{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T13:17:45Z","timestamp":1775999865969,"version":"3.50.1"},"reference-count":24,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental & Comparative Immunology"],"published-print":{"date-parts":[[2008,1]]},"DOI":"10.1016\/j.dci.2008.04.003","type":"journal-article","created":{"date-parts":[[2008,5,13]],"date-time":"2008-05-13T08:12:40Z","timestamp":1210666360000},"page":"1242-1247","source":"Crossref","is-referenced-by-count":16,"title":["An immunoregulatory peptide from salivary glands of the horsefly, Hybomitra atriperoides"],"prefix":"10.1016","volume":"32","author":[{"given":"Xiuwen","family":"Yan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haining","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaolong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingze","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren","family":"Lai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.dci.2008.04.003_bib1","first-page":"143","article-title":"Blood-feeding arthropods: live syringes or invertebrate pharmacologists?","volume":"4","author":"Ribeiro","year":"1995","journal-title":"Infect Agents Dis"},{"issue":"26","key":"10.1016\/j.dci.2008.04.003_bib2","doi-asserted-by":"crossref","first-page":"15155","DOI":"10.1073\/pnas.96.26.15155","article-title":"Toward an understanding of the biochemical and pharmacological complexity of the saliva of a hematophagous sand fly Lutzomyia longipalpis","volume":"96","author":"Charlab","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"issue":"Pt 2","key":"10.1016\/j.dci.2008.04.003_bib3","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1242\/jeb.02003","article-title":"Vasotab, a vasoactive peptide from horse fly Hybomitra bimaculata (Diptera, Tabanidae) salivary glands","volume":"209","author":"Tak\u00e1c","year":"2006","journal-title":"J Exp Biol"},{"key":"10.1016\/j.dci.2008.04.003_bib4","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1242\/jeb.165.1.61","article-title":"Characterization of a vasodilator from the salivary glands of the yellow fever mosquito Aedes aegypti","volume":"165","author":"Ribeiro","year":"1992","journal-title":"J Exp Biol"},{"issue":"4","key":"10.1016\/j.dci.2008.04.003_bib5","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1073\/pnas.96.4.1516","article-title":"Trapping cDNAs encoding secreted proteins from the salivary glands of the malaria vector Anopheles gambiae","volume":"96","author":"Arca","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"issue":"2","key":"10.1016\/j.dci.2008.04.003_bib6","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1097\/00001721-199903000-00001","article-title":"Invertebrate compounds acting on the hemostatic mechanism","volume":"10","author":"Arocha-Pi\u00f1ango","year":"1999","journal-title":"Blood Coagul Fibrinolysis"},{"issue":"3","key":"10.1016\/j.dci.2008.04.003_bib7","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1055\/s-0038-1648892","article-title":"Inventory of coagulation inhibitors from animals feeding on blood. A report prepared on behalf of the scientific and standardization committee's registry of exogenous hemostatic factors","volume":"72","author":"Markwardt","year":"1994","journal-title":"Thromb Haemost"},{"issue":"3-6","key":"10.1016\/j.dci.2008.04.003_bib8","first-page":"294","article-title":"Identification of anticoagulant activities in salivary gland extracts of four horsefly species (Diptera, tabanidae)","volume":"31","author":"Kazim\u00edrov\u00e1","year":"2001","journal-title":"Haemostasis"},{"key":"10.1016\/j.dci.2008.04.003_bib9","series-title":"The immunology of host\u2013ectoparasitic arthropod relationships","author":"Wikel","year":"1996"},{"issue":"3","key":"10.1016\/j.dci.2008.04.003_bib10","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/0014-4894(87)90046-4","article-title":"Ixodes dammini: salivary anti-complement activity","volume":"64","author":"Ribeiro","year":"1987","journal-title":"Exp Parasitol"},{"issue":"2","key":"10.1016\/j.dci.2008.04.003_bib11","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/0014-4894(86)90034-2","article-title":"Ixodes dammini: salivary anaphylatoxin inactivating activity","volume":"62","author":"Ribeiro","year":"1986","journal-title":"Exp Parasitol"},{"issue":"4","key":"10.1016\/j.dci.2008.04.003_bib12","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/0014-4894(90)90121-R","article-title":"Saliva of the tick Ixodes dammini inhibits neutrophil function","volume":"70","author":"Ribeiro","year":"1990","journal-title":"Exp Parasitol"},{"issue":"3","key":"10.1016\/j.dci.2008.04.003_bib13","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1084\/jem.180.3.1077","article-title":"Saliva of the Lyme disease vector, Ixodes dammini, blocks cell activation by a nonprostaglandin E2-dependent mechanism","volume":"180","author":"Urioste","year":"1994","journal-title":"J Exp Med"},{"issue":"4","key":"10.1016\/j.dci.2008.04.003_bib14","first-page":"169","article-title":"Suppressive effect of Ixodes ricinus salivary gland extract on mechanisms of natural immunity in vitro","volume":"20","author":"Kopecky","year":"1998","journal-title":"Parasite Immunol"},{"issue":"3","key":"10.1016\/j.dci.2008.04.003_bib15","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1046\/j.1365-2567.1999.00683.x","article-title":"Successive tick infestations selectively promote a T-helper 2 cytokine profile in mice","volume":"96","author":"Ferreira","year":"1999","journal-title":"Immunology"},{"issue":"7","key":"10.1016\/j.dci.2008.04.003_bib16","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1046\/j.1365-3024.1999.00233.x","article-title":"Salivary gland extract from Ixodes ricinus ticks inhibits production of interferon-\u03b3 by the upregulation of interleukin-10","volume":"21","author":"Kopecky","year":"1999","journal-title":"Parasite Immunol"},{"issue":"12","key":"10.1016\/j.dci.2008.04.003_bib17","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1111\/j.1365-3024.2006.00899.x","article-title":"Anti-tumour necrosis factor-alpha activity in Ixodes ricinus saliva","volume":"28","author":"Kon\u00edk","year":"2006","journal-title":"Parasite Immunol"},{"issue":"3","key":"10.1016\/j.dci.2008.04.003_bib18","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1111\/j.1574-695X.2007.00223.x","article-title":"T-cell signaling pathways inhibited by the tick saliva immunosuppressor, Salp15","volume":"49","author":"Juncadella","year":"2007","journal-title":"FEMS Immunol Med Microbiol"},{"issue":"7050","key":"10.1016\/j.dci.2008.04.003_bib19","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/nature03812","article-title":"The Lyme disease agent exploits a tick protein to infect the mammalian host","volume":"436","author":"Ramamoorthi","year":"2005","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.dci.2008.04.003_bib20","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.bbrc.2006.02.188","article-title":"A tick B-cell inhibitory protein from salivary glands of the hard tick, Hyalomma asiaticum asiaticum","volume":"343","author":"Yu","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"issue":"3","key":"10.1016\/j.dci.2008.04.003_bib21","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1074\/mcp.M700497-MCP200","article-title":"Toward an understanding of the molecular mechanism for successfully blood-feeding by proteomics analysis coupling with pharmacological testing of horse fly salivary glands","volume":"7","author":"Xu","year":"2008","journal-title":"Mol Cell Proteomics"},{"issue":"3","key":"10.1016\/j.dci.2008.04.003_bib22","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1093\/jee\/73.3.431","article-title":"Impact of tabanids on cattle: blood meal size and preferred feeding sites","volume":"73","author":"Hollander","year":"1980","journal-title":"J Econ Entomol"},{"issue":"4","key":"10.1016\/j.dci.2008.04.003_bib23","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1590\/S0001-37652005000400008","article-title":"Haematophagous arthropod saliva and host defense system: a tale of tear and blood","volume":"77","author":"Andrade","year":"2005","journal-title":"Ann Acad Bras Cienc"},{"issue":"1","key":"10.1016\/j.dci.2008.04.003_bib24","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1046\/j.1365-3024.2003.00605.x","article-title":"Ixodes ricinus tick salivary gland extract inhibits IL-10 secretion and CD69 expression by mitogen-stimulated murine splenocytes and induces hyporesponsiveness in B lymphocytes","volume":"25","author":"Hannier","year":"2003","journal-title":"Parasite Immunol"}],"container-title":["Developmental & Comparative Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145305X08000992?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145305X08000992?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,9,10]],"date-time":"2021-09-10T11:12:34Z","timestamp":1631272354000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0145305X08000992"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1]]},"references-count":24,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2008,1]]}},"alternative-id":["S0145305X08000992"],"URL":"https:\/\/doi.org\/10.1016\/j.dci.2008.04.003","relation":{},"ISSN":["0145-305X"],"issn-type":[{"value":"0145-305X","type":"print"}],"subject":[],"published":{"date-parts":[[2008,1]]}}}