{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T20:07:18Z","timestamp":1772050038220,"version":"3.50.1"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"name":"Strategic Research Foundation"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental &amp; Comparative Immunology"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1016\/j.dci.2016.02.006","type":"journal-article","created":{"date-parts":[[2016,2,5]],"date-time":"2016-02-05T12:45:56Z","timestamp":1454676356000},"page":"229-239","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Identification and characterization of a novel intelectin in the digestive tract of Xenopus laevis"],"prefix":"10.1016","volume":"59","author":[{"given":"Saburo","family":"Nagata","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.dci.2016.02.006_bib1","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1046\/j.1432-1327.1999.00238.x","article-title":"A\u00a0unique primary structure, cDNA cloning and function of a galactose-specific lectin from ascidian plasma","volume":"261","author":"Abe","year":"1999","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.dci.2016.02.006_bib2","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1093\/jb\/mvt073","article-title":"A\u00a0lactoferrin-receptor, intelectin 1, affects uptake, sub-cellular localization and release of immunochemically detectable lactoferrin by intestinal epithelial Caco-2 cells","volume":"154","author":"Akiyama","year":"2013","journal-title":"J.\u00a0Biochem."},{"key":"10.1016\/j.dci.2016.02.006_bib3","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1016\/j.biocel.2013.04.028","article-title":"Anti-inflammatory mechanisms of bioactive milk proteins in the intestine of newborns","volume":"45","author":"Chatterton","year":"2013","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"50","key":"10.1016\/j.dci.2016.02.006_bib4","first-page":"51","article-title":"Expression and regulation of INTELECTIN1 in human granulosa-lutein cells: role in IGF-1-induced steroidogenesis through NAMPT","volume":"91","author":"Cloix","year":"2014","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.dci.2016.02.006_bib5","doi-asserted-by":"crossref","first-page":"14000","DOI":"10.1073\/pnas.1510084112","article-title":"Crohn's disease-derived monocytes fail to induce Paneth cell defensins","volume":"112","author":"Courth","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.dci.2016.02.006_bib6","doi-asserted-by":"crossref","first-page":"4025","DOI":"10.1128\/IAI.73.7.4025-4033.2005","article-title":"Identification of novel genes in intestinal tissue that are regulated after infection with an intestinal nematode parasite","volume":"73","author":"Datta","year":"2005","journal-title":"Infect. Immun."},{"key":"10.1016\/j.dci.2016.02.006_bib7","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1051\/vetres\/2009035","article-title":"Expression of three intelectins in sheep and response to a Th2 environment","volume":"40","author":"French","year":"2009","journal-title":"Vet. Res."},{"key":"10.1016\/j.dci.2016.02.006_bib8","doi-asserted-by":"crossref","first-page":"L290","DOI":"10.1152\/ajplung.90612.2008","article-title":"Intelectin is required for IL-13-induced monocyte chemotactic protein-1 and -3 expression in lung epithelial cells and promotes allergic airway inflammation","volume":"298","author":"Gu","year":"2010","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.dci.2016.02.006_bib9","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1093\/jb\/mvm048","article-title":"Identification of novel members of the Xenopus Ca2+ -dependent lectin family and analysis of their gene expression during tail regeneration and development","volume":"141","author":"Ishino","year":"2007","journal-title":"J.\u00a0Biochem."},{"key":"10.1016\/j.dci.2016.02.006_bib10","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1164\/rccm.201312-2220LE","article-title":"Intelectin-1 is a prominent protein constituent of pathologic mucus associated with eosinophilic airway inflammation in asthma","volume":"189","author":"Kerr","year":"2014","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.dci.2016.02.006_bib11","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1006\/bbrc.1998.9513","article-title":"Cloning of the novel gene intelectin, which is expressed in intestinal paneth cells in mice","volume":"251","author":"Komiya","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.dci.2016.02.006_bib39","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1517\/14656566.6.6.863","article-title":"Therapeutic perspectives of adipocytokines","volume":"6","author":"Kralisch","year":"2005","journal-title":"Expert Opin. Pharmacother."},{"key":"10.1016\/j.dci.2016.02.006_bib12","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1093\/glycob\/11.1.65","article-title":"Human homologs of the Xenopus oocyte cortical granule lectin XL35","volume":"11","author":"Lee","year":"2001","journal-title":"Glycobiology"},{"key":"10.1016\/j.dci.2016.02.006_bib13","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/s10719-004-5534-6","article-title":"The X-lectins: a new family with homology to the Xenopus laevis oocyte lectin XL-35","volume":"21","author":"Lee","year":"2004","journal-title":"Glycoconj. J."},{"key":"10.1016\/j.dci.2016.02.006_bib14","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1074\/jbc.M111.261818","article-title":"Fat-derived factor omentin stimulates endothelial cell function and ischemia-induced revascularization via endothelial nitric oxide synthase-dependent mechanism","volume":"287","author":"Maruyama","year":"2012","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.dci.2016.02.006_bib15","doi-asserted-by":"crossref","first-page":"25790","DOI":"10.1074\/jbc.M702438200","article-title":"Haploinsufficient prostate tumor suppression by Nkx3.1: a role for chromatin accessibility in dosage-sensitive gene regulation","volume":"282","author":"Mogal","year":"2007","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.dci.2016.02.006_bib16","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1007\/s00427-003-0341-9","article-title":"Developmental expression of XEEL, a novel molecule of the Xenopus oocyte cortical granule lectin family","volume":"213","author":"Nagata","year":"2003","journal-title":"Dev. Genes Evol."},{"key":"10.1016\/j.dci.2016.02.006_bib17","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1093\/glycob\/cwi010","article-title":"Isolation, characterization, and extra-embryonic secretion of the Xenopus laevis embryonic epidermal lectin, XEEL","volume":"15","author":"Nagata","year":"2005","journal-title":"Glycobiology"},{"key":"10.1016\/j.dci.2016.02.006_bib18","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.dci.2013.02.008","article-title":"Bacterial lipopolysaccharides stimulate production of XCL1, a calcium-dependent lipopolysaccharide-binding serum lectin, in Xenopus laevis","volume":"40","author":"Nagata","year":"2013","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.dci.2016.02.006_bib19","doi-asserted-by":"crossref","first-page":"6013","DOI":"10.1021\/bi00368a027","article-title":"Isolation and characterization of a lectin from the cortical granules of Xenopus laevis eggs","volume":"25","author":"Nishihara","year":"1986","journal-title":"Biochemistry"},{"key":"10.1016\/j.dci.2016.02.006_bib20","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.4049\/jimmunol.173.3.1894","article-title":"Innate BALB\/c enteric epithelial responses to Trichinella spiralis: inducible expression of a novel goblet cell lectin, intelectin-2, and its natural deletion in C57BL\/10 mice","volume":"173","author":"Pemberton","year":"2004","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.dci.2016.02.006_bib21","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.fsi.2008.02.018","article-title":"Identification, cloning and tissue localization of a rainbow trout (Oncorhynchus mykiss) intelectin-like protein that binds bacteria and chitin","volume":"25","author":"Russell","year":"2008","journal-title":"Fish. Shellfish Immunol."},{"key":"10.1016\/j.dci.2016.02.006_bib22","doi-asserted-by":"crossref","first-page":"53R","DOI":"10.1093\/glycob\/cwh122","article-title":"History of lectins: from hemagglutinins to biological recognition molecules","volume":"14","author":"Sharon","year":"2004","journal-title":"Glycobiology"},{"key":"10.1016\/j.dci.2016.02.006_bib23","series-title":"Early Development of Xenopus laevis: a Laboratory Mannual","author":"Sive","year":"2000"},{"key":"10.1016\/j.dci.2016.02.006_bib24","doi-asserted-by":"crossref","first-page":"15771","DOI":"10.1021\/bi0155899","article-title":"Molecular cloning and functional expression of a human intestinal lactoferrin receptor","volume":"40","author":"Suzuki","year":"2001","journal-title":"Biochemistry"},{"key":"10.1016\/j.dci.2016.02.006_bib25","doi-asserted-by":"crossref","first-page":"10915","DOI":"10.1021\/bi8012164","article-title":"The N1 domain of human lactoferrin is required for internalization by caco-2 cells and targeting to the nucleus","volume":"47","author":"Suzuki","year":"2008","journal-title":"Biochemistry"},{"key":"10.1016\/j.dci.2016.02.006_bib26","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.tcm.2010.12.002","article-title":"Omentin: a novel link between inflammation, diabesity, and cardiovascular disease","volume":"20","author":"Tan","year":"2010","journal-title":"Trends Cardiovasc. Med."},{"key":"10.1016\/j.dci.2016.02.006_bib27","doi-asserted-by":"crossref","first-page":"23456","DOI":"10.1074\/jbc.M103162200","article-title":"Human intelectin is a novel soluble lectin that recognizes galactofuranose in carbohydrate chains of bacterial cell wall","volume":"276","author":"Tsuji","year":"2001","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.dci.2016.02.006_bib28","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1093\/glycob\/cwp013","article-title":"Capture of heat-killed Mycobacterium bovis bacillus Calmette-Guerin by intelectin-1 deposited on cell surfaces","volume":"19","author":"Tsuji","year":"2009","journal-title":"Glycobiology"},{"key":"10.1016\/j.dci.2016.02.006_bib29","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1093\/jb\/mvr085","article-title":"A\u00a0unique epidermal mucus lectin identified from catfish (Silurus asotus): first evidence of intelectin in fish skin slime","volume":"150","author":"Tsutsui","year":"2011","journal-title":"J.\u00a0Biochem."},{"key":"10.1016\/j.dci.2016.02.006_bib30","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.M115.709212","article-title":"Structures of Xenopus embryonic epidermal lectin reveal a conserved mechanism of microbial glycan recognition","author":"Wangkanont","year":"2016","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.dci.2016.02.006_bib31","doi-asserted-by":"crossref","first-page":"e39889","DOI":"10.1371\/journal.pone.0039889","article-title":"Specific expression of human intelectin-1 in malignant pleural mesothelioma and gastrointestinal goblet cells","volume":"7","author":"Washimi","year":"2012","journal-title":"PloS One"},{"issue":"Suppl.\u00a01","key":"10.1016\/j.dci.2016.02.006_bib32","doi-asserted-by":"crossref","first-page":"4607","DOI":"10.1073\/pnas.1000092107","article-title":"Epithelial crosstalk at the microbiota-mucosal interface","volume":"108","author":"Wells","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.dci.2016.02.006_bib33","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/nsmb.3053","article-title":"Recognition of microbial glycans by human intelectin-1","volume":"22","author":"Wesener","year":"2015","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.dci.2016.02.006_bib34","doi-asserted-by":"crossref","first-page":"9188","DOI":"10.1021\/bi060570x","article-title":"Intelectin: a novel lipid raft-associated protein in the enterocyte brush border","volume":"45","author":"Wrackmeyer","year":"2006","journal-title":"Biochemistry"},{"key":"10.1016\/j.dci.2016.02.006_bib35","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1073\/pnas.71.5.2067","article-title":"Agglutination of jelly coat and cortical granule components and the block to polyspermy in the amphibian Xenopus laevis","volume":"71","author":"Wyrick","year":"1974","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.dci.2016.02.006_bib36","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.fsi.2012.03.023","article-title":"Identification of an amphioxus intelectin homolog that preferably agglutinates gram-positive over gram-negative bacteria likely due to different binding capacity to LPS and PGN","volume":"33","author":"Yan","year":"2012","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2016.02.006_bib37","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/j.fsi.2013.01.017","article-title":"Characterization and comparative analyses of two amphioxus intelectins involved in the innate immune response","volume":"34","author":"Yan","year":"2013","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2016.02.006_bib38","doi-asserted-by":"crossref","first-page":"E1253","DOI":"10.1152\/ajpendo.00572.2004","article-title":"Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action","volume":"290","author":"Yang","year":"2006","journal-title":"Am. J. Physiol. Endocrinol. Metab."}],"container-title":["Developmental &amp; Comparative Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145305X16300301?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145305X16300301?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T01:36:15Z","timestamp":1758936975000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0145305X16300301"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":39,"alternative-id":["S0145305X16300301"],"URL":"https:\/\/doi.org\/10.1016\/j.dci.2016.02.006","relation":{},"ISSN":["0145-305X"],"issn-type":[{"value":"0145-305X","type":"print"}],"subject":[],"published":{"date-parts":[[2016,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification and characterization of a novel intelectin in the digestive tract of Xenopus laevis","name":"articletitle","label":"Article Title"},{"value":"Developmental & Comparative Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dci.2016.02.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}