{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:48:03Z","timestamp":1791388083349,"version":"4.3.3"},"reference-count":54,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental & Comparative Immunology"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1016\/j.dci.2014.05.005","type":"journal-article","created":{"date-parts":[[2014,5,21]],"date-time":"2014-05-21T09:32:03Z","timestamp":1400664723000},"page":"333-340","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["A novel lineage transcription factor based analysis reveals differences in T helper cell subpopulation development in infected and intrauterine growth restricted (IUGR) piglets"],"prefix":"10.1016","volume":"46","author":[{"given":"F.","family":"Ebner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Rausch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Scharek-Tedin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Pieper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Burwinkel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Zentek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Hartmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.dci.2014.05.005_b0005","first-page":"1229","article-title":"Cytokine profiles in peripheral blood mononuclear cells and lymph node cells from piglets infected in utero with porcine reproductive and respiratory syndrome virus","volume":"9","author":"Aasted","year":"2002","journal-title":"Clin. Diagn. Lab. Immunol."},{"key":"10.1016\/j.dci.2014.05.005_b0010","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1071\/RD12021","article-title":"Intra-uterine growth retardation affects birthweight and postnatal development in pigs, impairing muscle accretion, duodenal mucosa morphology and carcass traits","volume":"25","author":"Alvarenga","year":"2013","journal-title":"Reprod. Fertil. Dev."},{"key":"10.1016\/j.dci.2014.05.005_b0015","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.dci.2008.07.003","article-title":"The mucosal immune system: recent developments and future directions in the pig","volume":"33","author":"Bailey","year":"2009","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.dci.2014.05.005_b0020","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.vetimm.2012.09.022","article-title":"The evolutionary basis for differences between the immune systems of man, mouse, pig and ruminants","volume":"152","author":"Bailey","year":"2013","journal-title":"Vet. Immunol. Immunopathol."},{"issue":"160","key":"10.1016\/j.dci.2014.05.005_b0025","doi-asserted-by":"crossref","first-page":"3453","DOI":"10.4049\/jimmunol.160.7.3453","article-title":"A critical role for IL-13 in resistance to intestinal nematode infection","volume":"1950","author":"Bancroft","year":"1998","journal-title":"J. Immunol."},{"key":"10.1016\/j.dci.2014.05.005_b0030","first-page":"219","article-title":"Subsets of null and gamma delta T-cell receptor+ T lymphocytes in the blood of young pigs identified by specific monoclonal antibodies","volume":"77","author":"Binns","year":"1992","journal-title":"Immunology"},{"key":"10.1016\/j.dci.2014.05.005_b0035","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.vetimm.2008.10.321","article-title":"The piglet as a model for B cell and immune system development","volume":"128","author":"Butler","year":"2009","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.dci.2014.05.005_b0040","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0053647","article-title":"Deoxynivalenol as a new factor in the persistence of intestinal inflammatory diseases: an emerging hypothesis through possible modulation of Th17-mediated response","volume":"8","author":"Cano","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.dci.2014.05.005_b0045","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/ni1473","article-title":"Dynamic changes in histone-methylation \u201cmarks\u201d across the locus encoding interferon-gamma during the differentiation of T helper type 2 cells","volume":"8","author":"Chang","year":"2007","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.dci.2014.05.005_b0050","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1017\/S1466252307001235","article-title":"Biology of porcine T lymphocytes","volume":"7","author":"Charerntantanakul","year":"2006","journal-title":"Anim. Health Res. Rev."},{"key":"10.1016\/j.dci.2014.05.005_b0055","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1203\/PDR.0b013e31821f6e75","article-title":"Intrauterine growth restriction alters T-lymphocyte cell number and dual specificity phosphatase 1 levels in the thymus of newborn and juvenile rats","volume":"70","author":"Contreras","year":"2011","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.dci.2014.05.005_b0060","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.livsci.2010.06.015","article-title":"Intrauterine growth restriction reduces intestinal structure and modifies the response to colostrum in preterm and term piglets","volume":"133","author":"D\u2019Inca","year":"2010","journal-title":"Livest. Sci."},{"key":"10.1016\/j.dci.2014.05.005_b0065","doi-asserted-by":"crossref","first-page":"925","DOI":"10.3945\/jn.109.116822","article-title":"Intrauterine growth restriction modifies the developmental pattern of intestinal structure, transcriptomic profile, and bacterial colonization in neonatal pigs","volume":"140","author":"D\u2019Inca","year":"2010","journal-title":"J. Nutr."},{"key":"10.1016\/j.dci.2014.05.005_b0070","doi-asserted-by":"crossref","first-page":"2576","DOI":"10.1128\/IAI.00827-07","article-title":"Localized Th1-, Th2-, T regulatory cell-, and inflammation-associated hepatic and pulmonary immune responses in Ascaris suum-infected swine are increased by retinoic acid","volume":"77","author":"Dawson","year":"2009","journal-title":"Infect. Immun."},{"key":"10.1016\/j.dci.2014.05.005_b0075","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1128\/IAI.73.2.1116-1128.2005","article-title":"Localized multigene expression patterns support an evolving Th1\/Th2-like paradigm in response to infections with Toxoplasma gondii and Ascaris suum","volume":"73","author":"Dawson","year":"2005","journal-title":"Infect. Immun."},{"key":"10.1016\/j.dci.2014.05.005_b0080","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.vetimm.2004.03.006","article-title":"Identification of key immune mediators regulating T helper 1 responses in swine","volume":"100","author":"Dawson","year":"2004","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.dci.2014.05.005_b0085","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/j.0105-2896.2004.00192.x","article-title":"Interleukin-4- and interleukin-13-mediated host protection against intestinal nematode parasites","volume":"201","author":"Finkelman","year":"2004","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.dci.2014.05.005_b0090","first-page":"213","article-title":"Prenatal programming of postnatal development in the pig","volume":"66","author":"Foxcroft","year":"2009","journal-title":"Soc. Reprod. Fertil. Suppl."},{"key":"10.1016\/j.dci.2014.05.005_b0095","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.dci.2008.06.003","article-title":"Porcine T lymphocytes and NK cells \u2013 an update","volume":"33","author":"Gerner","year":"2009","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.dci.2014.05.005_b0100","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1017\/S0954422410000077","article-title":"Nutritional programming of gastrointestinal tract development. Is the pig a good model for man?","volume":"23","author":"Guilloteau","year":"2010","journal-title":"Nutr. Res. Rev."},{"key":"10.1016\/j.dci.2014.05.005_b9000","first-page":"15","article-title":"GATA-3 - not just for Th2 cells anymore","volume":"4","author":"Ho","year":"2007","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.dci.2014.05.005_b0105","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0033707","article-title":"Neonatal colonisation expands a specific intestinal antigen-presenting cell subset prior to CD4 T-cell expansion, without altering T-cell repertoire","volume":"7","author":"Inman","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.dci.2014.05.005_b0110","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1084\/jem.20062175","article-title":"Conventional T-bet+Foxp3\u2212 Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection","volume":"204","author":"Jankovic","year":"2007","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.dci.2014.05.005_b0115","doi-asserted-by":"crossref","first-page":"17876","DOI":"10.1073\/pnas.0909357106","article-title":"The transcription factors T-bet and GATA-3 control alternative pathways of T-cell differentiation through a shared set of target genes","volume":"106","author":"Jenner","year":"2009","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.dci.2014.05.005_b0120","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1002\/j.1460-2075.1991.tb07706.x","article-title":"A T-cell specific TCR delta DNA binding protein is a member of the human GATA family","volume":"10","author":"Joulin","year":"1991","journal-title":"EMBO J."},{"key":"10.1016\/j.dci.2014.05.005_b0125","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.vetimm.2008.05.007","article-title":"Detection of Foxp3 protein expression in porcine T lymphocytes","volume":"125","author":"K\u00e4ser","year":"2008","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.dci.2014.05.005_b0130","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.ijpara.2006.04.008","article-title":"A time course study of immunological responses in Trichuris suis infected pigs demonstrates induction of a local type 2 response associated with worm burden","volume":"36","author":"Kringel","year":"2006","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.dci.2014.05.005_b0135","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1038\/nri3536","article-title":"T-bet: a bridge between innate and adaptive immunity","volume":"13","author":"Lazarevic","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.dci.2014.05.005_b0140","doi-asserted-by":"crossref","first-page":"179","DOI":"10.7150\/ijbs.3.179","article-title":"Advances in swine biomedical model genomics","volume":"3","author":"Lunney","year":"2007","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.dci.2014.05.005_b0145","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.coi.2012.06.003","article-title":"Susceptibility and immunity to helminth parasites","volume":"24","author":"Maizels","year":"2012","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.dci.2014.05.005_b0150","doi-asserted-by":"crossref","first-page":"12798","DOI":"10.1128\/JVI.79.20.12798-12806.2005","article-title":"T-bet is required for protection against vaccinia virus infection","volume":"79","author":"Matsui","year":"2005","journal-title":"J. Virol."},{"key":"10.1016\/j.dci.2014.05.005_b0155","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/S0042-6822(03)00009-6","article-title":"Gradual development of the interferon-\u03b3 response of swine to porcine reproductive and respiratory syndrome virus infection or vaccination","volume":"309","author":"Meier","year":"2003","journal-title":"Virology"},{"key":"10.1016\/j.dci.2014.05.005_b0160","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0028279","article-title":"Restricting microbial exposure in early life negates the immune benefits associated with gut colonization in environments of high microbial diversity","volume":"6","author":"Mulder","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.dci.2014.05.005_b0165","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1017\/S1751731111000401","article-title":"Birth weight and postnatal dietary protein level affect performance, muscle metabolism and meat quality in pigs","volume":"5","author":"Nissen","year":"2011","journal-title":"Anim. Int. J. Anim. Biosci."},{"key":"10.1016\/j.dci.2014.05.005_b0170","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.siny.2012.01.003","article-title":"Long term respiratory consequences of intrauterine growth restriction","volume":"17","author":"Pike","year":"2012","journal-title":"Semin. Fetal Neonatal Med."},{"key":"10.1016\/j.dci.2014.05.005_b0175","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1128\/IAI.01233-07","article-title":"Functional analysis of effector and regulatory T cells in a parasitic nematode infection","volume":"76","author":"Rausch","year":"2008","journal-title":"Infect. Immun."},{"key":"10.1016\/j.dci.2014.05.005_b0180","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/j.vaccine.2003.08.026","article-title":"Th-1\/Th-2 type cytokine profiles of pig T-cells cultured with antigen-treated monocyte-derived dendritic cells","volume":"22","author":"Raymond","year":"2004","journal-title":"Vaccine"},{"key":"10.1016\/j.dci.2014.05.005_b0185","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1297-9716-44-18","article-title":"CD27 expression discriminates porcine T helper cells with functionally distinct properties","volume":"44","author":"Reutner","year":"2013","journal-title":"Vet. Res."},{"key":"10.1016\/j.dci.2014.05.005_b0190","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0145-305X(03)00137-X","article-title":"2E3, a new marker that selectively identifies porcine CD4+ naive T cells","volume":"28","author":"Revilla","year":"2004","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.dci.2014.05.005_b0195","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1203\/00006450-199103000-00004","article-title":"The postnatal development of gut lamina propria lymphocytes: number, proliferation, and T and B cell subsets in conventional and germ-free pigs","volume":"29","author":"Rothk\u00f6tter","year":"1991","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.dci.2014.05.005_b0200","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1002\/eji.1830170912","article-title":"Simultaneous expression of CD4 and CD8 antigens by a substantial proportion of resting porcine T lymphocytes","volume":"17","author":"Saalm\u00fcller","year":"1987","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.dci.2014.05.005_b0205","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0165-2427(02)00045-4","article-title":"T-helper cells from naive to committed","volume":"87","author":"Saalm\u00fcller","year":"2002","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.dci.2014.05.005_b0210","doi-asserted-by":"crossref","first-page":"4713","DOI":"10.2527\/jas.2013-6359","article-title":"Invited review: the preterm pig as a model in pediatric gastroenterology","volume":"91","author":"Sangild","year":"2013","journal-title":"J. Anim. Sci."},{"key":"10.1016\/j.dci.2014.05.005_b0215","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1128\/CVI.00555-12","article-title":"Effect of heat-killed Escherichia coli, lipopolysaccharide, and muramyl dipeptide treatments on the immune response phenotype and allergy in neonatal pigs sensitized to the egg white protein ovomucoid","volume":"19","author":"Schmied","year":"2012","journal-title":"Clin. Vaccine Immunol."},{"key":"10.1016\/j.dci.2014.05.005_b0220","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1051\/animres:2004020","article-title":"Postnatal development of intestinal immune system in piglets: implications for the process of weaning","volume":"53","author":"Stokes","year":"2004","journal-title":"Anim. Res."},{"key":"10.1016\/j.dci.2014.05.005_b0225","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1084\/jem.20052165","article-title":"T-bet regulates Th1 responses through essential effects on GATA-3 function rather than on IFNG gene acetylation and transcription","volume":"203","author":"Usui","year":"2006","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.dci.2014.05.005_b0230","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1515\/JPEM.2010.23.3.215","article-title":"Intrauterine growth restriction as a potential risk factor for disease onset in adulthood","volume":"23","author":"Varvarigou","year":"2010","journal-title":"J. Pediatr. Endocrinol. Metab."},{"key":"10.1016\/j.dci.2014.05.005_b0235","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1111\/j.1365-2567.2012.03617.x","article-title":"CD4+ CD25\u2212 FoxP3+ regulatory cells are the predominant responding regulatory T cells after human rotavirus infection or vaccination in gnotobiotic pigs","volume":"137","author":"Wen","year":"2012","journal-title":"Immunology"},{"key":"10.1016\/j.dci.2014.05.005_b0240","doi-asserted-by":"crossref","first-page":"2316","DOI":"10.2527\/jas.2006-156","article-title":"BOARD-INVITED REVIEW: intrauterine growth retardation: implications for the animal sciences","volume":"84","author":"Wu","year":"2006","journal-title":"J. Anim. Sci."},{"key":"10.1016\/j.dci.2014.05.005_b0245","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1046\/j.1365-2567.1996.d01-705.x","article-title":"Phenotypic classification of porcine lymphocyte subpopulations in blood and lymphoid tissues","volume":"89","author":"Yang","year":"1996","journal-title":"Immunology"},{"key":"10.1016\/j.dci.2014.05.005_b0250","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/S0092-8674(00)80240-8","article-title":"The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells","volume":"89","author":"Zheng","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.dci.2014.05.005_b0255","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s12192-012-0326-6","article-title":"Impairment of cellular immunity is associated with overexpression of heat shock protein 70 in neonatal pigs with intrauterine growth retardation","volume":"17","author":"Zhong","year":"2012","journal-title":"Cell Stress Chaperones"},{"key":"10.1016\/j.dci.2014.05.005_b0260","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1046\/j.1365-2567.1996.494570.x","article-title":"Distribution of porcine CD4\/CD8 double-positive T lymphocytes in mucosa-associated lymphoid tissues","volume":"87","author":"Zuckermann","year":"1996","journal-title":"Immunology"},{"key":"10.1016\/j.dci.2014.05.005_b0265","first-page":"500","article-title":"Functional and phenotypic analysis of porcine peripheral blood CD4\/CD8 double-positive T cells","volume":"87","author":"Zuckermann","year":"1996","journal-title":"Immunology"}],"container-title":["Developmental & Comparative Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145305X14001414?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145305X14001414?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,7,13]],"date-time":"2023-07-13T08:43:06Z","timestamp":1689237786000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0145305X14001414"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":54,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["S0145305X14001414"],"URL":"https:\/\/doi.org\/10.1016\/j.dci.2014.05.005","relation":{},"ISSN":["0145-305X"],"issn-type":[{"value":"0145-305X","type":"print"}],"subject":[],"published":{"date-parts":[[2014,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A novel lineage transcription factor based analysis reveals differences in T helper cell subpopulation development in infected and intrauterine growth restricted (IUGR) piglets","name":"articletitle","label":"Article Title"},{"value":"Developmental & Comparative Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dci.2014.05.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}