{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T03:50:42Z","timestamp":1782791442251,"version":"3.54.5"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,1,10]],"date-time":"2019-01-10T00:00:00Z","timestamp":1547078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000368","name":"Brain Research Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000368","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001320","name":"Wolfson Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001320","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000320","name":"Alzheimer's Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000320","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008721","name":"University College London Hospitals NHS Foundation Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008721","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp;amp; Dem Diag Ass &amp;amp; Dis Mo"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Frontotemporal dementia (FTD) is a heterogeneous neurodegenerative disorder with multiple genetic and pathological causes. It is characterized by both cortical and subcortical atrophies, with previous studies showing early involvement of the amygdala. However, no prior study has specifically investigated the atrophy of different subnuclei of the amygdala.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using an automated segmentation tool for T1\u2010weighted volumetric magnetic resonance imaging, we investigated amygdalar subnuclei (AS) involvement in a cohort of 132 patients with genetic or pathologically confirmed FTD (age: mean = 61 years (standard deviation = 8); disease duration: 5 (3) years) compared with 107 age\u2010matched controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>AS were affected in all genetic and pathological forms of FTD. <jats:italic>MAPT<\/jats:italic> mutations\/FTDP\u201017, Pick's disease, and transactive response DNA binding protein 43 kDa type C were the forms with the smallest amygdala (35%\u201350% smaller than controls in the most affected hemisphere, <jats:italic>P<\/jats:italic> &lt; .0005). In most FTD groups, medial subnuclei (particularly the superficial, accessory basal and basal\/paralaminar subnuclei) tended to be affected more than the lateral subnuclei, except for the progressive supranuclear palsy group, in which the corticoamygdaloid transition area was the least\u2010affected area.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Differential involvement of the AS was seen in the different genetic and pathological forms of FTD. In general, the most affected subnuclei were the superficial, accessory basal and basal\/paralaminar subnuclei, which form part of a network of regions that control reward and emotion regulation, functions known to be particularly affected in FTD.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.dadm.2018.12.006","type":"journal-article","created":{"date-parts":[[2019,1,27]],"date-time":"2019-01-27T07:16:27Z","timestamp":1548573387000},"page":"136-141","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Amygdala subnuclei are differentially affected in the different genetic and pathological forms of frontotemporal dementia"],"prefix":"10.1002","volume":"11","author":[{"given":"Martina","family":"Bocchetta","sequence":"first","affiliation":[{"name":"Dementia Research Centre Department of Neurodegenerative Disease UCL Queen Square Institute of Neurology, University College London London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Eugenio","family":"Iglesias","sequence":"additional","affiliation":[{"name":"Centre for Medical Image Computing Department of Medical Physics and Biomedical Engineering University College London London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Cash","sequence":"additional","affiliation":[{"name":"Dementia Research Centre Department of Neurodegenerative Disease UCL Queen Square Institute of Neurology, University College London London United Kingdom"},{"name":"Centre for Medical Image Computing Department of Medical Physics and Biomedical Engineering University College London London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason D.","family":"Warren","sequence":"additional","affiliation":[{"name":"Dementia Research Centre Department of Neurodegenerative Disease UCL Queen Square Institute of Neurology, University College London London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan D.","family":"Rohrer","sequence":"additional","affiliation":[{"name":"Dementia Research Centre Department of Neurodegenerative Disease UCL Queen Square Institute of Neurology, University College London London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,10]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0b013e32834cd442"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.13588"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/nan.12250"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws001"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.12.088"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70324-2"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00227731"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-013-1238-y"},{"key":"e_1_2_7_10_2","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.neubiorev.2011.08.007","article-title":"Where and what is the paralaminar nucleus? 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