{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T03:47:36Z","timestamp":1778644056680,"version":"3.51.4"},"reference-count":80,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T00:00:00Z","timestamp":1750723200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["CTS-151"],"award-info":[{"award-number":["CTS-151"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011011","name":"Junta de Andaluc\u00eda","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011011","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009042","name":"Universidad de Sevilla","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009042","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016970","name":"Consejer\u00eda de Econom\u00eda, Conocimiento, Empresas y Universidad, Junta de Andaluc\u00eda","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016970","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytokine & Growth Factor Reviews"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.cytogfr.2025.06.006","type":"journal-article","created":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T19:17:35Z","timestamp":1750792655000},"page":"114-119","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Leptin as a mechanistic link between obesity and systemic lupus erythematous"],"prefix":"10.1016","volume":"84","author":[{"given":"Daniel J.","family":"Garc\u00eda-Dom\u00ednguez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lourdes","family":"Hontecillas-Prieto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Lucenilla-Barrenechea","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roc\u00edo","family":"Flores-Campos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquel","family":"Mu\u00f1oz-Pacheco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco J.","family":"Toyos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blanca","family":"Hern\u00e1ndez-Cruz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan A.","family":"Flores-Cordero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"P\u00e9rez-P\u00e9rez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Vilari\u00f1o-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V\u00edctor","family":"S\u00e1nchez-Margalet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.cytogfr.2025.06.006_bib1","doi-asserted-by":"crossref","DOI":"10.1172\/JCI144918","article-title":"Bite of the wolf: innate immune responses propagate autoimmunity in lupus","volume":"131","author":"Gupta","year":"2021","journal-title":"J. Clin. Investig."},{"issue":"17","key":"10.1016\/j.cytogfr.2025.06.006_bib2","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1001\/jama.2024.2315","article-title":"Systemic lupus erythematosus: a review","volume":"331","author":"Siegel","year":"2024","journal-title":"Jama"},{"issue":"1","key":"10.1016\/j.cytogfr.2025.06.006_bib3","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s43556-024-00217-8","article-title":"Systemic lupus erythematosus: pathogenesis and targeted therapy","volume":"5","author":"Su","year":"2024","journal-title":"Mol. Biomed."},{"issue":"7","key":"10.1016\/j.cytogfr.2025.06.006_bib4","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.molmed.2017.05.006","article-title":"Pathogenesis of human systemic lupus erythematosus: a cellular perspective","volume":"23","author":"Moulton","year":"2017","journal-title":"Trends Mol. Med"},{"issue":"3","key":"10.1016\/j.cytogfr.2025.06.006_bib5","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/s41574-023-00932-2","article-title":"Emerging mechanisms of obesity-associated immune dysfunction","volume":"20","author":"Shaikh","year":"2024","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.cytogfr.2025.06.006_bib6","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/343746","article-title":"Adipokines, metabolic syndrome and rheumatic diseases","volume":"2014","author":"Abella","year":"2014","journal-title":"J. Immunol. Res"},{"issue":"9","key":"10.1016\/j.cytogfr.2025.06.006_bib7","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.autrev.2014.07.001","article-title":"Obesity in autoimmune diseases: not a passive bystander","volume":"13","author":"Versini","year":"2014","journal-title":"Autoimmun. Rev."},{"issue":"22","key":"10.1016\/j.cytogfr.2025.06.006_bib8","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph192214768","article-title":"Obesity, diabetes, and cardiovascular risk burden in systemic lupus erythematosus: current approaches and knowledge gaps-a rapid scoping review","volume":"19","author":"Hernandez-Negrin","year":"2022","journal-title":"Int J. Environ. Res. Public Health"},{"issue":"2","key":"10.1016\/j.cytogfr.2025.06.006_bib9","doi-asserted-by":"crossref","DOI":"10.3390\/nu13020504","article-title":"The impact of obesity and a high-fat diet on clinical and immunological features in systemic lupus erythematosus","volume":"13","author":"Kono","year":"2021","journal-title":"Nutrients"},{"issue":"11","key":"10.1016\/j.cytogfr.2025.06.006_bib10","doi-asserted-by":"crossref","DOI":"10.3390\/nu11112683","article-title":"Relationship of excess weight with clinical activity and dietary intake deficiencies in systemic lupus erythematosus patients","volume":"11","author":"Meza-Meza","year":"2019","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.cytogfr.2025.06.006_bib11","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/s12955-022-01974-2","article-title":"Mental health and quality of life in different obesity phenotypes: a systematic review","volume":"20","author":"Abiri","year":"2022","journal-title":"Health Qual. Life Outcomes"},{"issue":"10354","key":"10.1016\/j.cytogfr.2025.06.006_bib12","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/S0140-6736(22)01349-6","article-title":"Autoimmune diseases and cardiovascular risk: a population-based study on 19 autoimmune diseases and 12 cardiovascular diseases in 22 million individuals in the UK","volume":"400","author":"Conrad","year":"2022","journal-title":"Lancet"},{"issue":"12","key":"10.1016\/j.cytogfr.2025.06.006_bib13","doi-asserted-by":"crossref","DOI":"10.3390\/nu13124482","article-title":"Impact of obesity in kidney diseases","volume":"13","author":"Kotsis","year":"2021","journal-title":"Nutrients"},{"issue":"6","key":"10.1016\/j.cytogfr.2025.06.006_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2020.165767","article-title":"Diet, inflammation and the gut microbiome: mechanisms for obesity-associated cognitive impairment","volume":"1866","author":"Leigh","year":"2020","journal-title":"Biochim Biophys. Acta Mol. Basis Dis."},{"issue":"2","key":"10.1016\/j.cytogfr.2025.06.006_bib15","doi-asserted-by":"crossref","first-page":"T47","DOI":"10.1530\/JOE-13-0339","article-title":"Adipocytokines in obesity and metabolic disease","volume":"220","author":"Cao","year":"2014","journal-title":"J. Endocrinol."},{"issue":"10","key":"10.1016\/j.cytogfr.2025.06.006_bib16","doi-asserted-by":"crossref","first-page":"2398","DOI":"10.1172\/JCI119422","article-title":"Leptin secretion from adipose tissue in women. Relationship to plasma levels and gene expression","volume":"99","author":"Lonnqvist","year":"1997","journal-title":"J. Clin. Invest"},{"issue":"9","key":"10.1016\/j.cytogfr.2025.06.006_bib17","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1038\/nrrheum.2011.107","article-title":"What's new in our understanding of the role of adipokines in rheumatic diseases?","volume":"7","author":"Gomez","year":"2011","journal-title":"Nat. Rev. Rheuma"},{"issue":"1","key":"10.1016\/j.cytogfr.2025.06.006_bib18","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.rdc.2004.10.004","article-title":"The neuroendocrine-immune interactions in systemic lupus erythematosus: a basis for understanding disease pathogenesis and complexity","volume":"31","author":"Szyper-Kravitz","year":"2005","journal-title":"Rheum. Dis. Clin. North Am."},{"issue":"4","key":"10.1016\/j.cytogfr.2025.06.006_bib19","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1007\/s00296-013-2774-4","article-title":"Association between leptin and systemic lupus erythematosus","volume":"34","author":"Xu","year":"2014","journal-title":"Rheuma Int."},{"issue":"2","key":"10.1016\/j.cytogfr.2025.06.006_bib20","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s10067-019-04831-8","article-title":"Leptin: an unappreciated key player in SLE","volume":"39","author":"Yuan","year":"2020","journal-title":"Clin. Rheuma"},{"issue":"38","key":"10.1016\/j.cytogfr.2025.06.006_bib21","doi-asserted-by":"crossref","first-page":"10637","DOI":"10.1073\/pnas.1607101113","article-title":"Leptin promotes systemic lupus erythematosus by increasing autoantibody production and inhibiting immune regulation","volume":"113","author":"Lourenco","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"5","key":"10.1016\/j.cytogfr.2025.06.006_bib22","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1161\/01.HYP.0000243612.02929.df","article-title":"Insulin resistance and obesity in a mouse model of systemic lupus erythematosus","volume":"48","author":"Ryan","year":"2006","journal-title":"Hypertension"},{"issue":"12","key":"10.1016\/j.cytogfr.2025.06.006_bib23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0051118","article-title":"Metabolic alterations and increased liver mTOR expression precede the development of autoimmune disease in a murine model of lupus erythematosus","volume":"7","author":"Vila","year":"2012","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.cytogfr.2025.06.006_bib24","doi-asserted-by":"crossref","DOI":"10.1136\/lupus-2023-000898","article-title":"Lupus pathogenesis and autoimmunity are exacerbated by high fat diet-induced obesity in MRL\/lpr mice","volume":"10","author":"Zhang","year":"2023","journal-title":"Lupus Sci. Med"},{"issue":"1","key":"10.1016\/j.cytogfr.2025.06.006_bib25","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-21381-3","article-title":"Effects of high fat diet-induced obesity on pathophysiology, immune cells, and therapeutic efficacy in systemic lupus erythematosus","volume":"12","author":"Choi","year":"2022","journal-title":"Sci. Rep."},{"issue":"7","key":"10.1016\/j.cytogfr.2025.06.006_bib26","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1080\/1744666X.2019.1620601","article-title":"Metabolic syndrome and systemic lupus erythematosus: the connection","volume":"15","author":"Mok","year":"2019","journal-title":"Expert Rev. Clin. Immunol."},{"issue":"11","key":"10.1016\/j.cytogfr.2025.06.006_bib27","volume":"63","author":"Romero-Diaz","year":"2011","journal-title":"Arthritis Care Res."},{"issue":"9","key":"10.1016\/j.cytogfr.2025.06.006_bib28","doi-asserted-by":"crossref","first-page":"4205","DOI":"10.1093\/rheumatology\/keaa909","article-title":"Contribution of abnormal BMI to adverse health-related quality of life outcomes after a 52-week therapy in patients with SLE","volume":"60","author":"Borg","year":"2021","journal-title":"Rheumatology"},{"key":"10.1016\/j.cytogfr.2025.06.006_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.nut.2024.112559","article-title":"Obesity as an aggravating factor of systemic lupus erythematosus disease: what we already know and what we must explore. A rapid scoping review","volume":"128","author":"Carvalho","year":"2024","journal-title":"Nutrition"},{"key":"10.1016\/j.cytogfr.2025.06.006_bib30","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.729672","article-title":"Physical fitness attenuates the impact of higher body mass and adiposity on inflammation in women with systemic lupus erythematosus","volume":"12","author":"Sola-Rodriguez","year":"2021","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.cytogfr.2025.06.006_bib31","doi-asserted-by":"crossref","DOI":"10.1136\/lupus-2020-000436","article-title":"Associations of metabolic syndrome in SLE","volume":"7","author":"Apostolopoulos","year":"2020","journal-title":"Lupus Sci. Med."},{"issue":"1","key":"10.1016\/j.cytogfr.2025.06.006_bib32","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.rdc.2009.12.004","article-title":"The metabolic syndrome in systemic lupus erythematosus","volume":"36","author":"Parker","year":"2010","journal-title":"Rheum. Dis. Clin. North Am."},{"issue":"12","key":"10.1016\/j.cytogfr.2025.06.006_bib33","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1093\/rheumatology\/kei142","article-title":"'Not only\u2026but also': factors that contribute to accelerated atherosclerosis and premature coronary heart disease in systemic lupus erythematosus","volume":"44","author":"Bruce","year":"2005","journal-title":"Rheumatology"},{"issue":"6505","key":"10.1016\/j.cytogfr.2025.06.006_bib34","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/372425a0","article-title":"Positional cloning of the mouse obese gene and its human homologue","volume":"372","author":"Zhang","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.cytogfr.2025.06.006_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2024.156056","article-title":"Leptin physiology and pathophysiology in energy homeostasis, immune function, neuroendocrine regulation and bone health","volume":"161","author":"Stefanakis","year":"2024","journal-title":"Metabolism"},{"issue":"3","key":"10.1016\/j.cytogfr.2025.06.006_bib36","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1079\/BJN20041213","article-title":"Adipokines: inflammation and the pleiotropic role of white adipose tissue","volume":"92","author":"Trayhurn","year":"2004","journal-title":"Br. J. Nutr."},{"issue":"1","key":"10.1016\/j.cytogfr.2025.06.006_bib37","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1046\/j.1365-2249.2003.02190.x","article-title":"Role of leptin as an immunomodulator of blood mononuclear cells: mechanisms of action","volume":"133","author":"Sanchez-Margalet","year":"2003","journal-title":"Clin. Exp. Immunol."},{"issue":"1","key":"10.1016\/j.cytogfr.2025.06.006_bib38","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1006\/cimm.1999.1490","article-title":"Human leptin stimulates proliferation and activation of human circulating monocytes","volume":"194","author":"Santos-Alvarez","year":"1999","journal-title":"Cell Immunol."},{"key":"10.1016\/j.cytogfr.2025.06.006_bib39","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.cytogfr.2017.03.001","article-title":"Role of leptin as a link between metabolism and the immune system","volume":"35","author":"Perez-Perez","year":"2017","journal-title":"Cytokine Growth Factor Rev."},{"issue":"1","key":"10.1016\/j.cytogfr.2025.06.006_bib40","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1006\/cimm.1999.1594","article-title":"Human leptin enhances activation and proliferation of human circulating T lymphocytes","volume":"199","author":"Martin-Romero","year":"2000","journal-title":"Cell Immunol."},{"issue":"5","key":"10.1016\/j.cytogfr.2025.06.006_bib41","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1186\/ar2004","article-title":"The role of leptin in innate and adaptive immune responses","volume":"8","author":"Bernotiene","year":"2006","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.cytogfr.2025.06.006_bib42","doi-asserted-by":"crossref","DOI":"10.1155\/2010\/568343","article-title":"Role of leptin in the activation of immune cells","volume":"2010","author":"Fernandez-Riejos","year":"2010","journal-title":"Mediat. Inflamm."},{"issue":"4","key":"10.1016\/j.cytogfr.2025.06.006_bib43","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1189\/jlb.68.4.437","article-title":"Leptin in the regulation of immunity, inflammation, and hematopoiesis","volume":"68","author":"Fantuzzi","year":"2000","journal-title":"J. Leukoc. Biol."},{"issue":"1","key":"10.1016\/j.cytogfr.2025.06.006_bib44","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1515\/cclm-2014-0387","article-title":"Role of leptin in female reproduction","volume":"53","author":"Perez-Perez","year":"2015","journal-title":"Clin. Chem. Lab. Med."},{"issue":"10","key":"10.1016\/j.cytogfr.2025.06.006_bib45","doi-asserted-by":"crossref","first-page":"6093","DOI":"10.1074\/jbc.272.10.6093","article-title":"The leptin receptor","volume":"272","author":"Tartaglia","year":"1997","journal-title":"J. Biol. Chem."},{"issue":"6704","key":"10.1016\/j.cytogfr.2025.06.006_bib46","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1038\/27376","article-title":"Leptin and the regulation of body weight in mammals","volume":"395","author":"Friedman","year":"1998","journal-title":"Nature"},{"issue":"13","key":"10.1016\/j.cytogfr.2025.06.006_bib47","doi-asserted-by":"crossref","first-page":"6231","DOI":"10.1073\/pnas.93.13.6231","article-title":"Defective STAT signaling by the leptin receptor in diabetic mice","volume":"93","author":"Ghilardi","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cytogfr.2025.06.006_bib48","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1146\/annurev.physiol.70.113006.100707","article-title":"Mechanisms of leptin action and leptin resistance","volume":"70","author":"Myers","year":"2008","journal-title":"Annu Rev. Physiol."},{"issue":"1","key":"10.1016\/j.cytogfr.2025.06.006_bib49","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1006\/cimm.2001.1815","article-title":"Human leptin signaling in human peripheral blood mononuclear cells: activation of the JAK-STAT pathway","volume":"211","author":"Sanchez-Margalet","year":"2001","journal-title":"Cell Immunol."},{"issue":"19","key":"10.1016\/j.cytogfr.2025.06.006_bib50","doi-asserted-by":"crossref","first-page":"14563","DOI":"10.1074\/jbc.275.19.14563","article-title":"Jr., Activation of downstream signals by the long form of the leptin receptor","volume":"275","author":"Banks","year":"2000","journal-title":"J. Biol. Chem."},{"issue":"7","key":"10.1016\/j.cytogfr.2025.06.006_bib51","doi-asserted-by":"crossref","first-page":"2771","DOI":"10.2741\/3885","article-title":"Leptin receptor signaling: pathways to leptin resistance","volume":"16","author":"Wauman","year":"2011","journal-title":"Front. Biosci."},{"issue":"12","key":"10.1016\/j.cytogfr.2025.06.006_bib52","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22126445","article-title":"Impaired leptin signalling in obesity: is leptin a new thermolipokine?","volume":"22","author":"Genchi","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.cytogfr.2025.06.006_bib53","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/s41392-022-01073-0","article-title":"Trends in insulin resistance: insights into mechanisms and therapeutic strategy","volume":"7","author":"Li","year":"2022","journal-title":"Signal Transduct. Target Ther."},{"issue":"16","key":"10.1016\/j.cytogfr.2025.06.006_bib54","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21165887","article-title":"Role of leptin in inflammation and vice versa","volume":"21","author":"Perez-Perez","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cytogfr.2025.06.006_bib55","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1146\/annurev.med.56.062904.144924","article-title":"S. O\u2032Rahilly, Monogenic obesity in humans","volume":"56","author":"Farooqi","year":"2005","journal-title":"Annu. Rev. Med."},{"issue":"5","key":"10.1016\/j.cytogfr.2025.06.006_bib56","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/nri1350","article-title":"The weight of leptin in immunity","volume":"4","author":"Cava","year":"2004","journal-title":"Nat. Rev. Immunol."},{"issue":"3","key":"10.1016\/j.cytogfr.2025.06.006_bib57","doi-asserted-by":"crossref","first-page":"979","DOI":"10.4049\/jimmunol.1301685","article-title":"Deficient leptin signaling ameliorates systemic lupus erythematosus lesions in MRL\/Mp-Fas lpr mice","volume":"192","author":"Fujita","year":"2014","journal-title":"J. Immunol."},{"issue":"3","key":"10.1016\/j.cytogfr.2025.06.006_bib58","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.clim.2013.09.002","article-title":"Leptin promotes lupus T-cell autoimmunity","volume":"149","author":"Amarilyo","year":"2013","journal-title":"Clin. Immunol."},{"issue":"11","key":"10.1016\/j.cytogfr.2025.06.006_bib59","doi-asserted-by":"crossref","first-page":"3800","DOI":"10.1096\/fj.201600522R","article-title":"The AMP analog AICAR modulates the Treg\/Th17 axis through enhancement of fatty acid oxidation","volume":"30","author":"Gualdoni","year":"2016","journal-title":"FASEB J."},{"issue":"5","key":"10.1016\/j.cytogfr.2025.06.006_bib60","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.it.2009.02.002","article-title":"The multiple facets of mTOR in immunity","volume":"30","author":"Weichhart","year":"2009","journal-title":"Trends Immunol."},{"issue":"6","key":"10.1016\/j.cytogfr.2025.06.006_bib61","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/j.immuni.2010.11.024","article-title":"An oscillatory switch in mTOR kinase activity sets regulatory T cell responsiveness","volume":"33","author":"Procaccini","year":"2010","journal-title":"Immunity"},{"issue":"6982","key":"10.1016\/j.cytogfr.2025.06.006_bib62","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/nature02440","article-title":"AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus","volume":"428","author":"Minokoshi","year":"2004","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.cytogfr.2025.06.006_bib63","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1177\/1753425919886643","article-title":"Leptin facilitates the differentiation of Th17 cells from MRL\/Mp-Fas lpr lupus mice by activating NLRP3 inflammasome","volume":"26","author":"Yu","year":"2020","journal-title":"Innate Immun."},{"issue":"3","key":"10.1016\/j.cytogfr.2025.06.006_bib64","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1177\/0961203317725587","article-title":"Association between circulating leptin levels and systemic lupus erythematosus: an updated meta-analysis","volume":"27","author":"Lee","year":"2018","journal-title":"Lupus"},{"issue":"13","key":"10.1016\/j.cytogfr.2025.06.006_bib65","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1177\/0961203317703497","article-title":"Leptin levels in patients with systemic lupus erythematosus inversely correlate with regulatory T cell frequency","volume":"26","author":"Wang","year":"2017","journal-title":"Lupus"},{"key":"10.1016\/j.cytogfr.2025.06.006_bib66","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.aanat.2018.02.012","article-title":"Salivary biomarkers of inflammation in systemic lupus erythematosus","volume":"219","author":"Stanescu","year":"2018","journal-title":"Ann. Anat."},{"issue":"5","key":"10.1016\/j.cytogfr.2025.06.006_bib67","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1007\/s00296-008-0526-7","article-title":"Serum leptin in systemic lupus erythematosus","volume":"28","author":"Wislowska","year":"2008","journal-title":"Rheuma Int"},{"issue":"7","key":"10.1016\/j.cytogfr.2025.06.006_bib68","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.arcmed.2015.09.005","article-title":"Plasma\/Serum Leptin Levels in Patients with Systemic Lupus Erythematosus: a Meta-analysis","volume":"46","author":"Li","year":"2015","journal-title":"Arch. Med Res."},{"key":"10.1016\/j.cytogfr.2025.06.006_bib69","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.cyto.2018.08.002","article-title":"Adipokine interactions promote the pathogenesis of systemic lupus erythematosus","volume":"111","author":"Chougule","year":"2018","journal-title":"Cytokine"},{"issue":"6","key":"10.1016\/j.cytogfr.2025.06.006_bib70","first-page":"1238","article-title":"Circulating leptin level, soluble leptin receptor level and their gene polymorphism in patients with systemic lupus erythematosus: a systematic review and meta-analysis","volume":"38","author":"Yuan","year":"2020","journal-title":"Clin. Exp. Rheumtol."},{"issue":"2","key":"10.1016\/j.cytogfr.2025.06.006_bib71","doi-asserted-by":"crossref","first-page":"113","DOI":"10.3109\/08820139.2014.909457","article-title":"Serum leptin levels, leptin receptor gene (LEPR) polymorphism, and the risk of systemic lupus erythematosus in Kashmiri population","volume":"44","author":"Afroze","year":"2015","journal-title":"Immunol. Invest."},{"issue":"11","key":"10.1016\/j.cytogfr.2025.06.006_bib72","doi-asserted-by":"crossref","first-page":"3465","DOI":"10.1007\/s10067-020-05120-5","article-title":"Role of serum leptin levels and leptin receptor gene polymorphisms in systemic lupus erythematosus","volume":"39","author":"Afifi","year":"2020","journal-title":"Clin. Rheumatol."},{"issue":"2","key":"10.1016\/j.cytogfr.2025.06.006_bib73","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.clim.2015.09.007","article-title":"Genetic associations of leptin-related polymorphisms with systemic lupus erythematosus","volume":"161","author":"Zhao","year":"2015","journal-title":"Clin. Immunol."},{"issue":"9","key":"10.1016\/j.cytogfr.2025.06.006_bib74","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1111\/jcmm.13093","article-title":"Association of leptin and leptin receptor gene polymorphisms with systemic lupus erythematosus in a Chinese population","volume":"21","author":"Li","year":"2017","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.cytogfr.2025.06.006_bib75","doi-asserted-by":"crossref","DOI":"10.1177\/03946320231154988","article-title":"High serum leptin and adiponectin levels as biomarkers of disease progression in Egyptian patients with active systemic lupus erythematosus","volume":"37","author":"Kamel","year":"2023","journal-title":"Int. J. Immunopathol. Pharm."},{"issue":"4","key":"10.1016\/j.cytogfr.2025.06.006_bib76","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25042338","article-title":"Role of leptin in obesity, cardiovascular disease, and type 2 diabetes","volume":"25","author":"Vilarino-Garcia","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"9","key":"10.1016\/j.cytogfr.2025.06.006_bib77","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1136\/ard.2010.142737","article-title":"High plasma leptin levels confer increased risk of atherosclerosis in women with systemic lupus erythematosus, and are associated with inflammatory oxidised lipids","volume":"70","author":"McMahon","year":"2011","journal-title":"Ann. Rheum. Dis."},{"issue":"23","key":"10.1016\/j.cytogfr.2025.06.006_bib78","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1042\/CS20230924","article-title":"Leptin antagonism attenuates hypertension and renal injury in an experimental model of autoimmune disease","volume":"137","author":"Kalusche","year":"2023","journal-title":"Clin. Sci."},{"issue":"4","key":"10.1016\/j.cytogfr.2025.06.006_bib79","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1056\/NEJMc2403743","article-title":"Anti-CD19 CAR T cells in refractory immune thrombocytopenia of SLE","volume":"391","author":"Li","year":"2024","journal-title":"N. Engl. J. Med."},{"issue":"9","key":"10.1016\/j.cytogfr.2025.06.006_bib80","doi-asserted-by":"crossref","first-page":"3453","DOI":"10.1007\/s00277-024-05836-3","article-title":"Obesity is associated with adverse outcomes in primary immune thrombocytopenia - a retrospective single-center study","volume":"103","author":"Xiao","year":"2024","journal-title":"Ann. Hematol."}],"container-title":["Cytokine & Growth Factor Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1359610125000802?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1359610125000802?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T19:37:11Z","timestamp":1762371431000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1359610125000802"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":80,"alternative-id":["S1359610125000802"],"URL":"https:\/\/doi.org\/10.1016\/j.cytogfr.2025.06.006","relation":{},"ISSN":["1359-6101"],"issn-type":[{"value":"1359-6101","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Leptin as a mechanistic link between obesity and systemic lupus erythematous","name":"articletitle","label":"Article Title"},{"value":"Cytokine & Growth Factor Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cytogfr.2025.06.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}