformation and PDGF-induced mitogenesis","volume":"98","author":"Bowman","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0335","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1128\/MCB.21.2.603-613.2001","article-title":"Mice devoid of fer protein-tyrosine kinase activity are viable and fertile but display reduced cortactin phosphorylation","volume":"21","author":"Craig","year":"2001","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0340","doi-asserted-by":"crossref","first-page":"15736","DOI":"10.1074\/jbc.M113.476424","article-title":"The Fer tyrosine kinase is important for platelet-derived growth factor-BB-induced signal transducer and activator of transcription 3 (STAT3) protein phosphorylation, colony formation in soft agar, and tumor growth in vivo","volume":"288","author":"Lennartsson","year":"2013","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0345","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.bbapap.2003.11.009","article-title":"Structure, regulation and function of PKB\/AKT \u2013 a major therapeutic target","volume":"1697","author":"Hanada","year":"2004","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0350","first-page":"F79","article-title":"Signal transduction via platelet-derived growth factor receptors","volume":"1378","author":"Heldin","year":"1998","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0355","doi-asserted-by":"crossref","first-page":"10334","DOI":"10.1074\/jbc.M808848200","article-title":"The transcription of FOXO genes is stimulated by FOXO3 and repressed by growth factors","volume":"284","author":"Essaghir","year":"2009","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0360","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1053\/j.gastro.2007.01.033","article-title":"The forkhead transcription factor FoxO1 regulates proliferation and transdifferentiation of hepatic stellate cells","volume":"132","author":"Adachi","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0365","doi-asserted-by":"crossref","first-page":"29864","DOI":"10.1074\/jbc.M502149200","article-title":"Forkhead transcription factors inhibit vascular smooth muscle cell proliferation and neointimal hyperplasia","volume":"280","author":"Abid","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0370","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/43474","article-title":"NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling","volume":"401","author":"Romashkova","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0375","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0014-5793(00)01957-8","article-title":"PDGF-induced Akt phosphorylation does not activate NF-kappa B in human vascular smooth muscle cells and fibroblasts","volume":"481","author":"Rauch","year":"2000","journal-title":"FEBS Lett"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0380","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.cardiores.2004.10.031","article-title":"Activation of vascular smooth muscle cells by TNF and PDGF: overlapping and complementary signal transduction mechanisms","volume":"65","author":"Peppel","year":"2005","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0385","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.3324\/haematol.2011.047530","article-title":"ETV6-PDGFRB and FIP1L1-PDGFRA stimulate human hematopoietic progenitor proliferation and differentiation into eosinophils: role of NF-kappaB","volume":"97","author":"Montano-Almendras","year":"2012","journal-title":"Haematologica"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0390","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1006\/excr.2001.5449","article-title":"Activation of NF-kappaB is required for PDGF-B chain to transform NIH3T3 cells","volume":"274","author":"Shimamura","year":"2002","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0395","doi-asserted-by":"crossref","first-page":"8081","DOI":"10.1073\/pnas.95.14.8081","article-title":"Evidence for a role of NF-kappaB in the survival of hematopoietic cells mediated by interleukin 3 and the oncogenic TEL\/platelet-derived growth factor receptor beta fusion protein","volume":"95","author":"Besancon","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0400","doi-asserted-by":"crossref","first-page":"35392","DOI":"10.1074\/jbc.M405924200","article-title":"Platelet-derived growth factor stimulates membrane lipid synthesis through activation of phosphatidylinositol 3-kinase and sterol regulatory element-binding proteins","volume":"279","author":"Demoulin","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0405","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.cmet.2005.04.010","article-title":"Control of lipid metabolism by phosphorylation-dependent degradation of the SREBP family of transcription factors by SCF(Fbw7)","volume":"1","author":"Sundqvist","year":"2005","journal-title":"Cell Metab"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0410","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.cmet.2008.07.007","article-title":"SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth","volume":"8","author":"Porstmann","year":"2008","journal-title":"Cell Metab"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0415","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S1534-5807(01)00103-4","article-title":"An allelic series at the PDGFalphaR locus indicates unequal contributions of distinct signaling pathways during development","volume":"2","author":"Klinghoffer","year":"2002","journal-title":"Dev Cell"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0420","doi-asserted-by":"crossref","first-page":"2593","DOI":"10.1128\/MCB.25.7.2593-2606.2005","article-title":"Role of phosphoinositide 3-kinase regulatory isoforms in development and actin rearrangement","volume":"25","author":"Brachmann","year":"2005","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0425","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1038\/sj.emboj.7600979","article-title":"PTEN tumor suppressor associates with NHERF proteins to attenuate PDGF receptor signaling","volume":"25","author":"Takahashi","year":"2006","journal-title":"EMBO J"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0430","doi-asserted-by":"crossref","first-page":"8352","DOI":"10.1128\/MCB.20.22.8352-8363.2000","article-title":"Platelet-derived growth factor receptor association with Na(+)\/H(+) exchanger regulatory factor potentiates receptor activity","volume":"20","author":"Maudsley","year":"2000","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0435","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1042\/bj20030385","article-title":"Ligand-induced recruitment of Na+\/H+-exchanger regulatory factor to the PDGF (platelet-derived growth factor) receptor regulates actin cytoskeleton reorganization by PDGF","volume":"376","author":"Demoulin","year":"2003","journal-title":"Biochem J"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0440","doi-asserted-by":"crossref","first-page":"8681","DOI":"10.1038\/sj.onc.1207962","article-title":"NHERF (Na+\/H+ exchanger regulatory factor) gene mutations in human breast cancer","volume":"23","author":"Dai","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0445","doi-asserted-by":"crossref","first-page":"17897","DOI":"10.1074\/jbc.M312996200","article-title":"Gab1 contributes to cytoskeletal reorganization and chemotaxis in response to platelet-derived growth factor","volume":"279","author":"Kallin","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0450","doi-asserted-by":"crossref","first-page":"3696","DOI":"10.1038\/sj.onc.1202705","article-title":"SHP-2 binds to Tyr763 and Tyr1009 in the PDGF beta-receptor and mediates PDGF-induced activation of the Ras\/MAP kinase pathway and chemotaxis","volume":"18","author":"Ronnstrand","year":"1999","journal-title":"Oncogene"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0455","doi-asserted-by":"crossref","first-page":"4904","DOI":"10.1074\/jbc.273.9.4904","article-title":"The Shp-2 tyrosine phosphatase has opposite effects in mediating the activation of extracellular signal-regulated and c-Jun NH2-terminal mitogen-activated protein kinases","volume":"273","author":"Shi","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0460","doi-asserted-by":"crossref","first-page":"6926","DOI":"10.1128\/MCB.16.12.6926","article-title":"Phosphorylation of tyrosine 720 in the platelet-derived growth factor alpha receptor is required for binding of Grb2 and SHP-2 but not for activation of Ras or cell proliferation","volume":"16","author":"Bazenet","year":"1996","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0465","doi-asserted-by":"crossref","DOI":"10.1016\/j.molonc.2014.02.003","article-title":"The tyrosine phosphatase SHP2 is required for cell transformation by the receptor tyrosine kinase mutants FIP1L1-PDGFRA and PDGFRA D842V","author":"No\u00ebl","year":"2014","journal-title":"Mol Oncol"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0470","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.cell.2007.03.051","article-title":"Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice","volume":"129","author":"Gupta","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0475","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1038\/sj.onc.1205210","article-title":"SHP-2 is involved in heterodimer specific loss of phosphorylation of Tyr771 in the PDGF beta-receptor","volume":"21","author":"Ekman","year":"2002","journal-title":"Oncogene"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0480","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1038\/35074525","article-title":"Tyrosine-phosphorylated SOCS-3 inhibits STAT activation but binds to p120 RasGAP and activates Ras","volume":"3","author":"Cacalano","year":"2001","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0485","doi-asserted-by":"crossref","first-page":"4626","DOI":"10.1074\/jbc.M808490200","article-title":"Negative and positive regulation of MAPK phosphatase 3 controls platelet-derived growth factor-induced Erk activation","volume":"284","author":"Jurek","year":"2009","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0490","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.cellsig.2010.01.020","article-title":"Erk 5 is necessary for sustained PDGF-induced Akt phosphorylation and inhibition of apoptosis","volume":"22","author":"Lennartsson","year":"2010","journal-title":"Cell Signal"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0495","doi-asserted-by":"crossref","first-page":"22173","DOI":"10.1074\/jbc.M513307200","article-title":"c-Jun N-terminal kinase is necessary for platelet-derived growth factor-mediated chemotaxis in primary fibroblasts","volume":"281","author":"Amagasaki","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0500","doi-asserted-by":"crossref","first-page":"13954","DOI":"10.1074\/jbc.274.20.13954","article-title":"Platelet-derived growth factor activates p38 mitogen-activated protein kinase through a Ras-dependent pathway that is important for actin reorganization and cell migration","volume":"274","author":"Matsumoto","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0505","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1002\/jcb.10717","article-title":"Platelet-derived growth factor-BB phosphorylates heat shock protein 27 in cardiac myocytes","volume":"91","author":"Takenaka","year":"2004","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0510","doi-asserted-by":"crossref","first-page":"5615","DOI":"10.1093\/emboj\/17.19.5615","article-title":"Stress-activated protein kinases are negatively regulated by cell density","volume":"17","author":"Lallemand","year":"1998","journal-title":"EMBO J"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0515","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1161\/01.ATV.0000066132.32063.F2","article-title":"Role of JNK, p38, and ERK in platelet-derived growth factor-induced vascular proliferation, migration, and gene expression","volume":"23","author":"Zhan","year":"2003","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0520","doi-asserted-by":"crossref","first-page":"3759","DOI":"10.1158\/0008-5472.CAN-06-4183","article-title":"Molecular mechanisms underlying FIP1L1-PDGFRA-mediated myeloproliferation","volume":"67","author":"Buitenhuis","year":"2007","journal-title":"Cancer Res"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0525","doi-asserted-by":"crossref","first-page":"3878","DOI":"10.1038\/sj.onc.1202734","article-title":"The oncogenic TEL\/PDGFR beta fusion protein induces cell death through JNK\/SAPK pathway","volume":"18","author":"Atfi","year":"1999","journal-title":"Oncogene"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0530","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1182\/blood-2002-09-2974","article-title":"The coupling of TEL\/PDGFbetaR to distinct functional responses is modulated by the presence of cytokine: involvement of mitogen-activated protein kinases","volume":"102","author":"Wheadon","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0535","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1291\/hypres.30.1107","article-title":"Big mitogen-activated protein kinase 1 (BMK1)\/extracellular signal regulated kinase 5 (ERK5) is involved in platelet-derived growth factor (PDGF)-induced vascular smooth muscle cell migration","volume":"30","author":"Izawa","year":"2007","journal-title":"Hypertens Res"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0540","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.jhep.2007.08.010","article-title":"ERK5 differentially regulates PDGF-induced proliferation and migration of hepatic stellate cells","volume":"48","author":"Rovida","year":"2008","journal-title":"J Hepatol"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0545","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.cellsig.2011.11.001","article-title":"MKP3 negatively modulates PDGF-induced Akt and Erk5 phosphorylation as well as chemotaxis","volume":"24","author":"Razmara","year":"2012","journal-title":"Cell Signal"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0550","doi-asserted-by":"crossref","first-page":"3179","DOI":"10.1101\/gad.844700","article-title":"Retention of PDGFR-beta function in mice in the absence of phosphatidylinositol 3\u2032-kinase and phospholipase Cgamma signaling pathways","volume":"14","author":"Tallquist","year":"2000","journal-title":"Genes Dev"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0555","doi-asserted-by":"crossref","first-page":"8627","DOI":"10.1074\/jbc.C100030200","article-title":"Phospholipase C-gamma1 is required for the induction of immediate early genes by platelet-derived growth factor","volume":"276","author":"Liao","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0560","first-page":"268","article-title":"The mitochondrial reactive oxygen species regulator p66Shc controls PDGF-induced signaling and migration through protein tyrosine phosphatase oxidation","volume":"68C","author":"Frijhoff","year":"2013","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0565","doi-asserted-by":"crossref","first-page":"15774","DOI":"10.1073\/pnas.1007909107","article-title":"12\/15-lipoxygenase-derived lipid peroxides control receptor tyrosine kinase signaling through oxidation of protein tyrosine phosphatases","volume":"107","author":"Conrad","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0570","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/nature03587","article-title":"Regulation of PDGF signalling and vascular remodelling by peroxiredoxin II","volume":"435","author":"Choi","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0575","doi-asserted-by":"crossref","first-page":"13398","DOI":"10.1073\/pnas.1302891110","article-title":"Selective activation of oxidized PTP1B by the thioredoxin system modulates PDGF-\u03b2 receptor tyrosine kinase signaling","volume":"110","author":"Dagnell","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0580","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/sj.onc.1201555","article-title":"Activation of Stat5 by platelet-derived growth factor (PDGF) is dependent on phosphorylation sites in PDGF beta-receptor juxtamembrane and kinase insert domains","volume":"16","author":"Valgeirsdottir","year":"1998","journal-title":"Oncogene"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0585","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1042\/0264-6021:3450759","article-title":"Platelet-derived growth factor (PDGF)-induced activation of signal transducer and activator of transcription (Stat) 5 is mediated by PDGF beta-receptor and is not dependent on c-src, fyn, jak1 or jak2 kinases","volume":"345","author":"Paukku","year":"2000","journal-title":"Biochem J"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0590","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1128\/MCB.16.4.1759","article-title":"Platelet-derived growth factor induces phosphorylation of multiple JAK family kinases and STAT proteins","volume":"16","author":"Vignais","year":"1996","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0595","doi-asserted-by":"crossref","first-page":"7294","DOI":"10.1038\/sj.onc.1203148","article-title":"Consequences of Stat6 deletion on Sis\/PDGF- and IL-4-induced proliferation and transcriptional activation in murine fibroblasts","volume":"18","author":"Kriebel","year":"1999","journal-title":"Oncogene"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0600","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.3324\/haematol.2011.040147","article-title":"Multiple oligomerization domains of KANK1-PDGFRB are required for JAK2-independent hematopoietic cell proliferation and signaling via STAT5 and ERK","volume":"96","author":"Medves","year":"2011","journal-title":"Haematologica"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0605","doi-asserted-by":"crossref","first-page":"4710","DOI":"10.1128\/MCB.16.9.4710","article-title":"A single tyrosine of the interleukin-9 (IL-9) receptor is required for STAT activation, antiapoptotic activity, and growth regulation by IL-9","volume":"16","author":"Demoulin","year":"1996","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0610","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1038\/sj.onc.1203548","article-title":"Activation of Stat3 preassembled with platelet-derived growth factor beta receptors requires Src kinase activity","volume":"19","author":"Wang","year":"2000","journal-title":"Oncogene"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0615","doi-asserted-by":"crossref","first-page":"3385","DOI":"10.3748\/wjg.v11.i22.3385","article-title":"Activation of JAK-STAT pathway is required for platelet-derived growth factor-induced proliferation of pancreatic stellate cells","volume":"11","author":"Masamune","year":"2005","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0620","doi-asserted-by":"crossref","first-page":"46122","DOI":"10.1074\/jbc.M406922200","article-title":"An essential role of the Jak-2\/STAT-3\/cytosolic phospholipase A(2) axis in platelet-derived growth factor BB-induced vascular smooth muscle cell motility","volume":"279","author":"Neeli","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0625","doi-asserted-by":"crossref","first-page":"3727","DOI":"10.1128\/MCB.19.5.3727","article-title":"Distinct mechanisms of activation of Stat1 and Stat3 by platelet-derived growth factor receptor in a cell-free system","volume":"19","author":"Vignais","year":"1999","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0630","doi-asserted-by":"crossref","first-page":"9986","DOI":"10.1074\/jbc.M211276200","article-title":"Cytosolic phospholipase A2 is an effector of Jak\/STAT signaling and is involved in platelet-derived growth factor BB-induced growth in vascular smooth muscle cells","volume":"278","author":"Yellaturu","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0635","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/S0092-8674(00)81288-X","article-title":"Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway","volume":"84","author":"Meraz","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0640","doi-asserted-by":"crossref","first-page":"25855","DOI":"10.1074\/jbc.274.36.25855","article-title":"Distinct roles for STAT1, STAT3, and STAT5 in differentiation gene induction and apoptosis inhibition by interleukin-9","volume":"274","author":"Demoulin","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0645","doi-asserted-by":"crossref","first-page":"e120","DOI":"10.1093\/nar\/gkq149","article-title":"Transcription factor regulation can be accurately predicted from the presence of target gene signatures in microarray gene expression data","volume":"38","author":"Essaghir","year":"2010","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0650","doi-asserted-by":"crossref","first-page":"2514","DOI":"10.1091\/mbc.E09-04-0344","article-title":"The interferon-gamma-induced murine guanylate-binding protein-2 inhibits rac activation during cell spreading on fibronectin and after platelet-derived growth factor treatment: role for phosphatidylinositol 3-kinase","volume":"21","author":"Messmer-Blust","year":"2010","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0655","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/emboj\/19.2.263","article-title":"Regulation of c-myc expression by IFN-gamma through Stat1-dependent and -independent pathways","volume":"19","author":"Ramana","year":"2000","journal-title":"EMBO J"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0660","doi-asserted-by":"crossref","first-page":"2576","DOI":"10.1101\/gad.224089.113","article-title":"Ephrin-B2 controls PDGFRbeta internalization and signaling","volume":"27","author":"Nakayama","year":"2013","journal-title":"Genes Dev"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0665","doi-asserted-by":"crossref","first-page":"14308","DOI":"10.1074\/jbc.M109.046672","article-title":"Low density lipoprotein receptor-related protein 1 (LRP1) forms a signaling complex with platelet-derived growth factor receptor-beta in endosomes and regulates activation of the MAPK pathway","volume":"285","author":"Muratoglu","year":"2010","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0670","doi-asserted-by":"crossref","first-page":"39152","DOI":"10.1074\/jbc.M608489200","article-title":"Alix facilitates the interaction between c-Cbl and platelet-derived growth factor beta-receptor and thereby modulates receptor down-regulation","volume":"281","author":"Lennartsson","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0675","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1126\/science.286.5438.309","article-title":"The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase","volume":"286","author":"Joazeiro","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0680","doi-asserted-by":"crossref","first-page":"8038","DOI":"10.1074\/jbc.M311494200","article-title":"Platelet-derived growth factor receptor-mediated signal transduction from endosomes","volume":"279","author":"Wang","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0685","doi-asserted-by":"crossref","first-page":"4508","DOI":"10.1128\/MCB.00015-09","article-title":"Cell migration is regulated by platelet-derived growth factor receptor endocytosis","volume":"29","author":"Kawada","year":"2009","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0690","doi-asserted-by":"crossref","first-page":"ra45","DOI":"10.1126\/scisignal.2004015","article-title":"AKT facilitates EGFR trafficking and degradation by phosphorylating and activating PIKfyve","volume":"6","author":"Er","year":"2013","journal-title":"Sci Signal"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0695","doi-asserted-by":"crossref","first-page":"2856","DOI":"10.1091\/mbc.E08-12-1228","article-title":"Activation of protein kinase C alpha is necessary for sorting the PDGF beta-receptor to Rab4a-dependent recycling","volume":"20","author":"Hellberg","year":"2009","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0700","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.3324\/haematol.2008.001149","article-title":"The fusion proteins TEL-PDGFRbeta and FIP1L1-PDGFRalpha escape ubiquitination and degradation","volume":"94","author":"Toffalini","year":"2009","journal-title":"Haematologica"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0705","doi-asserted-by":"crossref","first-page":"12268","DOI":"10.1074\/jbc.M109.076638","article-title":"Critical role of the platelet-derived growth factor receptor (PDGFR)-beta transmembrane domain in the TEL-PDGFRbeta cytosolic oncoprotein","volume":"285","author":"Toffalini","year":"2010","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0710","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1038\/sj.onc.1206160","article-title":"A human brain tumor-derived PDGFR-alpha deletion mutant is transforming","volume":"22","author":"Clarke","year":"2003","journal-title":"Oncogene"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0715","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1038\/nrd4204","article-title":"PI3K and cancer: lessons, challenges and opportunities","volume":"13","author":"Fruman","year":"2014","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0720","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.humpath.2007.06.009","volume":"39","author":"Patel","year":"2008","journal-title":"Hum Pathol"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0725","article-title":"Neo-adjuvant imatinib in advanced primary or locally recurrent dermatofibrosarcoma protuberans: a multicenter phase-II DeCOG trial with long-term follow-up","author":"Ugurel","year":"2013","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0730","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1182\/blood-2006-05-024828","article-title":"Durable responses to imatinib in patients with PDGFRB fusion gene-positive and BCR-ABL-negative chronic myeloproliferative disorders","volume":"109","author":"David","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0735","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1111\/j.1365-2141.2008.07294.x","article-title":"Safety and efficacy of imatinib in chronic eosinophilic leukaemia and hypereosinophilic syndrome: a phase-II study","volume":"143","author":"Metzgeroth","year":"2008","journal-title":"Br J Haematol"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0740","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1038\/leu.2010.13","article-title":"KANK1, a candidate tumor suppressor gene, is fused to PDGFRB in an imatinib-responsive myeloid neoplasm with severe thrombocythemia","volume":"24","author":"Medves","year":"2010","journal-title":"Leukemia"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0745","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1007\/s00432-013-1529-7","article-title":"Effect of the tyrosine kinase inhibitor nilotinib in patients with hypereosinophilic syndrome\/chronic eosinophilic leukemia: analysis of the phase 2, open-label, single-arm A2101 study","volume":"139","author":"Hochhaus","year":"2013","journal-title":"J Cancer Res Clin Oncol"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0750","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.1182\/blood-2010-05-286757","article-title":"Novel imatinib-sensitive PDGFRA-activating point mutations in hypereosinophilic syndrome induce growth factor independence and leukemia-like disease","volume":"117","author":"Elling","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0755","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1182\/blood-2013-05-504340","article-title":"Mutation of NRAS but not KRAS significantly reduces myeloma sensitivity to single-agent bortezomib therapy","volume":"123","author":"Mulligan","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0760","doi-asserted-by":"crossref","first-page":"5357","DOI":"10.1200\/JCO.2005.14.068","article-title":"PDGFRA mutations in gastrointestinal stromal tumors: frequency, spectrum and in vitro sensitivity to imatinib","volume":"23","author":"Corless","year":"2005","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0765","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1053\/j.gastro.2003.10.079","article-title":"PDGFRA germline mutation in a family with multiple cases of gastrointestinal stromal tumor","volume":"126","author":"Chompret","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0770","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1365-2559.2012.04203.x","article-title":"Activating PDGFRA mutations in inflammatory fibroid polyps occur in exons 12, 14 and 18 and are associated with tumour localization","volume":"61","author":"Huss","year":"2012","journal-title":"Histopathology"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0775","doi-asserted-by":"crossref","first-page":"6935","DOI":"10.1158\/1078-0432.CCR-13-1266","article-title":"Large-scale analysis of PDGFRA mutations in melanomas and evaluation of their sensitivity to tyrosine kinase inhibitors imatinib and crenolanib","volume":"19","author":"Dai","year":"2013","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0780","doi-asserted-by":"crossref","first-page":"6219","DOI":"10.1158\/0008-5472.CAN-13-1491","article-title":"Novel oncogenic PDGFRA mutations in pediatric high-grade gliomas","volume":"73","author":"Paugh","year":"2013","journal-title":"Cancer Res"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0785","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.ccr.2009.12.020","article-title":"Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1","volume":"17","author":"Verhaak","year":"2010","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0790","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1101\/gad.1972310","article-title":"PDGFRA gene rearrangements are frequent genetic events in PDGFRA-amplified glioblastomas","volume":"24","author":"Ozawa","year":"2010","journal-title":"Genes Dev"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0795","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/j.ajhg.2013.04.024","article-title":"Mutations in PDGFRB cause autosomal-dominant infantile myofibromatosis","volume":"92","author":"Martignetti","year":"2013","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.cytogfr.2014.03.003_bib0800","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1016\/j.ajhg.2013.04.026","article-title":"A recurrent PDGFRB mutation causes familial infantile myofibromatosis","volume":"92","author":"Cheung","year":"2013","journal-title":"Am J Hum Genet"}],"container-title":["Cytokine & Growth Factor Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1359610114000239?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1359610114000239?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T19:43:50Z","timestamp":1648669430000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1359610114000239"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6]]},"references-count":160,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["S1359610114000239"],"URL":"https:\/\/doi.org\/10.1016\/j.cytogfr.2014.03.003","relation":{},"ISSN":["1359-6101"],"issn-type":[{"value":"1359-6101","type":"print"}],"subject":[],"published":{"date-parts":[[2014,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"PDGF receptor signaling networks in normal and cancer cells","name":"articletitle","label":"Article Title"},{"value":"Cytokine & Growth Factor Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cytogfr.2014.03.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}