{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T04:58:48Z","timestamp":1788325128678,"version":"build-2803163510"},"reference-count":53,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Foundation of the Finnish Anti-Tuberculosis Association (HM), Finnish Academy","award":["277495"],"award-info":[{"award-number":["277495"]}]},{"name":"Sigrid Juselius Foundation"},{"DOI":"10.13039\/501100004012","name":"Jane and Aatos Erkko Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004012","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Expert Responsibility Area of Tampere University Hospital"},{"name":"Expert Responsibility area of Oulu University Hospital"},{"DOI":"10.13039\/501100006706","name":"Tampere Tuberculosis Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006706","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental & Comparative Immunology"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1016\/j.dci.2015.09.001","type":"journal-article","created":{"date-parts":[[2015,9,11]],"date-time":"2015-09-11T20:17:00Z","timestamp":1442002620000},"page":"89-96","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["DNA vaccination boosts Bacillus Calmette\u2013Gu\u00e9rin protection against mycobacterial infection in zebrafish"],"prefix":"10.1016","volume":"54","author":[{"given":"Kaisa E.","family":"Oksanen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henna","family":"Myllym\u00e4ki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarit J.","family":"Ahava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leena","family":"M\u00e4kinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mataleena","family":"Parikka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika","family":"R\u00e4met","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.dci.2015.09.001_bib1","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/j.1365-2249.2012.04614.x","article-title":"Is interferon-gamma the right marker for bacille Calmette-Guerin-induced immune protection? The missing link in our understanding of tuberculosis immunology","volume":"169","author":"Abebe","year":"2012","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.dci.2015.09.001_bib2","first-page":"5","article-title":"The importance of animal models in tuberculosis vaccine development","volume":"18","author":"Acosta","year":"2011","journal-title":"Malays. J. Med. Sci."},{"key":"10.1016\/j.dci.2015.09.001_bib3","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/nrmicro1211","article-title":"The success and failure of BCG \u2013 implications for a novel tuberculosis vaccine","volume":"3","author":"Andersen","year":"2005","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.dci.2015.09.001_bib4","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a018523","article-title":"Novel vaccination strategies against tuberculosis","volume":"4","author":"Andersen","year":"2014","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.dci.2015.09.001_bib5","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.it.2014.04.006","article-title":"Tuberculosis vaccines \u2013 rethinking the current paradigm","volume":"35","author":"Andersen","year":"2014","journal-title":"Trends Immunol."},{"key":"10.1016\/j.dci.2015.09.001_bib6","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1038\/nm.3153","article-title":"Bettering BCG: a tough task for a TB vaccine?","volume":"19","author":"Bishai","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.dci.2015.09.001_bib7","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.vetmic.2011.02.021","article-title":"Update on vaccination of cattle and wildlife populations against tuberculosis","volume":"151","author":"Buddle","year":"2011","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.dci.2015.09.001_bib8","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1054\/tube.2000.0254","article-title":"Vaccination of cattle against Mycobacterium bovis","volume":"81","author":"Buddle","year":"2001","journal-title":"Tuberc. (Edinb)"},{"key":"10.1016\/j.dci.2015.09.001_bib53","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.vaccine.2012.11.042","article-title":"Prime-boost BCG vaccination with DNA vaccines based in \u03b2-defensin-2 and mycobacterial antigens ESAT6 or Ag85B improve protection in a tuberculosis experimental model","volume":"31","author":"Cervantes-Villagrana","year":"2013","journal-title":"Vaccine"},{"key":"10.1016\/j.dci.2015.09.001_bib9","doi-asserted-by":"crossref","first-page":"2817","DOI":"10.1016\/S0264-410X(00)00078-5","article-title":"Nanogram quantities of a DNA vaccine protect rainbow trout fry against heterologous strains of infectious hematopoietic necrosis virus","volume":"18","author":"Corbeil","year":"2000","journal-title":"Vaccine"},{"key":"10.1016\/j.dci.2015.09.001_bib10","doi-asserted-by":"crossref","first-page":"152","DOI":"10.3389\/fimmu.2014.00152","article-title":"Recombinant BCG: innovations on an old vaccine. Scope of BCG strains and strategies to improve long-lasting memory","volume":"5","author":"da Costa","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.dci.2015.09.001_bib11","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.vetimm.2014.01.010","article-title":"Effect of dose and route of immunisation on the immune response induced in cattle by heterologous Bacille Calmette-Guerin priming and recombinant adenoviral vector boosting","volume":"158","author":"Dean","year":"2014","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.dci.2015.09.001_bib12","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1128\/IAI.66.4.1527-1533.1998","article-title":"Vaccination with plasmid DNA encoding mycobacterial antigen 85A stimulates a CD4+ and CD8+ T-cell epitopic repertoire broader than that stimulated by Mycobacterium tuberculosis H37Rv infection","volume":"66","author":"Denis","year":"1998","journal-title":"Infect. Immun."},{"key":"10.1016\/j.dci.2015.09.001_bib13","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.smim.2014.04.003","article-title":"Tumor necrosis factor alpha in mycobacterial infection","volume":"26","author":"Dorhoi","year":"2014","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.dci.2015.09.001_bib14","series-title":"HIV I-Base\/Treatment Action Group","first-page":"233","article-title":"The tuberculosis vaccines pipeline. Back to basic science","author":"Frick","year":"2014"},{"key":"10.1016\/j.dci.2015.09.001_bib15","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1002\/eji.201141569","article-title":"IL-23-dependent IL-17 drives Th1-cell responses following Mycobacterium bovis BCG vaccination","volume":"42","author":"Gopal","year":"2012","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.dci.2015.09.001_bib16","doi-asserted-by":"crossref","first-page":"e1004190","DOI":"10.1371\/journal.ppat.1004190","article-title":"Adequate th2-type response associates with restricted bacterial growth in latent mycobacterial infection of zebrafish","volume":"10","author":"Hammaren","year":"2014","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.dci.2015.09.001_bib17","first-page":"521","article-title":"The contribution of diverse animal models in the evaluation of new vaccines against TB","volume":"520","author":"Hernandez-Pando","year":"2014"},{"key":"10.1016\/j.dci.2015.09.001_bib18","doi-asserted-by":"crossref","first-page":"32","DOI":"10.4236\/wjv.2013.32006","article-title":"Identification of growth promoting effect of rBCG\/BCG culture supernatant and its potential applications","volume":"3","author":"Jin","year":"2013","journal-title":"World J. Vaccines"},{"key":"10.1016\/j.dci.2015.09.001_bib19","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.fsi.2010.11.002","article-title":"Vaccine efficacy of Mycobacterium bovis BCG against Mycobacterium sp. infection in amberjack Seriola dumerili","volume":"30","author":"Kato","year":"2011","journal-title":"Fish. Shellfish Immunol."},{"key":"10.1016\/j.dci.2015.09.001_bib20","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.dci.2009.08.013","article-title":"BCG vaccine confers adaptive immunity against Mycobacterium sp. infection in fish","volume":"34","author":"Kato","year":"2010","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.dci.2015.09.001_bib21","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.fsi.2012.05.002","article-title":"Mycobacterium bovis BCG vaccine induces non-specific immune responses in Japanese flounder against Nocardia seriolae","volume":"33","author":"Kato","year":"2012","journal-title":"Fish. Shellfish Immunol."},{"key":"10.1016\/j.dci.2015.09.001_bib22","doi-asserted-by":"crossref","first-page":"11497","DOI":"10.1073\/pnas.201404898","article-title":"Divergent effect of bacillus Calmette-Guerin (BCG) vaccination on Mycobacterium tuberculosis infection in highly related macaque species: implications for primate models in tuberculosis vaccine research","volume":"98","author":"Langermans","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.dci.2015.09.001_bib23","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/j.1651-2227.2012.02835.x","article-title":"The zebrafish as a model for paediatric diseases","volume":"102","author":"Lohi","year":"2013","journal-title":"Acta Paediatr."},{"key":"10.1016\/j.dci.2015.09.001_bib24","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1046\/j.1365-3083.1997.d01-99.x","article-title":"Cross-reactive immune responses against Mycobacterium bovis BCG in mice infected with non-tuberculous mycobacteria belonging to the MAIS-Group","volume":"46","author":"Lozes","year":"1997","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.dci.2015.09.001_bib25","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1093\/cid\/cit790","article-title":"Protection by BCG vaccine against tuberculosis: a systematic review of randomized controlled trials","volume":"58","author":"Mangtani","year":"2014","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.dci.2015.09.001_bib26","doi-asserted-by":"crossref","first-page":"2782","DOI":"10.1098\/rstb.2011.0097","article-title":"Tuberculosis vaccines: beyond bacille Calmette-Guerin","volume":"366","author":"McShane","year":"2011","journal-title":"Philos. Trans. R. Soc. Lond B Biol. Sci."},{"key":"10.1016\/j.dci.2015.09.001_bib27","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1093\/cid\/cit793","article-title":"Understanding BCG is the key to improving it","volume":"58","author":"McShane","year":"2014","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.dci.2015.09.001_bib28","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.2174\/138945011795677809","article-title":"Host-pathogen interactions made transparent with the zebrafish model","volume":"12","author":"Meijer","year":"2011","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.dci.2015.09.001_bib29","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1517\/17460441.2015.1049529","article-title":"Animal models in tuberculosis research \u2013 where is the beef?","volume":"10","author":"Myllym\u00e4ki","year":"2015","journal-title":"Expert Opin. Drug Discov."},{"key":"10.1016\/j.dci.2015.09.001_bib30","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1146\/annurev-immunol-032712-095939","article-title":"The immune response in tuberculosis","volume":"31","author":"O'Garra","year":"2013","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.dci.2015.09.001_bib31","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1128\/IAI.03135-14","article-title":"The proprotein convertase subtilisin\/kexin furinA regulates zebrafish host response against Mycobacterium marinum","volume":"83","author":"Ojanen","year":"2015","journal-title":"Infect. Immun."},{"key":"10.1016\/j.dci.2015.09.001_bib32","doi-asserted-by":"crossref","first-page":"5202","DOI":"10.1016\/j.vaccine.2013.08.093","article-title":"An adult zebrafish model for preclinical tuberculosis vaccine development","volume":"31","author":"Oksanen","year":"2013","journal-title":"Vaccine"},{"key":"10.1016\/j.dci.2015.09.001_bib33","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1007\/s12265-013-9496-6","article-title":"T\u00a0helper cell polarization in healthy people: implications for cardiovascular disease","volume":"6","author":"Olson","year":"2013","journal-title":"J.\u00a0Cardiovasc. Transl. Res."},{"key":"10.1016\/j.dci.2015.09.001_bib34","doi-asserted-by":"crossref","first-page":"e1002944","DOI":"10.1371\/journal.ppat.1002944","article-title":"Mycobacterium marinum causes a latent infection that can be reactivated by gamma irradiation in adult zebrafish","volume":"8","author":"Parikka","year":"2012","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.dci.2015.09.001_bib35","doi-asserted-by":"crossref","first-page":"4079","DOI":"10.4049\/jimmunol.1201061","article-title":"Blockade of IL-10 signaling during bacillus Calmette-Guerin vaccination enhances and sustains Th1, Th17, and innate lymphoid IFN-gamma and IL-17 responses and increases protection to Mycobacterium tuberculosis infection","volume":"189","author":"Pitt","year":"2012","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.dci.2015.09.001_bib36","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1242\/dmm.007138","article-title":"A\u00a0model 450 million years in the making: zebrafish and vertebrate immunity","volume":"5","author":"Renshaw","year":"2012","journal-title":"Dis. Model Mech."},{"key":"10.1016\/j.dci.2015.09.001_bib37","doi-asserted-by":"crossref","first-page":"161","DOI":"10.3109\/00365548.2013.871645","article-title":"Novel approaches to tuberculosis prevention: DNA vaccines","volume":"46","author":"Rivas-Santiago","year":"2015","journal-title":"Scand. J. Infect. Dis."},{"key":"10.1016\/j.dci.2015.09.001_bib38","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.cell.2013.03.022","article-title":"TNF dually mediates resistance and susceptibility to mycobacteria via mitochondrial reactive oxygen species","volume":"153","author":"Roca","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.dci.2015.09.001_bib39","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1126\/science.1184784","article-title":"Tuberculosis: what we don't know can, and does, hurt us","volume":"328","author":"Russell","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.dci.2015.09.001_bib40","doi-asserted-by":"crossref","first-page":"137","DOI":"10.4049\/jimmunol.67.2.137","article-title":"Effect of BCG vaccination and chemotherapy on experimental tuberculosis in mice","volume":"67","author":"Siebenmann","year":"1951","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.dci.2015.09.001_bib41","first-page":"501","article-title":"Induction of delayed-type hypersensitivity to Mycobacterium leprae in healthy individuals","volume":"44","author":"Smelt","year":"1981","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.dci.2015.09.001_bib42","series-title":"The Global Plan to Stop TB 2011\u20132015","author":"StopTBPartnership","year":"2011"},{"key":"10.1016\/j.dci.2015.09.001_bib43","doi-asserted-by":"crossref","first-page":"6108","DOI":"10.1128\/IAI.00887-06","article-title":"Mycobacterium marinum infection of adult zebrafish causes caseating granulomatous tuberculosis and is moderated by adaptive immunity","volume":"74","author":"Swaim","year":"2006","journal-title":"Infect. Immun."},{"key":"10.1016\/j.dci.2015.09.001_bib44","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/S0140-6736(13)60177-4","article-title":"Safety and efficacy of MVA85A, a new tuberculosis vaccine, in infants previously vaccinated with BCG: a randomised, placebo-controlled phase 2b trial","volume":"381","author":"Tameris","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.dci.2015.09.001_bib45","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.cell.2011.12.023","article-title":"Host genotype-specific therapies can optimize the inflammatory response to mycobacterial infections","volume":"148","author":"Tobin","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.dci.2015.09.001_bib46","doi-asserted-by":"crossref","first-page":"3786","DOI":"10.4049\/jimmunol.178.6.3786","article-title":"IL-17-mediated regulation of innate and acquired immune response against pulmonary Mycobacterium bovis bacille Calmette-Guerin infection","volume":"178","author":"Umemura","year":"2007","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.dci.2015.09.001_bib47","article-title":"Animal models of tuberculosis: zebrafish","volume":"5","author":"van Leeuwen","year":"2014","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.dci.2015.09.001_bib48","doi-asserted-by":"crossref","first-page":"6240","DOI":"10.1016\/j.vaccine.2014.09.024","article-title":"HBHA vaccination may require both Th1 and Th17 immune responses to protect mice against tuberculosis","volume":"32","author":"Verwaerde","year":"2014","journal-title":"Vaccine"},{"key":"10.1016\/j.dci.2015.09.001_bib49","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1126\/science.1179663","article-title":"Tuberculous granuloma induction via interaction of a bacterial secreted protein with host epithelium","volume":"327","author":"Volkman","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.dci.2015.09.001_bib50","doi-asserted-by":"crossref","first-page":"e88149","DOI":"10.1371\/journal.pone.0088149","article-title":"Evidence for a role for interleukin-17, Th17 cells and iron homeostasis in protective immunity against tuberculosis in cynomolgus macaques","volume":"9","author":"Wareham","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.dci.2015.09.001_bib51","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1111\/joim.12212","article-title":"Recent advances towards tuberculosis control: vaccines and biomarkers","volume":"275","author":"Weiner","year":"2014","journal-title":"J.\u00a0Intern Med."},{"key":"10.1016\/j.dci.2015.09.001_bib52","series-title":"Global Tuberculosis Report 2014","author":"World Health Organization","year":"2014"}],"container-title":["Developmental & Comparative Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145305X15300355?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145305X15300355?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,8,14]],"date-time":"2023-08-14T00:30:15Z","timestamp":1691973015000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0145305X15300355"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":53,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["S0145305X15300355"],"URL":"https:\/\/doi.org\/10.1016\/j.dci.2015.09.001","relation":{},"ISSN":["0145-305X"],"issn-type":[{"value":"0145-305X","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"DNA vaccination boosts Bacillus Calmette\u2013Gu\u00e9rin protection against mycobacterial infection in zebrafish","name":"articletitle","label":"Article Title"},{"value":"Developmental & Comparative Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dci.2015.09.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}