{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T03:10:51Z","timestamp":1787627451356,"version":"build-2736575974"},"reference-count":45,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental &amp; Comparative Immunology"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1016\/j.dci.2014.05.015","type":"journal-article","created":{"date-parts":[[2014,6,7]],"date-time":"2014-06-07T20:48:54Z","timestamp":1402174134000},"page":"423-429","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"title":["Interleukin 17A is an immune marker for chlamydial disease severity and pathogenesis in the koala (Phascolarctos cinereus)"],"prefix":"10.1016","volume":"46","author":[{"given":"Marina","family":"Mathew","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney","family":"Waugh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth W.","family":"Beagley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Timms","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Polkinghorne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.dci.2014.05.015_b0005","first-page":"45","article-title":"Effects of stress on cytokine production","volume":"14","author":"Abraham","year":"1991","journal-title":"Methods Achiev. Exp. Pathol."},{"key":"10.1016\/j.dci.2014.05.015_b0010","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.clim.2008.10.004","article-title":"Protective or pathogenic immune response to genital chlamydial infection in women \u2013 a possible role of cytokine secretion profile of cervical mucosal cells","volume":"130","author":"Agrawal","year":"2009","journal-title":"Clin. Immunol."},{"issue":"9","key":"10.1016\/j.dci.2014.05.015_b0015","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0076664","article-title":"The duration of Chlamydia muridarum genital tract infection and associated chronic pathological changes are reduced in IL-17 knockout mice but protection is not increased further by immunization","volume":"8","author":"Andrew","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.dci.2014.05.015_b0020","doi-asserted-by":"crossref","first-page":"5886","DOI":"10.4049\/jimmunol.0901584","article-title":"IL-17\/Th17 promotes type 1 T cell immunity against pulmonary intracellular bacterial infection through modulating dendritic cell function","volume":"183","author":"Bai","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.dci.2014.05.015_b0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.jri.2014.01.002","article-title":"Frequency of Chlamydia trachomatis-specific T cell interferon-gamma and interleukin-17 responses in CD4-enriched peripheral blood mononuclear cells of sexually active adolescent females","author":"Barral","year":"2014","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.dci.2014.05.015_b0035","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/nri2800","article-title":"Innate IL-17-producing cells: the sentinels of the immune system","volume":"10","author":"Cua","year":"2010","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.dci.2014.05.015_b0040","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1086\/652397","article-title":"Pathogenesis of genital tract disease due to Chlamydia trachomatis","volume":"201","author":"Darville","year":"2010","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.dci.2014.05.015_b0045","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.vetimm.2004.04.006","article-title":"Induction of inflammatory host immune responses by organisms belonging to the genera Chlamydia\/Chlamydophila","volume":"100","author":"Entrican","year":"2004","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.dci.2014.05.015_b0050","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1086\/425077","article-title":"Epidemiological and genetic correlates of incident Chlamydia trachomatis infection in North American adolescents","volume":"190","author":"Geisler","year":"2004","journal-title":"J. Infect. Dis."},{"issue":"Suppl. 2","key":"10.1016\/j.dci.2014.05.015_b0055","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1086\/652402","article-title":"Duration of untreated, uncomplicated Chlamydia trachomatis genital infection and factors associated with chlamydia resolution: a review of human studies","volume":"201","author":"Geisler","year":"2010","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.dci.2014.05.015_b0060","doi-asserted-by":"crossref","first-page":"18","DOI":"10.7589\/2012-05-135","article-title":"A retrospective study of admission trends of koalas to a rehabilitation facility over 30 years","volume":"49","author":"Griffith","year":"2013","journal-title":"J. Wildl. Dis."},{"key":"10.1016\/j.dci.2014.05.015_b0065","doi-asserted-by":"crossref","DOI":"10.1038\/mi.2007.19","article-title":"Chlamydia trachomatis infection: host immune responses and potential vaccines","author":"Hafner","year":"2008","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.dci.2014.05.015_b0070","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0021-9975(97)80003-5","article-title":"Histopathological and immunohistochemical investigation of naturally occurring chlamydial conjunctivitis and urogenital inflammation in koalas (Phascolarctos cinereus)","volume":"116","author":"Hemsley","year":"1997","journal-title":"J. Comp. Pathol."},{"key":"10.1016\/j.dci.2014.05.015_b0075","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1128\/IAI.72.4.1843-1855.2004","article-title":"Chlamydial persistence: beyond the biphasic paradigm","volume":"72","author":"Hogan","year":"2004","journal-title":"Infect. Immun."},{"key":"10.1016\/j.dci.2014.05.015_b0085","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.micinf.2010.10.012","article-title":"Spontaneous secretion of interleukin-17 and -22 by human cervical cells in Chlamydia trachomatis infection","volume":"13","author":"Jha","year":"2011","journal-title":"Microbes Infect."},{"key":"10.1016\/j.dci.2014.05.015_b0090","doi-asserted-by":"crossref","DOI":"10.1038\/emi.2013.58","article-title":"IL-17 cytokines in immunity and inflammation","volume":"2","author":"Jin","year":"2013","journal-title":"Emerg. Microbes. Infect."},{"key":"10.1016\/j.dci.2014.05.015_b0095","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1016\/j.vaccine.2011.12.125","article-title":"Vaccination of healthy and diseased koalas (Phascolarctos cinereus) with a Chlamydia pecorum multi-subunit vaccine: Evaluation of immunity and pathology","volume":"30","author":"Kollipara","year":"2012","journal-title":"Vaccine"},{"key":"10.1016\/j.dci.2014.05.015_b0100","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.vetmic.2013.08.009","article-title":"Genetic diversity of Chlamydia pecorum strains in wild koala locations across Australia and the implications for a recombinant C. pecorum major outer membrane protein based vaccine","volume":"167","author":"Kollipara","year":"2013","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.dci.2014.05.015_b0105","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1071\/ZO12075","article-title":"Genetic diversity in natural and introduced island populations of koalas in Queensland","volume":"60","author":"Lee","year":"2013","journal-title":"Aust. J. Zool."},{"key":"10.1016\/j.dci.2014.05.015_b0110","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.immuni.2009.08.025","article-title":"Interleukin-17 is required for T helper 1 cell immunity and host resistance to the intracellular pathogen Francisella tularensis","volume":"31","author":"Lin","year":"2009","journal-title":"Immunity"},{"key":"10.1016\/j.dci.2014.05.015_b0115","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using Real-Time Quantitative PCR and the 2\u2212\u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.dci.2014.05.015_b0120","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1053\/jcpa.2002.0629","article-title":"Animal chlamydioses and zoonotic implications","volume":"128","author":"Longbottom","year":"2003","journal-title":"J. Comp. Pathol."},{"key":"10.1016\/j.dci.2014.05.015_b0125","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S1369-5274(02)00291-6","article-title":"T cell responses to Chlamydia trachomatis","volume":"5","author":"Loomis","year":"2002","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.dci.2014.05.015_b0130","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.280","article-title":"Expression profiles of the immune genes CD4, CD8\u03b2, IFN\u03b3, IL-4, IL-6 and IL-10 in mitogen-stimulated koala lymphocytes (Phascolarctos cinereus) by qRT-PCR","author":"Maher","year":"2014","journal-title":"PeerJ"},{"key":"10.1016\/j.dci.2014.05.015_b0135","doi-asserted-by":"crossref","DOI":"10.5402\/2011\/436936","article-title":"Immunopathogenesis in Chlamydia trachomatis infected women","author":"Mascellino","year":"2011","journal-title":"ISRN Obstet. Gynecol."},{"key":"10.1016\/j.dci.2014.05.015_b0140","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0059958","article-title":"Preliminary characterisation of tumor necrosis factor alpha and interleukin-10 responses to Chlamydia pecorum infection in the koala (Phascolarctos cinereus)","volume":"8","author":"Mathew","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.dci.2014.05.015_b0145","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.gene.2013.06.019","article-title":"Molecular characterisation and expression analysis of Interferon gamma in response to natural Chlamydia infection in the koala, Phascolarctos cinereus","volume":"527","author":"Mathew","year":"2013","journal-title":"Gene"},{"key":"10.1016\/j.dci.2014.05.015_b0150","article-title":"Human female genital tract infection by the obligate intracellular bacterium Chlamydia trachomatis elicits robust Type 2 immunity","volume":"8","author":"Miguel","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.dci.2014.05.015_b0155","article-title":"Recent advances in the understanding of Chlamydophila pecorum infections, sixteen years after it was named as the fourth species of the Chlamydiaceae family","volume":"41","author":"Mohamad","year":"2010","journal-title":"Vet. Res."},{"key":"10.1016\/j.dci.2014.05.015_b0160","doi-asserted-by":"crossref","DOI":"10.1071\/ZO13105","article-title":"The koala immunological toolkit: sequence identification and comparison of key markers of the koala (Phascolarctos cinereus) immune response","author":"Morris","year":"2014","journal-title":"Aust. J. Zool."},{"key":"10.1016\/j.dci.2014.05.015_b0165","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0061962","article-title":"(a). Immunization with a MOMP-based vaccine protects mice against a pulmonary Chlamydia challenge and identifies a disconnection between infection and pathology","volume":"8","author":"O\u2019Meara","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.dci.2014.05.015_b0170","article-title":"Immunity against a Chlamydia infection and disease may be determined by a balance of IL-17 signaling","volume":"10","author":"O\u2019Meara","year":"2013","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.dci.2014.05.015_b0180","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.vetmic.2013.02.026","article-title":"Recent advances in understanding the biology, epidemiology and control of chlamydial infections in koalas","volume":"165","author":"Polkinghorne","year":"2013","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.dci.2014.05.015_b0185","doi-asserted-by":"crossref","DOI":"10.1186\/1742-2094-9-104","article-title":"IFN-gamma protects from lethal IL-17 mediated viral encephalomyelitis independent of neutrophils","volume":"9","author":"Savarin","year":"2012","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.dci.2014.05.015_b0190","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.bpa.2004.01.002","article-title":"Effects of general anaesthesia on inflammation","volume":"18","author":"Schneemilch","year":"2004","journal-title":"Best Pract. Res. Clin. Anaesthesiol."},{"key":"10.1016\/j.dci.2014.05.015_b0195","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1128\/IAI.00984-10","article-title":"Interleukin-17 contributes to generation of Th1 immunity and neutrophil recruitment during Chlamydia muridarum genital tract infection but is not required for macrophage influx or normal resolution of infection","volume":"79","author":"Scurlock","year":"2011","journal-title":"Infect. Immun."},{"key":"10.1016\/j.dci.2014.05.015_b0205","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1111\/j.1574-695X.2006.00196.x","article-title":"Primary and secondary immune response of mucosal and peripheral lymphocytes during Chlamydia trachomatis infection","volume":"49","author":"Vats","year":"2007","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"10.1016\/j.dci.2014.05.015_b0210","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1111\/j.1751-0813.2011.00827.x","article-title":"Using quantitative polymerase chain reaction to correlate Chlamydia pecorum infectious load with ocular, urinary and reproductive tract disease in the koala (Phascolarctos cinereus)","volume":"89","author":"Wan","year":"2011","journal-title":"Aust. Vet. J."},{"key":"10.1016\/j.dci.2014.05.015_b0215","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1086\/428592","article-title":"Human leukocyte antigen and cytokine gene variants as predictors of recurrent Chlamydia trachomatis infection in high-risk adolescents","volume":"191","author":"Wang","year":"2005","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.dci.2014.05.015_b0220","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1002\/jemt.1093","article-title":"Distinct function of Th1 and Th2 type delayed type hypersensitivity: protective and pathological reactions to chlamydial infection","volume":"53","author":"Yang","year":"2001","journal-title":"Microsc. Res. Tech."},{"key":"10.1016\/j.dci.2014.05.015_b0225","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1165\/ajrcmb.25.3.4424","article-title":"Interleukin-17 and lung host defense against Klebsiella pneumoniae infection","volume":"25","author":"Ye","year":"2001","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.dci.2014.05.015_b0230","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.1128\/IAI.01374-09","volume":"78","author":"Yu","year":"2010","journal-title":"Infect. Immun."},{"key":"10.1016\/j.dci.2014.05.015_b0235","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.4049\/jimmunol.0803075","article-title":"A MyD88-dependent early IL-17 production protects mice against airway infection with the obligate intracellular pathogen Chlamydia muridarum","volume":"183","author":"Zhang","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.dci.2014.05.015_b0240","article-title":"IL-17A synergizes with IFN-gamma to upregulate iNOS and NO production and inhibit chlamydial growth","volume":"7","author":"Zhang","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.dci.2014.05.015_b0245","doi-asserted-by":"crossref","first-page":"5059","DOI":"10.1128\/IAI.00403-09","article-title":"Critical role of the Interleukin-17\/Interleukin-17 receptor axis in regulating host susceptibility to respiratory infection with Chlamydia species","volume":"77","author":"Zhou","year":"2009","journal-title":"Infect. Immun."}],"container-title":["Developmental &amp; Comparative Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145305X14001517?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145305X14001517?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,3]],"date-time":"2018-10-03T10:27:20Z","timestamp":1538562440000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0145305X14001517"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":45,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["S0145305X14001517"],"URL":"https:\/\/doi.org\/10.1016\/j.dci.2014.05.015","relation":{},"ISSN":["0145-305X"],"issn-type":[{"value":"0145-305X","type":"print"}],"subject":[],"published":{"date-parts":[[2014,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Interleukin 17A is an immune marker for chlamydial disease severity and pathogenesis in the koala (Phascolarctos cinereus)","name":"articletitle","label":"Article Title"},{"value":"Developmental & Comparative Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dci.2014.05.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}