{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T01:55:17Z","timestamp":1783994117150,"version":"3.55.0"},"reference-count":103,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytokine & Growth Factor Reviews"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1016\/j.cytogfr.2018.03.010","type":"journal-article","created":{"date-parts":[[2018,4,6]],"date-time":"2018-04-06T00:14:22Z","timestamp":1522973662000},"page":"90-98","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Deciphering natural control of HIV-1: A valuable strategy to achieve antiretroviral therapy termination"],"prefix":"10.1016","volume":"40","author":[{"given":"Hamza","family":"Loucif","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Gouard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Dagenais-Lussier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armstrong","family":"Murira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"St\u00e4ger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Tremblay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Van Grevenynghe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.cytogfr.2018.03.010_bib0005","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1038\/nrmicro3132","article-title":"Past, present and future: 30 years of HIV research","volume":"11","author":"Barre-Sinoussi","year":"2013","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.cytogfr.2018.03.010_bib0010","doi-asserted-by":"crossref","first-page":"759","DOI":"10.12688\/f1000research.11164.1","article-title":"Novel approaches to HIV therapy","volume":"6","author":"Daar","year":"2017","journal-title":"F1000Research"},{"issue":"11","key":"10.1016\/j.cytogfr.2018.03.010_bib0015","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1080\/17425247.2017.1288212","article-title":"Long-acting slow effective release antiretroviral therapy","volume":"14","author":"Edagwa","year":"2017","journal-title":"Expert Opin. Drug Deliv."},{"issue":"5","key":"10.1016\/j.cytogfr.2018.03.010_bib0020","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1007\/s13346-016-0293-z","article-title":"Nano-ART and NeuroAIDS","volume":"6","author":"Das","year":"2016","journal-title":"Drug Deliv. Transl. Res."},{"issue":"1","key":"10.1016\/j.cytogfr.2018.03.010_bib0025","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s11481-016-9716-3","article-title":"Nanoformulated antiretrovirals for penetration of the Central nervous system: State of the art","volume":"12","author":"Fiandra","year":"2017","journal-title":"J. Neuroimmune Pharmacol."},{"issue":"1","key":"10.1016\/j.cytogfr.2018.03.010_bib0030","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/s41467-017-02294-6","article-title":"Development of an oral once-weekly drug delivery system for HIV antiretroviral therapy","volume":"9","author":"Kirtane","year":"2018","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.cytogfr.2018.03.010_bib0035","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1097\/COH.0000000000000228","article-title":"Immune activation during acute HIV infection and the impact of early antiretroviral therapy","volume":"11","author":"Krebs","year":"2016","journal-title":"Curr. Opin. HIV AIDS"},{"issue":"2","key":"10.1016\/j.cytogfr.2018.03.010_bib0040","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1007\/s11904-018-0387-y","article-title":"Serious non-AIDS conditions in HIV: benefit of early ART","volume":"15","author":"Lundgren","year":"2018","journal-title":"Curr. HIV\/AIDS Rep."},{"issue":"3","key":"10.1016\/j.cytogfr.2018.03.010_bib0045","doi-asserted-by":"crossref","first-page":"e1003211","DOI":"10.1371\/journal.ppat.1003211","article-title":"Post-treatment HIV-1 controllers with a long-term virological remission after the interruption of early initiated antiretroviral therapy ANRS VISCONTI study","volume":"9","author":"Saez-Cirion","year":"2013","journal-title":"PLoS Pathog."},{"issue":"3","key":"10.1016\/j.cytogfr.2018.03.010_bib0050","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1056\/NEJMoa1110039","article-title":"Short-course antiretroviral therapy in primary HIV infection","volume":"368","author":"Investigators","year":"2013","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"10.1016\/j.cytogfr.2018.03.010_bib0055","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1097\/COH.0000000000000127","article-title":"Very early combination antiretroviral therapy in infants: prospects for cure","volume":"10","author":"Rainwater-Lovett","year":"2015","journal-title":"Curr. Opin. HIV AIDS"},{"issue":"17","key":"10.1016\/j.cytogfr.2018.03.010_bib0060","doi-asserted-by":"crossref","first-page":"5467","DOI":"10.1073\/pnas.1419162112","article-title":"Post-treatment control of HIV infection","volume":"112","author":"Conway","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"12","key":"10.1016\/j.cytogfr.2018.03.010_bib0065","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1038\/nm1511","article-title":"Microbial translocation is a cause of systemic immune activation in chronic HIV infection","volume":"12","author":"Brenchley","year":"2006","journal-title":"Nat. Med."},{"issue":"2","key":"10.1016\/j.cytogfr.2018.03.010_bib0070","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1093\/cid\/civ809","article-title":"Early initiation rather than prolonged duration of antiretroviral therapy in HIV infection contributes to the normalization of CD8 T-cell counts","volume":"62","author":"Cao","year":"2016","journal-title":"Clin. Infect. Dis."},{"issue":"17","key":"10.1016\/j.cytogfr.2018.03.010_bib0075","doi-asserted-by":"crossref","first-page":"7967","DOI":"10.1128\/JVI.00994-16","article-title":"Kynurenine reduces memory CD4 T-cell survival by interfering with interleukin-2 signaling early during HIV-1 infection","volume":"90","author":"Dagenais-Lussier","year":"2016","journal-title":"J. Virol."},{"issue":"1","key":"10.1016\/j.cytogfr.2018.03.010_bib0080","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1186\/s12879-017-2456-z","article-title":"Tryptophan catabolism and immune activation in primary and chronic HIV infection","volume":"17","author":"Gelpi","year":"2017","journal-title":"BMC Infect. Dis."},{"issue":"10","key":"10.1016\/j.cytogfr.2018.03.010_bib0085","doi-asserted-by":"crossref","first-page":"e78146","DOI":"10.1371\/journal.pone.0078146","article-title":"Distinct tryptophan catabolism and Th17\/Treg balance in HIV progressors and elite controllers","volume":"8","author":"Jenabian","year":"2013","journal-title":"PLoS One"},{"issue":"17","key":"10.1016\/j.cytogfr.2018.03.010_bib0090","doi-asserted-by":"crossref","first-page":"2643","DOI":"10.1097\/00002030-200012010-00003","article-title":"Rapid restoration of CD4 T cell subsets in subjects receiving antiretroviral therapy during primary HIV-1 infection","volume":"14","author":"Kaufmann","year":"2000","journal-title":"Aids"},{"issue":"19","key":"10.1016\/j.cytogfr.2018.03.010_bib0095","doi-asserted-by":"crossref","first-page":"7939","DOI":"10.1073\/pnas.0901702106","article-title":"Timing of HAART defines the integrity of memory B cells and the longevity of humoral responses in HIV-1 vertically-infected children","volume":"106","author":"Pensieroso","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"10","key":"10.1016\/j.cytogfr.2018.03.010_bib0100","doi-asserted-by":"crossref","first-page":"e0140435","DOI":"10.1371\/journal.pone.0140435","article-title":"Beneficial effects of cART initiated during primary and chronic HIV-1 infection on immunoglobulin-expression of memory B-cell subsets","volume":"10","author":"Pogliaghi","year":"2015","journal-title":"PLoS One"},{"issue":"12","key":"10.1016\/j.cytogfr.2018.03.010_bib0105","doi-asserted-by":"crossref","first-page":"e1004543","DOI":"10.1371\/journal.ppat.1004543","article-title":"Initiation of ART during early acute HIV infection preserves mucosal Th17 function and reverses HIV-related immune activation","volume":"10","author":"Schuetz","year":"2014","journal-title":"PLoS Pathog."},{"issue":"8","key":"10.1016\/j.cytogfr.2018.03.010_bib0110","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1093\/infdis\/jit311","article-title":"Antiretroviral therapy initiated within 6 months of HIV infection is associated with lower T-cell activation and smaller HIV reservoir size","volume":"208","author":"Jain","year":"2013","journal-title":"J. Infect. Dis."},{"issue":"2","key":"10.1016\/j.cytogfr.2018.03.010_bib0115","doi-asserted-by":"crossref","DOI":"10.1002\/rmv.1924","article-title":"Mechanisms of HIV persistence in HIV reservoirs","volume":"27","author":"Mzingwane","year":"2017","journal-title":"Rev. Med. Virol."},{"issue":"17","key":"10.1016\/j.cytogfr.2018.03.010_bib0120","doi-asserted-by":"crossref","first-page":"10056","DOI":"10.1128\/JVI.01046-14","article-title":"Long-term antiretroviral treatment initiated at primary HIV-1 infection affects the size, composition, and decay kinetics of the reservoir of HIV-1-infected CD4 T cells","volume":"88","author":"Buzon","year":"2014","journal-title":"J. Virol."},{"issue":"8","key":"10.1016\/j.cytogfr.2018.03.010_bib0125","doi-asserted-by":"crossref","first-page":"855","DOI":"10.3851\/IMP2963","article-title":"How often does treatment of primary HIV lead to post-treatment control?","volume":"20","author":"Maenza","year":"2015","journal-title":"Antivir. Ther."},{"issue":"2","key":"10.1016\/j.cytogfr.2018.03.010_bib0130","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.ramb.2012.11.003","article-title":"Lipid profile of HIV-infected patients in relation to antiretroviral therapy: a review","volume":"59","author":"Souza","year":"2013","journal-title":"Rev. Assoc. Med. Bras. (1992)"},{"issue":"1","key":"10.1016\/j.cytogfr.2018.03.010_bib0135","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jiac.2016.10.002","article-title":"Current status of HIV\/AIDS in the ART era","volume":"23","author":"Yoshimura","year":"2017","journal-title":"J. Infect. Chemother."},{"issue":"3","key":"10.1016\/j.cytogfr.2018.03.010_bib0140","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.smim.2008.07.008","article-title":"Lymph node architecture collapse and consequent modulation of FOXO3a pathway on memory T- and B-cells during HIV infection","volume":"20","author":"van Grevenynghe","year":"2008","journal-title":"Semin. Immunol."},{"issue":"15","key":"10.1016\/j.cytogfr.2018.03.010_bib0145","doi-asserted-by":"crossref","first-page":"2914","DOI":"10.1182\/blood-2012-07-445783","article-title":"Impaired T-cell responses to sphingosine-1-phosphate in HIV-1 infected lymph nodes","volume":"121","author":"Mudd","year":"2013","journal-title":"Blood"},{"issue":"Suppl. 2","key":"10.1016\/j.cytogfr.2018.03.010_bib0150","doi-asserted-by":"crossref","first-page":"S58","DOI":"10.1093\/infdis\/jiw258","article-title":"Gut mucosal barrier dysfunction, microbial dysbiosis, and their role in HIV-1 disease progression","volume":"214","author":"Mudd","year":"2016","journal-title":"J. Infect. Dis."},{"issue":"6","key":"10.1016\/j.cytogfr.2018.03.010_bib0155","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.cytogfr.2015.09.001","article-title":"Current topics in HIV-1 pathogenesis: the emergence of deregulated immuno-metabolism in HIV-infected subjects","volume":"26","author":"Dagenais-Lussier","year":"2015","journal-title":"Cytokine Growth Factor Rev."},{"issue":"1","key":"10.1016\/j.cytogfr.2018.03.010_bib0160","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s12879-017-2925-4","article-title":"Adipokines levels in HIV infected patients: lipocalin-2 and fatty acid binding protein-4 as possible markers of HIV and antiretroviral therapy-related adipose tissue inflammation","volume":"18","author":"Morieri","year":"2018","journal-title":"BMC Infect. Dis."},{"issue":"1","key":"10.1016\/j.cytogfr.2018.03.010_bib0165","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1097\/COH.0000000000000426","article-title":"Gut microbial diversity in HIV infection post combined antiretroviral therapy: a key target for prevention of cardiovascular disease","volume":"13","author":"El-Far","year":"2018","journal-title":"Curr. Opin. HIV AIDS"},{"issue":"18","key":"10.1016\/j.cytogfr.2018.03.010_bib0170","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1097\/QAD.0000000000000869","article-title":"Gut microbiota diversity predicts immune status in HIV-1 infection","volume":"29","author":"Nowak","year":"2015","journal-title":"AIDS"},{"issue":"4","key":"10.1016\/j.cytogfr.2018.03.010_bib0175","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1038\/mi.2014.107","article-title":"Altered metabolism of gut microbiota contributes to chronic immune activation in HIV-infected individuals","volume":"8","author":"Vazquez-Castellanos","year":"2015","journal-title":"Mucosal Immunol."},{"issue":"20","key":"10.1016\/j.cytogfr.2018.03.010_bib0180","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.95726","article-title":"Reevaluation of immune activation in the era of cART and an aging HIV-infected population","volume":"2","author":"de Armas","year":"2017","journal-title":"JCI Insight"},{"key":"10.1016\/j.cytogfr.2018.03.010_bib0185","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.ebiom.2017.12.003","article-title":"What Is the most important for elite control: genetic background of patient, genetic background of partner, both or neither? Description of complete natural history within a couple of MSM","volume":"27","author":"Bendenoun","year":"2018","journal-title":"EBioMedicine"},{"issue":"3","key":"10.1016\/j.cytogfr.2018.03.010_bib0190","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1097\/COH.0b013e32834589a1","article-title":"Unique features of memory T cells in HIV elite controllers: a systems biology perspective","volume":"6","author":"Fonseca","year":"2011","journal-title":"Curr. Opin. HIV AIDS"},{"issue":"2","key":"10.1016\/j.cytogfr.2018.03.010_bib0195","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1172\/JCI80563","article-title":"Hematopoietic stem cell transplantation for HIV cure","volume":"126","author":"Kuritzkes","year":"2016","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.cytogfr.2018.03.010_bib0200","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1186\/s12916-015-0517-y","article-title":"HIV-1 functional cure: will the dream come true?","volume":"13","author":"Liu","year":"2015","journal-title":"BMC Med."},{"key":"10.1016\/j.cytogfr.2018.03.010_bib0205","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.virol.2014.02.021","article-title":"HIV cure research: advances and prospects","volume":"454\u2013455","author":"Passaes","year":"2014","journal-title":"Virology"},{"key":"10.1016\/j.cytogfr.2018.03.010_bib0210","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.coviro.2016.02.001","article-title":"Which therapeutic strategy will achieve a cure for HIV-1?","volume":"18","author":"Cillo","year":"2016","journal-title":"Curr. Opin. Virol."},{"issue":"2","key":"10.1016\/j.cytogfr.2018.03.010_bib0215","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.tim.2014.11.003","article-title":"Elite control of HIV: is this the right model for a functional cure?","volume":"23","author":"Cockerham","year":"2015","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.cytogfr.2018.03.010_bib0220","doi-asserted-by":"crossref","first-page":"20497","DOI":"10.7448\/IAS.18.1.20497","article-title":"Evaluating the efficacy of therapeutic HIV vaccines through analytical treatment interruptions","volume":"18","author":"Graziani","year":"2015","journal-title":"J. Int. AIDS Soc."},{"issue":"4","key":"10.1016\/j.cytogfr.2018.03.010_bib0225","doi-asserted-by":"crossref","first-page":"407","DOI":"10.2217\/imt.13.23","article-title":"T-cell therapies for HIV","volume":"5","author":"Lam","year":"2013","journal-title":"Immunotherapy"},{"issue":"3","key":"10.1016\/j.cytogfr.2018.03.010_bib0230","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.it.2016.12.003","article-title":"HIV latency: should we shock or lock?","volume":"38","author":"Darcis","year":"2017","journal-title":"Trends Immunol."},{"issue":"1","key":"10.1016\/j.cytogfr.2018.03.010_bib0235","doi-asserted-by":"crossref","first-page":"16799","DOI":"10.1038\/s41598-017-17057-y","article-title":"Peripheral T follicular helper cells make a difference in HIV reservoir size between elite controllers and patients on successful cART","volume":"7","author":"Garcia","year":"2017","journal-title":"Sci. Rep."},{"issue":"14","key":"10.1016\/j.cytogfr.2018.03.010_bib0240","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1097\/QAD.0b013e328362692f","article-title":"Comparison of HIV DNA and RNA in gut-associated lymphoid tissue of HIV-infected controllers and noncontrollers","volume":"27","author":"Hatano","year":"2013","journal-title":"AIDS"},{"issue":"14","key":"10.1016\/j.cytogfr.2018.03.010_bib0245","doi-asserted-by":"crossref","first-page":"3799","DOI":"10.1182\/blood-2010-12-322727","article-title":"Increased HIV-specific CD8++ T-cell cytotoxic potential in HIV elite controllers is associated with T-bet expression","volume":"117","author":"Hersperger","year":"2011","journal-title":"Blood"},{"issue":"5","key":"10.1016\/j.cytogfr.2018.03.010_bib0250","doi-asserted-by":"crossref","first-page":"e1000917","DOI":"10.1371\/journal.ppat.1000917","article-title":"Perforin expression directly ex vivo by HIV-specific CD8 T-cells is a correlate of HIV elite control","volume":"6","author":"Hersperger","year":"2010","journal-title":"PLoS Pathog."},{"issue":"9","key":"10.1016\/j.cytogfr.2018.03.010_bib0255","doi-asserted-by":"crossref","first-page":"5170","DOI":"10.1128\/JVI.02379-12","article-title":"HIV-specific CD8+ T cells from elite controllers are primed for survival","volume":"87","author":"Yan","year":"2013","journal-title":"J. Virol."},{"issue":"1","key":"10.1016\/j.cytogfr.2018.03.010_bib0260","doi-asserted-by":"crossref","first-page":"e29717","DOI":"10.1371\/journal.pone.0029717","article-title":"CTL responses of high functional avidity and broad variant cross-reactivity are associated with HIV control","volume":"7","author":"Mothe","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.cytogfr.2018.03.010_bib0265","doi-asserted-by":"crossref","first-page":"746","DOI":"10.3389\/fimmu.2017.00746","article-title":"Enrichment of HLA types and single-nucleotide polymorphism associated with non-progression in a strictly defined cohort of HIV-1 controllers","volume":"8","author":"Westrop","year":"2017","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.cytogfr.2018.03.010_bib0270","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/icb.2014.68","article-title":"Protective genotypes in HIV infection reflect superior function of KIR3DS1+ over KIR3DL1+ CD8+ T cells","volume":"93","author":"Zipperlen","year":"2015","journal-title":"Immunol. Cell Biol."},{"issue":"1","key":"10.1016\/j.cytogfr.2018.03.010_bib0275","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1080\/14787210.2017.1250624","article-title":"Strategies to limit immune-activation in HIV patients","volume":"15","author":"Bandera","year":"2017","journal-title":"Expert Rev. Anti Infect. Ther."},{"issue":"3","key":"10.1016\/j.cytogfr.2018.03.010_bib0280","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1002\/iid3.160","article-title":"Probiotic supplementation promotes a reduction in T-cell activation, an increase in Th17 frequencies, and a recovery of intestinal epithelium integrity and mitochondrial morphology in ART-treated HIV-1-positive patients","volume":"5","author":"d\u2019Ettorre","year":"2017","journal-title":"Immun. Inflamm. Dis."},{"issue":"1","key":"10.1016\/j.cytogfr.2018.03.010_bib0285","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1097\/COH.0000000000000434","article-title":"The microbiome and HIV persistence: implications for viral remission and cure","volume":"13","author":"Koay","year":"2018","journal-title":"Curr. Opin. HIV AIDS"},{"key":"10.1016\/j.cytogfr.2018.03.010_bib0290","doi-asserted-by":"crossref","first-page":"22902","DOI":"10.1038\/srep22902","article-title":"Proinflammatory isoforms of IL-32 as novel and robust biomarkers for control failure in HIV-infected slow progressors","volume":"6","author":"El-Far","year":"2016","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.cytogfr.2018.03.010_bib0295","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.01805-17","article-title":"Factors leading to the loss of natural elite control of HIV-1 infection","volume":"92","author":"Pernas","year":"2018","journal-title":"J. Virol."},{"issue":"11","key":"10.1016\/j.cytogfr.2018.03.010_bib0300","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1093\/infdis\/jiu809","article-title":"Hospitalization rates and reasons among HIV elite controllers and persons with medically controlled HIV infection","volume":"211","author":"Crowell","year":"2015","journal-title":"J. Infect. Dis."},{"issue":"6","key":"10.1016\/j.cytogfr.2018.03.010_bib0305","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1093\/infdis\/jit581","article-title":"Evidence for innate immune system activation in HIV type 1-infected elite controllers","volume":"209","author":"Krishnan","year":"2014","journal-title":"J. Infect. Dis."},{"issue":"1","key":"10.1016\/j.cytogfr.2018.03.010_bib0310","doi-asserted-by":"crossref","first-page":"ofu117","DOI":"10.1093\/ofid\/ofu117","article-title":"Differential levels of soluble inflammatory markers by human immunodeficiency virus controller status and demographics","volume":"2","author":"Li","year":"2015","journal-title":"Open Forum Infect. Dis."},{"issue":"18","key":"10.1016\/j.cytogfr.2018.03.010_bib0315","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1097\/QAD.0b013e32835a9950","article-title":"Increased coronary atherosclerosis and immune activation in HIV-1 elite controllers","volume":"26","author":"Pereyra","year":"2012","journal-title":"AIDS"},{"issue":"5","key":"10.1016\/j.cytogfr.2018.03.010_bib0320","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1093\/cid\/ciw833","article-title":"HLA-B*57 and IFNL4-related polymorphisms are associated with protection against HIV-1 disease progression in controllers","volume":"64","author":"Dominguez-Molina","year":"2017","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.cytogfr.2018.03.010_bib0325","doi-asserted-by":"crossref","first-page":"134","DOI":"10.3389\/fimmu.2016.00134","article-title":"Suppression of HIV replication by CD8(+) regulatory T-Cells in elite controllers","volume":"7","author":"Lu","year":"2016","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.cytogfr.2018.03.010_bib0330","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1097\/QAI.0b013e318224d2e9","article-title":"Interleukin-2 production by polyfunctional HIV-1-specific CD8 T cells is associated with enhanced viral suppression","volume":"58","author":"Akinsiku","year":"2011","journal-title":"J. Acquir. Immune Defic. Syndr."},{"issue":"5","key":"10.1016\/j.cytogfr.2018.03.010_bib0335","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1097\/QAI.0b013e3182454fcd","article-title":"HIV controllers are distinguished by chemokine expression profile and HIV-specific T-cell proliferative potential","volume":"59","author":"Card","year":"2012","journal-title":"JAIDS J. Acquir. Immune Defic. Syndr."},{"issue":"12","key":"10.1016\/j.cytogfr.2018.03.010_bib0340","doi-asserted-by":"crossref","first-page":"6959","DOI":"10.1128\/JVI.00531-12","article-title":"Elite controllers with low to absent effector CD8+ T cell responses maintain highly functional, broadly directed central memory responses","volume":"86","author":"Ndhlovu","year":"2012","journal-title":"J. Virol."},{"issue":"6","key":"10.1016\/j.cytogfr.2018.03.010_bib0345","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1189\/jlb.4A0915-422R","article-title":"Elite controller CD8+ T cells exhibit comparable viral inhibition capacity, but better sustained effector properties compared to chronic progressors","volume":"100","author":"Shasha","year":"2016","journal-title":"J. Leukoc. Biol."},{"issue":"5","key":"10.1016\/j.cytogfr.2018.03.010_bib0350","doi-asserted-by":"crossref","first-page":"2316","DOI":"10.1128\/JVI.01476-10","article-title":"Interleukin-21-producing HIV-1-specific CD8 T cells are preferentially seen in elite controllers","volume":"85","author":"Williams","year":"2011","journal-title":"J. Virol."},{"key":"10.1016\/j.cytogfr.2018.03.010_bib0355","doi-asserted-by":"crossref","first-page":"40354","DOI":"10.1038\/srep40354","article-title":"Perturbed CD8(+) T cell TIGIT\/CD226\/PVR axis despite early initiation of antiretroviral treatment in HIV infected individuals","volume":"7","author":"Tauriainen","year":"2017","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.cytogfr.2018.03.010_bib0360","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/nm1728","article-title":"Transcription factor FOXO3a controls the persistence of memory CD4(+) T cells during HIV infection","volume":"14","author":"van Grevenynghe","year":"2008","journal-title":"Nat. Med."},{"issue":"24","key":"10.1016\/j.cytogfr.2018.03.010_bib0365","doi-asserted-by":"crossref","first-page":"13904","DOI":"10.1128\/JVI.01401-07","article-title":"Preserved central memory and activated effector memory CD4+ T-cell subsets in human immunodeficiency virus controllers: an ANRS EP36 study","volume":"81","author":"Potter","year":"2007","journal-title":"J. Virol."},{"issue":"1","key":"10.1016\/j.cytogfr.2018.03.010_bib0370","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1084\/jem.20061681","article-title":"Convergence of TCR and cytokine signaling leads to FOXO3a phosphorylation and drives the survival of CD4+ central memory T cells","volume":"204","author":"Riou","year":"2007","journal-title":"J. Exp. Med."},{"issue":"6","key":"10.1016\/j.cytogfr.2018.03.010_bib0375","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1172\/JCI83792","article-title":"Public T cell receptors confer high-avidity CD4 responses to HIV controllers","volume":"126","author":"Benati","year":"2016","journal-title":"J. Clin. Invest."},{"issue":"14","key":"10.1016\/j.cytogfr.2018.03.010_bib0380","doi-asserted-by":"crossref","first-page":"e00497","DOI":"10.1128\/JVI.00497-17","article-title":"Preservation of peripheral T follicular helper cell function in HIV controllers","volume":"91","author":"Buranapraditkun","year":"2017","journal-title":"J. Virol."},{"issue":"4","key":"10.1016\/j.cytogfr.2018.03.010_bib0385","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.immuni.2013.08.031","article-title":"Human circulating PD-1+CXCR3-CXCR5+ memory Tfh cells are highly functional and correlate with broadly neutralizing HIV antibody responses","volume":"39","author":"Locci","year":"2013","journal-title":"Immunity"},{"issue":"2","key":"10.1016\/j.cytogfr.2018.03.010_bib0390","doi-asserted-by":"crossref","first-page":"e89574","DOI":"10.1172\/jci.insight.89574","article-title":"Circulating CXCR5(+)CXCR3(+)PD-1(lo) Tfh-like cells in HIV-1 controllers with neutralizing antibody breadth","volume":"2","author":"Martin-Gayo","year":"2017","journal-title":"JCI Insight"},{"issue":"12","key":"10.1016\/j.cytogfr.2018.03.010_bib0395","doi-asserted-by":"crossref","first-page":"5625","DOI":"10.4049\/jimmunol.1501524","article-title":"Reversible reprogramming of circulating memory T follicular helper cell function during chronic HIV infection","volume":"195","author":"Cubas","year":"2015","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.cytogfr.2018.03.010_bib0400","doi-asserted-by":"crossref","first-page":"114","DOI":"10.4049\/jimmunol.0901967","article-title":"Dynamics and consequences of IL-21 production in HIV-infected individuals: a longitudinal and cross-sectional study","volume":"184","author":"Iannello","year":"2010","journal-title":"J. Immunol."},{"issue":"6","key":"10.1016\/j.cytogfr.2018.03.010_bib0405","doi-asserted-by":"crossref","first-page":"3015","DOI":"10.1128\/JVI.01846-10","article-title":"Transcriptional profiling of CD4 T cells identifies distinct subgroups of HIV-1 elite controllers","volume":"85","author":"Vigneault","year":"2011","journal-title":"J. Virol."},{"issue":"5","key":"10.1016\/j.cytogfr.2018.03.010_bib0410","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1182\/blood-2005-11-013383","article-title":"Loss of memory B cells impairs maintenance of long-term serologic memory during HIV-1 infection","volume":"108","author":"Titanji","year":"2006","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.cytogfr.2018.03.010_bib0415","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1093\/infdis\/jiw163","article-title":"Maintenance of hiv-specific memory B-cell responses in elite controllers despite low viral burdens","volume":"214","author":"Buckner","year":"2016","journal-title":"J. Infect. Dis."},{"issue":"10","key":"10.1016\/j.cytogfr.2018.03.010_bib0420","doi-asserted-by":"crossref","first-page":"3877","DOI":"10.1172\/JCI59211","article-title":"Loss of memory B cells during chronic HIV infection is driven by Foxo3a- and TRAIL-mediated apoptosis","volume":"121","author":"van Grevenynghe","year":"2011","journal-title":"J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.cytogfr.2018.03.010_bib0425","doi-asserted-by":"crossref","first-page":"e1005315","DOI":"10.1371\/journal.ppat.1005315","article-title":"Polyfunctional HIV-specific antibody responses are associated with spontaneous HIV control","volume":"12","author":"Ackerman","year":"2016","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.cytogfr.2018.03.010_bib0430","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.ebiom.2017.05.029","article-title":"HIV-specific B cell frequency correlates with neutralization breadth in patients naturally controlling HIV-infection","volume":"21","author":"Rouers","year":"2017","journal-title":"EBioMedicine"},{"issue":"1","key":"10.1016\/j.cytogfr.2018.03.010_bib0435","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1189\/jlb.0913514","article-title":"Activation of NK cells is associated with HIV-1 disease progression","volume":"96","author":"Kuri-Cervantes","year":"2014","journal-title":"J. Leukoc. Biol."},{"issue":"1","key":"10.1016\/j.cytogfr.2018.03.010_bib0440","doi-asserted-by":"crossref","first-page":"e1003867","DOI":"10.1371\/journal.ppat.1003867","article-title":"HIV protective KIR3DL1\/S1-HLA-B genotypes influence NK cell-mediated inhibition of HIV replication in autologous CD4 targets","volume":"10","author":"Song","year":"2014","journal-title":"PLoS Pathog."},{"issue":"15","key":"10.1016\/j.cytogfr.2018.03.010_bib0445","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1097\/QAD.0b013e32835861b0","article-title":"Impact of protective killer inhibitory receptor\/human leukocyte antigen genotypes on natural killer cell and T-cell function in HIV-1-infected controllers","volume":"26","author":"Tomescu","year":"2012","journal-title":"AIDS"},{"issue":"8","key":"10.1016\/j.cytogfr.2018.03.010_bib0450","doi-asserted-by":"crossref","first-page":"4245","DOI":"10.1128\/JVI.07114-11","article-title":"Plasmacytoid dendritic cells reduce HIV production in elite controllers","volume":"86","author":"Machmach","year":"2012","journal-title":"J. Virol."},{"key":"10.1016\/j.cytogfr.2018.03.010_bib0455","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cytogfr.2016.01.001","article-title":"Current topics in HIV pathogenesis, part 2: inflammation drives a Warburg-like effect on the metabolism of HIV-infected subjects","volume":"28","author":"Aounallah","year":"2016","journal-title":"Cytokine Growth Factor Rev."},{"issue":"1","key":"10.1016\/j.cytogfr.2018.03.010_bib0460","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s12981-017-0164-9","article-title":"Potential contribution of gut microbiota and systemic inflammation on HIV vaccine effectiveness and vaccine design","volume":"14","author":"Routy","year":"2017","journal-title":"AIDS Res. Ther."},{"issue":"1","key":"10.1016\/j.cytogfr.2018.03.010_bib0465","doi-asserted-by":"crossref","first-page":"6269","DOI":"10.1038\/s41598-017-06675-1","article-title":"Richer gut microbiota with distinct metabolic profile in HIV infected elite controllers","volume":"7","author":"Vesterbacka","year":"2017","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.cytogfr.2018.03.010_bib0470","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1002\/cpt.363","article-title":"Complexities of gut microbiome dysbiosis in the context of HIV infection and antiretroviral therapy","volume":"99","author":"Li","year":"2016","journal-title":"Clin. Pharmacol. Ther."},{"issue":"193","key":"10.1016\/j.cytogfr.2018.03.010_bib0475","doi-asserted-by":"crossref","first-page":"193ra","DOI":"10.1126\/scitranslmed.3006438","article-title":"Dysbiosis of the gut microbiota is associated with HIV disease progression and tryptophan catabolism","volume":"5","author":"Vujkovic-Cvijin","year":"2013","journal-title":"Sci. Transl. Med."},{"issue":"7","key":"10.1016\/j.cytogfr.2018.03.010_bib0480","doi-asserted-by":"crossref","first-page":"e100446","DOI":"10.1371\/journal.pone.0100446","article-title":"Anti-retroviral therapy decreases but does not normalize indoleamine 2,3-dioxygenase activity in HIV-infected patients","volume":"9","author":"Chen","year":"2014","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.cytogfr.2018.03.010_bib0485","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1006\/clim.2002.5231","article-title":"Effective antiretroviral therapy reduces degradation of tryptophan in patients with HIV-1 infection","volume":"104","author":"Zangerle","year":"2002","journal-title":"Clin. Immunol."},{"issue":"1","key":"10.1016\/j.cytogfr.2018.03.010_bib0490","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1128\/CMR.00050-12","article-title":"Microbial translocation in the pathogenesis of HIV infection and AIDS","volume":"26","author":"Marchetti","year":"2013","journal-title":"Clin. Microbiol. Rev."},{"issue":"5","key":"10.1016\/j.cytogfr.2018.03.010_bib0495","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1097\/QAI.0000000000000359","article-title":"Antiretroviral therapy in HIV-infected elite controllers: impact on gut immunology, microbial translocation, and biomarkers of serious non-AIDS conditions","volume":"67","author":"Kim","year":"2014","journal-title":"J. Acquir. Immune Defic. Syndr."},{"issue":"28","key":"10.1016\/j.cytogfr.2018.03.010_bib0500","doi-asserted-by":"crossref","first-page":"9860","DOI":"10.1073\/pnas.0503463102","article-title":"Gut mucosal T cell responses and gene expression correlate with protection against disease in long-term HIV-1-infected nonprogressors","volume":"102","author":"Sankaran","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.cytogfr.2018.03.010_bib0505","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/mi.2016.34","article-title":"Bacteroides are associated with GALT iNKT cell function and reduction of microbial translocation in HIV-1 infection","volume":"10","author":"Paquin-Proulx","year":"2017","journal-title":"Mucosal Immunol."},{"issue":"7","key":"10.1016\/j.cytogfr.2018.03.010_bib0510","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.4161\/auto.28678","article-title":"Autophagy plays an important role in the containment of HIV-1 in nonprogressor-infected patients","volume":"10","author":"Nardacci","year":"2014","journal-title":"Autophagy"},{"issue":"5","key":"10.1016\/j.cytogfr.2018.03.010_bib0515","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1111\/joim.12596","article-title":"Role of autophagy in HIV infection and pathogenesis","volume":"281","author":"Nardacci","year":"2017","journal-title":"J. Intern. Med."}],"container-title":["Cytokine & Growth Factor Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1359610118300418?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1359610118300418?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T13:11:21Z","timestamp":1751548281000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1359610118300418"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":103,"alternative-id":["S1359610118300418"],"URL":"https:\/\/doi.org\/10.1016\/j.cytogfr.2018.03.010","relation":{},"ISSN":["1359-6101"],"issn-type":[{"value":"1359-6101","type":"print"}],"subject":[],"published":{"date-parts":[[2018,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Deciphering natural control of HIV-1: A valuable strategy to achieve antiretroviral therapy termination","name":"articletitle","label":"Article Title"},{"value":"Cytokine & Growth Factor Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cytogfr.2018.03.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Crown Copyright \u00a9 2018 Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}