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Exp. Med."},{"issue":"9","key":"10.1016\/j.cytogfr.2018.10.002_bib0375","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1084\/jem.187.9.1463","article-title":"Production of mice deficient in genes for interleukin (IL)-1alpha, IL-1beta, IL-1alpha\/beta, and IL-1 receptor antagonist shows that IL-1beta is crucial in turpentine-induced fever development and glucocorticoid secretion","volume":"187","author":"Horai","year":"1998","journal-title":"J. Exp. Med."},{"issue":"1","key":"10.1016\/j.cytogfr.2018.10.002_bib0380","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1210\/en.2006-0692","article-title":"Interleukin-1beta-induced insulin resistance in adipocytes through down-regulation of insulin receptor substrate-1 expression","volume":"148","author":"Jager","year":"2007","journal-title":"Endocrinology"},{"issue":"27","key":"10.1016\/j.cytogfr.2018.10.002_bib0385","doi-asserted-by":"crossref","first-page":"3493","DOI":"10.1038\/onc.2014.286","article-title":"Th17-type cytokines, IL-6 and TNF-alpha synergistically activate STAT3 and NF-kB to promote colorectal cancer cell growth","volume":"34","author":"De Simone","year":"2015","journal-title":"Oncogene"},{"key":"10.1016\/j.cytogfr.2018.10.002_bib0390","doi-asserted-by":"crossref","first-page":"385352","DOI":"10.1155\/2014\/385352","article-title":"TNFalpha promotes Th17 cell differentiation through IL-6 and IL-1beta produced by monocytes in rheumatoid arthritis","volume":"2014","author":"Zheng","year":"2014","journal-title":"J. Immunol. Res."},{"issue":"4","key":"10.1016\/j.cytogfr.2018.10.002_bib0395","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.immuni.2009.02.007","article-title":"Critical regulation of early Th17 cell differentiation by interleukin-1 signaling","volume":"30","author":"Chung","year":"2009","journal-title":"Immunity"},{"issue":"1","key":"10.1016\/j.cytogfr.2018.10.002_bib0400","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.immuni.2009.12.003","article-title":"The receptor SIGIRR suppresses Th17 cell proliferation via inhibition of the interleukin-1 receptor pathway and mTOR kinase activation","volume":"32","author":"Gulen","year":"2010","journal-title":"Immunity"},{"issue":"3","key":"10.1016\/j.cytogfr.2018.10.002_bib0405","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1182\/blood-2009-08-236521","article-title":"Regulating human Th17 cells via differential expression of IL-1 receptor","volume":"115","author":"Lee","year":"2010","journal-title":"Blood"},{"issue":"32","key":"10.1016\/j.cytogfr.2018.10.002_bib0410","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.0906988106","article-title":"IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells","volume":"106","author":"Guo","year":"2009","journal-title":"PNAS"},{"issue":"9","key":"10.1016\/j.cytogfr.2018.10.002_bib0415","doi-asserted-by":"crossref","first-page":"4835","DOI":"10.4049\/jimmunol.1102048","article-title":"IL-1alpha and IL-1beta recruit different myeloid cells and promote different stages of sterile inflammation","volume":"187","author":"Rider","year":"2011","journal-title":"J. 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Chem."},{"issue":"3","key":"10.1016\/j.cytogfr.2018.10.002_bib0440","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s00011-009-8090-5","article-title":"Telopeptides of type II collagen upregulate proteinases and damage cartilage but are less effective than highly active fibronectin fragments","volume":"58","author":"Guo","year":"2009","journal-title":"Inflammation Res."},{"issue":"7","key":"10.1016\/j.cytogfr.2018.10.002_bib0445","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.joca.2006.01.008","article-title":"Activation by IL-1 of bovine articular chondrocytes in culture within a 3D collagen-based scaffold. An in vitro model to address the effect of compounds with therapeutic potential in osteoarthritis","volume":"14","author":"Cortial","year":"2006","journal-title":"Osteoarthr. 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Res."},{"issue":"1","key":"10.1016\/j.cytogfr.2018.10.002_bib0550","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0002-9440(10)65266-2","article-title":"Tumor necrosis factor-alpha mediates orthopedic implant osteolysis","volume":"154","author":"Merkel","year":"1999","journal-title":"Am. J. Pathol."},{"issue":"6","key":"10.1016\/j.cytogfr.2018.10.002_bib0555","doi-asserted-by":"crossref","first-page":"863","DOI":"10.2106\/00004623-199306000-00007","article-title":"Production of cytokines around loosened cemented acetabular components. Analysis with immunohistochemical techniques and in situ hybridization","volume":"75","author":"Jiranek","year":"1993","journal-title":"J. Bone Jt. Surg. Am. Vol."},{"issue":"8","key":"10.1016\/j.cytogfr.2018.10.002_bib0560","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1038\/ncb0805-758","article-title":"Ubiquitin signalling in the NF-kappaB pathway","volume":"7","author":"Chen","year":"2005","journal-title":"Nat. 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