{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,14]],"date-time":"2026-11-14T11:31:59Z","timestamp":1794655919464,"version":"4.9.1"},"reference-count":198,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009564","name":"Health and Family Planning Commission of Sichuan Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009564","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011488","name":"Health and Family Planning Committee of Pudong New Area","doi-asserted-by":"publisher","award":["PW2022B-17"],"award-info":[{"award-number":["PW2022B-17"]}],"id":[{"id":"10.13039\/501100011488","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82174189"],"award-info":[{"award-number":["82174189"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010876","name":"Shanghai University of Traditional Chinese Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010876","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019978","name":"Shanghai Pudong New Area Health Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019978","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytokine &amp; Growth Factor Reviews"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.cytogfr.2025.09.006","type":"journal-article","created":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T01:39:32Z","timestamp":1759541972000},"page":"57-70","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Targeting the NLRP3 inflammasome in sepsis: Molecular mechanisms and therapeutic strategies"],"prefix":"10.1016","volume":"86","author":[{"given":"Yuhui","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialei","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6122-3361","authenticated-orcid":false,"given":"Fangyuan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cytogfr.2025.09.006_bib1","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/s41392-021-00816-9","article-title":"Signaling pathways and intervention therapies in sepsis","volume":"6","author":"Zhang","year":"2021","journal-title":"Sig Transduct. Target Ther."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib2","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s13054-021-03862-5","article-title":"Biomarkers for sepsis: more than just fever and leukocytosis-a narrative review","volume":"26","author":"Barichello","year":"2022","journal-title":"Crit. Care"},{"key":"10.1016\/j.cytogfr.2025.09.006_bib3","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0140-6736(18)30696-2","article-title":"Sepsis and septic shock","volume":"392","author":"Cecconi","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.cytogfr.2025.09.006_bib4","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1007\/s00134-024-07694-z","article-title":"Sepsis: key insights, future directions, and immediate goals. A review and expert opinion","volume":"50","author":"Martin-Loeches","year":"2024","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.cytogfr.2025.09.006_bib5","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.mcna.2020.02.011","article-title":"Sepsis and septic shock - basics of diagnosis, pathophysiology and clinical decision making","volume":"104","author":"Font","year":"2020","journal-title":"Med. Clin. North Am."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib6","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.3390\/biom11071011","article-title":"Inflammation and cell death of the innate and adaptive immune system during sepsis","volume":"11","author":"Nedeva","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.cytogfr.2025.09.006_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2022.104318","article-title":"Current sepsis therapeutics","volume":"86","author":"Vincent","year":"2022","journal-title":"eBioMedicine"},{"key":"10.1016\/j.cytogfr.2025.09.006_bib8","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/S0140-6736(19)32989-7","article-title":"Global, regional, and national sepsis incidence and mortality, 1990-2017: analysis for the global burden of disease study","volume":"395","author":"Rudd","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.cytogfr.2025.09.006_bib9","doi-asserted-by":"crossref","first-page":"7770","DOI":"10.3390\/ijms25147770","article-title":"From molecular mechanisms to clinical therapy: understanding Sepsis-Induced multiple organ dysfunction","volume":"25","author":"Srdi\u0107","year":"2024","journal-title":"IJMS"},{"key":"10.1016\/j.cytogfr.2025.09.006_bib10","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S2213-2600(23)00330-2","article-title":"Profiling the dysregulated immune response in sepsis: overcoming challenges to achieve the goal of precision Medicine","volume":"12","author":"Cajander","year":"2024","journal-title":"Lancet Respir. Med."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib11","first-page":"56","article-title":"Sepsis-induced immunosuppression: mechanisms, diagnosis and current treatment options","volume":"9","author":"Liu","year":"2022","journal-title":"Mil. Med Res"},{"key":"10.1016\/j.cytogfr.2025.09.006_bib12","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1042\/CS20220556","article-title":"The double sides of NLRP3 inflammasome activation in sepsis","volume":"137","author":"Vigneron","year":"2023","journal-title":"Clin. Sci."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib13","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2022.962139","article-title":"Molecular mechanisms and functions of pyroptosis in sepsis and sepsis-associated organ dysfunction","volume":"12","author":"Wen","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib14","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1109938","article-title":"The mechanism of NLRP3 inflammasome activation and its pharmacological inhibitors","volume":"13","author":"Zhan","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.109697","article-title":"The role of NLRP3 inflammasome in sepsis: a potential therapeutic target","volume":"115","author":"He","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib16","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.cytogfr.2023.09.003","article-title":"Protein-protein interactions and related inhibitors involved in the NLRP3 inflammasome pathway","volume":"74","author":"Ma","year":"2023","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib17","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.thromres.2016.11.007","article-title":"Coagulation and sepsis","volume":"149","author":"Levi","year":"2017","journal-title":"Thromb. Res"},{"key":"10.1016\/j.cytogfr.2025.09.006_bib18","article-title":"Inflammasome-Dependent coagulation activation in sepsis","volume":"12","author":"Wu","year":"2021","journal-title":"Front Immunol."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2022.175047","article-title":"Fudosteine attenuates acute lung injury in septic mice by inhibiting pyroptosis via the TXNIP\/NLRP3\/GSDMD pathway","volume":"926","author":"He","year":"2022","journal-title":"Eur. J. Pharm."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib20","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1097\/CCM.0000000000001402","article-title":"Interleukin-1 receptor blockade is associated with reduced mortality in sepsis patients with features of macrophage activation syndrome: reanalysis of a prior phase III trial","volume":"44","author":"Shakoory","year":"2016","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib21","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/s41419-020-02985-x","article-title":"NLRP3 inflammasome in endothelial dysfunction","volume":"11","author":"Bai","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib22","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1093\/jleuko\/qiad161","article-title":"Persistent NLRP3 inflammasome activation is associated with delayed immunosuppression in septic patients","volume":"115","author":"Coudereau","year":"2024","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib23","doi-asserted-by":"crossref","DOI":"10.1002\/ardp.202400459","article-title":"MCC950 as a promising candidate for blocking NLRP3 inflammasome activation: a review of preclinical research and future directions","volume":"357","author":"Zheng","year":"2024","journal-title":"Arch. Pharm."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib24","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1021\/tx400343t","article-title":"Analysis of pfizer compounds in EPA\u2019s ToxCast chemicals-assay space","volume":"27","author":"Shah","year":"2014","journal-title":"Chem. Res Toxicol."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib25","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1038\/nrd.2018.97","article-title":"Targeting the NLRP3 inflammasome in inflammatory diseases","volume":"17","author":"Mangan","year":"2018","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib26","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/nri.2017.36","article-title":"The immunopathology of sepsis and potential therapeutic targets","volume":"17","author":"van der Poll","year":"2017","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib27","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1007\/s00281-017-0639-8","article-title":"Cytokine storm and sepsis disease pathogenesis","volume":"39","author":"Chousterman","year":"2017","journal-title":"Semin Immunopathol."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib28","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1378\/chest.101.6.1481","article-title":"The ACCP-SCCM consensus conference on sepsis and organ failure","volume":"101","author":"Bone","year":"1992","journal-title":"Chest"},{"key":"10.1016\/j.cytogfr.2025.09.006_bib29","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1097\/01.CCM.0000050454.01978.3B","article-title":"SCCM\/ESICM\/ACCP\/ATS\/SIS, 2001 SCCM\/ESICM\/ACCP\/ATS\/SIS international sepsis definitions conference","volume":"31","author":"Levy","year":"2003","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib30","doi-asserted-by":"crossref","first-page":"5376","DOI":"10.3390\/ijms20215376","article-title":"The pathogenesis of sepsis and potential therapeutic targets","volume":"20","author":"Huang","year":"2019","journal-title":"IJMS"},{"key":"10.1016\/j.cytogfr.2025.09.006_bib31","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The third international consensus definitions for sepsis and septic shock (Sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"key":"10.1016\/j.cytogfr.2025.09.006_bib32","first-page":"707","article-title":"The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction\/failure","volume":"22","author":"Vincent","year":"1996","journal-title":"Work. Group SepsisRelat. Probl. Eur. Soc. Intensive Care Med. Intensive Care Med."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib33","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1001\/jama.2016.0288","article-title":"Assessment of clinical criteria for sepsis: for the third international consensus definitions for sepsis and septic shock (Sepsis-3)","volume":"315","author":"Seymour","year":"2016","journal-title":"JAMA"},{"key":"10.1016\/j.cytogfr.2025.09.006_bib34","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1001\/jama.2016.0289","article-title":"Sepsis definitions task force, developing a new definition and assessing new clinical criteria for septic shock: for the third international consensus definitions for sepsis and septic shock (Sepsis-3)","volume":"315","author":"Shankar-Hari","year":"2016","journal-title":"JAMA"},{"key":"10.1016\/j.cytogfr.2025.09.006_bib35","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1164\/rccm.201604-0854OC","article-title":"Quick Sepsis-related organ failure assessment, systemic inflammatory response syndrome, and early warning scores for detecting clinical deterioration in infected patients outside the intensive care unit","volume":"195","author":"Churpek","year":"2017","journal-title":"Am. J. Respir. Crit. Care Med"},{"key":"10.1016\/j.cytogfr.2025.09.006_bib36","doi-asserted-by":"crossref","first-page":"266","DOI":"10.7326\/M17-2820","article-title":"Prognostic accuracy of the quick sequential organ failure assessment for mortality in patients with suspected infection: a systematic review and Meta-analysis","volume":"168","author":"Fernando","year":"2018","journal-title":"Ann. Intern Med"},{"key":"10.1016\/j.cytogfr.2025.09.006_bib37","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1146\/annurev-physiol-061121-040214","article-title":"Sepsis-Induced immunosuppression","volume":"84","author":"Torres","year":"2022","journal-title":"Annu Rev. Physiol."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib38","doi-asserted-by":"crossref","first-page":"2450","DOI":"10.1016\/j.immuni.2021.10.012","article-title":"The immunology of sepsis","volume":"54","author":"van der Poll","year":"2021","journal-title":"Immunity"},{"key":"10.1016\/j.cytogfr.2025.09.006_bib39","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/S1473-3099(07)70265-7","article-title":"Host-pathogen interactions in sepsis","volume":"8","author":"van der Poll","year":"2008","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib40","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.ccc.2010.11.001","article-title":"Fungal sepsis: optimizing antifungal therapy in the critical care setting","volume":"27","author":"Lepak","year":"2011","journal-title":"Crit. Care Clin."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib41","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1001\/jama.2009.1754","article-title":"EPIC II group of investigators, international study of the prevalence and outcomes of infection in intensive care units","volume":"302","author":"Vincent","year":"2009","journal-title":"JAMA"},{"key":"10.1016\/j.cytogfr.2025.09.006_bib42","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.cell.2010.01.022","article-title":"Pattern recognition receptors and inflammation","volume":"140","author":"Takeuchi","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.cytogfr.2025.09.006_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.107909","article-title":"Pattern recognition receptors as therapeutic targets for bacterial, viral and fungal sepsis","volume":"98","author":"Yuki","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib44","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1056\/NEJMra021333","article-title":"The pathophysiology and treatment of sepsis","volume":"348","author":"Hotchkiss","year":"2003","journal-title":"N. Engl. J. Med"},{"key":"10.1016\/j.cytogfr.2025.09.006_bib45","doi-asserted-by":"crossref","first-page":"36","DOI":"10.4161\/viru.25436","article-title":"Host innate immune responses to sepsis","volume":"5","author":"Wiersinga","year":"2014","journal-title":"Virulence"},{"key":"10.1016\/j.cytogfr.2025.09.006_bib46","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1177\/0884533617695243","article-title":"Sepsis: current definition, pathophysiology, diagnosis, and management","volume":"32","author":"Taeb","year":"2017","journal-title":"Nutr. Clin. Pr."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib47","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1002\/path.2274","article-title":"The immunology of sepsis","volume":"214","author":"Sriskandan","year":"2008","journal-title":"J. Pathol."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib48","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1182\/blood-2016-09-741298","article-title":"Platelets and neutrophil extracellular traps collaborate to promote intravascular coagulation during sepsis in mice","volume":"129","author":"McDonald","year":"2017","journal-title":"Blood"},{"key":"10.1016\/j.cytogfr.2025.09.006_bib49","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1159\/000489829","article-title":"Neutrophil extracellular traps in the second decade","volume":"10","author":"Brinkmann","year":"2018","journal-title":"J. Innate Immun."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib50","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/nm1565","article-title":"Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood","volume":"13","author":"Clark","year":"2007","journal-title":"Nat. Med."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib51","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/s41423-020-00591-7","article-title":"Potentiation of NETs release is novel characteristic of TREM-1 activation and the pharmacological inhibition of TREM-1 could prevent from the deleterious consequences of NETs release in sepsis","volume":"18","author":"Boufenzer","year":"2021","journal-title":"Cell Mol. Immunol."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib52","doi-asserted-by":"crossref","first-page":"257","DOI":"10.3389\/fimmu.2015.00257","article-title":"Complement system part II: role in immunity","volume":"6","author":"Merle","year":"2015","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib53","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1097\/SHK.0000000000001504","article-title":"Complement activation in human sepsis is related to Sepsis-Induced disseminated intravascular coagulation","volume":"54","author":"Abe","year":"2020","journal-title":"Shock"},{"key":"10.1016\/j.cytogfr.2025.09.006_bib54","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/nrneph.2016.70","article-title":"Complement in disease: a defence system turning offensive","volume":"12","author":"Ricklin","year":"2016","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib55","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/nri2402","article-title":"Harmful molecular mechanisms in sepsis","volume":"8","author":"Rittirsch","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib56","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/nri3345","article-title":"Thrombosis as an intravascular effector of innate immunity","volume":"13","author":"Engelmann","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib57","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s40560-023-00672-5","article-title":"The pathophysiology, diagnosis, and management of sepsis-associated disseminated intravascular coagulation","volume":"11","author":"Iba","year":"2023","journal-title":"J. Intensive Care"},{"key":"10.1016\/j.cytogfr.2025.09.006_bib58","article-title":"Disseminated intravascular coagulation","volume":"2","author":"Gando","year":"2016","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib59","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.ccc.2019.12.002","article-title":"Role of antithrombin III and tissue factor pathway in the pathogenesis of sepsis","volume":"36","author":"Sungurlu","year":"2020","journal-title":"Crit. Care Clin."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib60","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1161\/ATVBAHA.117.309846","article-title":"Tissue factor: an essential mediator of hemostasis and trigger of thrombosis","volume":"38","author":"Grover","year":"2018","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib61","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1055\/a-2091-7006","article-title":"Monocyte tissue factor expression: lipopolysaccharide induction and roles in pathological activation of coagulation","volume":"123","author":"Sachetto","year":"2023","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib62","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1055\/s-0034-1398376","article-title":"Coagulation in patients with severe sepsis","volume":"41","author":"Levi","year":"2015","journal-title":"Semin Thromb. Hemost."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib63","doi-asserted-by":"crossref","first-page":"S26","DOI":"10.1097\/CCM.0b013e3181c98d21","article-title":"Inflammation and coagulation","volume":"38","author":"Levi","year":"2010","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib64","article-title":"Sepsis-induced immunosuppression: mechanisms, biomarkers and immunotherapy","volume":"16","author":"Gao","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib65","doi-asserted-by":"crossref","first-page":"2594","DOI":"10.1001\/jama.2011.1829","article-title":"Immunosuppression in patients who die of sepsis and multiple organ failure","volume":"306","author":"Boomer","year":"2011","journal-title":"JAMA"},{"key":"10.1016\/j.cytogfr.2025.09.006_bib66","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/s41590-023-01660-5","article-title":"The pathophysiology of sepsis and precision-Medicine-based immunotherapy","volume":"25","author":"Giamarellos-Bourboulis","year":"2024","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib67","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1038\/nri3552","article-title":"Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy","volume":"13","author":"Hotchkiss","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib68","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2022.104363","article-title":"Immunopathophysiology of human sepsis","volume":"86","author":"Wiersinga","year":"2022","journal-title":"EBioMedicine"},{"key":"10.1016\/j.cytogfr.2025.09.006_bib69","doi-asserted-by":"crossref","first-page":"977","DOI":"10.4049\/jimmunol.1001147","article-title":"Modulation of dendritic cell differentiation in the bone marrow mediates sustained immunosuppression after polymicrobial sepsis","volume":"186","author":"Pastille","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib70","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S1074-7613(04)00046-9","article-title":"NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder","volume":"20","author":"Agostini","year":"2004","journal-title":"Immunity"},{"key":"10.1016\/j.cytogfr.2025.09.006_bib71","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/s41419-019-1413-8","article-title":"Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors","volume":"10","author":"Yang","year":"2019","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib72","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1038\/nri.2016.151","article-title":"Homeostasis-altering molecular processes as mechanisms of inflammasome activation","volume":"17","author":"Liston","year":"2017","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib73","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2025.1586364","article-title":"The key players of inflammasomes and pyroptosis in sepsis-induced pathogenesis and organ dysfunction","volume":"16","author":"Zhu","year":"2025","journal-title":"Front Pharm."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib74","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/nature10759","article-title":"Inflammasomes in health and disease","volume":"481","author":"Strowig","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.cytogfr.2025.09.006_bib75","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/s41589-019-0277-7","article-title":"MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition","volume":"15","author":"Coll","year":"2019","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib76","doi-asserted-by":"crossref","first-page":"8041","DOI":"10.1073\/pnas.0611496104","article-title":"Cryopyrin\/NALP3 binds ATP\/dATP, is an ATPase, and requires ATP binding to mediate inflammatory signaling","volume":"104","author":"Duncan","year":"2007","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib77","doi-asserted-by":"crossref","first-page":"5182","DOI":"10.1038\/s41467-018-07573-4","article-title":"NLRP3 lacking the leucine-rich repeat domain can be fully activated via the canonical inflammasome pathway","volume":"9","author":"Hafner-Bratkovi\u010d","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib78","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/ni1459","article-title":"A crucial function of SGT1 and HSP90 in inflammasome activity links mammalian and plant innate immune responses","volume":"8","author":"Mayor","year":"2007","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib79","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/s41577-019-0165-0","article-title":"The NLRP3 inflammasome: molecular activation and regulation to therapeutics","volume":"19","author":"Swanson","year":"2019","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib80","doi-asserted-by":"crossref","first-page":"41732","DOI":"10.1074\/jbc.M112.381228","article-title":"Multiple binding sites on the pyrin domain of ASC protein allow self-association and interaction with NLRP3 protein","volume":"287","author":"Vajjhala","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib81","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/j.cell.2014.02.008","article-title":"Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes","volume":"156","author":"Lu","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.cytogfr.2025.09.006_bib82","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1681\/ASN.2010080798","article-title":"The inflammasomes in kidney disease","volume":"22","author":"Anders","year":"2011","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib83","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/s41581-019-0158-z","article-title":"The role of inflammasomes in kidney disease","volume":"15","author":"Komada","year":"2019","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib84","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/s41586-021-03218-7","article-title":"NINJ1 mediates plasma membrane rupture during lytic cell death","volume":"591","author":"Kayagaki","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.cytogfr.2025.09.006_bib85","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1016\/j.cell.2024.03.008","article-title":"NINJ1 mediates plasma membrane rupture by cutting and releasing membrane disks","volume":"187","author":"David","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.cytogfr.2025.09.006_bib86","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.tibs.2024.05.007","article-title":"Programmed cell death: NINJ1 and mechanisms of plasma membrane rupture","volume":"49","author":"Ramos","year":"2024","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib87","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.711939","article-title":"The role and mechanism of pyroptosis and potential therapeutic targets in sepsis: a review","volume":"12","author":"Zheng","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib88","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1038\/s41423-022-00922-w","article-title":"How location and cellular signaling combine to activate the NLRP3 inflammasome","volume":"19","author":"Akbal","year":"2022","journal-title":"Cell Mol. Immunol."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib89","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13623","article-title":"Amyloid-\u03b2 activates NLRP3 inflammasomes by affecting microglial immunometabolism through the Syk-AMPK pathway","volume":"21","author":"Jung","year":"2022","journal-title":"Aging Cell"},{"key":"10.1016\/j.cytogfr.2025.09.006_bib90","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.918551","article-title":"Complement membrane attack complex is an immunometabolic regulator of NLRP3 activation and IL-18 secretion in human macrophages","volume":"13","author":"Jimenez-Duran","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib91","article-title":"Inhibition of sphingosine-1-phosphate receptor 3 suppresses ATP-induced NLRP3 inflammasome activation in macrophages via TWIK2-mediated potassium efflux","volume":"14","author":"Wang","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib92","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1136\/gutjnl-2023-331447","article-title":"Neutrophil extracellular traps activate hepatic stellate cells and monocytes via NLRP3 sensing in alcohol-induced acceleration of MASH fibrosis","volume":"73","author":"Babuta","year":"2024","journal-title":"Gut"},{"key":"10.1016\/j.cytogfr.2025.09.006_bib93","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.it.2014.10.003","article-title":"Prion-like polymerization as a signaling mechanism","volume":"35","author":"Cai","year":"2014","journal-title":"Trends Immunol."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib94","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpha.2024.101106","article-title":"Targeting ceramide-induced microglial pyroptosis: icariin is a promising therapy for Alzheimer\u2019s disease","volume":"15","author":"Li","year":"2025","journal-title":"J. Pharm. Anal."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib95","article-title":"Targeting microglial \u03b1-Synuclein\/TLRs\/NF-kappaB\/NLRP3 inflammasome axis in Parkinson\u2019s disease","volume":"12","author":"Li","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib96","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.immuni.2012.01.009","article-title":"Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis","volume":"36","author":"Shimada","year":"2012","journal-title":"Immunity"},{"key":"10.1016\/j.cytogfr.2025.09.006_bib97","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2014.576","article-title":"The NLRP3 inflammasome is activated by nanoparticles through ATP, ADP and adenosine","volume":"6","author":"Baron","year":"2015","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib98","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1016\/j.immuni.2013.05.016","article-title":"K+ efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter","volume":"38","author":"Mu\u00f1oz-Planillo","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.cytogfr.2025.09.006_bib99","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1038\/ni.1631","article-title":"Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization","volume":"9","author":"Hornung","year":"2008","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib100","doi-asserted-by":"crossref","first-page":"570","DOI":"10.3389\/fimmu.2015.00570","article-title":"Bacterial exotoxins and the inflammasome","volume":"6","author":"Greaney","year":"2015","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib101","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1167\/iovs.12-11047","article-title":"IL-1\u03b2 triggered by peptidoglycan and lipopolysaccharide through TLR2\/4 and ROS-NLRP3 inflammasome-dependent pathways is involved in ocular Beh\u00e7et\u2019s disease","volume":"54","author":"Liang","year":"2013","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib102","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1016\/j.cub.2004.10.027","article-title":"Identification of bacterial muramyl dipeptide as activator of the NALP3\/cryopyrin inflammasome","volume":"14","author":"Martinon","year":"2004","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib103","doi-asserted-by":"crossref","first-page":"4214","DOI":"10.4049\/jimmunol.1400582","article-title":"Cytosolic double-stranded RNA activates the NLRP3 inflammasome via MAVS-induced membrane permeabilization and K+ efflux","volume":"193","author":"Franchi","year":"2014","journal-title":"J. Immunol."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib104","doi-asserted-by":"crossref","first-page":"4358","DOI":"10.4049\/jimmunol.1301170","article-title":"The mitochondrial antiviral protein MAVS associates with NLRP3 and regulates its inflammasome activity","volume":"191","author":"Park","year":"2013","journal-title":"J. Immunol."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib105","doi-asserted-by":"crossref","first-page":"20574","DOI":"10.1074\/jbc.M109.023689","article-title":"Fungal zymosan and mannan activate the cryopyrin inflammasome","volume":"284","author":"Lamkanfi","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib106","doi-asserted-by":"crossref","first-page":"6335","DOI":"10.4049\/jimmunol.0903019","article-title":"1,3)-beta-glucans activate both dectin-1 and NLRP3 inflammasome in human macrophages","volume":"184","author":"Kankkunen","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib107","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/ni.2231","article-title":"Sensing and reacting to microbes through the inflammasomes","volume":"13","author":"Franchi","year":"2012","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib108","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.molmed.2016.12.007","article-title":"Inflammasome priming in sterile inflammatory disease","volume":"23","author":"Patel","year":"2017","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib109","doi-asserted-by":"crossref","first-page":"787","DOI":"10.4049\/jimmunol.0901363","article-title":"Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression","volume":"183","author":"Bauernfeind","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib110","doi-asserted-by":"crossref","first-page":"792","DOI":"10.4049\/jimmunol.0900173","article-title":"G. N\u00fa\u00f1ez, Cutting edge: TNF-alpha mediates sensitization to ATP and silica via the NLRP3 inflammasome in the absence of microbial stimulation","volume":"183","author":"Franchi","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib111","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.4049\/jimmunol.1700175","article-title":"Cutting edge: TRAF6 mediates TLR\/IL-1R Signaling-Induced nontranscriptional priming of the NLRP3 inflammasome","volume":"199","author":"Xing","year":"2017","journal-title":"J. Immunol."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib112","doi-asserted-by":"crossref","first-page":"36617","DOI":"10.1074\/jbc.M112.407130","article-title":"Non-transcriptional priming and deubiquitination regulate NLRP3 inflammasome activation","volume":"287","author":"Juliana","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib113","doi-asserted-by":"crossref","first-page":"15195","DOI":"10.1016\/S0021-9258(17)36591-2","article-title":"Interleukin-1 beta maturation and release in response to ATP and nigericin. Evidence that potassium depletion mediated by these agents is a necessary and common feature of their activity","volume":"269","author":"Perregaux","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib114","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1038\/nature08938","article-title":"NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals","volume":"464","author":"Duewell","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.cytogfr.2025.09.006_bib115","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/nature04516","article-title":"Gout-associated uric acid crystals activate the NALP3 inflammasome","volume":"440","author":"Martinon","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.cytogfr.2025.09.006_bib116","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/j.tibs.2016.09.002","article-title":"Mechanism and regulation of NLRP3 inflammasome activation","volume":"41","author":"He","year":"2016","journal-title":"Trends Biochem Sci."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib117","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/s41577-024-00995-w","article-title":"Mechanistic insights from inflammasome structures","volume":"24","author":"Fu","year":"2024","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib118","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1093\/abbs\/gmaa155","article-title":"A mini-review on ion fluxes that regulate NLRP3 inflammasome activation","volume":"53","author":"Li","year":"2021","journal-title":"Acta Biochim Biophys. Sin. (Shanghai)"},{"key":"10.1016\/j.cytogfr.2025.09.006_bib119","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1038\/sj.cdd.4402195","article-title":"Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration","volume":"14","author":"P\u00e9trilli","year":"2007","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib120","doi-asserted-by":"crossref","first-page":"18810","DOI":"10.1074\/jbc.M610762200","article-title":"Differential requirement of P2X7 receptor and intracellular K+ for caspase-1 activation induced by intracellular and extracellular bacteria","volume":"282","author":"Franchi","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib121","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.immuni.2018.04.032","article-title":"The TWIK2 potassium efflux channel in macrophages mediates NLRP3 Inflammasome-Induced inflammation","volume":"49","author":"Di","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.cytogfr.2025.09.006_bib122","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.13663","article-title":"Disruption of glycolytic flux is a signal for inflammasome signaling and pyroptotic cell death","volume":"5","author":"Sanman","year":"2016","journal-title":"eLife"},{"key":"10.1016\/j.cytogfr.2025.09.006_bib123","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.immuni.2016.08.010","article-title":"K+ Efflux-Independent NLRP3 inflammasome activation by small molecules targeting mitochondria","volume":"45","author":"Gro\u00df","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.cytogfr.2025.09.006_bib124","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.adl2993","article-title":"NEK7 phosphorylation amplifies NLRP3 inflammasome activation downstream of potassium efflux and gasdermin d","volume":"10","author":"Xu","year":"2025","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib125","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1146\/annurev.pathol.1.110304.100218","article-title":"Calcium in cell injury and death","volume":"1","author":"Dong","year":"2006","journal-title":"Annu Rev. Pathol."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib126","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1038\/cr.2010.135","article-title":"Chemical probing reveals insights into the signaling mechanism of inflammasome activation","volume":"20","author":"Gong","year":"2010","journal-title":"Cell Res."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib127","doi-asserted-by":"crossref","first-page":"11282","DOI":"10.1073\/pnas.1117765109","article-title":"Critical role for calcium mobilization in activation of the NLRP3 inflammasome","volume":"109","author":"Murakami","year":"2012","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib128","doi-asserted-by":"crossref","first-page":"3029","DOI":"10.4049\/jimmunol.170.6.3029","article-title":"Ca2+ stores and Ca2+ entry differentially contribute to the release of IL-1 beta and IL-1 alpha from murine macrophages","volume":"170","author":"Brough","year":"2003","journal-title":"J. Immunol."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib129","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1189\/jlb.0309164","article-title":"Cholesterol-dependent cytolysins induce rapid release of mature IL-1beta from murine macrophages in a NLRP3 inflammasome and cathepsin B-dependent manner","volume":"86","author":"Chu","year":"2009","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib130","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1016\/j.cub.2007.05.074","article-title":"The inflammasome mediates UVB-induced activation and secretion of interleukin-1beta by keratinocytes","volume":"17","author":"Feldmeyer","year":"2007","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib131","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2015.277","article-title":"K(+) regulates Ca(2+) to drive inflammasome signaling: dynamic visualization of ion flux in live cells","volume":"6","author":"Yaron","year":"2015","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib132","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1161\/CIRCRESAHA.119.316306","article-title":"Role of mitochondrial calcium and the permeability transition pore in regulating cell death","volume":"126","author":"Bauer","year":"2020","journal-title":"Circ. Res."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib133","first-page":"C1082","article-title":"Mitochondrial reactive oxygen species and Ca2+ signaling, am j physiol cell physiol","volume":"291","author":"Camello-Almaraz","year":"2006"},{"key":"10.1016\/j.cytogfr.2025.09.006_bib134","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1038\/nrm3412","article-title":"Mitochondria as sensors and regulators of calcium signalling","volume":"13","author":"Rizzuto","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib135","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1038\/ncomms2608","article-title":"TRPM2 links oxidative stress to NLRP3 inflammasome activation","volume":"4","author":"Zhong","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib136","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.coi.2020.01.005","article-title":"TRPM2, linking oxidative stress and Ca2+ permeation to NLRP3 inflammasome activation","volume":"62","author":"Wang","year":"2020","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib137","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.4049\/jimmunol.1500509","article-title":"Multiple cathepsins promote Pro-IL-1\u03b2 synthesis and NLRP3-Mediated IL-1\u03b2 activation","volume":"195","author":"Orlowski","year":"2015","journal-title":"J. Immunol."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib138","doi-asserted-by":"crossref","first-page":"C83","DOI":"10.1152\/ajpcell.00298.2015","article-title":"NLRP3 inflammasome signaling is activated by low-level lysosome disruption but inhibited by extensive lysosome disruption: roles for K+ efflux and Ca2+ influx","volume":"311","author":"Katsnelson","year":"2016","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib139","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1089\/ars.2014.5994","article-title":"Redox regulation of NLRP3 inflammasomes: ROS as trigger or effector?","volume":"22","author":"Abais","year":"2015","journal-title":"Antioxid. Redox Signal"},{"key":"10.1016\/j.cytogfr.2025.09.006_bib140","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1038\/s41590-022-01185-3","article-title":"Mitochondrial electron transport chain is necessary for NLRP3 inflammasome activation","volume":"23","author":"Billingham","year":"2022","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib141","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/nature08780","article-title":"Circulating mitochondrial DAMPs cause inflammatory responses to injury","volume":"464","author":"Zhang","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.cytogfr.2025.09.006_bib142","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/s41586-018-0372-z","article-title":"New mitochondrial DNA synthesis enables NLRP3 inflammasome activation","volume":"560","author":"Zhong","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.cytogfr.2025.09.006_bib143","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nature09663","article-title":"A role for mitochondria in NLRP3 inflammasome activation","volume":"469","author":"Zhou","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.cytogfr.2025.09.006_bib144","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.cell.2013.02.054","article-title":"The adaptor MAVS promotes NLRP3 mitochondrial localization and inflammasome activation","volume":"153","author":"Subramanian","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.cytogfr.2025.09.006_bib145","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.4049\/jimmunol.1701723","article-title":"Cutting edge: mitochondrial assembly of the NLRP3 inflammasome complex is initiated at priming","volume":"200","author":"Elliott","year":"2018","journal-title":"J. Immunol."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib146","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.immuni.2013.08.001","article-title":"Mitochondrial cardiolipin is required for Nlrp3 inflammasome activation","volume":"39","author":"Iyer","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.cytogfr.2025.09.006_bib147","article-title":"Detection of in vivo inflammasome activation for predicting sepsis mortality","volume":"11","author":"Cui","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib148","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000661","article-title":"IL-1beta processing in host defense: beyond the inflammasomes","volume":"6","author":"Netea","year":"2010","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib149","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1146\/annurev.immunol.021908.132612","article-title":"Immunological and inflammatory functions of the interleukin-1 family","volume":"27","author":"Dinarello","year":"2009","journal-title":"Annu Rev. Immunol."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib150","doi-asserted-by":"crossref","first-page":"649","DOI":"10.3390\/ijms20030649","article-title":"Interleukin-18 in health and disease","volume":"20","author":"Yasuda","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib151","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/j.1600-065X.2008.00624.x","article-title":"IL-1, IL-18, and IL-33 families of cytokines","volume":"223","author":"Arend","year":"2008","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib152","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2021.155725","article-title":"Serum NLRP3: a biomarker for identifying high-risk septic patients","volume":"149","author":"Huang","year":"2022","journal-title":"Cytokine"},{"key":"10.1016\/j.cytogfr.2025.09.006_bib153","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1111\/imm.12719","article-title":"The NLRP3 inflammasome contributes to host protection during sporothrix schenckii infection","volume":"151","author":"Gon\u00e7alves","year":"2017","journal-title":"Immunology"},{"key":"10.1016\/j.cytogfr.2025.09.006_bib154","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0131645","article-title":"IL-1 receptor antagonist treatment aggravates staphylococcal septic arthritis and sepsis in mice","volume":"10","author":"Ali","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.cytogfr.2025.09.006_bib155","doi-asserted-by":"crossref","first-page":"2536","DOI":"10.4049\/jimmunol.169.5.2536","article-title":"IL-18 levels and the outcome of innate immune response to lipopolysaccharide: importance of a positive feedback loop with caspase-1 in IL-18 expression","volume":"169","author":"Joshi","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib156","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.canlet.2021.06.014","article-title":"NLRP3-activated bone marrow dendritic cells play antileukemic roles via IL-1\u03b2\/Th1\/IFN-\u03b3 in acute myeloid leukemia","volume":"520","author":"Liu","year":"2021","journal-title":"Cancer Lett."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib157","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1097\/SHK.0000000000001521","article-title":"Sequential changes of NLRP3 inflammasome activation in sepsis and its relationship with death","volume":"54","author":"Garnacho-Montero","year":"2020","journal-title":"Shock"},{"key":"10.1016\/j.cytogfr.2025.09.006_bib158","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1111\/cei.12971","article-title":"Inflammasome gene profile is modulated in septic patients, with a greater magnitude in non-survivors","volume":"189","author":"Esquerdo","year":"2017","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib159","article-title":"A gain-of-function NLRP3 3\u2019-UTR polymorphism causes miR-146a-mediated suppression of NLRP3 expression and confers protection against sepsis progression","volume":"11","author":"Lu","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib160","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1164\/rccm.201604-0892OC","article-title":"NLRP3 inflammasome deficiency protects against microbial sepsis via increased lipoxin B4 synthesis","volume":"196","author":"Lee","year":"2017","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib161","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.4049\/jimmunol.1601745","article-title":"Deletion of Nlrp3 augments survival during polymicrobial sepsis by decreasing autophagy and enhancing phagocytosis","volume":"198","author":"Jin","year":"2017","journal-title":"J. Immunol."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib162","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155159","article-title":"Helenine blocks NLRP3 activation by disrupting the NEK7-NLRP3 interaction and ameliorates inflammatory diseases","volume":"122","author":"Fang","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.cytogfr.2025.09.006_bib163","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.1449","article-title":"Dracorhodin targeting CMPK2 attenuates inflammation: a novel approach to sepsis therapy","volume":"13","author":"Zhang","year":"2023","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib164","doi-asserted-by":"crossref","first-page":"5203","DOI":"10.1002\/ptr.7191","article-title":"Emodin alleviates LPS-induced myocardial injury through inhibition of NLRP3 inflammasome activation","volume":"35","author":"Dai","year":"2021","journal-title":"Phytother. Res"},{"key":"10.1016\/j.cytogfr.2025.09.006_bib165","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2021.174644","article-title":"Syringaresinol attenuates sepsis-induced cardiac dysfunction by inhibiting inflammation and pyroptosis in mice","volume":"913","author":"Wei","year":"2021","journal-title":"Eur. J. Pharm."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib166","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s00011-023-01819-8","article-title":"Tangeretin attenuates acute lung injury in septic mice by inhibiting ROS-mediated NLRP3 inflammasome activation via regulating PLK1\/AMPK\/DRP1 signaling axis","volume":"73","author":"Liu","year":"2024","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib167","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1038\/s41418-022-00966-5","article-title":"The lipid peroxidation product 4-hydroxynonenal inhibits NLRP3 inflammasome activation and macrophage pyroptosis","volume":"29","author":"Hsu","year":"2022","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib168","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s10020-023-00631-8","article-title":"4-Octyl itaconate attenuates LPS-induced acute kidney injury by activating Nrf2 and inhibiting STAT3 signaling","volume":"29","author":"Xu","year":"2023","journal-title":"Mol. Med."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib169","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.112527","article-title":"Micheliolide ameliorates lipopolysaccharide-induced acute kidney injury through suppression of NLRP3 activation by promoting mitophagy via Nrf2\/PINK1\/Parkin axis","volume":"138","author":"Lei","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib170","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154427","article-title":"Prim-O-glucosycimifugin attenuates liver injury in septic mice by inhibiting NLRP3 inflammasome\/caspase-1 signaling cascades in macrophages","volume":"106","author":"Liu","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.cytogfr.2025.09.006_bib171","doi-asserted-by":"crossref","first-page":"8460","DOI":"10.1021\/acs.jafc.3c02781","article-title":"L-AP alleviates liver injury in septic mice by inhibiting macrophage activation via suppressing NF-\u03baB and NLRP3 Inflammasome\/Caspase-1 signal pathways","volume":"72","author":"Liu","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib172","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1007\/s10753-024-02105-3","article-title":"Dichloroacetate prevents sepsis associated encephalopathy by inhibiting microglia pyroptosis through PDK4\/NLRP3","volume":"48","author":"Huang","year":"2025","journal-title":"Inflammation"},{"key":"10.1016\/j.cytogfr.2025.09.006_bib173","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2023.175616","article-title":"Puerarin protects against sepsis-associated encephalopathy by inhibiting NLRP3\/Caspase-1\/GSDMD pyroptosis pathway and reducing blood-brain barrier damage","volume":"945","author":"Zhou","year":"2023","journal-title":"Eur. J. Pharm."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib174","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1159\/000446615","article-title":"Induction of Myeloid-Derived suppressor cells in Cryopyrin-Associated periodic syndromes","volume":"8","author":"Ballbach","year":"2016","journal-title":"J. Innate Immun."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib175","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003885","article-title":"Malaria-induced NLRP12\/NLRP3-dependent caspase-1 activation mediates inflammation and hypersensitivity to bacterial superinfection","volume":"10","author":"Ataide","year":"2014","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib176","doi-asserted-by":"crossref","first-page":"905","DOI":"10.4049\/jimmunol.1002102","article-title":"Cecal ligation and puncture-induced impairment of innate immune function does not occur in the absence of caspase-1","volume":"187","author":"Murphey","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib177","doi-asserted-by":"crossref","first-page":"2030","DOI":"10.1016\/j.cell.2024.03.036","article-title":"From periphery to center stage: 50 years of advancements in innate immunity","volume":"187","author":"Carpenter","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.cytogfr.2025.09.006_bib178","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0022-3565(24)29317-4","article-title":"Identification and characterization of a novel class of interleukin-1 post-translational processing inhibitors","volume":"299","author":"Perregaux","year":"2001","journal-title":"J. Pharm. Exp. Ther."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib179","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/nm.3806","article-title":"A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases","volume":"21","author":"Coll","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib180","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.bbi.2016.12.014","article-title":"Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-\u03b2 and cognitive function in APP\/PS1 mice","volume":"61","author":"Dempsey","year":"2017","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib181","doi-asserted-by":"crossref","first-page":"522","DOI":"10.3390\/molecules23030522","article-title":"Inhibiting the NLRP3 inflammasome activation with MCC950 ameliorates diabetic encephalopathy in db\/db mice","volume":"23","author":"Zhai","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.cytogfr.2025.09.006_bib182","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1161\/ATVBAHA.117.309575","article-title":"NLRP3 inflammasome inhibition by MCC950 reduces atherosclerotic lesion development in apolipoprotein E-Deficient Mice-Brief report","volume":"37","author":"van der Heijden","year":"2017","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib183","doi-asserted-by":"crossref","first-page":"8618","DOI":"10.1038\/s41598-018-26775-w","article-title":"MCC950, a specific small molecule inhibitor of NLRP3 inflammasome attenuates colonic inflammation in spontaneous colitis mice","volume":"8","author":"Perera","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib184","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1038\/s41589-019-0278-6","article-title":"MCC950 closes the active conformation of NLRP3 to an inactive state","volume":"15","author":"Tapia-Abell\u00e1n","year":"2019","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib185","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1172\/JCI25495","article-title":"ATP-sensitive potassium channelopathies: focus on insulin secretion","volume":"115","author":"Ashcroft","year":"2005","journal-title":"J. Clin. Invest"},{"key":"10.1016\/j.cytogfr.2025.09.006_bib186","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1083\/jcb.200903124","article-title":"Glyburide inhibits the Cryopyrin\/Nalp3 inflammasome","volume":"187","author":"Lamkanfi","year":"2009","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib187","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.tips.2025.04.007","article-title":"Targeting the NLRP3 inflammasome for inflammatory disease therapy","volume":"46","author":"Cabral","year":"2025","journal-title":"Trends Pharm. Sci."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib188","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1089\/neu.2019.6538","article-title":"Magnetic resonance imaging pilot study of intravenous glyburide in traumatic brain injury","volume":"37","author":"Eisenberg","year":"2020","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.cytogfr.2025.09.006_bib189","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1002\/cpdd.1162","article-title":"Safety, tolerability, pharmacokinetics, and pharmacodynamics of the oral NLRP3 inflammasome inhibitor ZYIL1: First-in-Human phase 1 studies (Single Ascending Dose and Multiple Ascending Dose)","volume":"12","author":"Parmar","year":"2023","journal-title":"Clin. Pharm. Drug Dev."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib190","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1002\/cpdd.1318","article-title":"Safety, tolerability, pharmacokinetics, and pharmacodynamics of ZY-IL1 in three patients with Cryopyrin-Associated periodic syndromes","volume":"13","author":"Hissaria","year":"2024","journal-title":"Clin. Pharm. Drug Dev."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib191","doi-asserted-by":"crossref","first-page":"5529","DOI":"10.1021\/acs.jmedchem.4c02759","article-title":"Discovery of DFV890, a potent Sulfonimidamide-Containing NLRP3 inflammasome inhibitor","volume":"68","author":"Shen","year":"2025","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib192","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/s41573-023-00822-2","article-title":"Drugging the NLRP3 inflammasome: from signalling mechanisms to therapeutic targets","volume":"23","author":"Vande Walle","year":"2024","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib193","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1007\/s15010-022-01904-w","article-title":"Study group, DFV890: a new oral NLRP3 inhibitor-tested in an early phase 2a randomised clinical trial in patients with COVID-19 pneumonia and impaired respiratory function","volume":"51","author":"Madurka","year":"2023","journal-title":"Infection"},{"key":"10.1016\/j.cytogfr.2025.09.006_bib194","doi-asserted-by":"crossref","first-page":"E1530","DOI":"10.1073\/pnas.1716095115","article-title":"OLT1177, a \u03b2-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation","volume":"115","author":"Marchetti","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cytogfr.2025.09.006_bib195","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1097\/FJC.0000000000000931","article-title":"Phase 1B, randomized, Double-Blinded, dose escalation, Single-Center, repeat dose safety and pharmacodynamics study of the oral NLRP3 inhibitor dapansutrile in subjects with NYHA II-III systolic heart failure","volume":"77","author":"Wohlford","year":"2020","journal-title":"J. Cardiovasc Pharm."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib196","doi-asserted-by":"crossref","first-page":"e270","DOI":"10.1016\/S2665-9913(20)30065-5","article-title":"Dapansutrile, an oral selective NLRP3 inflammasome inhibitor, for treatment of gout flares: an open-label, dose-adaptive, proof-of-concept, phase 2a trial","volume":"2","author":"Kl\u00fcck","year":"2020","journal-title":"Lancet Rheuma"},{"key":"10.1016\/j.cytogfr.2025.09.006_bib197","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1021\/acs.jmedchem.0c01307","article-title":"Strategies for targeting the NLRP3 inflammasome in the clinical and preclinical space","volume":"64","author":"Schwaid","year":"2021","journal-title":"J. Med Chem."},{"key":"10.1016\/j.cytogfr.2025.09.006_bib198","doi-asserted-by":"crossref","first-page":"AB206","DOI":"10.1016\/j.jaad.2023.07.826","article-title":"43073 pharmacokinetics, safety and pharmacodynamics of VTX2735, a potent and selective NLRP3 inhibitor, in healthy adult volunteers","volume":"89","author":"Sandborn","year":"2023","journal-title":"J. Am. Acad. Dermatol."}],"container-title":["Cytokine &amp; Growth Factor Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1359610125001340?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1359610125001340?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T03:24:02Z","timestamp":1781234642000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1359610125001340"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":198,"alternative-id":["S1359610125001340"],"URL":"https:\/\/doi.org\/10.1016\/j.cytogfr.2025.09.006","relation":{},"ISSN":["1359-6101"],"issn-type":[{"value":"1359-6101","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeting the NLRP3 inflammasome in sepsis: Molecular mechanisms and therapeutic strategies","name":"articletitle","label":"Article Title"},{"value":"Cytokine & Growth Factor Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cytogfr.2025.09.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}