{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T09:35:46Z","timestamp":1791192946647,"version":"4.1.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"1","content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental & Comparative Immunology"],"published-print":{"date-parts":[[2014,7]]},"DOI":"10.1016\/j.dci.2014.02.019","type":"journal-article","created":{"date-parts":[[2014,3,13]],"date-time":"2014-03-13T19:31:32Z","timestamp":1394739092000},"page":"190-197","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"title":["Identification of IRAK-4 in grouper (Epinephelus coioides) that impairs MyD88-dependent NF-\u03baB activation"],"prefix":"10.1016","volume":"45","author":[{"given":"Yan-Wei","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu-Bing","family":"Mo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Ming","family":"Dan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Chun","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An-Xing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.dci.2014.02.019_b0005","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.cell.2006.02.015","article-title":"Pathogen recognition and innate immunity","volume":"124","author":"Akira","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.dci.2014.02.019_b0010","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/978-1-4419-0901-5_2","article-title":"Pattern recognition by Toll-like receptors","volume":"653","author":"Bauer","year":"2009","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.dci.2014.02.019_b0015","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1002\/jlb.67.4.508","article-title":"The interleukin-1 receptor\/Toll-like receptor superfamily: signal generators for pro-inflammatory interleukins and microbial products","volume":"67","author":"Bowie","year":"2000","journal-title":"J. Leukocyte Biol."},{"key":"10.1016\/j.dci.2014.02.019_b0020","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.fsi.2013.11.005","article-title":"Characterization of the interleukin 1 receptor-associated kinase 4 (IRAK4)-encoding gene in salmonid fish: The functional copy is rearranged in Oncorhynchus mykiss and that factor can impair TLR signaling in mammalian cells","volume":"36","author":"Brietzke","year":"2014","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2014.02.019_b0025","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1126\/science.271.5252.1128","article-title":"IRAK: a kinase associated with the interleukin-1 receptor","volume":"271","author":"Cao","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.dci.2014.02.019_b0030","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.bbrc.2006.11.068","article-title":"Regulation of IRAK-4 kinase activity via autophosphorylation within its activation loop","volume":"352","author":"Cheng","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.dci.2014.02.019_b0035","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1023\/A:1018360323287","article-title":"Cryptocaryon irritans Brown 1951, the cause of \u2018white spot disease\u2019 in marine fish: an update","volume":"1","author":"Colorni","year":"1997","journal-title":"Aquat. Sci. Conserv."},{"key":"10.1016\/j.dci.2014.02.019_b0040","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1016\/j.bcp.2010.06.020","article-title":"The interleukin-1 receptor-associated kinases: critical regulators of innate immune signalling","volume":"80","author":"Flannery","year":"2010","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.dci.2014.02.019_b0045","doi-asserted-by":"crossref","first-page":"31697","DOI":"10.1074\/jbc.M804779200","article-title":"The kinase activity of IL-1 receptor-associated kinase 4 is required for Interleukin-1 receptor\/Toll-like receptor-induced TAK1-dependent NF\u03baB activation","volume":"283","author":"Fr\u0105czek","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.dci.2014.02.019_b0050","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1084\/jem.20061523","article-title":"Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor-mediated immune responses but not in TCR signaling","volume":"204","author":"Kawagoe","year":"2007","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.dci.2014.02.019_b0055","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1084\/jem.20061825","article-title":"A critical role for IRAK4 kinase activity in Toll-like receptor-mediated innate immunity","volume":"204","author":"Kim","year":"2007","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.dci.2014.02.019_b0060","doi-asserted-by":"crossref","first-page":"13552","DOI":"10.1074\/jbc.M700548200","article-title":"IRAK-4 kinase activity is required for Interleukin-1 (IL-1) receptor- and Toll-like receptor 7-mediated signaling and gene expression","volume":"282","author":"Koziczak-Holbro","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.dci.2014.02.019_b0065","doi-asserted-by":"crossref","first-page":"4175","DOI":"10.4049\/jimmunol.175.7.4175","article-title":"Molecular structure of the TLR-associated kinase-4 death domain and its implications for TLR signaling","volume":"175","author":"Lasker","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.dci.2014.02.019_b0075","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1002\/eji.200838161","article-title":"IRAK4 in TLR\/IL-1R signaling: possible clinical applications","volume":"38","author":"Li","year":"2008","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.dci.2014.02.019_b0070","doi-asserted-by":"crossref","first-page":"5567","DOI":"10.1073\/pnas.082100399","article-title":"IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase","volume":"99","author":"Li","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.dci.2014.02.019_b0080","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1016\/j.fsi.2011.04.012","article-title":"Orange-spotted grouper (Epinephelus coioides) TLR2, MyD88 and IL-1\u03b2 involved in anti-Cryptocaryon irritans response","volume":"30","author":"Li","year":"2011","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2014.02.019_b0085","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1038\/nature09121","article-title":"Helical assembly in the MyD88\u2013IRAK4\u2013IRAK2 complex in TLR\/IL-1R signalling","volume":"465","author":"Lin","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.dci.2014.02.019_b0090","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/j.fsi.2012.05.035","article-title":"Lipopolysaccharide-induced gene expression of interleukin-1 receptor-associated kinase 4 and interleukin-1\u03b2 in roughskin sculpin (Trachidermus fasciatus)","volume":"33","author":"Liu","year":"2012","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2014.02.019_b0095","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212\u0394\u0394Ct method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.dci.2014.02.019_b0100","doi-asserted-by":"crossref","first-page":"25404","DOI":"10.1074\/jbc.M109.022392","article-title":"An oligomeric signaling platform formed by the Toll-like receptor signal transducers MyD88 and IRAK-4","volume":"284","author":"Motshwene","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.dci.2014.02.019_b0105","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1126\/science.278.5343.1612","article-title":"IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling","volume":"278","author":"Muzio","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.dci.2014.02.019_b0110","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1189\/jlb.0507290","article-title":"Threonine 66 in the death domain of IRAK-1 is critical for interaction with signaling molecules but is not a target site for autophosphorylation","volume":"84","author":"Neumann","year":"2008","journal-title":"J. Leukocyte Biol."},{"key":"10.1016\/j.dci.2014.02.019_b0115","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/j.dci.2011.03.006","article-title":"Toll-like receptors in bony fish: from genomics to function","volume":"35","author":"Palti","year":"2011","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.dci.2014.02.019_b0120","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/j.molimm.2004.11.005","article-title":"Functional characterization of full-length TLR3, IRAK-4, and TRAF6 in zebrafish (Danio rerio)","volume":"42","author":"Phelan","year":"2005","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.dci.2014.02.019_b0125","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1126\/science.1081902","article-title":"Pyogenic bacterial infections in humans with IRAK-4 deficiency","volume":"299","author":"Picard","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.dci.2014.02.019_b0130","doi-asserted-by":"crossref","first-page":"26748","DOI":"10.1074\/jbc.M400785200","article-title":"IRAK4 kinase activity is redundant for Interleukin-1 (IL-1) receptor-associated kinase phosphorylation and IL-1 responsiveness","volume":"279","author":"Qin","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.dci.2014.02.019_b0135","doi-asserted-by":"crossref","first-page":"21013","DOI":"10.1074\/jbc.M512908200","article-title":"TLR8-mediated NF-\u03baB and JNK activation are TAK1-independent and MEKK3-dependent","volume":"281","author":"Qin","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.dci.2014.02.019_b0140","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.vetimm.2009.09.021","article-title":"Toll-like receptor signaling in bony fish","volume":"134","author":"Rebl","year":"2010","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.dci.2014.02.019_b0145","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.dci.2010.08.012","article-title":"Salmonid Tollip and MyD88 factors can functionally replace their mammalian orthologues in TLR-mediated trout SAA promoter activation","volume":"35","author":"Rebl","year":"2011","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.dci.2014.02.019_b0150","doi-asserted-by":"crossref","first-page":"37414","DOI":"10.1074\/jbc.M205160200","article-title":"Identification of Threonine 66 as a functionally critical residue of the Interleukin-1 receptor-associated kinase","volume":"277","author":"Ross","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.dci.2014.02.019_b0155","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1016\/j.molimm.2008.12.012","article-title":"The kinase activities of interleukin-1 receptor associated kinase (IRAK)-1 and 4 are redundant in the control of inflammatory cytokine expression in human cells","volume":"46","author":"Song","year":"2009","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.dci.2014.02.019_b0160","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1038\/nature736","article-title":"Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4","volume":"416","author":"Suzuki","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.dci.2014.02.019_b0165","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3147\/jsfp.45.1","article-title":"Evidence of molecular Toll-like receptor mechanisms in teleosts","volume":"45","author":"Takano","year":"2010","journal-title":"Fish Pathol."},{"key":"10.1016\/j.dci.2014.02.019_b0170","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.cell.2010.01.022","article-title":"Pattern recognition receptors and inflammation","volume":"140","author":"Takeuchi","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.dci.2014.02.019_b0175","doi-asserted-by":"crossref","first-page":"486","DOI":"10.17221\/3294-VETMED","article-title":"Innate and adaptive immunity in teleost fish: a review","volume":"56","author":"Uribe","year":"2011","journal-title":"Vet. Med."},{"key":"10.1016\/j.dci.2014.02.019_b0180","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1016\/j.str.2006.11.001","article-title":"Crystal structures of IRAK-4 kinase in complex with inhibitors: a serine\/threonine kinase with tyrosine as a gatekeeper","volume":"14","author":"Wang","year":"2006","journal-title":"Structure"},{"key":"10.1016\/j.dci.2014.02.019_b0185","doi-asserted-by":"crossref","first-page":"19403","DOI":"10.1074\/jbc.274.27.19403","article-title":"IRAK-M is a novel member of the Pelle\/interleukin-1 receptor-associated kinase (IRAK) family","volume":"274","author":"Wesche","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.dci.2014.02.019_b0190","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/35047056","article-title":"Structural basis for signal transduction by the Toll\/interleukin-1 receptor domains","volume":"408","author":"Xu","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.dci.2014.02.019_b0195","doi-asserted-by":"crossref","first-page":"20711","DOI":"10.1073\/pnas.1305273110","article-title":"Toll-like receptor 9 and 21 have different ligand recognition profiles and cooperatively mediate activity of CpG-oligodeoxynucleotides in zebrafish","volume":"110","author":"Yeh","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.dci.2014.02.019_b0200","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.fsi.2011.12.011","article-title":"Identification and characterization of IL-1 receptor-associated kinase-4 (IRAK-4) in half-smooth tongue sole Cynoglossus semilaevis","volume":"32","author":"Yu","year":"2012","journal-title":"Fish Shellfish Immunol."}],"container-title":["Developmental & Comparative Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145305X14000603?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145305X14000603?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T08:54:47Z","timestamp":1565254487000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0145305X14000603"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["S0145305X14000603"],"URL":"https:\/\/doi.org\/10.1016\/j.dci.2014.02.019","relation":{},"ISSN":["0145-305X"],"issn-type":[{"value":"0145-305X","type":"print"}],"subject":[],"published":{"date-parts":[[2014,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification of IRAK-4 in grouper (Epinephelus coioides) that impairs MyD88-dependent NF-\u03baB activation","name":"articletitle","label":"Article Title"},{"value":"Developmental & Comparative Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dci.2014.02.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}