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We defined ventriculomegaly as EI\u00a0\u2265\u00a00.30, and the participants were stratified into EI\u00a0\u2265\u00a00.30 group and EI\u00a0&lt;\u00a00.30 group. Neuropsychological, imaging, and fluid biomarker profiles between the two groups were then compared using regression models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 96 (22.5%) individuals who had ventriculomegaly performed worse on the cognitive tests; showed smaller hippocampal volume but larger caudate, cingulate, and paracentral gyrus volumes; and displayed lower positron emission tomography [<jats:sup>18<\/jats:sup>F]fluorodeoxyglucose standardized uptake value ratio but higher amyloid burden represented by higher [<jats:sup>18<\/jats:sup>F]florbetapir standardized uptake value ratio and lower cerebrospinal fluid amyloid \u03b2 1\u201342 levels compared to those without ventriculomegaly.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Asymptomatic ventriculomegaly might be an early imaging signature of preclinical Alzheimer's disease and\/or normal pressure hydrocephalus.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.dadm.2017.08.001","type":"journal-article","created":{"date-parts":[[2017,9,5]],"date-time":"2017-09-05T18:15:44Z","timestamp":1504635344000},"page":"12-21","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Characterizing biomarker features of cognitively normal individuals with ventriculomegaly"],"prefix":"10.1002","volume":"10","author":[{"given":"Xiaofeng","family":"Li","sequence":"first","affiliation":[{"name":"Department of Neurology The Second Affiliated Hospital of Chongqing Medical University Chongqing PR China"},{"name":"Alzheimer's Disease Research Unit The McGill University Research Centre for Studies in Aging, McGill University Montreal Canada"},{"name":"Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging Montreal 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