{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T03:40:12Z","timestamp":1775792412461,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"vor","delay-in-days":59,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2002\u20105462"],"award-info":[{"award-number":["2002\u20105462"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001725","name":"Royal Swedish Academy of Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008587","name":"Stiftelsen Psykiatriska Forskningsfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp;amp; Dem Diag Ass &amp;amp; Dis Mo"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Previous research on structural changes in early\u2010onset Alzheimer's disease (EOAD) and late\u2010onset Alzheimer's disease (LOAD) have reported inconsistent findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In the present substudy of the Gothenburg MCI study, 1.5\u00a0T scans were used to estimate lobar and hippocampal volumes using FreeSurfer. Study participants (N = 145) included 63 patients with AD, (24 patients with EOAD [aged \u226465 years], 39 patients with LOAD [aged &gt;65 years]), 25 healthy controls aged \u226465 years, and 57 healthy controls aged &gt;65 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Hippocampal atrophy is the most prominent feature of both EOAD and LOAD compared with controls. Direct comparison between EOAD and LOAD showed that the differences between the groups did not remain after correcting for age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Structurally, EOAD and LOAD does not seem to be different nosological entities. The difference in brain volumes between the groups compared with controls is likely due to age\u2010related atrophy.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.dadm.2018.02.001","type":"journal-article","created":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T10:34:39Z","timestamp":1519900479000},"page":"253-259","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Similar pattern of atrophy in early\u2010 and late\u2010onset Alzheimer's disease"],"prefix":"10.1002","volume":"10","author":[{"given":"Carl","family":"Eckerstr\u00f6m","sequence":"first","affiliation":[{"name":"Institute of Neuroscience and Physiology, University of Gothenburg Gothenberg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niklas","family":"Klasson","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience and Physiology, University of Gothenburg Gothenberg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik","family":"Olsson","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience and Physiology, University of Gothenburg Gothenberg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Per","family":"Selnes","sequence":"additional","affiliation":[{"name":"Department of Neurology Akershus University Hospital L\u00f8renskog Norway"},{"name":"Institute of Clinical Medicine Campus Ahus University of Oslo Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sindre","family":"Rolstad","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience and Physiology, University of Gothenburg Gothenberg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"Wallin","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience and Physiology, University of Gothenburg Gothenberg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/YCO.0b013e32816ebc7b"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00308809"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0891988706297086"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2010-1337"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2015.04.019"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2013.02.013"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-142292"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl377"},{"key":"e_1_2_8_10_1","first-page":"333","article-title":"Voxel\u2010based morphometric comparison between early\u2010 and late\u2010onset mild Alzheimer's disease and assessment of diagnostic performance of z score images","volume":"26","author":"Ishii K.","year":"2005","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2013.01.001"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2014.03.009"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2015.147"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/089198879600900406"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.32.6.1318"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.34.7.939"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.56.6.673"},{"key":"e_1_2_8_18_1","unstructured":"FreeSurfer website. Home page. Available at:https:\/\/surfer.nmr.mgh.harvard.edu\/. Accessed March 9 2018."},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1998.0395"},{"key":"e_1_2_8_20_1","unstructured":"FreeSurfer website. Pipeline Overview.\u00a02015. Available at:http:\/\/surfer.nmr.mgh.harvard.edu\/fswiki\/FreeSurferAnalysisPipelineOverview. Accessed March 9 2018."},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.200033797"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1109\/42.906426"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2006.887364"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhg087"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00569-X"},{"key":"e_1_2_8_26_1","unstructured":"FreeSurfer website. ReconAllDevTable.\u00a02015. Available at:https:\/\/surfer.nmr.mgh.harvard.edu\/fswiki\/ReconAllDevTable. Accessed March 9 2018."},{"key":"e_1_2_8_27_1","unstructured":"FreeSurfer website. Cortical Parcellation.\u00a02016. Available at:https:\/\/surfer.nmr.mgh.harvard.edu\/fswiki\/CorticalParcellation. Accessed March 9 2018."},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2008.04.024"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1159\/000151241"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22927"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000194240.47892.4d"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2017.02.010"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1177\/1533317512454711"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2014.02.004"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0114478"}],"container-title":["Alzheimer's &amp; Dementia: Diagnosis, Assessment &amp; Disease Monitoring"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352872918300095?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352872918300095?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.dadm.2018.02.001","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.dadm.2018.02.001","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.dadm.2018.02.001","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.dadm.2018.02.001","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T19:55:48Z","timestamp":1760385348000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1016\/j.dadm.2018.02.001"}},"subtitle":[],"editor":[{"given":"David","family":"Wolk","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Victor","family":"Villemagne","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Bradford","family":"Dickerson","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["10.1016\/j.dadm.2018.02.001"],"URL":"https:\/\/doi.org\/10.1016\/j.dadm.2018.02.001","archive":["Portico"],"relation":{},"ISSN":["2352-8729","2352-8729"],"issn-type":[{"value":"2352-8729","type":"print"},{"value":"2352-8729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"2018-03-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}