{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T21:39:35Z","timestamp":1793050775149,"version":"4.5.0"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,12,22]],"date-time":"2015-12-22T00:00:00Z","timestamp":1450742400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008188","name":"Hollywood Private Hospital Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000943","name":"Commonwealth Scientific and Industrial Research Organisation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000943","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1009292"],"award-info":[{"award-number":["APP1009292"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002986","name":"Dementia Collaborative Research Centres, Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002986","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp;amp; Dem Diag Ass &amp;amp; Dis Mo"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>For early detection of Alzheimer's disease (AD), the field needs biomarkers that can be used to detect disease status with high sensitivity and specificity. Apolipoprotein J (ApoJ, also known as clusterin) has long been associated with AD pathogenesis through various pathways. The aim of this study was to investigate the potential of plasma apoJ as a blood biomarker for AD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using the Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging, the present study assayed plasma apoJ levels over baseline and 18\u00a0months in 833 individuals. Plasma ApoJ levels were analyzed with respect to clinical classification, age, gender, apolipoprotein E (<jats:italic>APOE)<\/jats:italic> \u03b54 allele status, mini\u2010mental state examination score, plasma amyloid beta (A\u03b2), neocortical A\u03b2 burden (as measured by Pittsburgh compound B\u2010positron emission tomography), and total adjusted hippocampus volume.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>ApoJ was significantly higher in both mild cognitive impairment (MCI) and AD groups as compared with healthy controls (HC; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.0001). ApoJ significantly correlated with both \u201cstandardized uptake value ratio\u201d (SUVR) and hippocampus volume and weakly correlated with the plasma A\u03b21\u201342\/A\u03b21\u201340 ratio. Plasma apoJ predicted both MCI and AD from HC with greater than 80% accuracy for AD and greater than 75% accuracy for MCI at both baseline and 18\u2010month time points.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Mean apoJ levels were significantly higher in both MCI and AD groups. ApoJ was able to differentiate between HC with high SUVR and HC with low SUVR via <jats:italic>APOE<\/jats:italic> \u03b54 allele status, indicating that it may be included in a biomarker panel to identify AD before the onset of clinical symptoms.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.dadm.2015.12.001","type":"journal-article","created":{"date-parts":[[2015,12,22]],"date-time":"2015-12-22T18:01:29Z","timestamp":1450807289000},"page":"18-26","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Plasma apolipoprotein J as a potential biomarker for Alzheimer's disease: Australian Imaging, Biomarkers and Lifestyle study of aging"],"prefix":"10.1002","volume":"3","author":[{"given":"Veer Bala","family":"Gupta","sequence":"first","affiliation":[{"name":"School of Medical Sciences, Edith Cowan University Joondalup WA Australia"},{"name":"Cooperative Research Centre for Mental Health Melbourne 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