{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T13:33:34Z","timestamp":1790688814667,"version":"4.1.0"},"reference-count":100,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,9,12]],"date-time":"2019-09-12T00:00:00Z","timestamp":1568246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"European Research Council (ERC) under the European Union\u2019s Horizon 2020 research and innovation programme","award":["681798"],"award-info":[{"award-number":["681798"]}]},{"name":"Italian Ministry of Education, Universities and Research (MIUR), Progetto FARE Ricerca in Italia"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytokine & Growth Factor Reviews"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.cytogfr.2019.09.001","type":"journal-article","created":{"date-parts":[[2019,9,13]],"date-time":"2019-09-13T19:13:20Z","timestamp":1568402000000},"page":"59-69","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":98,"special_numbering":"C","title":["Collagen and non-collagenous proteins molecular crosstalk in the pathophysiology of osteoporosis"],"prefix":"10.1016","volume":"49","author":[{"given":"Caterina","family":"Licini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Vitale-Brovarone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Mattioli-Belmonte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cytogfr.2019.09.001_bib0005","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s11914-012-0103-6","article-title":"Effects of bone matrix proteins on fracture and fragility in osteoporosis","volume":"10","author":"Sroga","year":"2012","journal-title":"Curr. Osteoporos. Rep."},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0010","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1007\/s00198-012-2228-y","article-title":"Bone mineralization: from tissue to crystal in normal and pathological contexts","volume":"24","author":"Bala","year":"2013","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0015","doi-asserted-by":"crossref","DOI":"10.1038\/bonekey.2013.215","article-title":"Coupling the activities of bone formation and resorption: a multitude of signals within the basic multicellular unit","volume":"3","author":"Sims","year":"2014","journal-title":"Bonekey Rep."},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0020","first-page":"1","article-title":"Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. Report of a WHO Study Group","volume":"843","year":"1994","journal-title":"World Health Organ. Tech. Rep. Ser."},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0025","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1007\/s00198-006-0087-0","article-title":"Reductions in degree of mineralization and enzymatic collagen cross-links and increases in glycation-induced pentosidine in the femoral neck cortex in cases of femoral neck fracture","volume":"17","author":"Saito","year":"2006","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0030","doi-asserted-by":"crossref","first-page":"e2043","DOI":"10.1097\/MD.0000000000002043","article-title":"Histomorphometric assessment of cancellous and cortical bone material distribution in the proximal humerus of normal and osteoporotic individuals: significantly reduced bone stock in the metaphyseal and subcapital regions of osteoporotic individuals","volume":"94","author":"Sprecher","year":"2015","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0035","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1016\/S0140-6736(10)60320-0","article-title":"Intracortical remodelling and porosity in the distal radius and post-mortem femurs of women: a cross-sectional study","volume":"375","author":"Zebaze","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0040","doi-asserted-by":"crossref","DOI":"10.1038\/bonekey.2013.181","article-title":"Bone composition: relationship to bone fragility and antiosteoporotic drug effects","volume":"2","author":"Boskey","year":"2013","journal-title":"Bonekey Rep."},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0045","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.jmbbm.2016.08.030","article-title":"Raman spectroscopic investigation on the molecular structure of apatite and collagen in osteoporotic cortical bone","volume":"65","author":"Pezzotti","year":"2017","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0050","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.steroids.2015.07.006","article-title":"Variance of spinal osteoporosis induced by dexamethasone and methylprednisolone and its associated mechanism","volume":"102","author":"Ren","year":"2015","journal-title":"Steroids"},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0055","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1007\/s11914-008-0013-9","article-title":"The cell biology of parathyroid hormone in osteoblasts","volume":"6","author":"Kousteni","year":"2008","journal-title":"Curr. Osteoporos. Rep."},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0060","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1210\/jcem-60-3-615","article-title":"Short-term 1,25-dihydroxyvitamn D3 administration raises serum osteocalcin in patients with postmenopausal osteoporosis","volume":"60","author":"Zerwekh","year":"1985","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0065","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1007\/BF03324733","article-title":"Long-term 1,25(OH)2 vitamin D therapy increases bone mineral density in osteopenic women. Comparison with the effect of plain vitamin D","volume":"19","author":"Zofkova","year":"2007","journal-title":"Aging Clin. Exp. Res."},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0070","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1056\/NEJM197907053010104","article-title":"The biosynthesis of collagen and its disorders (first of two parts)","volume":"301","author":"Prockop","year":"1979","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0075","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.matbio.2016.01.001","article-title":"Enzymatic and non-enzymatic functions of the lysyl oxidase family in bone","volume":"52\u201354","author":"Trackman","year":"2016","journal-title":"Matrix Biol."},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0080","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1007\/s00223-015-9985-5","article-title":"Effects of collagen crosslinking on bone material properties in health and disease","volume":"97","author":"Saito","year":"2015","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0085","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/S0736-0266(01)00047-X","article-title":"The role of collagen in determining bone mechanical properties","volume":"19","author":"Wang","year":"2001","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0090","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/S8756-3282(96)00283-9","article-title":"Reduced concentration of collagen reducible cross links in human trabecular bone with respect to age and osteoporosis","volume":"19","author":"Oxlund","year":"1996","journal-title":"Bone"},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0095","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s00198-010-1501-1","article-title":"IOF-IFCC Bone Marker Standards Working Group, Markers of bone turnover for the prediction of fracture risk and monitoring of osteoporosis treatment: a need for international reference standards","volume":"22","author":"Vasikaran","year":"2011","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0100","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.bone.2011.04.009","article-title":"In situ accumulation of advanced glycation endproducts (AGEs) in bone matrix and its correlation with osteoclastic bone resorption","volume":"49","author":"Dong","year":"2011","journal-title":"Bone"},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0105","doi-asserted-by":"crossref","first-page":"17474","DOI":"10.1073\/pnas.1414126111","article-title":"Structural basis of collagen fiber degradation by cathepsin K","volume":"111","author":"Aguda","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0110","doi-asserted-by":"crossref","DOI":"10.2147\/MNM.S92187","article-title":"Matrix metalloproteinases in bone development and pathology: current knowledge and potential clinical utility","author":"Liang","year":"2016","journal-title":"Metalloproteinases Med."},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0115","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1080\/13813450701602523","article-title":"Advanced glycation endproducts influence the mRNA expression of RAGE, RANKL and various osteoblastic genes in human osteoblasts","volume":"113","author":"Franke","year":"2007","journal-title":"Arch. Physiol. Biochem."},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0120","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/j.bbrc.2005.12.107","article-title":"Disordered osteoclast formation in RAGE-deficient mouse establishes an essential role for RAGE in diabetes related bone loss","volume":"340","author":"Ding","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0125","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.matbio.2008.11.003","article-title":"Decorin modulates collagen matrix assembly and mineralization","volume":"28","author":"Mochida","year":"2009","journal-title":"Matrix Biol."},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0130","doi-asserted-by":"crossref","first-page":"2728","DOI":"10.1016\/S0021-9258(18)89422-4","article-title":"Isolation and characterization of native adult osteonectin","volume":"260","author":"Romberg","year":"1985","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0135","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.bbrc.2012.02.024","article-title":"Post-translational modification of osteopontin: effects on in vitro hydroxyapatite formation and growth","volume":"419","author":"Boskey","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0140","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.matbio.2008.06.004","article-title":"Bone sialoprotein-collagen interaction promotes hydroxyapatite nucleation","volume":"27","author":"Baht","year":"2008","journal-title":"Matrix Biol."},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0145","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1096\/fasebj.13.15.2105","article-title":"Specificity, diversity, and regulation in TGF-beta superfamily signaling","volume":"13","author":"Piek","year":"1999","journal-title":"FASEB J."},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0150","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1002\/jbmr.5650050109","article-title":"Characterization of the latent transforming growth factor beta complex in bone","volume":"5","author":"Pfeilschifter","year":"1990","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0155","doi-asserted-by":"crossref","first-page":"21352","DOI":"10.1074\/jbc.M111663200","article-title":"Proteolysis of latent transforming growth factor-beta (TGF-beta)-binding protein-1 by osteoclasts. A cellular mechanism for release of TGF-beta from bone matrix","volume":"277","author":"Dallas","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0160","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/nature10152","article-title":"Latent TGF-\u03b2 structure and activation","volume":"474","author":"Shi","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0165","doi-asserted-by":"crossref","first-page":"5353","DOI":"10.1093\/emboj\/16.17.5353","article-title":"TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4","volume":"16","author":"Nakao","year":"1997","journal-title":"EMBO J."},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0170","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1038\/nm.1979","article-title":"TGF-beta1-induced migration of bone mesenchymal stem cells couples bone resorption with formation","volume":"15","author":"Tang","year":"2009","journal-title":"Nat. Med."},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0175","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0014073","article-title":"TGF-\u03b21 As possible link between loss of bone mineral density and chronic inflammation","volume":"5","author":"Ehnert","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0180","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1046\/j.1365-2362.2000.00645.x","article-title":"Production and action of transforming growth factor-beta in human osteoblast cultures: dependence on cell differentiation and modulation by calcitriol","volume":"30","author":"Kassem","year":"2000","journal-title":"Eur. J. Clin. Invest."},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0185","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1359\/jbmr.1998.13.5.793","article-title":"Osteoblast programmed cell death (apoptosis): modulation by growth factors and cytokines","volume":"13","author":"Jilka","year":"1998","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0190","doi-asserted-by":"crossref","first-page":"e5275","DOI":"10.1371\/journal.pone.0005275","article-title":"Pharmacologic inhibition of the TGF-\u03b2 type I receptor kinase has anabolic and anti-catabolic effects on bone","volume":"4","author":"Mohammad","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0195","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1002\/jcp.20036","article-title":"Roles of stromal cell RANKL, OPG, and M-CSF expression in biphasic TGF-beta regulation of osteoclast differentiation","volume":"200","author":"Karst","year":"2004","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0200","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1038\/nm1096-1132","article-title":"Estrogen promotes apoptosis of murine osteoclasts mediated by TGF-beta","volume":"2","author":"Hughes","year":"1996","journal-title":"Nat. Med."},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0205","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1097\/00001665-200103000-00016","article-title":"Osteoblast gene expression is differentially regulated by TGF-beta isoforms","volume":"12","author":"Fagenholz","year":"2001","journal-title":"J. Craniofac. Surg."},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0210","doi-asserted-by":"crossref","first-page":"32634","DOI":"10.1016\/S0021-9258(18)31681-8","article-title":"Bone matrix decorin binds transforming growth factor-beta and enhances its bioactivity","volume":"269","author":"Takeuchi","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0215","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1006\/cbir.2002.0966","article-title":"Effects of transforming growth factor-beta 1 and fibronectin on SPARC expression in cultures of human periodontal ligament cells","volume":"26","author":"Fujita","year":"2002","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0220","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1002\/jcp.1041330303","article-title":"Type beta transforming growth factor (TGF beta) regulation of alkaline phosphatase expression and other phenotype-related mRNAs in osteoblastic rat osteosarcoma cells","volume":"133","author":"Noda","year":"1987","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0225","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1007\/s001980050163","article-title":"The role of serum TGF-beta isoforms as potential markers of osteoporosis","volume":"9","author":"Grainger","year":"1999","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0230","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S8756-3282(02)00971-7","article-title":"Polymorphisms in the transforming growth factor beta 1 gene and osteoporosis","volume":"32","author":"Langdahl","year":"2003","journal-title":"Bone"},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0235","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1016\/j.humimm.2013.03.005","article-title":"Association between osteoporosis and polymorphisms of the IL-10 and TGF-beta genes in Turkish postmenopausal women","volume":"74","author":"Tural","year":"2013","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0240","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1359\/jbmr.1998.13.10.1569","article-title":"Association of a polymorphism of the transforming growth factor-beta1 gene with genetic susceptibility to osteoporosis in postmenopausal Japanese women","volume":"13","author":"Yamada","year":"1998","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0245","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1359\/jbmr.2000.15.4.634","article-title":"Transforming growth factor-beta1 gene polymorphism, bone turnover, and bone mass in Italian postmenopausal women","volume":"15","author":"Bertoldo","year":"2000","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0250","first-page":"77","article-title":"Genetic polymorphisms of TGF-beta, PAI-1, and COL1A-1, and determination of bone mineral density in Caucasian females","volume":"40","author":"Hubacek","year":"2006","journal-title":"Endocr. Regul."},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0255","doi-asserted-by":"crossref","first-page":"9389","DOI":"10.1021\/bi020084j","article-title":"Structural origins of the functional divergence of human insulin-like growth factor-I and insulin","volume":"41","author":"Brzozowski","year":"2002","journal-title":"Biochemistry"},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0260","doi-asserted-by":"crossref","first-page":"20424","DOI":"10.1074\/jbc.270.35.20424","article-title":"Studies on the mechanisms by which insulin-like growth factor (IGF) binding protein-4 (IGFBP-4) and IGFBP-5 modulate IGF actions in bone cells","volume":"270","author":"Mohan","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0265","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/8756-3282(94)90282-8","article-title":"Regional variation of insulin-like growth factor-I gene expression in mature rat bone and cartilage","volume":"15","author":"Lazowski","year":"1994","journal-title":"Bone"},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0270","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1186\/1479-5876-11-271","article-title":"IGF-I increases markers of osteoblastic activity and reduces bone resorption via osteoprotegerin and RANK-ligand","volume":"11","author":"Guerra-Men\u00e9ndez","year":"2013","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0275","doi-asserted-by":"crossref","first-page":"5706","DOI":"10.1210\/en.2007-0608","article-title":"Conditional deletion of insulin-like growth factor-I in collagen type 1alpha2-expressing cells results in postnatal lethality and a dramatic reduction in bone accretion","volume":"148","author":"Govoni","year":"2007","journal-title":"Endocrinology"},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0280","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/8756-3282(94)00051-4","article-title":"Parathyroid hormone restores bone mass and enhances osteoblast insulin-like growth factor I gene expression in ovariectomized rats","volume":"16","author":"Watson","year":"1995","journal-title":"Bone"},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0285","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1359\/jbmr.1998.13.1.36","article-title":"Regulation of osteocalcin production and bone resorption by 1,25-dihydroxyvitamin D3 in mouse long bones: interaction with the bone-derived growth factors TGF-beta and IGF-I","volume":"13","author":"Staal","year":"1998","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0290","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1210\/endo.131.3.1505451","article-title":"Insulin-like growth factor-I supports formation and activation of osteoclasts","volume":"131","author":"Mochizuki","year":"1992","journal-title":"Endocrinology"},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0295","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s00774-007-0799-z","article-title":"IGF-1 as an early marker for low bone mass or osteoporosis in premenopausal and postmenopausal women","volume":"26","author":"Liu","year":"2008","journal-title":"J. Bone Miner. Metab."},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0300","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1359\/jbmr.1998.13.8.1343","article-title":"Gender differences in insulin-like growth factor and bone mineral density association in old age: the Rancho Bernardo Study","volume":"13","author":"Barrett-Connor","year":"1998","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0305","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0014-5793(96)00407-3","article-title":"Amino-terminal deletions in the decorin core protein leads to the biosynthesis of proteoglycans with shorter glycosaminoglycan chains","volume":"386","author":"Oldberg","year":"1996","journal-title":"FEBS Lett."},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0310","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.matbio.2015.02.003","article-title":"Proteoglycan form and function: a comprehensive nomenclature of proteoglycans","volume":"42","author":"Iozzo","year":"2015","journal-title":"Matrix Biol."},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0315","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1177\/38.11.2212616","article-title":"Expression and localization of the two small proteoglycans biglycan and decorin in developing human skeletal and non-skeletal tissues","volume":"38","author":"Bianco","year":"1990","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0320","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1359\/jbmr.2002.17.7.1180","article-title":"Phenotypic effects of biglycan deficiency are linked to collagen fibril abnormalities, are synergized by decorin deficiency, and mimic Ehlers-Danlos-like changes in bone and other connective tissues","volume":"17","author":"Corsi","year":"2002","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0325","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/S8756-3282(97)00299-8","article-title":"Immunolocalization and Quantification of Noncollagenous Bone Matrix Proteins In Methylmethacrylate-Embedded Adult Human Bone In Combination With Histomorphometry","volume":"22","author":"Derkx","year":"1998","journal-title":"Bone."},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0330","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/S0006-291X(03)00693-4","article-title":"Decorin modulates matrix mineralization in vitro","volume":"305","author":"Mochida","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0335","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1002\/jbm.a.31501","article-title":"Influence of collagen-fibril-based coatings containing decorin and biglycan on osteoblast behavior","volume":"84","author":"Douglas","year":"2008","journal-title":"J. Biomed. Mater. Res. A."},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0340","doi-asserted-by":"crossref","first-page":"3778","DOI":"10.1093\/emboj\/16.13.3778","article-title":"Crystal structure of a pair of follistatin-like and EF-hand calcium-binding domains in BM-40","volume":"16","author":"Hohenester","year":"1997","journal-title":"EMBO J."},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0345","doi-asserted-by":"crossref","first-page":"H841","DOI":"10.1152\/ajpheart.01247.2010","article-title":"SPARC regulates collagen interaction with cardiac fibroblast cell surfaces","volume":"301","author":"Harris","year":"2011","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0350","first-page":"4453","article-title":"Osteonectin promotes prostate cancer cell migration and invasion: a possible mechanism for metastasis to bone","volume":"59","author":"Jacob","year":"1999","journal-title":"Cancer Res."},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0355","doi-asserted-by":"crossref","first-page":"2588","DOI":"10.1210\/en.2002-221044","article-title":"Osteonectin-null mutation compromises osteoblast formation, maturation, and survival","volume":"144","author":"Delany","year":"2003","journal-title":"Endocrinology."},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0360","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.bone.2008.03.024","article-title":"Accentuated osteoclastic response to parathyroid hormone undermines bone mass acquisition in osteonectin-null mice","volume":"43","author":"Machado do Reis","year":"2008","journal-title":"Bone."},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0365","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1007\/s00198-007-0523-9","article-title":"Osteonectin\/SPARC polymorphisms in Caucasian men with idiopathic osteoporosis","volume":"19","author":"Delany","year":"2008","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0370","doi-asserted-by":"crossref","first-page":"6990","DOI":"10.1021\/bi050109p","article-title":"Comprehensive identification of post-translational modifications of rat bone osteopontin by mass spectrometry","volume":"44","author":"Keykhosravani","year":"2005","journal-title":"Biochemistry."},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0375","doi-asserted-by":"crossref","DOI":"10.1038\/srep43718","article-title":"Extracellular proteasome-osteopontin circuit regulates cell migration with implications in multiple sclerosis","volume":"7","author":"Dianzani","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0380","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.bone.2003.11.027","article-title":"Osteopontin is a negative regulator of proliferation and differentiation in MC3T3-E1 pre-osteoblastic cells","volume":"34","author":"Huang","year":"2004","journal-title":"Bone."},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0385","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1093\/jb\/mvh136","article-title":"In vitro and in vivo effects of the overexpression of osteopontin on osteoblast differentiation using a recombinant adenoviral vector","volume":"136","author":"Kojima","year":"2004","journal-title":"J. Biochem."},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0390","doi-asserted-by":"crossref","first-page":"28261","DOI":"10.1074\/jbc.M103608200","article-title":"Osteopontin, a Novel Substrate for Matrix Metalloproteinase-3 (Stromelysin-1) and Matrix Metalloproteinase-7 (Matrilysin)","volume":"276","author":"Agnihotri","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0395","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1007\/s00726-016-2290-4","article-title":"Comparison of tissue transglutaminase 2 and bone biological markers osteocalcin, osteopontin and sclerostin expression in human osteoporosis and osteoarthritis","volume":"49","author":"Tarquini","year":"2017","journal-title":"Amino Acids"},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0400","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1042\/BJ20140702","article-title":"Osteopontin mediates mineralization and not osteogenic cell development in vitro","volume":"464","author":"Holm","year":"2014","journal-title":"Biochem. J."},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0405","doi-asserted-by":"crossref","first-page":"15872","DOI":"10.1074\/jbc.M701116200","article-title":"Pyrophosphate inhibits mineralization of osteoblast cultures by binding to mineral, up-regulating osteopontin, and inhibiting alkaline phosphatase activity","volume":"282","author":"Addison","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0410","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1111\/j.1749-6632.1995.tb44630.x","article-title":"Interaction of osteopontin with osteoclast integrins","volume":"760","author":"Horton","year":"1995","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0415","doi-asserted-by":"crossref","first-page":"17767","DOI":"10.1073\/pnas.1109402108","article-title":"Sympathetic control of bone mass regulated by osteopontin","volume":"108","author":"Nagao","year":"2011","journal-title":"Proc Natl Acad Sci U S A."},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0420","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.bbrc.2014.08.149","article-title":"Anti-osteopontin monoclonal antibody prevents ovariectomy-induced osteoporosis in mice by promotion of osteoclast apoptosis","volume":"452","author":"Zhang","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0425","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3109\/00365513.2015.1087045","article-title":"Serum osteopontin levels in relation to bone mineral density and bone turnover markers in postmenopausal women","volume":"76","author":"Wei","year":"2016","journal-title":"Scand. J. Clin. Lab. Invest."},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0430","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.jmgm.2012.10.007","article-title":"A structural and functional model for human bone sialoprotein","volume":"39","author":"Vincent","year":"2013","journal-title":"J. Mol. Graph. Model."},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0435","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.bone.2014.10.007","article-title":"Loss of bone sialoprotein leads to impaired endochondral bone development and mineralization","volume":"71","author":"Holm","year":"2015","journal-title":"Bone."},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0440","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.bone.2007.04.191","article-title":"Bone sialoprotein expression enhances osteoblast differentiation and matrix mineralization in vitro","volume":"41","author":"Gordon","year":"2007","journal-title":"Bone."},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0445","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3109\/03008209609028892","article-title":"Regulation of bone sialoprotein and osteopontin mRNA expression by dexamethasone and 1,25-dihydroxyvitamin D3 in rat bone organ cultures","volume":"34","author":"Chen","year":"1996","journal-title":"Connect. Tissue Res."},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0450","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/S8756-3282(01)00637-8","article-title":"Osteopontin posttranslational modifications, possibly phosphorylation, are required for in vitro bone resorption but not osteoclast adhesion","volume":"30","author":"Razzouk","year":"2002","journal-title":"Bone"},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0455","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1084\/jem.20071294","article-title":"Bone sialoprotein plays a functional role in bone formation and osteoclastogenesis","volume":"205","author":"Malaval","year":"2008","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0460","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1080\/003655101753218274","article-title":"Serum bone sialoprotein: a marker of bone resorption in postmenopausal osteoporosis","volume":"61","author":"Shaarawy","year":"2001","journal-title":"Scand. J. Clin. Lab. Invest."},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0465","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1002\/jbmr.5650091220","article-title":"Direct demonstration that the vitamin K-dependent bone Gla protein is incompletely gamma-carboxylated in humans","volume":"9","author":"Cairns","year":"1994","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0470","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18010159","article-title":"Osteocalcin mediates biomineralization during osteogenic maturation in human mesenchymal stromal cells","volume":"18","author":"Tsao","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0475","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/382448a0","article-title":"Increased bone formation in osteocalcin-deficient mice","volume":"382","author":"Ducy","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0480","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1083\/jcb.92.1.227","article-title":"Recruitment of osteoclast precursors by purified bone matrix constituents","volume":"92","author":"Malone","year":"1982","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0485","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1002\/jcp.21267","article-title":"1alpha,25-dihydroxy vitamin D3-enhanced expression of the osteocalcin gene involves increased promoter occupancy of basal transcription regulators and gradual recruitment of the 1alpha,25-dihydroxy vitamin D3 receptor-SRC-1 coactivator complex","volume":"214","author":"Carvallo","year":"2008","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0490","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s00774-004-0503-5","article-title":"Osteocalcin fragment in bone matrix enhances osteoclast maturation at a late stage of osteoclast differentiation","volume":"22","author":"Ishida","year":"2004","journal-title":"J. Bone Miner. Metab."},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0495","doi-asserted-by":"crossref","first-page":"18361","DOI":"10.1074\/jbc.M314324200","article-title":"Release of intact and fragmented osteocalcin molecules from bone matrix during bone resorption in vitro","volume":"279","author":"Ivaska","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cytogfr.2019.09.001_bib0500","first-page":"RC04","article-title":"Serum osteocalcin as a diagnostic biomarker for primary osteoporosis in women","volume":"9","author":"Singh","year":"2015","journal-title":"J. Clin. Diagn. Res."}],"container-title":["Cytokine & Growth Factor Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1359610119300668?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1359610119300668?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T10:55:14Z","timestamp":1761216914000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1359610119300668"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":100,"alternative-id":["S1359610119300668"],"URL":"https:\/\/doi.org\/10.1016\/j.cytogfr.2019.09.001","relation":{},"ISSN":["1359-6101"],"issn-type":[{"value":"1359-6101","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Collagen and non-collagenous proteins molecular crosstalk in the pathophysiology of osteoporosis","name":"articletitle","label":"Article Title"},{"value":"Cytokine & Growth Factor Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cytogfr.2019.09.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}