{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T11:15:14Z","timestamp":1778843714521,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,8,14]],"date-time":"2017-08-14T00:00:00Z","timestamp":1502668800000},"content-version":"vor","delay-in-days":225,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R13 AG030995"],"award-info":[{"award-number":["R13 AG030995"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp; Dem Diag Ass &amp; Dis Mo"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>We hypothesized that, like apolipoprotein E (<jats:italic>APOE<\/jats:italic>), other late\u2010onset Alzheimer's disease (LOAD) genetic susceptibility loci predict mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used a weighted genetic risk score (GRS) from 21 non\u2010<jats:italic>APOE<\/jats:italic> LOAD risk variants to predict survival in the Adult Changes in Thought and the Health and Retirement Studies. We meta\u2010analyzed hazard ratios and examined models adjusted for cognitive performance or limited to participants with dementia. For replication, we assessed the GRS\u2010longevity association in the Cohorts for Heart and Aging Research in Genomic Epidemiology, comparing cases surviving to age \u226590\u00a0years with controls who died between ages 55 and 80\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Higher GRS predicted mortality (hazard ratio\u00a0=\u00a01.05; 95% confidence interval: 1.00\u20131.10, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.04). After adjusting for cognitive performance or restricting to participants with dementia, the relationship was attenuated and no longer significant. In case\u2010control analysis, the GRS was associated with reduced longevity (odds ratio\u00a0=\u00a00.64; 95% confidence interval: 0.41\u20131.00, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Non\u2010<jats:italic>APOE<\/jats:italic> LOAD susceptibility loci confer risk for mortality, likely through effects on dementia incidence.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.dadm.2017.07.002","type":"journal-article","created":{"date-parts":[[2017,8,15]],"date-time":"2017-08-15T00:30:12Z","timestamp":1502757012000},"page":"188-195","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Alzheimer's disease genetic risk variants beyond <i>APOE<\/i> \u03b54 predict mortality"],"prefix":"10.1002","volume":"8","author":[{"given":"Jesse","family":"Mez","sequence":"first","affiliation":[{"name":"Alzheimer's Disease and Chronic Traumatic Encephalopathy Center Boston University School of Medicine Boston MA USA"},{"name":"Department of Neurology Boston University School of Medicine Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica R.","family":"Marden","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Harvard T.H. 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