{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T12:11:29Z","timestamp":1760443889447,"version":"build-2065373602"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,6,7]],"date-time":"2019-06-07T00:00:00Z","timestamp":1559865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp;amp; Dem Diag Ass &amp;amp; Dis Mo"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>There is observational evidence that low circulating levels of vitamin B12 are associated with an increased risk of Alzheimer's disease<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used a two\u2010sample summary\u2010statistics\u2013based Mendelian randomization design to assess the relationship of genetic factors contributing to vitamin B12 with late\u2010onset Alzheimer's disease risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our results do not support a causal role of decreased vitamin B12 levels on Alzheimer's disease risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>This work encourages research on other modifiable biomarkers for Alzheimer's disease risk.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.dadm.2019.04.007","type":"journal-article","created":{"date-parts":[[2019,6,7]],"date-time":"2019-06-07T11:45:36Z","timestamp":1559907936000},"page":"430-434","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Genetic determinants of low vitamin B12 levels in Alzheimer's disease risk"],"prefix":"10.1002","volume":"11","author":[{"given":"Sarah A.","family":"Gagliano Taliun","sequence":"first","affiliation":[{"name":"Center for Statistical Genetics, University of Michigan School of Public Health Ann Arbor MI USA"},{"name":"Center for Statistical Genetics, University of Michigan School of Public Health Ann Arbor Michigan USA"},{"name":"Department of Biostatistics University of Michigan School of Public Health Ann Arbor MI USA"},{"name":"Department of Biostatistics University of Michigan School of Public Health Ann Arbor Michigan 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