{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T03:13:50Z","timestamp":1778987630309,"version":"3.51.4"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan, R.O.C.","doi-asserted-by":"crossref","award":["MOST-105-2321-B-037-001"],"award-info":[{"award-number":["MOST-105-2321-B-037-001"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan, R.O.C.","doi-asserted-by":"crossref","award":["MOST-104-2321-B-037-001"],"award-info":[{"award-number":["MOST-104-2321-B-037-001"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan, R.O.C.","doi-asserted-by":"crossref","award":["MOST 101-2320-B-010-055"],"award-info":[{"award-number":["MOST 101-2320-B-010-055"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Ministry of Education, Aiming for the Top University Plan"},{"name":"Center for Infectious Disease and Cancer Research, Kaohsiung Medical University","award":["KMUTP104E04"],"award-info":[{"award-number":["KMUTP104E04"]}]},{"name":"Kaohsiung Medical University Research Foundation","award":["KMU-Q105010"],"award-info":[{"award-number":["KMU-Q105010"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental & Comparative Immunology"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1016\/j.dci.2016.10.010","type":"journal-article","created":{"date-parts":[[2016,10,27]],"date-time":"2016-10-27T05:03:15Z","timestamp":1477544595000},"page":"8-17","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Generation and characterization of new monoclonal antibodies against swine origin 2009 influenza A (H1N1) virus and evaluation of their prophylactic and therapeutic efficacy in a mouse model"],"prefix":"10.1016","volume":"67","author":[{"given":"Sheng-Fan","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung-Pin","family":"Tseng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"El-Wui","family":"Loh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Hung","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-Chun","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuan-Hsuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wan-Chi","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan-Ming","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huan-Yuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fu-Tong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Ming","family":"Arthur Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason C.","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.dci.2016.10.010_bib1","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/978-1-59745-450-6_13","article-title":"Epitope mapping using phage display peptide libraries","volume":"524","author":"Bottger","year":"2009","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.dci.2016.10.010_bib2","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1083\/jcb.114.3.401","article-title":"Folding of influenza hemagglutinin in the endoplasmic reticulum","volume":"114","author":"Braakman","year":"1991","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.dci.2016.10.010_bib3","doi-asserted-by":"crossref","first-page":"6852","DOI":"10.1016\/j.vaccine.2007.07.027","article-title":"Influenza vaccine: the challenge of antigenic drift","volume":"25","author":"Carrat","year":"2007","journal-title":"Vaccine"},{"key":"10.1016\/j.dci.2016.10.010_bib4","series-title":"Interim Estimates of 2015\/16 Vaccine Effectiveness against Influenza A(H1N1)pdm09, Canada","author":"Chambers","year":"2016"},{"key":"10.1016\/j.dci.2016.10.010_bib5","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1016\/j.bios.2008.08.019","article-title":"Localized surface plasmon coupled fluorescence fiber-optic biosensor for alpha-fetoprotein detection in human serum","volume":"24","author":"Chang","year":"2009","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.dci.2016.10.010_bib6","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1016\/j.bios.2010.08.060","article-title":"Detection of swine-origin influenza A (H1N1) viruses using a localized surface plasmon coupled fluorescence fiber-optic biosensor","volume":"26","author":"Chang","year":"2010","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.dci.2016.10.010_bib7","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.tibtech.2011.04.007","article-title":"Vaccine design of hemagglutinin glycoprotein against influenza","volume":"29","author":"Chen","year":"2011","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.dci.2016.10.010_bib8","doi-asserted-by":"crossref","first-page":"e43845","DOI":"10.1371\/journal.pone.0043845","article-title":"Potent neutralization of botulinum neurotoxin\/B by synergistic action of antibodies recognizing protein and ganglioside receptor binding domain","volume":"7","author":"Chen","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.dci.2016.10.010_bib9","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1331\/JAPhA.2013.13511","article-title":"Influenza vaccine safety in patients with egg allergy","volume":"53","author":"Croegaert","year":"2003","journal-title":"J.\u00a0Am. Pharm. Assoc."},{"key":"10.1016\/j.dci.2016.10.010_bib10","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/1472-6750-12-77","article-title":"Pandemic influenza vaccine: characterization of A\/California\/07\/2009 (H1N1) recombinant hemagglutinin protein and insights into H1N1 antigen stability","volume":"12","author":"Feshchenko","year":"2012","journal-title":"BMC Biotechnol."},{"key":"10.1016\/j.dci.2016.10.010_bib11","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.anai.2012.09.011","article-title":"Safe administration of the seasonal trivalent influenza vaccine to children with severe egg allergy","volume":"109","author":"Greenhawt","year":"2012","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"10.1016\/j.dci.2016.10.010_bib12","doi-asserted-by":"crossref","first-page":"4592","DOI":"10.1073\/pnas.1214913110","article-title":"Structure and accessibility of HA trimers on intact 2009 H1N1 pandemic influenza virus to stem region-specific neutralizing antibodies","volume":"110","author":"Harris","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.dci.2016.10.010_bib13","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1111\/j.1745-7254.2005.00078.x","article-title":"Baculovirus as a highly efficient expression vector in insect and mammalian cells","volume":"26","author":"Hu","year":"2005","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.dci.2016.10.010_bib14","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.bios.2009.07.012","article-title":"Detection of severe acute respiratory syndrome (SARS) coronavirus nucleocapsid protein in human serum using a localized surface plasmon coupled fluorescence fiber-optic biosensor","volume":"25","author":"Huang","year":"2009","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.dci.2016.10.010_bib15","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.jcv.2008.04.013","article-title":"Testing human sera for antibodies against avian influenza viruses: horse RBC hemagglutination inhibition vs. microneutralization assays","volume":"43","author":"Kayali","year":"2008","journal-title":"J.\u00a0Clin. Virol."},{"key":"10.1016\/j.dci.2016.10.010_bib16","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1111\/irv.12026","article-title":"Lower respiratory tract hemorrhage associated with 2009 pandemic influenza A (H1N1) virus infection","volume":"7","author":"Kennedy","year":"2013","journal-title":"Influenza Other Respir. Viruses"},{"key":"10.1016\/j.dci.2016.10.010_bib17","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1055\/s-0031-1283279","article-title":"Pandemic novel 2009 H1N1 influenza: what have we learned?","volume":"32","author":"LaRussa","year":"2011","journal-title":"Semin. Respir. Crit. Care Med."},{"key":"10.1016\/j.dci.2016.10.010_bib18","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1002\/jmv.21074","article-title":"Genetic and antigenic analysis of epidemic influenza viruses isolated during 2006-2007 season in Taiwan","volume":"80","author":"Lin","year":"2008","journal-title":"J.\u00a0Med. Virol."},{"key":"10.1016\/j.dci.2016.10.010_bib19","doi-asserted-by":"crossref","first-page":"e20052","DOI":"10.1371\/journal.pone.0020052","article-title":"Recombinant trimeric HA protein immunogenicity of H5N1 avian influenza viruses and their combined use with inactivated or adenovirus vaccines","volume":"6","author":"Lin","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.dci.2016.10.010_bib20","doi-asserted-by":"crossref","first-page":"19618","DOI":"10.1016\/S0021-9258(19)36561-5","article-title":"Post-translational folding of influenza hemagglutinin in isolated endoplasmic reticulum-derived microsomes","volume":"268","author":"Marquardt","year":"1993","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.dci.2016.10.010_bib21","doi-asserted-by":"crossref","first-page":"12364","DOI":"10.1128\/JVI.01381-14","article-title":"Epitope mapping of the hemagglutinin molecule of A\/(H1N1)pdm09 influenza virus by using monoclonal antibody escape mutants","volume":"88","author":"Matsuzaki","year":"2014","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.dci.2016.10.010_bib22","doi-asserted-by":"crossref","first-page":"187ra170","DOI":"10.1126\/scitranslmed.3005996","article-title":"Glycosylations in the globular head of the hemagglutinin protein modulate the virulence and antigenic properties of the H1N1 influenza viruses","volume":"5","author":"Medina","year":"2013","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.dci.2016.10.010_bib23","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/978-1-62703-992-5_28","article-title":"Epitope mapping with random phage display library","volume":"1131","author":"Midoro-Horiuti","year":"2014","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.dci.2016.10.010_bib24","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1164\/rccm.200912-1876ED","article-title":"Swine-origin influenza virus and the 2009 pandemic","volume":"181","author":"Rossman","year":"2010","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.dci.2016.10.010_bib25","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1128\/JCM.37.4.937-943.1999","article-title":"Detection of antibody to avian influenza A (H5N1) virus in human serum by using a combination of serologic assays","volume":"37","author":"Rowe","year":"1999","journal-title":"J.\u00a0Clin. Microbiol."},{"key":"10.1016\/j.dci.2016.10.010_bib26","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1128\/JVI.01920-08","article-title":"Live attenuated influenza viruses containing NS1 truncations as vaccine candidates against H5N1 highly pathogenic avian influenza","volume":"83","author":"Steel","year":"2009","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.dci.2016.10.010_bib27","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.bbrc.2009.03.119","article-title":"Generating and characterizing monoclonal and polyclonal antibodies against avian H5N1 hemagglutinin protein","volume":"382","author":"Wang","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.dci.2016.10.010_bib28","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1002\/jmv.21531","article-title":"Influenza A virus in Taiwan, 1980-2006: phylogenetic and antigenic characteristics of the hemagglutinin gene","volume":"81","author":"Wang","year":"2009","journal-title":"J.\u00a0Med. Virol."},{"key":"10.1016\/j.dci.2016.10.010_bib29","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1126\/science.1186430","article-title":"Structural basis of preexisting immunity to the 2009 H1N1 pandemic influenza virus","volume":"328","author":"Xu","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.dci.2016.10.010_bib30","doi-asserted-by":"crossref","first-page":"e1003150","DOI":"10.1371\/journal.ppat.1003150","article-title":"Human monoclonal antibodies broadly neutralizing against influenza B virus","volume":"9","author":"Yasugi","year":"2013","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.dci.2016.10.010_bib31","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.biologicals.2011.10.002","article-title":"Development and validation of an egg-based potency assay for a trivalent live attenuated influenza vaccine","volume":"40","author":"Yeolekar","year":"2012","journal-title":"Biologicals"}],"container-title":["Developmental & Comparative Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145305X16303718?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145305X16303718?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,6,19]],"date-time":"2022-06-19T02:47:58Z","timestamp":1655606878000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0145305X16303718"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":31,"alternative-id":["S0145305X16303718"],"URL":"https:\/\/doi.org\/10.1016\/j.dci.2016.10.010","relation":{},"ISSN":["0145-305X"],"issn-type":[{"value":"0145-305X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Generation and characterization of new monoclonal antibodies against swine origin 2009 influenza A (H1N1) virus and evaluation of their prophylactic and therapeutic efficacy in a mouse model","name":"articletitle","label":"Article Title"},{"value":"Developmental & Comparative Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dci.2016.10.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}