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Retinal thickness decrease has been correlated to AD, however, without information on amyloid status. We correlated retinal (layer) thickness to AD biomarkers in amyloid\u2010positive early\u2010onset AD (EOAD) patients and amyloid\u2010negative controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We measured macular thickness and peripapillary retinal nerve fiber layer thickness with OCT in 15 EOAD patients and 15 controls and correlated retinal thickness to visual rating scores for atrophy on magnetic resonance imaging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Total macular thickness correlated to parietal cortical atrophy in both groups (Spearman \u03c1\u00a0\u22120.603, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.001). Macular and peripapillary retinal nerve fiber layer thicknesses were not significantly decreased in EOAD compared to controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Retinal thickness does not discriminate EOAD from controls but is correlated to parietal cortical atrophy in both groups. These findings may suggest reflection of cerebral cortical changes in the retina, independent of amyloid.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.dadm.2017.10.005","type":"journal-article","created":{"date-parts":[[2017,11,6]],"date-time":"2017-11-06T09:46:09Z","timestamp":1509961569000},"page":"49-55","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":85,"title":["Retinal thickness correlates with parietal cortical atrophy in early\u2010onset Alzheimer's disease and controls"],"prefix":"10.1002","volume":"10","author":[{"given":"Jurre","family":"den Haan","sequence":"first","affiliation":[{"name":"Department of Neurology, Alzheimer Center VU University Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah F.","family":"Janssen","sequence":"additional","affiliation":[{"name":"Ophthalmology Department VU University Medical Center Amsterdam The 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