{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T08:53:29Z","timestamp":1789980809571,"version":"4.0.1"},"reference-count":117,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,12,22]],"date-time":"2016-12-22T00:00:00Z","timestamp":1482364800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006483","name":"AbbVie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006483","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007742","name":"BioClinica","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007742","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005614","name":"Biogen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005614","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004312","name":"Eli Lilly and Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004312","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008337","name":"Norman Cousins Center for Psychoneuroimmunology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008337","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004328","name":"Genentech","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004328","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006775","name":"GE Healthcare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006775","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013327","name":"H. Lundbeck A\/S","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013327","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004334","name":"Merck","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004334","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008272","name":"Novartis Pharmaceuticals Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011725","name":"Servier","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008373","name":"Takeda Pharmaceutical Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008373","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009804","name":"Northern California Institute for Research and Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009804","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R21 AG051987"],"award-info":[{"award-number":["R21 AG051987"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp;amp; Dem Diag Ass &amp;amp; Dis Mo"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>One major factor that influences the heterogeneity of Alzheimer's disease (AD) is age: younger AD patients more frequently exhibit atypical forms of AD. We propose that this age\u2010related heterogeneity can be understood better by considering age\u2010related differences in atrophy in the context of large\u2010scale brain networks subserving cognitive functions that contribute to memory.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We examined data from 75 patients with mild AD dementia from Alzheimer's Disease Neuroimaging Initiative. These individuals were chosen because they have cerebrospinal fluid amyloid and p\u2010tau levels in the range suggesting the presence of AD neuropathology, and because they were either younger than age 65 years early\u2010onset AD (EOAD) or age 80 years or older late\u2010onset AD (LOAD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the EOAD group, the most prominent atrophy was present in the posterior cingulate cortex, whereas in the LOAD group, atrophy was most prominent in the medial temporal lobe. Structural covariance analysis showed that the magnitude of atrophy in these epicenters is strongly correlated with a distributed atrophy pattern similar to distinct intrinsic connectivity networks in the healthy brain. An examination of memory performance in EOAD dementia versus LOAD dementia demonstrated relatively more prominent impairment in encoding in the EOAD group than in the LOAD group, with similar performance in memory storage in LOAD and EOAD but greater impairment in semantic memory in LOAD than in EOAD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The observations provide novel insights about age as a major factor contributing to the heterogeneity in the topography of AD\u2010related cortical atrophy.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.dadm.2016.12.007","type":"journal-article","created":{"date-parts":[[2016,12,22]],"date-time":"2016-12-22T13:19:02Z","timestamp":1482412742000},"page":"122-135","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Alzheimer's disease: The influence of age on clinical heterogeneity through the human brain connectome"],"prefix":"10.1002","volume":"6","author":[{"given":"Bradford C.","family":"Dickerson","sequence":"first","affiliation":[{"name":"Department of Neurology Massachusetts General Hospital Boston MA USA"},{"name":"Department of Neurology Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Brickhouse","sequence":"additional","affiliation":[{"name":"Department of Neurology Massachusetts General Hospital Boston MA USA"},{"name":"Department of Neurology Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"McGinnis","sequence":"additional","affiliation":[{"name":"Department of Neurology Massachusetts General Hospital Boston MA USA"},{"name":"Department of Neurology Brigham and Women's Hospital Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Wolk","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Pennsylvania Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Alzheimer's Disease Neuroimaging Initiative","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,12,22]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.34.7.939"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.005"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1988.00520270037018"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/01688638608405178"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2014.12.007"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(89)91173-6"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.56.10.1233"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.50.4.979"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(11)70156-9"},{"key":"e_1_2_3_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2003.029876"},{"key":"e_1_2_3_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl377"},{"key":"e_1_2_3_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2015.10.014"},{"key":"e_1_2_3_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-007-0269-2"},{"key":"e_1_2_3_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2013.02.013"},{"key":"e_1_2_3_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1221536110"},{"key":"e_1_2_3_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05758"},{"key":"e_1_2_3_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0905267106"},{"key":"e_1_2_3_19_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2177-05.2005"},{"key":"e_1_2_3_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhm207"},{"key":"e_1_2_3_21_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0308627101"},{"key":"e_1_2_3_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.03.024"},{"key":"e_1_2_3_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.07.003"},{"key":"e_1_2_3_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.12.033"},{"key":"e_1_2_3_25_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1440.011"},{"key":"e_1_2_3_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.008"},{"key":"e_1_2_3_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21610"},{"key":"e_1_2_3_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.21049"},{"key":"e_1_2_3_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.02.059"},{"key":"e_1_2_3_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2009.199505"},{"key":"e_1_2_3_31_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31823efc6c"},{"key":"e_1_2_3_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2013.00055"},{"key":"e_1_2_3_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.08.042"},{"key":"e_1_2_3_34_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1001412107"},{"key":"e_1_2_3_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.09.005"},{"key":"e_1_2_3_36_1","volume-title":"L'examen clinique en psychologie Paris","author":"Rey A.","year":"1964"},{"key":"e_1_2_3_37_1","doi-asserted-by":"publisher","DOI":"10.1037\/0096-3445.117.1.34"},{"key":"e_1_2_3_38_1","volume-title":"The Boston Naming Test","author":"Kaplan E.","year":"1983"},{"key":"e_1_2_3_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.08.071"},{"key":"e_1_2_3_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.04.033"},{"key":"e_1_2_3_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhn113"},{"key":"e_1_2_3_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2010.09.021"},{"key":"e_1_2_3_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2014.03.009"},{"key":"e_1_2_3_44_1","first-page":"333","article-title":"Voxel\u2010based morphometric comparison between early\u2010 and late\u2010onset mild Alzheimer's disease and assessment of diagnostic performance of z score images","volume":"26","author":"Ishii K.","year":"2005","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_3_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(91)90199-V"},{"key":"e_1_2_3_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.06.010"},{"key":"e_1_2_3_47_1","doi-asserted-by":"publisher","DOI":"10.1159\/000151241"},{"key":"e_1_2_3_48_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000194240.47892.4d"},{"key":"e_1_2_3_49_1","doi-asserted-by":"publisher","DOI":"10.1017\/S104161029700433X"},{"key":"e_1_2_3_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.02.005"},{"key":"e_1_2_3_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2009.126"},{"key":"e_1_2_3_52_1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1212\/01.CON.0000368257.30791.3a","article-title":"Memory systems","volume":"16","author":"Wolk D.A.","year":"2010","journal-title":"Continuum (Minneap Minn)"},{"key":"e_1_2_3_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2006.08.011"},{"key":"e_1_2_3_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/35090048"},{"key":"e_1_2_3_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00858-9"},{"key":"e_1_2_3_56_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3662-08.2008"},{"key":"e_1_2_3_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19980824)398:2<179::AID-CNE3>3.0.CO;2-Y"},{"key":"e_1_2_3_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903500402"},{"key":"e_1_2_3_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2000.tb06716.x"},{"key":"e_1_2_3_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.22024"},{"key":"e_1_2_3_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3785"},{"key":"e_1_2_3_62_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00077.2008"},{"key":"e_1_2_3_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3338"},{"key":"e_1_2_3_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.12.043"},{"key":"e_1_2_3_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.21753"},{"key":"e_1_2_3_66_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2005.04299.x"},{"key":"e_1_2_3_67_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1401.008"},{"key":"e_1_2_3_68_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhv003"},{"key":"e_1_2_3_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2277"},{"key":"e_1_2_3_70_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.23408"},{"key":"e_1_2_3_71_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bht260"},{"key":"e_1_2_3_72_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.10883"},{"key":"e_1_2_3_73_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.21346"},{"key":"e_1_2_3_74_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.10243"},{"key":"e_1_2_3_75_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/1.1.103"},{"key":"e_1_2_3_76_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00308809"},{"key":"e_1_2_3_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70299-6"},{"key":"e_1_2_3_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2016.09.011"},{"key":"e_1_2_3_79_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-009-5040-7"},{"key":"e_1_2_3_80_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0600549103"},{"key":"e_1_2_3_81_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4315-03.2004"},{"key":"e_1_2_3_82_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-014-1349-0"},{"key":"e_1_2_3_83_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00546.2009"},{"key":"e_1_2_3_84_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0507729103"},{"key":"e_1_2_3_85_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0905314106"},{"key":"e_1_2_3_86_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19990802)410:3<343::AID-CNE1>3.0.CO;2-1"},{"key":"e_1_2_3_87_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00048.2006"},{"key":"e_1_2_3_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2005.07.001"},{"key":"e_1_2_3_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2006.05.023"},{"key":"e_1_2_3_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2006.11.004"},{"key":"e_1_2_3_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2007.05.001"},{"key":"e_1_2_3_92_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2213"},{"key":"e_1_2_3_93_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0267-11.2011"},{"key":"e_1_2_3_94_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0987-08.2008"},{"key":"e_1_2_3_95_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1337-10.2010"},{"key":"e_1_2_3_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2007.07.022"},{"key":"e_1_2_3_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2015.06.025"},{"key":"e_1_2_3_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.12.073"},{"key":"e_1_2_3_99_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000324924.91351.7d"},{"key":"e_1_2_3_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70200-4"},{"key":"e_1_2_3_101_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aww023"},{"key":"e_1_2_3_102_1","doi-asserted-by":"publisher","DOI":"10.1162\/jocn.2008.20501"},{"key":"e_1_2_3_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bandl.2010.12.001"},{"key":"e_1_2_3_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2010.12.002"},{"key":"e_1_2_3_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/0093-934X(91)90172-W"},{"key":"e_1_2_3_106_1","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.neuroimage.2012.06.018","article-title":"Naming impairment in Alzheimer's disease is associated with left anterior temporal lobe atrophy","volume":"63","author":"Domoto\u2010Reilly K.","year":"2013","journal-title":"Neuroimage"},{"key":"e_1_2_3_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2015.08.008"},{"key":"e_1_2_3_108_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617701755105"},{"key":"e_1_2_3_109_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.64.6.862"},{"key":"e_1_2_3_110_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.44.5.867"},{"key":"e_1_2_3_111_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000163773.21794.0B"},{"key":"e_1_2_3_112_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhp055"},{"key":"e_1_2_3_113_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2999-15.2016"},{"key":"e_1_2_3_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)81109-5"},{"key":"e_1_2_3_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.04.047"},{"key":"e_1_2_3_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.03.004"},{"key":"e_1_2_3_117_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2012.135"},{"key":"e_1_2_3_118_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1996.tb03748.x"}],"container-title":["Alzheimer's &amp; Dementia: Diagnosis, Assessment &amp; Disease Monitoring"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352872916300707?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352872916300707?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.dadm.2016.12.007","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.dadm.2016.12.007","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.dadm.2016.12.007","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.dadm.2016.12.007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T09:33:40Z","timestamp":1760348020000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1016\/j.dadm.2016.12.007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,22]]},"references-count":117,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.1016\/j.dadm.2016.12.007"],"URL":"https:\/\/doi.org\/10.1016\/j.dadm.2016.12.007","archive":["Portico"],"relation":{},"ISSN":["2352-8729","2352-8729"],"issn-type":[{"value":"2352-8729","type":"print"},{"value":"2352-8729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,22]]},"assertion":[{"value":"2016-12-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}