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Genetic variation in the cholesteryl ester transfer protein (<jats:italic>CETP<\/jats:italic>) locus is associated with altered HDL\u2010C. We aimed to assess AD risk by genetically predicted HDL\u2010C.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ten single nucleotide polymorphisms within the <jats:italic>CETP<\/jats:italic> locus predicting HDL\u2010C were applied to the International Genomics of Alzheimer's Project (IGAP) exome chip stage 1 results in up 16,097 late onset AD cases and 18,077 cognitively normal elderly controls. We performed instrumental variables analysis using inverse variance weighting, weighted median, and MR\u2010Egger.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Based on 10 single nucleotide polymorphisms distinctly predicting HDL\u2010C in the <jats:italic>CETP<\/jats:italic> locus, we found that HDL\u2010C was not associated with risk of AD (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a0.7).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Our study does not support the role of HDL\u2010C on risk of AD through HDL\u2010C altered by <jats:italic>CETP<\/jats:italic>. This study does not rule out other mechanisms by which HDL\u2010C affects risk of AD.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.dadm.2018.08.008","type":"journal-article","created":{"date-parts":[[2018,9,22]],"date-time":"2018-09-22T01:11:49Z","timestamp":1537578709000},"page":"595-598","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Genetically elevated high\u2010density lipoprotein cholesterol through the cholesteryl ester transfer protein gene does not associate with risk of Alzheimer's disease"],"prefix":"10.1002","volume":"10","author":[{"given":"Gina M.","family":"Peloso","sequence":"first","affiliation":[{"name":"Department of Biostatistics Boston University School of Public Health Boston MA USA"},{"name":"Department of Epidemiology Erasmus MC University Medical Center Rotterdam Netherlands"},{"name":"NHLBI's Framingham Heart Study Framingham MA USA"},{"name":"Department of Neurology Boston University School 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(IGAP)","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Sims","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Boston University School of Public Health Boston MA USA"},{"name":"Department of Epidemiology Erasmus MC University Medical Center Rotterdam Netherlands"},{"name":"NHLBI's Framingham Heart Study Framingham MA USA"},{"name":"Department of Neurology Boston University School of Medicine Boston MA USA"},{"name":"Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Sciences Center San Antonio TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.J.","family":"van der Lee","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Boston University School of Public Health Boston MA USA"},{"name":"Department of Epidemiology Erasmus MC University Medical Center Rotterdam Netherlands"},{"name":"NHLBI's 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