{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T20:22:50Z","timestamp":1787602970998,"version":"build-2736575974"},"reference-count":56,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental & Comparative Immunology"],"published-print":{"date-parts":[[2011,4]]},"DOI":"10.1016\/j.dci.2010.11.017","type":"journal-article","created":{"date-parts":[[2010,12,25]],"date-time":"2010-12-25T04:54:44Z","timestamp":1293252884000},"page":"490-500","source":"Crossref","is-referenced-by-count":19,"title":["Porcine S100A8 and S100A9: Molecular characterizations and crucial functions in response to Haemophilus parasuis infection"],"prefix":"10.1016","volume":"35","author":[{"given":"Hongbo","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan K.","family":"Lunney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengjin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.dci.2010.11.017_bib0005","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1038\/jid.2010.158","article-title":"The antimicrobial heterodimer S100A8\/S100A9 (calprotectin) is upregulated by bacterial flagellin in human epidermal keratinocytes","volume":"130","author":"Abtin","year":"2010","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.dci.2010.11.017_bib0010","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1292\/jvms.56.639","article-title":"Pathologic observations of pigs intranasally inoculated with serovar 1, 4 and 5 of Haemophilus parasuis using immunoperoxidase method","volume":"56","author":"Amano","year":"1994","journal-title":"J. Vet. Med. Sci."},{"key":"10.1016\/j.dci.2010.11.017_bib0015","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1136\/vr.151.17.502","article-title":"Protection of vaccinated pigs against experimental infections with homologous and heterologous Haemophilus parasuis","volume":"151","author":"Bak","year":"2002","journal-title":"Vet. Rec."},{"key":"10.1016\/j.dci.2010.11.017_bib0020","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1136\/vr.151.1.18","article-title":"Effect of vaccinating sows and their piglets on the development of Glasser's disease induced by a virulent strain of Haemophilus parasuis serovar 5","volume":"151","author":"Baumann","year":"2002","journal-title":"Vet. Rec."},{"key":"10.1016\/j.dci.2010.11.017_bib0025","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1038\/sj.jid.5700820","article-title":"HaCaT keratinocytes overexpressing the S100 proteins S100A8 and S100A9 show increased NADPH oxidase and NF-kappaB activities","volume":"127","author":"Benedyk","year":"2007","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.dci.2010.11.017_bib0030","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/j.1699-0463.1995.tb01100.x","article-title":"Effects of calprotectin in avridine-induced arthritis","volume":"103","author":"Brun","year":"1995","journal-title":"Apmis"},{"key":"10.1016\/j.dci.2010.11.017_bib0035","doi-asserted-by":"crossref","first-page":"7078","DOI":"10.1074\/jbc.M806605200","article-title":"Calprotectin S100A9 calcium-binding loops I and II are essential for keratinocyte resistance to bacterial invasion","volume":"284","author":"Champaiboon","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.dci.2010.11.017_bib0040","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1016\/j.molimm.2010.01.024","article-title":"Molecular characterization, induced expression, and transcriptional regulation of porcine S100A12 gene","volume":"47","author":"Chen","year":"2010","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.dci.2010.11.017_bib0045","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/1471-2164-10-64","article-title":"Understanding Haemophilus parasuis infection in porcine spleen through a transcriptomics approach","volume":"10","author":"Chen","year":"2009","journal-title":"BMC Genomics"},{"key":"10.1016\/j.dci.2010.11.017_bib0050","first-page":"69","article-title":"Regional assignment of genetic markers using a somatic cell hybrid panel: a WWW interactive program available for the pig genome","volume":"13","author":"Chevalet","year":"1997","journal-title":"Comput. Appl. Biosci."},{"key":"10.1016\/j.dci.2010.11.017_bib0055","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1007\/s00335-009-9234-1","article-title":"ANEXdb: an integrated animal ANnotation and microarray EXpression database","volume":"20","author":"Couture","year":"2009","journal-title":"Mamm. Genome"},{"key":"10.1016\/j.dci.2010.11.017_bib0060","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/1357-2725(95)00115-8","article-title":"Complex assembly of calgranulins A and B, two S100-like calcium-binding proteins from pig granulocytes","volume":"28","author":"Dell\u2019Angelica","year":"1996","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.dci.2010.11.017_bib0065","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1038\/326614a0","article-title":"A clue to the basic defect in cystic fibrosis from cloning the CF antigen gene","volume":"326","author":"Dorin","year":"1987","journal-title":"Nature"},{"key":"10.1016\/j.dci.2010.11.017_bib0070","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1189\/jlb.1008647","article-title":"The endogenous Toll-like receptor 4 agonist S100A8\/S100A9 (calprotectin) as innate amplifier of infection, autoimmunity, and cancer","volume":"86","author":"Ehrchen","year":"2009","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.dci.2010.11.017_bib0075","doi-asserted-by":"crossref","first-page":"2258","DOI":"10.4049\/jimmunol.0802683","article-title":"IL-10-dependent S100A8 gene induction in monocytes\/macrophages by double-stranded RNA","volume":"182","author":"Endoh","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.dci.2010.11.017_bib0080","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1186\/1471-2164-11-292","article-title":"Transcriptome analysis of porcine PBMCs after in vitro stimulation by LPS or PMA\/ionomycin using an expression array targeting the pig immune response","volume":"11","author":"Gao","year":"2010","journal-title":"BMC Genomics"},{"key":"10.1016\/j.dci.2010.11.017_bib0085","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1016\/j.bcp.2006.05.017","article-title":"S100A8 and S100A9 in inflammation and cancer","volume":"72","author":"Gebhardt","year":"2006","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.dci.2010.11.017_bib0090","doi-asserted-by":"crossref","DOI":"10.1007\/s00726-010-0528-0","article-title":"Inflammation-associated S100 proteins: new mechanisms that regulate function","author":"Goyette","year":"2010","journal-title":"Amino Acids"},{"key":"10.1016\/j.dci.2010.11.017_bib0095","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1139\/Y09-054","article-title":"S100A8\/A9: a mediator of severe asthma pathogenesis and morbidity?","volume":"87","author":"Halayko","year":"2009","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.dci.2010.11.017_bib0100","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/978-1-4020-6191-2_5","article-title":"Pathologies involving the S100 proteins and RAGE","volume":"45","author":"Heizmann","year":"2007","journal-title":"Subcell. Biochem."},{"key":"10.1016\/j.dci.2010.11.017_bib0105","doi-asserted-by":"crossref","first-page":"2564","DOI":"10.1128\/MCB.23.7.2564-2576.2003","article-title":"Myeloid cell function in MRP-14 (S100A9) null mice","volume":"23","author":"Hobbs","year":"2003","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.dci.2010.11.017_bib0110","doi-asserted-by":"crossref","first-page":"290","DOI":"10.2174\/187152309789838975","article-title":"Anti-infective protective properties of S100 calgranulins","volume":"8","author":"Hsu","year":"2009","journal-title":"Antiinflamm. Antiallergy Agents Med. Chem."},{"key":"10.1016\/j.dci.2010.11.017_bib0115","doi-asserted-by":"crossref","first-page":"2318","DOI":"10.4049\/jimmunol.174.4.2318","article-title":"Regulation of S100A8 by glucocorticoids","volume":"174","author":"Hsu","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.dci.2010.11.017_bib0120","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1001\/archoto.2008.513","article-title":"Gene expression differences in infected and noninfected middle ear complementary DNA libraries","volume":"135","author":"Kerschner","year":"2009","journal-title":"Arch. Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.dci.2010.11.017_bib0125","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1247\/csf.23.109","article-title":"Transcriptional regulation by C\/EBP alpha and -beta in the expression of the gene for the MRP14 myeloid calcium binding protein","volume":"23","author":"Kuruto-Niwa","year":"1998","journal-title":"Cell Struct. Funct."},{"key":"10.1016\/j.dci.2010.11.017_bib0130","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1155\/2008\/308942","article-title":"S100 calgranulin proteins S100A8 and S100A9 and S100A12 are expressed in the inflamed gastric mucosa of Helicobacter pylori-infected children","volume":"22","author":"Leach","year":"2008","journal-title":"Can. J. Gastroenterol."},{"key":"10.1016\/j.dci.2010.11.017_bib0135","doi-asserted-by":"crossref","first-page":"5627","DOI":"10.4049\/jimmunol.181.8.5627","article-title":"S-nitrosylated S100A8: novel anti-inflammatory properties","volume":"181","author":"Lim","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.dci.2010.11.017_bib0140","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1189\/jlb.1008608","article-title":"Oxidative modifications of S100 proteins: functional regulation by redox","volume":"86","author":"Lim","year":"2009","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.dci.2010.11.017_bib0145","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1038\/nm.2150","article-title":"The Toll-like receptor 4 ligands Mrp8 and Mrp14 are crucial in the development of autoreactive CD8+ T cells","volume":"16","author":"Loser","year":"2010","journal-title":"Nat. Med."},{"key":"10.1016\/j.dci.2010.11.017_bib0150","doi-asserted-by":"crossref","first-page":"2797","DOI":"10.1016\/j.molimm.2008.02.007","article-title":"Molecular characterization of the porcine GBP1 and GBP2 genes","volume":"45","author":"Ma","year":"2008","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.dci.2010.11.017_bib0155","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1128\/MCB.23.3.1034-1043.2003","article-title":"Loss of S100A9 (MRP14) results in reduced interleukin-8-induced CD11b surface expression, a polarized microfilament system, and diminished responsiveness to chemoattractants in vitro","volume":"23","author":"Manitz","year":"2003","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.dci.2010.11.017_bib0160","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1093\/bioinformatics\/16.6.558","article-title":"IMpRH server: an RH mapping server available on the Web","volume":"16","author":"Milan","year":"2000","journal-title":"Bioinformatics"},{"key":"10.1016\/j.dci.2010.11.017_bib0165","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/330080a0","article-title":"Two calcium-binding proteins in infiltrate macrophages of rheumatoid arthritis","volume":"330","author":"Odink","year":"1987","journal-title":"Nature"},{"key":"10.1016\/j.dci.2010.11.017_bib0170","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.vetmic.2003.12.001","article-title":"Haemophilus parasuis: new trends on diagnosis, epidemiology and control","volume":"99","author":"Oliveira","year":"2004","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.dci.2010.11.017_bib0175","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1080\/15569520903097754","article-title":"Transcriptional changes in porcine skin at 7 days following sulfur mustard and thermal burn injury","volume":"28","author":"Price","year":"2009","journal-title":"Cutan. Ocul. Toxicol."},{"key":"10.1016\/j.dci.2010.11.017_bib0180","article-title":"S100A8\/A9 induces apoptosis and inhibits metastasis of CasKi human cervical cancer cells","author":"Qin","year":"2009","journal-title":"Pathol. Oncol. Res."},{"key":"10.1016\/j.dci.2010.11.017_bib0185","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.ygeno.2004.02.002","article-title":"Probing the S100 protein family through genomic and functional analysis","volume":"84","author":"Ravasi","year":"2004","journal-title":"Genomics"},{"key":"10.1016\/j.dci.2010.11.017_bib0190","doi-asserted-by":"crossref","first-page":"4265","DOI":"10.1128\/IAI.00458-09","article-title":"Complicated urinary tract infection is associated with uroepithelial expression of proinflammatory protein S100A8","volume":"77","author":"Reyes","year":"2009","journal-title":"Infect. Immun."},{"key":"10.1016\/j.dci.2010.11.017_bib0195","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/0888-7543(95)80005-7","article-title":"Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family","volume":"25","author":"Schafer","year":"1995","journal-title":"Genomics"},{"key":"10.1016\/j.dci.2010.11.017_bib0200","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1574-695X.2008.00498.x","article-title":"Substitution of methionine 63 or 83 in S100A9 and cysteine 42 in S100A8 abrogate the antifungal activities of S100A8\/A9: potential role for oxidative regulation","volume":"55","author":"Sroussi","year":"2009","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"10.1016\/j.dci.2010.11.017_bib0205","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1097\/00042560-199712010-00002","article-title":"Elevated serum macrophage inhibitory factor-related protein (MRP) 8\/14 levels in advanced HIV infection and during disease exacerbation","volume":"16","author":"Strasser","year":"1997","journal-title":"J. Acquir. Immune Defic. Syndr. Hum. Retrovirol."},{"key":"10.1016\/j.dci.2010.11.017_bib0210","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1292\/jvms.63.487","article-title":"A cross-protection experiment in pigs vaccinated with Haemophilus parasuis serovars 2 and 5 bacterins, and evaluation of a bivalent vaccine under laboratory and field conditions","volume":"63","author":"Takahashi","year":"2001","journal-title":"J. Vet. Med. Sci."},{"key":"10.1016\/j.dci.2010.11.017_bib0215","doi-asserted-by":"crossref","first-page":"5116","DOI":"10.1073\/pnas.091062498","article-title":"Significance analysis of microarrays applied to the ionizing radiation response","volume":"98","author":"Tusher","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.dci.2010.11.017_bib0220","doi-asserted-by":"crossref","first-page":"2602","DOI":"10.4049\/jimmunol.171.5.2602","article-title":"Blockade of S100A8 and S100A9 suppresses neutrophil migration in response to lipopolysaccharide","volume":"171","author":"Vandal","year":"2003","journal-title":"J. Immunol."},{"key":"10.1016\/j.dci.2010.11.017_bib0225","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1164\/rccm.200810-1552OC","article-title":"Expression and role of myeloid-related protein-14 in clinical and experimental sepsis","volume":"180","author":"van Zoelen","year":"2009","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.dci.2010.11.017_bib0230","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1016\/j.bbamcr.2006.08.028","article-title":"Biophysical characterization of S100A8 and S100A9 in the absence and presence of bivalent cations","volume":"1763","author":"Vogl","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.dci.2010.11.017_bib0235","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1038\/nm1638","article-title":"Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock","volume":"13","author":"Vogl","year":"2007","journal-title":"Nat. Med."},{"key":"10.1016\/j.dci.2010.11.017_bib0240","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1186\/1471-2164-11-455","article-title":"Gene expression profiling in the lungs of pigs with different susceptibilities to Glasser's disease","volume":"11","author":"Wilkinson","year":"2010","journal-title":"BMC Genomics"},{"key":"10.1016\/j.dci.2010.11.017_bib0245","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/nbt0604-656b","article-title":"Preprocessing of oligonucleotide array data","volume":"22","author":"Wu","year":"2004","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.dci.2010.11.017_bib0250","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1198\/016214504000000683","article-title":"A model-based background adjustment for oligonucleotide expression arrays","volume":"99","author":"Wu","year":"2004","journal-title":"J. Am. Stat. Assoc."},{"key":"10.1016\/j.dci.2010.11.017_bib0255","doi-asserted-by":"crossref","first-page":"4916","DOI":"10.4049\/jimmunol.164.9.4916","article-title":"IFN-gamma and TNF regulate macrophage expression of the chemotactic S100 protein S100A8","volume":"164","author":"Xu","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.dci.2010.11.017_bib0260","doi-asserted-by":"crossref","first-page":"6358","DOI":"10.4049\/jimmunol.166.10.6358","article-title":"Il-10 up-regulates macrophage expression of the S100 protein S100A8","volume":"166","author":"Xu","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/j.dci.2010.11.017_bib0265","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1159\/000134338","article-title":"A somatic cell hybrid panel for pig regional gene mapping characterized by molecular cytogenetics","volume":"73","author":"Yerle","year":"1996","journal-title":"Cytogenet. Cell Genet."},{"key":"10.1016\/j.dci.2010.11.017_bib0270","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1159\/000015095","article-title":"Construction of a whole-genome radiation hybrid panel for high-resolution gene mapping in pigs","volume":"82","author":"Yerle","year":"1998","journal-title":"Cytogenet. Cell Genet."},{"key":"10.1016\/j.dci.2010.11.017_bib0275","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1002\/jlb.61.1.50","article-title":"Growth-inhibitory and apoptosis-inducing activities of calprotectin derived from inflammatory exudate cells on normal fibroblasts: regulation by metal ions","volume":"61","author":"Yui","year":"1997","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.dci.2010.11.017_bib0280","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1080\/09622935020138208","article-title":"Implication of extracellular zinc exclusion by recombinant human calprotectin (MRP8 and MRP14) from target cells in its apoptosis-inducing activity","volume":"11","author":"Yui","year":"2002","journal-title":"Mediators Inflamm."}],"container-title":["Developmental & Comparative Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145305X10003101?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145305X10003101?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,7]],"date-time":"2019-06-07T05:04:41Z","timestamp":1559883881000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0145305X10003101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4]]},"references-count":56,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,4]]}},"alternative-id":["S0145305X10003101"],"URL":"https:\/\/doi.org\/10.1016\/j.dci.2010.11.017","relation":{},"ISSN":["0145-305X"],"issn-type":[{"value":"0145-305X","type":"print"}],"subject":[],"published":{"date-parts":[[2011,4]]}}}