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Reluctance to perform the procedure is among others due to a lack of standards and guidelines to minimize the risk of complications, such as post\u2010LP headache or back pain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We provide consensus guidelines for the LP procedure to minimize the risk of complications. The recommendations are based on (1) data from a large multicenter LP feasibility study (evidence level II\u20102), (2) systematic literature review on LP needle characteristics and post\u2010LP complications (evidence level II\u20102), (3) discussion of best practice within the Joint Programme Neurodegenerative Disease Research Biomarkers for Alzheimer's disease and Parkinson's Disease and Biomarkers for Multiple Sclerosis consortia (evidence level III).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Our consensus guidelines address contraindications, as well as patient\u2010related and procedure\u2010related risk factors that can influence the development of post\u2010LP complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>When an LP is performed correctly, the procedure is well tolerated and accepted with a low complication rate.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.dadm.2017.04.007","type":"journal-article","created":{"date-parts":[[2017,5,18]],"date-time":"2017-05-18T10:00:59Z","timestamp":1495101659000},"page":"111-126","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":222,"title":["Consensus guidelines for lumbar puncture in patients with neurological diseases"],"prefix":"10.1002","volume":"8","author":[{"given":"Sebastiaan","family":"Engelborghs","sequence":"first","affiliation":[{"name":"Reference Center for Biological Markers of Dementia (BIODEM) Department of Biomedical Sciences Institute Born\u2010Bunge, University of Antwerp Antwerp Belgium"},{"name":"Department of Neurology and Memory Clinic Hospital Network Antwerp (ZNA) Middelheim and Hoge Beuken Antwerp 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