{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:11:28Z","timestamp":1791198688247,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,4,22]],"date-time":"2015-04-22T00:00:00Z","timestamp":1429660800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp; Dem Diag Ass &amp; Dis Mo"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Retinal nerve fiber layer (RNFL) thinning, assessed by optical coherence tomography (OCT), has recently been reported in various dementias.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a systematic review and meta\u2010analysis to investigate the diagnostic utility of RNFL thickness measurement using OCT in dementia (including Alzheimer's disease [AD] and mild cognitive impairment [MCI]) compared with healthy controls (HC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventeen studies comparing AD with HC (702 AD eyes and 790 HC eyes) were included, demonstrating a significant reduction in mean RNFL thickness in AD (weighted mean difference [WMD] 12.44, 95% confidence interval or CI [\u221216.64, \u22128.25], <jats:italic>P<\/jats:italic>\u00a0&lt;.0001). Five studies comparing MCI and HC (214 MCI eyes and 421 HC eyes) were included demonstrating a significant reduction in mean RNFL thickness in MCI (WMD \u22128.23, 95% CI [\u221214.00, \u22122.45], <jats:italic>P<\/jats:italic>\u00a0=.005). No relevant studies were identified for other dementias.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>OCT measurement of RNFL thickness appears diagnostically useful in discriminating between AD, or MCI, and HC.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.dadm.2015.03.001","type":"journal-article","created":{"date-parts":[[2015,4,24]],"date-time":"2015-04-24T15:26:03Z","timestamp":1429889163000},"page":"136-143","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":134,"title":["A systematic review and meta\u2010analysis of retinal nerve fiber layer change in dementia, using optical coherence tomography"],"prefix":"10.1002","volume":"1","author":[{"given":"Kelsey L.","family":"Thomson","sequence":"first","affiliation":[{"name":"College of Medicine and Veterinary Medicine, University of Edinburgh Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing Ming","family":"Yeo","sequence":"additional","affiliation":[{"name":"Royal Infirmary of Edinburgh Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Briony","family":"Waddell","sequence":"additional","affiliation":[{"name":"Anne Rowling Regenerative Neurology Clinic University of Edinburgh Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James R.","family":"Cameron","sequence":"additional","affiliation":[{"name":"Anne Rowling Regenerative Neurology Clinic University of Edinburgh Edinburgh UK"},{"name":"Centre for Clinical Brain Sciences University of Edinburgh Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suvankar","family":"Pal","sequence":"additional","affiliation":[{"name":"Anne Rowling Regenerative Neurology Clinic University of Edinburgh Edinburgh UK"},{"name":"Centre for Clinical Brain Sciences University of Edinburgh Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,4,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2012.227"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.45.1.68"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-010-0005-1"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0b013e328334e99b"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3906\/sag\u20101405\u2010114"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2014.51"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNO.0b013e318267fd5f"},{"key":"e_1_2_7_9_1","first-page":"173","article-title":"Decreased retinal thickness in patients with Alzheimer's disease","volume":"31","author":"Kang B.H.","year":"2013","journal-title":"J Korean Neurol Assoc"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-014-7374-z"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2011.02.014"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2007.02.090"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.wno.0000204645.56873.26"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-2457(01)00620-4"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.06-1029"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2013.12.023"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.34.7.939"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-3-25"},{"key":"e_1_2_7_19_1","volume-title":"RevMan: 5.3: Review Manager (RevMan) [Computer program]. 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