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We therefore measured retinal thickness in well\u2010characterized AD and control participants, considering ophthalmological confounders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included 57 amyloid\u2010proven AD cases and 85 cognitively normal, amyloid\u2010negative controls. All subjects underwent retinal thickness measurements with spectral domain optical coherence tomography and an ophthalmological assessment to exclude ocular disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Retinal thickness did not discriminate cases from controls, including stratified analyses for early\u2010 versus late\u2010onset AD. We found significant associations between macular thickness and global cortical atrophy [\u03b2 \u22120.358; <jats:italic>P<\/jats:italic> = .01] and parietal cortical atrophy on magnetic resonance imaging [\u03b2 \u22120.371; <jats:italic>P<\/jats:italic> &lt; .01] in AD cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>In this study, representing the largest optical coherence tomography cohort with amyloid\u2010proven AD cases, we show that retinal thickness does not discriminate AD from controls, despite evident changes on clinical, neuroimaging, and CSF measures, querying the use of retinal thickness measurements as an AD biomarker.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.dadm.2019.05.002","type":"journal-article","created":{"date-parts":[[2019,6,18]],"date-time":"2019-06-18T00:12:09Z","timestamp":1560816729000},"page":"463-471","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Retinal thickness as a potential biomarker in patients with amyloid\u2010proven early\u2010 and late\u2010onset Alzheimer's disease"],"prefix":"10.1002","volume":"11","author":[{"given":"Jurre","family":"den Haan","sequence":"first","affiliation":[{"name":"Department of Neurology Alzheimer Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam Amsterdam the Netherlands"},{"name":"Alzheimer Center Amsterdam Department of Neurology, Amsterdam Neuroscience Amsterdam UMC, Vrije Universiteit Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacoba A.","family":"van de 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