{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T14:06:20Z","timestamp":1785247580020,"version":"3.55.0"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"China Staple Freshwater Fishes Industry Technology System","award":["CARS\u201346\u201305"],"award-info":[{"award-number":["CARS\u201346\u201305"]}]},{"name":"Central Universities","award":["2662015PY019"],"award-info":[{"award-number":["2662015PY019"]}]},{"name":"Scientific Research and Development program of Hubei Province","award":["2013BHE006"],"award-info":[{"award-number":["2013BHE006"]}]},{"name":"The International Scientific and Technology Cooperation Program of Wuhan City","award":["2015030809020365"],"award-info":[{"award-number":["2015030809020365"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental &amp; Comparative Immunology"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1016\/j.dci.2016.09.005","type":"journal-article","created":{"date-parts":[[2016,9,15]],"date-time":"2016-09-15T19:01:27Z","timestamp":1473966087000},"page":"471-475","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Molecular characterization and immunological response analysis of toll-like receptors from the blunt snout bream ( Megalobrama amblycephala )"],"prefix":"10.1016","volume":"67","author":[{"given":"Rui-Fang","family":"Lai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Jakovli\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan-Bin","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Min","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.dci.2016.09.005_bib1","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nri1391","article-title":"Toll-like receptor signalling","volume":"4","author":"Akira","year":"2004","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.dci.2016.09.005_bib2","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1007\/s00251-006-0144-z","article-title":"Toll-like receptor 3 and TICAM genes in catfish: species-specific expression profiles following infection with Edwardsiella ictaluri","volume":"58","author":"Baoprasertkul","year":"2006","journal-title":"Immunogenetics"},{"key":"10.1016\/j.dci.2016.09.005_bib3","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.dci.2004.12.002","article-title":"Activation of TLR3 and TLR5 in channel catfish exposed to virulent Edwardsiella ictaluri","volume":"29","author":"Bilodeau","year":"2005","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.dci.2016.09.005_bib4","series-title":"China fisheries Yearbook","first-page":"23","author":"Bureau","year":"2013"},{"key":"10.1016\/j.dci.2016.09.005_bib5","doi-asserted-by":"crossref","first-page":"e42637","DOI":"10.1371\/journal.pone.0042637","article-title":"Transcriptome analysis and SSR\/SNP markers information of the blunt snout bream (Megalobrama amblycephala)","volume":"7","author":"Gao","year":"2012","journal-title":"PloS One"},{"key":"10.1016\/j.dci.2016.09.005_bib6","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.molimm.2003.10.001","article-title":"Toll-like receptor gene family and TIR-domain adapters in Danio rerio","volume":"40","author":"Jault","year":"2004","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.dci.2016.09.005_bib7","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.dci.2014.02.003","article-title":"Comparative studies of Toll-like receptor signalling using zebrafish","volume":"46","author":"Kanwal","year":"2014","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.dci.2016.09.005_bib8","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2014.00461","article-title":"Toll-like receptor signaling pathways","volume":"5","author":"Kawasaki","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.dci.2016.09.005_bib9","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.dci.2016.01.009","article-title":"Molecular cloning and expression of toll-like receptor 4 (tlr4) in the blunt snout bream (Megalobrama amblycephala)","volume":"59","author":"Lai","year":"2016","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.dci.2016.09.005_bib10","series-title":"China fisheries Yearbook","author":"Liu","year":"2009"},{"key":"10.1016\/j.dci.2016.09.005_bib11","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212 \u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.dci.2016.09.005_bib12","doi-asserted-by":"crossref","first-page":"2771","DOI":"10.1007\/s00018-005-5187-z","article-title":"Structural analysis of leucine-rich-repeat variants in proteins associated with human diseases","volume":"62","author":"Matsushima","year":"2005","journal-title":"Cell. Mol. Life Sci. CMLS"},{"key":"10.1016\/j.dci.2016.09.005_bib13","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/35100529","article-title":"Toll-like receptors and innate immunity","volume":"1","author":"Medzhitov","year":"2001","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.dci.2016.09.005_bib14","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3354\/dao046023","article-title":"Is Aeromonas hydrophila the dominant motile Aeromonas species that causes disease outbreaks in aquaculture production in the Zhejiang Province of China?","volume":"46","author":"Nielsen","year":"2001","journal-title":"Dis. Aquat. Org."},{"key":"10.1016\/j.dci.2016.09.005_bib15","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/nri2079","article-title":"The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling","volume":"7","author":"O'Neill","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.dci.2016.09.005_bib16","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nri3446","article-title":"The history of Toll-like receptors\u2014redefining innate immunity","volume":"13","author":"O'Neill","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.dci.2016.09.005_bib17","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/j.dci.2011.03.006","article-title":"Toll-like receptors in bony fish: from genomics to function","volume":"35","author":"Palti","year":"2011","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.dci.2016.09.005_bib18","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/s00251-013-0694-9","article-title":"Comprehensive survey and genomic characterization of Toll-like receptors (TLRs) in channel catfish, Ictalurus punctatus: identification of novel fish TLRs","volume":"65","author":"Quiniou","year":"2013","journal-title":"Immunogenetics"},{"key":"10.1016\/j.dci.2016.09.005_bib19","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.imlet.2013.11.013","article-title":"Toll-like receptors (TLRs) in aquatic animals: signaling pathways, expressions and immune responses","volume":"158","author":"Rauta","year":"2014","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.dci.2016.09.005_bib20","doi-asserted-by":"crossref","first-page":"9577","DOI":"10.1073\/pnas.0502272102","article-title":"The evolution of vertebrate Toll-like receptors","volume":"102","author":"Roach","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.dci.2016.09.005_bib21","first-page":"406","article-title":"The neighbor-joining method: a new method for reconstructing phylogenetic trees","volume":"4","author":"Saitou","year":"1987","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.dci.2016.09.005_bib22","doi-asserted-by":"crossref","first-page":"4670","DOI":"10.1074\/jbc.275.7.4670","article-title":"Identification of two major sites in the type I interleukin-1 receptor cytoplasmic region responsible for coupling to pro-inflammatory signaling pathways","volume":"275","author":"Slack","year":"2000","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.dci.2016.09.005_bib23","doi-asserted-by":"crossref","first-page":"986","DOI":"10.3724\/SP.J.1035.2009.50986","article-title":"cDNA cloning and characterization of Toll-like receptor 3 in bluntnose black bream, Megalobrama amblycephala","volume":"33","author":"Su","year":"2009","journal-title":"Acta Hydrobiol. Sin."},{"key":"10.1016\/j.dci.2016.09.005_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2148-12-256","article-title":"Diversification of the expanded teleost-specific toll-like receptor family in Atlantic cod, Gadus morhua","volume":"12","author":"Sundaram","year":"2012","journal-title":"BMC Evol. Biol."},{"key":"10.1016\/j.dci.2016.09.005_bib25","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1016\/j.molimm.2006.10.018","article-title":"Molecular cloning and characterization of Toll-like receptor 9 in Japanese flounder, Paralichthys olivaceus","volume":"44","author":"Takano","year":"2007","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.dci.2016.09.005_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/intimm\/dxh186","article-title":"Toll-like receptors in innate immunity","volume":"17","author":"Takeda","year":"2005","journal-title":"Int. Immunol."},{"key":"10.1016\/j.dci.2016.09.005_bib27","article-title":"MEGA6: molecular evolutionary genetics analysis version 6.0","volume":"197","author":"Tamura","year":"2013","journal-title":"Mol. Biol. Evol. Mst"},{"key":"10.1016\/j.dci.2016.09.005_bib28","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.fsi.2016.08.015","article-title":"Identification and characterization of a novel Toll-like receptor 4 homologue in blunt snout bream, Megalobrama amblycephala","volume":"57","author":"Tang","year":"2016","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2016.09.005_bib29","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.fsi.2015.01.034","article-title":"Transcriptome analysis and microsatellite discovery in the blunt snout bream (Megalobrama amblycephala) after challenge with Aeromonas hydrophila","volume":"45","author":"Tran","year":"2015","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2016.09.005_bib30","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.fsi.2015.06.017","article-title":"Structural characterization and evolutionary analysis of fish-specific TLR27","volume":"45","author":"Wang","year":"2015","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2016.09.005_bib31","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.dci.2016.05.001","article-title":"Identification and characteristic analysis of TLR28: a novel member of the TLR1 family in teleost","volume":"62","author":"Wang","year":"2016","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.dci.2016.09.005_bib32","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1111\/j.1744-313X.2008.00759.x","article-title":"Characterization, expression and evolution analysis of Toll-like receptor 1 gene in pufferfish (Tetraodon nigroviridis)","volume":"35","author":"Wu","year":"2008","journal-title":"Int. J. Immunogenet."},{"key":"10.1016\/j.dci.2016.09.005_bib33","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/35040600","article-title":"Structural basis for signal transduction by the Toll\/interleukin-1 receptor domains","volume":"408","author":"Xu","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.dci.2016.09.005_bib34","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.fsi.2014.09.022","article-title":"Toll-like receptor recognition of bacteria in fish: ligand specificity and signal pathways","volume":"41","author":"Zhang","year":"2014","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.dci.2016.09.005_bib35","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.dci.2013.01.009","article-title":"Pathogen recognition receptors in channel catfish: III Phylogeny and expression analysis of Toll-like receptors","volume":"40","author":"Zhang","year":"2013","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.dci.2016.09.005_bib36","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.jsb.2011.12.002","article-title":"Toll-like receptor 5 forms asymmetric dimers in the absence of flagellin","volume":"177","author":"Zhou","year":"2012","journal-title":"J.\u00a0Struct. Biol."}],"container-title":["Developmental &amp; Comparative Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145305X16302828?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145305X16302828?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,6,28]],"date-time":"2018-06-28T14:38:08Z","timestamp":1530196688000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0145305X16302828"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":36,"alternative-id":["S0145305X16302828"],"URL":"https:\/\/doi.org\/10.1016\/j.dci.2016.09.005","relation":{},"ISSN":["0145-305X"],"issn-type":[{"value":"0145-305X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Molecular characterization and immunological response analysis of toll-like receptors from the blunt snout bream (Megalobrama amblycephala)","name":"articletitle","label":"Article Title"},{"value":"Developmental & Comparative Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dci.2016.09.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}