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The strongest signal was observed at 16p12.1 (25\u00a0cM, 33\u00a0Mb; heterogeneity logarithm of odds\u00a0=\u00a05.3), \u223c3\u00a0Mb upstream of the ceroid lipofuscinosis 3 (<jats:italic>CLN3<\/jats:italic>) gene associated with juvenile neuronal ceroid lipofuscinosis (JNCL), which functions in retromer trafficking and has been reported to alter intracellular processing of the amyloid precursor protein.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>This study supports the notion that the genetic architectures of unexplained EOAD and late\u2010onset AD overlap partially, but not fully.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.dadm.2018.07.007","type":"journal-article","created":{"date-parts":[[2018,8,27]],"date-time":"2018-08-27T09:19:03Z","timestamp":1535361543000},"page":"554-562","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Linkage analysis of multiplex Caribbean Hispanic families loaded for unexplained early\u2010onset cases identifies novel Alzheimer's disease loci"],"prefix":"10.1002","volume":"10","author":[{"given":"Rong","family":"Cheng","sequence":"first","affiliation":[{"name":"The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University New York NY USA"},{"name":"The Gertrude H. 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