{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:13:18Z","timestamp":1788869598327,"version":"build-2803163510"},"reference-count":30,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"crossref","award":["2012CB114406"],"award-info":[{"award-number":["2012CB114406"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"name":"863 High Technology Project","award":["2012AA10A413-1"],"award-info":[{"award-number":["2012AA10A413-1"]}]},{"name":"Taishan Scholar Program of Shandong Province"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental & Comparative Immunology"],"published-print":{"date-parts":[[2014,2]]},"DOI":"10.1016\/j.dci.2013.09.001","type":"journal-article","created":{"date-parts":[[2013,9,20]],"date-time":"2013-09-20T17:34:14Z","timestamp":1379698454000},"page":"125-131","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Nuclear factor 45 of tongue sole (Cynoglossus semilaevis): Evidence for functional differentiation between two isoforms in immune defense against viral and bacterial pathogens"],"prefix":"10.1016","volume":"42","author":[{"given":"Heng","family":"Chi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-hua","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-zhong","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.dci.2013.09.001_b0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2013.07.016","article-title":"Nuclear factor 45 of half smooth tongue sole Cynoglossus semilaevis: gene structure, expression profile, and immunoregulatory property","author":"Chi","year":"2013","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2013.09.001_b0010","doi-asserted-by":"crossref","first-page":"7294","DOI":"10.4049\/jimmunol.162.12.7294","article-title":"Multiple NF-ATc isoforms with individual transcriptional properties are synthesized in T lymphocytes","volume":"162","author":"Chuvpilo","year":"1999","journal-title":"J. Immunol."},{"key":"10.1016\/j.dci.2013.09.001_b0015","doi-asserted-by":"crossref","first-page":"20682","DOI":"10.1016\/S0021-9258(17)32047-1","article-title":"Purification by DNA affinity chromatography of two polypeptides that contact the NF-AT DNA binding site in the interleukin 2 promoter","volume":"269","author":"Corthesy","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.dci.2013.09.001_b0020","doi-asserted-by":"crossref","first-page":"S67","DOI":"10.1016\/S0092-8674(02)00699-2","article-title":"NFAT signaling: choreographing the social lives of cells","volume":"109","author":"Crabtree","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.dci.2013.09.001_b0025","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.fsi.2010.11.015","article-title":"Cloning, characterization, and expression analysis of orange-spotted grouper (Epinephelus coioides) ILF2 gene (EcILF2)","volume":"30","author":"Cui","year":"2011","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2013.09.001_b0030","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1128\/MCB.8.4.1715","article-title":"Characterization of antigen receptor response elements within the interleukin-2 enhancer","volume":"8","author":"Durand","year":"1988","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.dci.2013.09.001_b0035","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1038\/352803a0","article-title":"Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A","volume":"352","author":"Flanagan","year":"1991","journal-title":"Nature"},{"key":"10.1016\/j.dci.2013.09.001_b0040","doi-asserted-by":"crossref","first-page":"e16687","DOI":"10.1371\/journal.pone.0016687","article-title":"NF90 binds the dengue virus RNA 3\u2032 terminus and is a positive regulator of dengue virus replication","volume":"6","author":"Gomila","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.dci.2013.09.001_b0045","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/j.jmb.2011.03.060","article-title":"HIV-1 replication and latency are regulated by translational control of cyclin T1","volume":"410","author":"Hoque","year":"2011","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.dci.2013.09.001_b0050","doi-asserted-by":"crossref","first-page":"4328","DOI":"10.1016\/j.vaccine.2011.04.021","article-title":"A bivalent Vibrio harveyi DNA vaccine induces strong protection in Japanese flounder (Paralichthys olivaceus)","volume":"29","author":"Hu","year":"2011","journal-title":"Vaccine"},{"key":"10.1016\/j.dci.2013.09.001_b0055","doi-asserted-by":"crossref","first-page":"3455","DOI":"10.4049\/jimmunol.161.7.3455","article-title":"Carboxyl-terminal 15-amino acid sequence of NFATx1 is possibly created by tissue-specific splicing and is essential for transactivation activity in T cells","volume":"161","author":"Imamura","year":"1998","journal-title":"J. Immunol."},{"key":"10.1016\/j.dci.2013.09.001_b0060","doi-asserted-by":"crossref","first-page":"5655","DOI":"10.1093\/emboj\/cdg562","article-title":"Members of the NF90\/NFAR protein group are involved in the life cycle of a positive-strand RNA virus","volume":"22","author":"Isken","year":"2003","journal-title":"EMBO J."},{"key":"10.1016\/j.dci.2013.09.001_b0065","doi-asserted-by":"crossref","first-page":"20691","DOI":"10.1016\/S0021-9258(17)32048-3","article-title":"Cloning and expression of cyclosporin A- and FK506-sensitive nuclear factor of activated T-cells: NF45 and NF90","volume":"269","author":"Kao","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.dci.2013.09.001_b0070","first-page":"201","article-title":"Overview of recent DNA vaccine development for fish","volume":"121","author":"Kurath","year":"2005","journal-title":"Dev. Biol. (Basel)"},{"key":"10.1016\/j.dci.2013.09.001_b0075","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.fsi.2006.01.003","article-title":"Molecular cloning, characterization and expression analysis of grass carp (Ctenopharyngodon idellus) NF45 (ILF2) cDNA, a subunit of the nuclear factor of activated T-cells (NF-AT)","volume":"21","author":"Lin","year":"2006","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2013.09.001_b0080","doi-asserted-by":"crossref","first-page":"201","DOI":"10.20506\/rst.24.1.1565","article-title":"DNA vaccines for aquacultured fish","volume":"24","author":"Lorenzen","year":"2005","journal-title":"Rev. Sci. Tech. Oie."},{"key":"10.1016\/j.dci.2013.09.001_b0085","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1038\/nri1632","article-title":"NFAT proteins: key regulators of T-cell development and function","volume":"5","author":"Macian","year":"2005","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.dci.2013.09.001_b0090","doi-asserted-by":"crossref","first-page":"20914","DOI":"10.1074\/jbc.271.34.20914","article-title":"Characterization of a new isoform of the NFAT (nuclear factor of activated T cells) gene family member NFATc","volume":"271","author":"Park","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.dci.2013.09.001_b0095","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1126\/science.3260404","article-title":"Identification of a putative regulator of early T cell activation genes","volume":"241","author":"Shaw","year":"1988","journal-title":"Science"},{"key":"10.1016\/j.dci.2013.09.001_b0100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.fsi.2008.03.007","article-title":"What happens to the DNA vaccine in fish? A review of current knowledge","volume":"25","author":"Tonheim","year":"2008","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2013.09.001_b0105","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1590\/S0100-879X2005000300003","article-title":"NFAT transcription factors: from cell cycle to tumor development","volume":"38","author":"Viola","year":"2005","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.dci.2013.09.001_b0110","first-page":"686","article-title":"Molecular cloning, characterization and expression analysis of an ILF2 homologue from Tetraodon nigroviridis","volume":"3039","author":"Wang","year":"2006","journal-title":"J. Biochem. Mol. Biol."},{"key":"10.1016\/j.dci.2013.09.001_b0115","doi-asserted-by":"crossref","first-page":"4047","DOI":"10.1016\/j.vaccine.2009.04.023","article-title":"Construction of an attenuated Pseudomonas fluorescens strain and evaluation of its potential as a cross-protective vaccine","volume":"27","author":"Wang","year":"2009","journal-title":"Vaccine"},{"key":"10.1016\/j.dci.2013.09.001_b0120","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.fsi.2011.05.012","article-title":"Ferritin M of Cynoglossus semilaevis: an iron binding protein and a broad-spectrum antimicrobial that depends on the integrity of the ferroxidase center and nucleation center for biological activity","volume":"31","author":"Wang","year":"2011","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2013.09.001_b0125","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1099\/mic.0.2008\/017343-0","article-title":"Regulation of autoinducer 2 production and luxS expression in a pathogenic Edwardsiella tarda strain","volume":"154","author":"Zhang","year":"2008","journal-title":"Microbiol.-SGM"},{"key":"10.1016\/j.dci.2013.09.001_b0130","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1111\/j.1365-2109.2011.02861.x","article-title":"Characterization of a megalocytivirus from cultured rock bream, Oplegnathus fasciatus (Temminck & Schlege) in China","volume":"43","author":"Zhang","year":"2012","journal-title":"Aquac. Res."},{"key":"10.1016\/j.dci.2013.09.001_b0155","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.dci.2013.03.005","article-title":"A NK-lysin from Cynoglossus semilaevis enhances antimicrobial defense against bacterial and viral pathogens","volume":"40","author":"Zhang","year":"2013","journal-title":"Dev Comp Immunol."},{"key":"10.1016\/j.dci.2013.09.001_b0140","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.yexcr.2004.12.030","article-title":"NF45\/ILF2 tissue expression, promoter analysis, and interleukin-2 transactivating function","volume":"305","author":"Zhao","year":"2005","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.dci.2013.09.001_b0145","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.fsi.2010.12.014","article-title":"Evaluation of housekeeping genes as references for quantitative real time RT-PCR analysis of gene expression in Japanese flounder (Paralichthys olivaceus)","volume":"30","author":"Zheng","year":"2011","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2013.09.001_b0150","first-page":"985","article-title":"The two Dps of Edwardsiella tarda are involved in resistance against oxidative stress and host infection","volume":"31","author":"Zheng","year":"2011","journal-title":"Fish Shellfish Immunol."}],"container-title":["Developmental & Comparative Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145305X1300253X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145305X1300253X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T14:40:04Z","timestamp":1688481604000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0145305X1300253X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["S0145305X1300253X"],"URL":"https:\/\/doi.org\/10.1016\/j.dci.2013.09.001","relation":{},"ISSN":["0145-305X"],"issn-type":[{"value":"0145-305X","type":"print"}],"subject":[],"published":{"date-parts":[[2014,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nuclear factor 45 of tongue sole (Cynoglossus semilaevis): Evidence for functional differentiation between two isoforms in immune defense against viral and bacterial pathogens","name":"articletitle","label":"Article Title"},{"value":"Developmental & Comparative Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dci.2013.09.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}