{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T11:40:33Z","timestamp":1789213233629,"version":"build-2803163510"},"reference-count":80,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004008","name":"Istituto Superiore di Sanit\u00e0","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004008","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytokine & Growth Factor Reviews"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1016\/j.cytogfr.2019.12.006","type":"journal-article","created":{"date-parts":[[2019,12,26]],"date-time":"2019-12-26T20:02:23Z","timestamp":1577390543000},"page":"40-48","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Extracellular vesicle-mediated intercellular communication in HIV-1 infection and its role in the reservoir maintenance"],"prefix":"10.1016","volume":"51","author":[{"given":"Eleonora","family":"Olivetta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Chiozzini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Arenaccio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Manfredi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia","family":"Ferrantelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Federico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.cytogfr.2019.12.006_bib0005","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/8394","article-title":"Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy","volume":"5","author":"Finzi","year":"1999","journal-title":"Nat. Med."},{"issue":"1","key":"10.1016\/j.cytogfr.2019.12.006_bib0010","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a007096","article-title":"HIV latency","volume":"1","author":"Siliciano","year":"2011","journal-title":"Cold Spring Harb. Perspect. Med."},{"issue":"22","key":"10.1016\/j.cytogfr.2019.12.006_bib0015","doi-asserted-by":"crossref","first-page":"14179","DOI":"10.1128\/JVI.79.22.14179-14188.2005","article-title":"Human immunodeficiency virus type 1 can establish latent infection in resting CD4+ T cells in the absence of activating stimuli","volume":"79","author":"Swiggard","year":"2005","journal-title":"J. Virol."},{"issue":"6200","key":"10.1016\/j.cytogfr.2019.12.006_bib0020","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1126\/science.1259452","article-title":"AIDS\/HIV. Rekindled HIV infection","volume":"345","author":"Siliciano","year":"2014","journal-title":"Science"},{"issue":"8","key":"10.1016\/j.cytogfr.2019.12.006_bib0025","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1038\/nm.1972","article-title":"HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation","volume":"15","author":"Chomont","year":"2009","journal-title":"Nat. Med."},{"issue":"10","key":"10.1016\/j.cytogfr.2019.12.006_bib0030","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1016\/j.jprot.2010.06.006","article-title":"Exosomes: extracellular organelles important in intercellular communication","volume":"73","author":"Mathivanan","year":"2010","journal-title":"J. Proteomics"},{"issue":"4","key":"10.1016\/j.cytogfr.2019.12.006_bib0035","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nrm.2017.125","article-title":"Shedding light on the cell biology of extracellular vesicles","volume":"19","author":"van Niel","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.cytogfr.2019.12.006_bib0040","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1146\/annurev-cellbio-101512-122326","article-title":"Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles","volume":"30","author":"Colombo","year":"2014","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.cytogfr.2019.12.006_bib0045","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/978-1-4939-3753-0_15","article-title":"Biogenesis and functions of exosomes and extracellular vesicles","volume":"1448","author":"Dreyer","year":"2016","journal-title":"Methods Mol. Biol."},{"issue":"2","key":"10.1016\/j.cytogfr.2019.12.006_bib0050","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1097\/COH.0b013e32835d6e1c","article-title":"Tracking replication-competent HIV reservoirs in infected individuals","volume":"8","author":"Chun","year":"2013","journal-title":"Curr. Opin. HIV AIDS"},{"issue":"10","key":"10.1016\/j.cytogfr.2019.12.006_bib0055","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1097\/QAD.0b013e328353f3f1","article-title":"HIV reservoirs: pathogenesis and obstacles to viral eradication and cure","volume":"26","author":"Chun","year":"2012","journal-title":"Aids"},{"issue":"2","key":"10.1016\/j.cytogfr.2019.12.006_bib0060","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1093\/aje\/kws321","article-title":"Cause-specific life expectancies after 35 years of age for human immunodeficiency syndrome-infected and human immunodeficiency syndrome-negative individuals followed simultaneously in long-term cohort studies, 1984-2008","volume":"177","author":"Wada","year":"2013","journal-title":"Am. J. Epidemiol."},{"issue":"4","key":"10.1016\/j.cytogfr.2019.12.006_bib0065","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.immuni.2013.10.001","article-title":"Systemic effects of inflammation on health during chronic HIV infection","volume":"39","author":"Deeks","year":"2013","journal-title":"Immunity"},{"issue":"9","key":"10.1016\/j.cytogfr.2019.12.006_bib0070","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1038\/nrmicro2848","article-title":"Microbial translocation in HIV infection: causes, consequences and treatment opportunities","volume":"10","author":"Sandler","year":"2012","journal-title":"Nat. Rev. Microbiol."},{"issue":"6","key":"10.1016\/j.cytogfr.2019.12.006_bib0075","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1093\/infdis\/jiv148","article-title":"The sordid affair between human herpesvirus and HIV","volume":"212","author":"Gianella","year":"2015","journal-title":"J. Infect. Dis."},{"issue":"2","key":"10.1016\/j.cytogfr.2019.12.006_bib0080","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1093\/infdis\/jiu417","article-title":"Cytomegalovirus coinfection is associated with an increased risk of severe non-AIDS-defining events in a large cohort of HIV-infected patients","volume":"211","author":"Lichtner","year":"2015","journal-title":"J. Infect. Dis."},{"issue":"9903","key":"10.1016\/j.cytogfr.2019.12.006_bib0085","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1016\/S0140-6736(13)61809-7","article-title":"The end of AIDS: HIV infection as a chronic disease","volume":"382","author":"Deeks","year":"2013","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.cytogfr.2019.12.006_bib0090","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/nm880","article-title":"Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells","volume":"9","author":"Siliciano","year":"2003","journal-title":"Nat. Med."},{"issue":"4\u20135","key":"10.1016\/j.cytogfr.2019.12.006_bib0095","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.cytogfr.2012.05.001","article-title":"The role of cytokines in the establishment, persistence and eradication of the HIV reservoir","volume":"23","author":"Vandergeeten","year":"2012","journal-title":"Cytokine Growth Factor Rev."},{"issue":"13","key":"10.1016\/j.cytogfr.2019.12.006_bib0100","doi-asserted-by":"crossref","first-page":"4161","DOI":"10.1182\/blood-2007-06-097907","article-title":"CCR7 ligands CCL19 and CCL21 increase permissiveness of resting memory CD4+ T cells to HIV-1 infection: a novel model of HIV-1 latency","volume":"110","author":"Saleh","year":"2007","journal-title":"Blood"},{"issue":"16","key":"10.1016\/j.cytogfr.2019.12.006_bib0105","doi-asserted-by":"crossref","first-page":"7773","DOI":"10.1128\/JVI.00695-08","article-title":"Virological consequences of early events following cell-cell contact between human immunodeficiency virus type 1-infected and uninfected CD4+ cells","volume":"82","author":"Ruggiero","year":"2008","journal-title":"J. Virol."},{"issue":"2","key":"10.1016\/j.cytogfr.2019.12.006_bib0110","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1128\/JVI.01629-06","article-title":"Inefficient human immunodeficiency virus replication in mobile lymphocytes","volume":"81","author":"Sourisseau","year":"2007","journal-title":"J. Virol."},{"key":"10.1016\/j.cytogfr.2019.12.006_bib0115","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.virusres.2019.03.014","article-title":"Mechanisms of HIV-1 cell-to-cell transmission and the establishment of the latent reservoir","volume":"265","author":"Pedro","year":"2019","journal-title":"Virus Res."},{"issue":"7362","key":"10.1016\/j.cytogfr.2019.12.006_bib0120","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/nature10347","article-title":"Cell-to-cell spread of HIV permits ongoing replication despite antiretroviral therapy","volume":"477","author":"Sigal","year":"2011","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.cytogfr.2019.12.006_bib0125","doi-asserted-by":"crossref","DOI":"10.1002\/rmv.1924","article-title":"Mechanisms of HIV persistence in HIV reservoirs","volume":"27","author":"Mzingwane","year":"2017","journal-title":"Rev. Med. Virol."},{"issue":"2","key":"10.1016\/j.cytogfr.2019.12.006_bib0130","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3851\/IMP1374","article-title":"Antiretroviral therapy in macrophages: implication for HIV eradication","volume":"20","author":"Gavegnano","year":"2009","journal-title":"Antivir. Chem. Chemother."},{"issue":"12","key":"10.1016\/j.cytogfr.2019.12.006_bib0135","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1093\/infdis\/jit118","article-title":"CD133+ hematopoietic progenitor cells harbor HIV genomes in a subset of optimally treated people with long-term viral suppression","volume":"207","author":"McNamara","year":"2013","journal-title":"J. Infect. Dis."},{"issue":"11","key":"10.1016\/j.cytogfr.2019.12.006_bib0140","doi-asserted-by":"crossref","first-page":"5548","DOI":"10.1128\/JVI.00124-08","article-title":"Characterization of the follicular dendritic cell reservoir of human immunodeficiency virus type 1","volume":"82","author":"Keele","year":"2008","journal-title":"J. Virol."},{"issue":"4","key":"10.1016\/j.cytogfr.2019.12.006_bib0145","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1016\/j.ajpath.2011.06.039","article-title":"Brain cell reservoirs of latent virus in presymptomatic HIV-infected individuals","volume":"179","author":"Thompson","year":"2011","journal-title":"Am. J. Pathol."},{"issue":"9","key":"10.1016\/j.cytogfr.2019.12.006_bib0150","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1093\/infdis\/jiv218","article-title":"Precise quantitation of the latent HIV-1 reservoir: implications for eradication strategies","volume":"212","author":"Crooks","year":"2015","journal-title":"J. Infect. Dis."},{"issue":"7646","key":"10.1016\/j.cytogfr.2019.12.006_bib0155","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/nature21710","article-title":"CD32a is a marker of a CD4 T-cell HIV reservoir harbouring replication-competent proviruses","volume":"543","author":"Descours","year":"2017","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.cytogfr.2019.12.006_bib0160","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1005761","article-title":"CD4+ t cells expressing PD-1, TIGIT and LAG-3 contribute to HIV persistence during ART","volume":"12","author":"Fromentin","year":"2016","journal-title":"PLoS Pathog."},{"issue":"20","key":"10.1016\/j.cytogfr.2019.12.006_bib0165","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00901-18","article-title":"CD32(+) and PD-1(+) Lymph Node CD4 T Cells Support Persistent HIV-1 Transcription in Treated Aviremic Individuals","volume":"92","author":"Noto","year":"2018","journal-title":"J. Virol."},{"issue":"9","key":"10.1016\/j.cytogfr.2019.12.006_bib0170","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1038\/nm.4156","article-title":"Defective proviruses rapidly accumulate during acute HIV-1 infection","volume":"22","author":"Bruner","year":"2016","journal-title":"Nat. Med."},{"issue":"3","key":"10.1016\/j.cytogfr.2019.12.006_bib0175","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.cell.2013.09.020","article-title":"Replication-competent noninduced proviruses in the latent reservoir increase barrier to HIV-1 cure","volume":"155","author":"Ho","year":"2013","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.cytogfr.2019.12.006_bib0180","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1056\/NEJM199501263320401","article-title":"Virologic and immunologic characterization of long-term survivors of human immunodeficiency virus type 1 infection","volume":"332","author":"Cao","year":"1995","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"10.1016\/j.cytogfr.2019.12.006_bib0185","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1089\/aid.1995.11.3","article-title":"Sequential determination of viral load and phenotype in human immunodeficiency virus type 1 infection","volume":"11","author":"Daar","year":"1995","journal-title":"AIDS Res. Hum. Retroviruses"},{"issue":"3","key":"10.1016\/j.cytogfr.2019.12.006_bib0190","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1128\/jvi.71.3.2233-2240.1997","article-title":"Accumulation of defective viral genomes in peripheral blood mononuclear cells of human immunodeficiency virus type 1-infected individuals","volume":"71","author":"Sanchez","year":"1997","journal-title":"J. Virol."},{"issue":"10","key":"10.1016\/j.cytogfr.2019.12.006_bib0195","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1093\/jac\/dks219","article-title":"HIV-1 genome is often defective in PBMCs and rectal tissues after long-term HAART as a result of APOBEC3 editing and correlates with the size of reservoirs","volume":"67","author":"Fourati","year":"2012","journal-title":"J. Antimicrob. Chemother."},{"issue":"2","key":"10.1016\/j.cytogfr.2019.12.006_bib0200","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003174","article-title":"Comparative analysis of measures of viral reservoirs in HIV-1 eradication studies","volume":"9","author":"Eriksson","year":"2013","journal-title":"PLoS Pathog."},{"issue":"15","key":"10.1016\/j.cytogfr.2019.12.006_bib0205","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1089\/088922202320567905","article-title":"Characterization of pol, vif, vpr, and vpu genes of HIV type 1 in AIDS patients with high viral load and stable CD4+ T cell counts on combination therapy","volume":"18","author":"Saurya","year":"2002","journal-title":"AIDS Res. Hum. Retroviruses"},{"issue":"13","key":"10.1016\/j.cytogfr.2019.12.006_bib0210","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1089\/088922202760265650","article-title":"Characterization of nef gene of HIV type 1 in highly active antiretroviral therapy treated AIDS patients with discordance between viral load and CD4+ T cell counts","volume":"18","author":"Saurya","year":"2002","journal-title":"AIDS Res. Hum. Retroviruses"},{"issue":"1","key":"10.1016\/j.cytogfr.2019.12.006_bib0215","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1089\/08892220360473998","article-title":"Characterization of gag gene of plasma HIV type 1 in combination therapy-treated AIDS patients with high viral load and stable CD4+ T cell counts","volume":"19","author":"Saurya","year":"2003","journal-title":"AIDS Res. Hum. Retroviruses"},{"issue":"2","key":"10.1016\/j.cytogfr.2019.12.006_bib0220","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/jmv.10459","article-title":"Deletions in env gene of HIV-1 in AIDS patients treated with highly active antiretroviral therapy (HAART)","volume":"71","author":"Saurya","year":"2003","journal-title":"J. Med. Virol."},{"issue":"4","key":"10.1016\/j.cytogfr.2019.12.006_bib0225","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.jcv.2005.05.003","article-title":"Defective rev response element (RRE) and rev gene in HAART treated AIDS patients with discordance between viral load and CD4+ T-cell counts","volume":"33","author":"Saurya","year":"2005","journal-title":"J. Clin. Virol."},{"issue":"4","key":"10.1016\/j.cytogfr.2019.12.006_bib0230","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.chom.2017.03.008","article-title":"Defective HIV-1 proviruses are expressed and can Be recognized by cytotoxic t lymphocytes, which shape the proviral landscape","volume":"21","author":"Pollack","year":"2017","journal-title":"Cell Host Microbe"},{"issue":"5","key":"10.1016\/j.cytogfr.2019.12.006_bib0235","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1016\/j.cell.2015.02.009","article-title":"A hardwired HIV latency program","volume":"160","author":"Razooky","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.cytogfr.2019.12.006_bib0240","doi-asserted-by":"crossref","first-page":"27066","DOI":"10.3402\/jev.v4.27066","article-title":"Biological properties of extracellular vesicles and their physiological functions","volume":"4","author":"Yanez-Mo","year":"2015","journal-title":"J. Extracell. Vesicles"},{"issue":"19","key":"10.1016\/j.cytogfr.2019.12.006_bib0245","doi-asserted-by":"crossref","first-page":"10592","DOI":"10.1073\/pnas.1831413100","article-title":"The Trojan exosome hypothesis","volume":"100","author":"Gould","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"27","key":"10.1016\/j.cytogfr.2019.12.006_bib0250","doi-asserted-by":"crossref","first-page":"20014","DOI":"10.1074\/jbc.M112.438895","article-title":"Exosomes derived from HIV-1-infected cells contain trans-activation response element RNA","volume":"288","author":"Narayanan","year":"2013","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.cytogfr.2019.12.006_bib0255","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1159\/000445852","article-title":"Human immunodeficiency virus (HIV)","volume":"43","year":"2016","journal-title":"Transfus. Med. Hemother."},{"issue":"3","key":"10.1016\/j.cytogfr.2019.12.006_bib0260","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1074\/jbc.M115.662171","article-title":"Exosomes from HIV-1-infected cells stimulate production of pro-inflammatory cytokines through trans-activating response (TAR) RNA","volume":"291","author":"Sampey","year":"2016","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.cytogfr.2019.12.006_bib0265","doi-asserted-by":"crossref","first-page":"4585","DOI":"10.1038\/s41467-018-07006-2","article-title":"Exosomes derived from HIV-1-infected cells promote growth and progression of cancer via HIV TAR RNA","volume":"9","author":"Chen","year":"2018","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.cytogfr.2019.12.006_bib0270","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1111\/cmi.12046","article-title":"Sequences within RNA coding for HIV-1 Gag p17 are efficiently targeted to exosomes","volume":"15","author":"Columba Cabezas","year":"2013","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.cytogfr.2019.12.006_bib0275","doi-asserted-by":"crossref","first-page":"2980","DOI":"10.1038\/ncomms3980","article-title":"Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs","volume":"4","author":"Villarroya-Beltri","year":"2013","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.cytogfr.2019.12.006_bib0280","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.celrep.2016.09.031","article-title":"The RNA-Binding protein SYNCRIP is a component of the hepatocyte exosomal machinery controlling MicroRNA sorting","volume":"17","author":"Santangelo","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.cytogfr.2019.12.006_bib0285","first-page":"57","article-title":"\u201cReverse genomics\u201d and human endogenous retroviruses","volume":"125","author":"Markovitz","year":"2014","journal-title":"Trans. Am. Clin. Climatol. Assoc."},{"key":"10.1016\/j.cytogfr.2019.12.006_bib0290","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s12977-015-0156-6","article-title":"Modulation of human endogenous retrovirus (HERV) transcription during persistent and de novo HIV-1 infection","volume":"12","author":"Vincendeau","year":"2015","journal-title":"Retrovirology"},{"issue":"Pt 1","key":"10.1016\/j.cytogfr.2019.12.006_bib0295","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1042\/BST0370181","article-title":"The ESCRT pathway and HIV-1 budding","volume":"37","author":"Usami","year":"2009","journal-title":"Biochem. Soc. Trans."},{"issue":"6","key":"10.1016\/j.cytogfr.2019.12.006_bib0300","doi-asserted-by":"crossref","first-page":"e158","DOI":"10.1371\/journal.pbio.0050158","article-title":"Higher-order oligomerization targets plasma membrane proteins and HIV gag to exosomes","volume":"5","author":"Fang","year":"2007","journal-title":"PLoS Biol."},{"issue":"1","key":"10.1016\/j.cytogfr.2019.12.006_bib0305","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1111\/j.1600-0854.2009.01006.x","article-title":"HIV Nef is secreted in exosomes and triggers apoptosis in bystander CD4+ T cells","volume":"11","author":"Lenassi","year":"2010","journal-title":"Traffic"},{"issue":"3","key":"10.1016\/j.cytogfr.2019.12.006_bib0310","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.chom.2009.06.009","article-title":"Massive secretion by T cells is caused by HIV Nef in infected cells and by Nef transfer to bystander cells","volume":"6","author":"Muratori","year":"2009","journal-title":"Cell Host Microbe"},{"issue":"2","key":"10.1016\/j.cytogfr.2019.12.006_bib0315","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1089\/aid.2009.0170","article-title":"HIV Type 1 Nef is released from infected cells in CD45(+) microvesicles and is present in the plasma of HIV-infected individuals","volume":"27","author":"Raymond","year":"2011","journal-title":"AIDS Res. Hum. Retroviruses"},{"issue":"2","key":"10.1016\/j.cytogfr.2019.12.006_bib0320","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s13365-015-0397-0","article-title":"Microglia-derived HIV Nef+ exosome impairment of the blood-brain barrier is treatable by nanomedicine-based delivery of Nef peptides","volume":"22","author":"Raymond","year":"2016","journal-title":"J. Neurovirol."},{"issue":"5","key":"10.1016\/j.cytogfr.2019.12.006_bib0325","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1007\/s13365-017-0552-x","article-title":"Nef is secreted in exosomes from Nef.GFP-expressing and HIV-1-infected human astrocytes","volume":"23","author":"Puzar Dominkus","year":"2017","journal-title":"J. Neurovirol."},{"issue":"1","key":"10.1016\/j.cytogfr.2019.12.006_bib0330","doi-asserted-by":"crossref","first-page":"e2542","DOI":"10.1038\/cddis.2016.467","article-title":"HIV-1 Nef is released in extracellular vesicles derived from astrocytes: evidence for Nef-mediated neurotoxicity","volume":"8","author":"Sami Saribas","year":"2017","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.cytogfr.2019.12.006_bib0335","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.02344-17","article-title":"Nef secretion into extracellular vesicles or exosomes is conserved across human and simian immunodeficiency viruses","volume":"9","author":"McNamara","year":"2018","journal-title":"MBio"},{"issue":"2","key":"10.1016\/j.cytogfr.2019.12.006_bib0340","doi-asserted-by":"crossref","first-page":"146","DOI":"10.3109\/10409231003628015","article-title":"ADAM-17: the enzyme that does it all","volume":"45","author":"Gooz","year":"2010","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"issue":"4","key":"10.1016\/j.cytogfr.2019.12.006_bib0345","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.molcel.2012.12.004","article-title":"HIV Nef, paxillin, and Pak1\/2 regulate activation and secretion of TACE\/ADAM10 proteases","volume":"49","author":"Lee","year":"2013","journal-title":"Mol. Cell"},{"issue":"19","key":"10.1016\/j.cytogfr.2019.12.006_bib0350","doi-asserted-by":"crossref","first-page":"11529","DOI":"10.1128\/JVI.01712-14","article-title":"Exosomes from human immunodeficiency virus type 1 (HIV-1)-infected cells license quiescent CD4+ T lymphocytes to replicate HIV-1 through a Nef- and ADAM17-dependent mechanism","volume":"88","author":"Arenaccio","year":"2014","journal-title":"J. Virol."},{"key":"10.1016\/j.cytogfr.2019.12.006_bib0355","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.ebiom.2018.01.004","article-title":"HIV activates the Tyrosine Kinase Hck to secrete ADAM protease-containing extracellular vesicles","volume":"28","author":"Lee","year":"2018","journal-title":"EBioMedicine"},{"key":"10.1016\/j.cytogfr.2019.12.006_bib0360","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/1742-4690-11-46","article-title":"Cell activation and HIV-1 replication in unstimulated CD4+ T lymphocytes ingesting exosomes from cells expressing defective HIV-1","volume":"11","author":"Arenaccio","year":"2014","journal-title":"Retrovirology"},{"key":"10.1016\/j.cytogfr.2019.12.006_bib0365","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/s12977-015-0216-y","article-title":"Latent HIV-1 is activated by exosomes from cells infected with either replication-competent or defective HIV-1","volume":"12","author":"Arenaccio","year":"2015","journal-title":"Retrovirology"},{"issue":"9","key":"10.1016\/j.cytogfr.2019.12.006_bib0370","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.1007\/s00705-017-3391-4","article-title":"Trans-dissemination of exosomes from HIV-1-infected cells fosters both HIV-1 trans-infection in resting CD4(+) T lymphocytes and reactivation of the HIV-1 reservoir","volume":"162","author":"Chiozzini","year":"2017","journal-title":"Arch. Virol."},{"issue":"1","key":"10.1016\/j.cytogfr.2019.12.006_bib0375","doi-asserted-by":"crossref","first-page":"15611","DOI":"10.1038\/s41598-017-15961-x","article-title":"Effects of exosome on the activation of CD4+ T cells in rhesus macaques: a potential application for HIV latency reactivation","volume":"7","author":"Hong","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cytogfr.2019.12.006_bib0380","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.ebiom.2016.03.004","article-title":"HIV-nef and ADAM17-Containing plasma extracellular vesicles induce and correlate with immune pathogenesis in chronic HIV infection","volume":"6","author":"Lee","year":"2016","journal-title":"EBioMedicine"},{"key":"10.1016\/j.cytogfr.2019.12.006_bib0385","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.ebiom.2016.10.027","article-title":"HIV nef- and Notch1-dependent endocytosis of ADAM17 induces vesicular TNF secretion in chronic HIV infection","volume":"13","author":"Ostalecki","year":"2016","journal-title":"EBioMedicine"},{"issue":"1","key":"10.1016\/j.cytogfr.2019.12.006_bib0390","doi-asserted-by":"crossref","first-page":"7227","DOI":"10.1038\/s41598-018-25515-4","article-title":"Exosome markers associated with immune activation and oxidative stress in HIV patients on antiretroviral therapy","volume":"8","author":"Chettimada","year":"2018","journal-title":"Sci. Rep."},{"issue":"11","key":"10.1016\/j.cytogfr.2019.12.006_bib0395","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1093\/infdis\/jiu676","article-title":"Association of cytokines with exosomes in the plasma of HIV-1-Seropositive individuals","volume":"211","author":"Konadu","year":"2015","journal-title":"J. Infect. Dis."},{"issue":"1","key":"10.1016\/j.cytogfr.2019.12.006_bib0400","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.chom.2012.05.016","article-title":"An analog of the natural steroidal alkaloid cortistatin A potently suppresses Tat-dependent HIV transcription","volume":"12","author":"Mousseau","year":"2012","journal-title":"Cell Host Microbe"}],"container-title":["Cytokine & Growth Factor Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1359610119301467?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1359610119301467?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T10:56:42Z","timestamp":1761217002000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1359610119301467"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":80,"alternative-id":["S1359610119301467"],"URL":"https:\/\/doi.org\/10.1016\/j.cytogfr.2019.12.006","relation":{},"ISSN":["1359-6101"],"issn-type":[{"value":"1359-6101","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Extracellular vesicle-mediated intercellular communication in HIV-1 infection and its role in the reservoir maintenance","name":"articletitle","label":"Article Title"},{"value":"Cytokine & Growth Factor Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cytogfr.2019.12.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}